MA32316B1 - Derives spiro-indoles pour le traitement de maladies parasitaires - Google Patents
Derives spiro-indoles pour le traitement de maladies parasitairesInfo
- Publication number
- MA32316B1 MA32316B1 MA33365A MA33365A MA32316B1 MA 32316 B1 MA32316 B1 MA 32316B1 MA 33365 A MA33365 A MA 33365A MA 33365 A MA33365 A MA 33365A MA 32316 B1 MA32316 B1 MA 32316B1
- Authority
- MA
- Morocco
- Prior art keywords
- treatment
- spiro
- plasmodium
- indole derivatives
- parasitic diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
L'invention concerne des composés organiques qui présentent des propriétés pharmaceutiques intéressantes. En particulier, les composés sont utiles dans le traitement et/ou la prévention d'infections telles que celles causées par plasmodium falciparum, plasmodium vivax, plasmodium malariae, plasmodium ovale, trypanosoma cruzi et des parasites du genre leishmania tels que, par exemple, leishmania donovani. L'invention concerne également des compositions pharmaceutiques contenant les composés, ainsi que des procédés pour leur préparation.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08155342 | 2008-04-29 | ||
EP09151117 | 2009-01-22 | ||
PCT/EP2009/053902 WO2009132921A1 (fr) | 2008-04-29 | 2009-04-01 | Dérivés spiro-indoles pour le traitement de maladies parasitaires |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32316B1 true MA32316B1 (fr) | 2011-05-02 |
Family
ID=40613087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33365A MA32316B1 (fr) | 2008-04-29 | 2010-11-19 | Derives spiro-indoles pour le traitement de maladies parasitaires |
Country Status (31)
Country | Link |
---|---|
US (2) | US8053442B2 (fr) |
EP (2) | EP2285808B1 (fr) |
JP (2) | JP5438098B2 (fr) |
KR (1) | KR101390081B1 (fr) |
CN (1) | CN102015711B (fr) |
AR (1) | AR071222A1 (fr) |
AU (1) | AU2009242279B2 (fr) |
BR (1) | BRPI0911577B8 (fr) |
CA (1) | CA2719365C (fr) |
CL (1) | CL2009001007A1 (fr) |
CO (1) | CO6300940A2 (fr) |
CY (1) | CY1114874T1 (fr) |
DK (1) | DK2285808T3 (fr) |
EA (1) | EA019601B1 (fr) |
EC (2) | ECSP10010646A (fr) |
ES (1) | ES2447590T3 (fr) |
HK (1) | HK1149935A1 (fr) |
HR (1) | HRP20140151T1 (fr) |
IL (1) | IL208357A (fr) |
JO (1) | JO2904B1 (fr) |
MA (1) | MA32316B1 (fr) |
MX (1) | MX2010011868A (fr) |
MY (2) | MY152021A (fr) |
NZ (1) | NZ588217A (fr) |
PE (1) | PE20091787A1 (fr) |
PL (1) | PL2285808T3 (fr) |
PT (1) | PT2285808E (fr) |
SI (1) | SI2285808T1 (fr) |
TW (1) | TWI442921B (fr) |
WO (1) | WO2009132921A1 (fr) |
ZA (1) | ZA201006752B (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2009242279B2 (en) * | 2008-04-29 | 2012-08-30 | Novartis Ag | Spiro-indole derivatives for the treatment of parasitic diseases |
CN102584835B (zh) * | 2011-01-17 | 2014-08-27 | 苏州大学 | 一种含吲哚结构的螺杂环化合物及其制备方法 |
AP2014007906A0 (en) * | 2012-03-23 | 2014-08-31 | Novartis Ag | Chemical process for preparing spiroindolones and intermediates thereof |
EP2828385B1 (fr) | 2012-03-23 | 2018-02-07 | Codexis, Inc. | Biocatalyseurs et procédés pour la synthèse de dérivés de tryptamine et d'analogues de tryptamine |
CN104185634B (zh) * | 2012-03-23 | 2017-05-03 | 诺华股份有限公司 | 制备螺旋吲哚酮和其中间体的化学工艺 |
JP6643987B2 (ja) | 2013-11-13 | 2020-02-12 | コデクシス, インコーポレイテッド | ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法 |
CN107002050A (zh) | 2014-11-25 | 2017-08-01 | 科德克希思公司 | 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法 |
KR20230113416A (ko) | 2014-12-18 | 2023-07-28 | 에프. 호프만-라 로슈 아게 | 테트라하이드로-피리도[3,4-b]인돌 에스트로겐 수용체조절제 및 이의 용도 |
CN107406452B (zh) * | 2015-01-23 | 2019-07-23 | 葛兰素史密斯克莱知识产权发展有限公司 | 吡唑并[3,4-d]嘧啶衍生物及其治疗利什曼病的用途 |
WO2016147205A1 (fr) * | 2015-03-13 | 2016-09-22 | Council Of Scientific & Industrial Research | Nouveaux 3-spirophosphoryl pyrazole-2-oxindoles substitués en tant qu'agents anti-infectieux et procédé de synthèse correspondant |
US11174267B2 (en) | 2015-06-12 | 2021-11-16 | The Regents Of The University Of California | Spiroindolinones and therapeutic uses thereof |
JP2017024992A (ja) * | 2015-07-15 | 2017-02-02 | 公益財団法人微生物化学研究会 | 化合物の製造方法 |
SG11202012171SA (en) | 2018-06-21 | 2021-01-28 | Hoffmann La Roche | Solid forms of 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use |
