PL2285808T3 - Spiro-indolowe pochodne do leczenia chorób pasożytniczych - Google Patents

Spiro-indolowe pochodne do leczenia chorób pasożytniczych

Info

Publication number
PL2285808T3
PL2285808T3 PL09737965T PL09737965T PL2285808T3 PL 2285808 T3 PL2285808 T3 PL 2285808T3 PL 09737965 T PL09737965 T PL 09737965T PL 09737965 T PL09737965 T PL 09737965T PL 2285808 T3 PL2285808 T3 PL 2285808T3
Authority
PL
Poland
Prior art keywords
spiro
treatment
indole derivatives
parasitic diseases
parasitic
Prior art date
Application number
PL09737965T
Other languages
English (en)
Inventor
Shi Hua Ang
Philipp Krastel
Seh Yong Leong
Liying Jocelyn Tan
Wei Lin Josephine Wong
Bryan Ks Yeung
Bin Zou
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40613087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2285808(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL2285808T3 publication Critical patent/PL2285808T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL09737965T 2008-04-29 2009-04-01 Spiro-indolowe pochodne do leczenia chorób pasożytniczych PL2285808T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP08155342 2008-04-29
EP09151117 2009-01-22
PCT/EP2009/053902 WO2009132921A1 (en) 2008-04-29 2009-04-01 Spiro-indole derivatives for the treatment of parasitic diseases
EP09737965.5A EP2285808B1 (en) 2008-04-29 2009-04-01 Spiro-indole derivatives for the treatment of parasitic diseases

Publications (1)

Publication Number Publication Date
PL2285808T3 true PL2285808T3 (pl) 2014-04-30

Family

ID=40613087

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09737965T PL2285808T3 (pl) 2008-04-29 2009-04-01 Spiro-indolowe pochodne do leczenia chorób pasożytniczych

Country Status (31)

Country Link
US (2) US8053442B2 (pl)
EP (2) EP2285808B1 (pl)
JP (2) JP5438098B2 (pl)
KR (1) KR101390081B1 (pl)
CN (1) CN102015711B (pl)
AR (1) AR071222A1 (pl)
AU (1) AU2009242279B2 (pl)
BR (1) BRPI0911577B8 (pl)
CA (1) CA2719365C (pl)
CL (1) CL2009001007A1 (pl)
CO (1) CO6300940A2 (pl)
CY (1) CY1114874T1 (pl)
DK (1) DK2285808T3 (pl)
EA (1) EA019601B1 (pl)
EC (2) ECSP10010646A (pl)
ES (1) ES2447590T3 (pl)
HK (1) HK1149935A1 (pl)
HR (1) HRP20140151T1 (pl)
IL (1) IL208357A (pl)
JO (1) JO2904B1 (pl)
MA (1) MA32316B1 (pl)
MX (1) MX2010011868A (pl)
MY (2) MY152021A (pl)
NZ (1) NZ588217A (pl)
PE (1) PE20091787A1 (pl)
PL (1) PL2285808T3 (pl)
PT (1) PT2285808E (pl)
SI (1) SI2285808T1 (pl)
TW (1) TWI442921B (pl)
WO (1) WO2009132921A1 (pl)
ZA (1) ZA201006752B (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2447590T3 (es) * 2008-04-29 2014-03-12 Novartis Ag Derivados de espiro-indol para el tratamiento de enfermedades parasitarias
CN102584835B (zh) * 2011-01-17 2014-08-27 苏州大学 一种含吲哚结构的螺杂环化合物及其制备方法
BR112014022909B1 (pt) * 2012-03-23 2021-11-03 Novartis Ag Processo para preparação de espiroindolonas e de seus intermediários
DK2828385T3 (en) 2012-03-23 2018-03-12 Codexis Inc BIOCATALIZATORS AND METHODS FOR SYNTHETIZING DERIVATIVES AND TRYPTAMIN AND TRYPTAMINE ANALOGS
CN104185634B (zh) * 2012-03-23 2017-05-03 诺华股份有限公司 制备螺旋吲哚酮和其中间体的化学工艺
WO2015073555A1 (en) 2013-11-13 2015-05-21 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
SG11201703258PA (en) 2014-11-25 2017-05-30 Codexis Inc Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN117865872A (zh) 2014-12-18 2024-04-12 豪夫迈·罗氏有限公司 四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途
CN107406452B (zh) * 2015-01-23 2019-07-23 葛兰素史密斯克莱知识产权发展有限公司 吡唑并[3,4-d]嘧啶衍生物及其治疗利什曼病的用途
WO2016147205A1 (en) * 2015-03-13 2016-09-22 Council Of Scientific & Industrial Research Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
US11174267B2 (en) 2015-06-12 2021-11-16 The Regents Of The University Of California Spiroindolinones and therapeutic uses thereof
JP2017024992A (ja) * 2015-07-15 2017-02-02 公益財団法人微生物化学研究会 化合物の製造方法
WO2019245974A1 (en) 2018-06-21 2019-12-26 Genentech, Inc. Solid forms of 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
CN110590795B (zh) * 2019-10-10 2021-01-22 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一类多并杂环螺羟吲哚类化合物的合成方法
WO2021186348A1 (en) * 2020-03-17 2021-09-23 The University Of Buea Dihydro-spiro[indoline-3:1'-isoquinolin]-2-ones as antimalarial agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
IL140402A0 (en) * 1998-07-14 2002-02-10 Bayer Ag Antiparasitic artemisinin derivatives (endoperoxides)
BR9916371A (pt) 1998-12-19 2001-09-18 Janssen Pharmaceutica Nv Composto de espiro anti-histamìnico
US20050137220A1 (en) 2003-07-23 2005-06-23 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
AR053710A1 (es) 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
BRPI0720004A2 (pt) 2006-12-07 2013-12-17 Hoffmann La Roche Derivados de espiro-piperidina como antagonista de receptor v1a
EP2219646A4 (en) * 2007-12-21 2010-12-22 Univ Rochester METHOD FOR MODIFYING THE LIFETIME OF EUKARYOTIC ORGANISMS
ES2403284T3 (es) 2008-01-09 2013-05-17 Array Biopharma, Inc. Pirimidil ciclopentanos como inhibidores de la proteína quinasa AKT
ES2447590T3 (es) * 2008-04-29 2014-03-12 Novartis Ag Derivados de espiro-indol para el tratamiento de enfermedades parasitarias