CN110590795B (zh) * | 2019-10-10 | 2021-01-22 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 一类多并杂环螺羟吲哚类化合物的合成方法 |
WO2021186348A1 (fr) * | 2020-03-17 | 2021-09-23 | The University Of Buea | Dihydro-spiro[indoline-3:1'-isoquinolin]-2-ones utiles en tant qu'agents antipaludiques |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2663935A1 (fr) * | 1990-06-27 | 1992-01-03 | Adir | Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
RU2236413C2 (ru) * | 1998-07-14 | 2004-09-20 | Байер Акциенгезельшафт | Производные артемизинина, способ их получения, фармацевтическая композиция на их основе и способ лечения |
EA004500B1 (ru) | 1998-12-19 | 2004-04-29 | Янссен Фармацевтика Н.В. | Антигистаминные спиросоединения |
US20050143371A1 (en) * | 2003-07-23 | 2005-06-30 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
MY145694A (en) | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
EP2102207B1 (fr) | 2006-12-07 | 2010-06-02 | F.Hoffmann-La Roche Ag | Dérivés de spiro-pipéridine |
EP2219646A4 (fr) * | 2007-12-21 | 2010-12-22 | Univ Rochester | Procédé permettant de modifier la durée de vie d'organismes eucaryotes |
PE20091315A1 (es) | 2008-01-09 | 2009-09-21 | Array Biopharma Inc | Ciclopentanos de pirimidilo como inhibidores de la proteina cinasa akt |
AU2009242279B2 (en) * | 2008-04-29 | 2012-08-30 | Novartis Ag | Spiro-indole derivatives for the treatment of parasitic diseases |
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2009
- 2009-04-01 AU AU2009242279A patent/AU2009242279B2/en active Active
- 2009-04-01 MY MYPI20104473 patent/MY152021A/en unknown
- 2009-04-01 DK DK09737965.5T patent/DK2285808T3/da active
- 2009-04-01 CA CA2719365A patent/CA2719365C/fr active Active
- 2009-04-01 CN CN2009801149364A patent/CN102015711B/zh active Active
- 2009-04-01 KR KR1020107026548A patent/KR101390081B1/ko active IP Right Grant
- 2009-04-01 PL PL09737965T patent/PL2285808T3/pl unknown
- 2009-04-01 EP EP09737965.5A patent/EP2285808B1/fr active Active
- 2009-04-01 NZ NZ588217A patent/NZ588217A/xx unknown
- 2009-04-01 SI SI200930847T patent/SI2285808T1/sl unknown
- 2009-04-01 MX MX2010011868A patent/MX2010011868A/es active IP Right Grant
- 2009-04-01 PT PT97379655T patent/PT2285808E/pt unknown
- 2009-04-01 WO PCT/EP2009/053902 patent/WO2009132921A1/fr active Application Filing
- 2009-04-01 EA EA201001689A patent/EA019601B1/ru not_active IP Right Cessation
- 2009-04-01 JP JP2011506638A patent/JP5438098B2/ja active Active
- 2009-04-01 ES ES09737965.5T patent/ES2447590T3/es active Active
- 2009-04-01 BR BRPI0911577A patent/BRPI0911577B8/pt active IP Right Grant
- 2009-04-01 EP EP13185962.1A patent/EP2722333A1/fr not_active Withdrawn
- 2009-04-01 MY MYPI2013001071A patent/MY156601A/en unknown
- 2009-04-27 US US12/430,625 patent/US8053442B2/en active Active
- 2009-04-27 AR ARP090101487A patent/AR071222A1/es active IP Right Grant
- 2009-04-28 PE PE2009000577A patent/PE20091787A1/es active IP Right Grant
- 2009-04-28 JO JO2009149A patent/JO2904B1/en active
- 2009-04-28 CL CL2009001007A patent/CL2009001007A1/es unknown
- 2009-04-28 TW TW098114086A patent/TWI442921B/zh active
-
2010
- 2010-09-21 IL IL208357A patent/IL208357A/en active IP Right Grant
- 2010-09-21 ZA ZA2010/06752A patent/ZA201006752B/en unknown
- 2010-11-19 MA MA33365A patent/MA32316B1/fr unknown
- 2010-11-25 CO CO10148514A patent/CO6300940A2/es active IP Right Grant
- 2010-11-29 EC EC2010010646A patent/ECSP10010646A/es unknown
-
2011
- 2011-04-27 HK HK11104203.2A patent/HK1149935A1/xx unknown
- 2011-07-19 US US13/186,035 patent/US8399453B2/en active Active
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2013
- 2013-12-12 JP JP2013257004A patent/JP2014065729A/ja active Pending
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2014
- 2014-02-18 HR HRP20140151AT patent/HRP20140151T1/hr unknown
- 2014-02-20 CY CY20141100135T patent/CY1114874T1/el unknown
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2017
- 2017-10-13 EC ECIEPI201768127A patent/ECSP17068127A/es unknown
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