Also Published As

Publication number Publication date
US20110275613A1 (en) 2011-11-10
SI2285808T1 (sl) 2014-03-31
EP2722333A1 (en) 2014-04-23
CY1114874T1 (el) 2016-12-14
DK2285808T3 (da) 2014-02-03
AR071222A1 (es) 2010-06-02
IL208357A (en) 2014-11-30
NZ588217A (en) 2012-10-26
PT2285808E (pt) 2014-02-24
CO6300940A2 (es) 2011-07-21
MX2010011868A (es) 2010-11-26
AU2009242279A1 (en) 2009-11-05
US20090275560A1 (en) 2009-11-05
WO2009132921A1 (en) 2009-11-05
CL2009001007A1 (es) 2010-06-11
HK1149935A1 (en) 2011-10-21
BRPI0911577A2 (pt) 2016-01-05
KR20100135320A (ko) 2010-12-24
CN102015711B (zh) 2013-05-01
ZA201006752B (en) 2011-05-25
HRP20140151T1 (hr) 2014-03-28
AU2009242279B2 (en) 2012-08-30
JP5438098B2 (ja) 2014-03-12
PE20091787A1 (es) 2009-12-14
US8053442B2 (en) 2011-11-08
EP2285808A1 (en) 2011-02-23
MA32316B1 (fr) 2011-05-02
US8399453B2 (en) 2013-03-19
ECSP10010646A (es) 2010-12-30
BRPI0911577B1 (pt) 2021-02-23
EA201001689A1 (ru) 2011-08-30
EA019601B1 (ru) 2014-04-30
BRPI0911577A8 (pt) 2018-03-06
JO2904B1 (en) 2015-09-15
MY156601A (en) 2016-03-15
JP2014065729A (ja) 2014-04-17
TW200948357A (en) 2009-12-01
CA2719365C (en) 2017-03-07
TWI442921B (zh) 2014-07-01
ES2447590T3 (es) 2014-03-12
IL208357A0 (en) 2010-12-30
CN102015711A (zh) 2011-04-13
JP2011518852A (ja) 2011-06-30
EP2285808B1 (en) 2013-11-20
KR101390081B1 (ko) 2014-04-29
BRPI0911577B8 (pt) 2021-05-25
ECSP17068127A (es) 2017-10-31
CA2719365A1 (en) 2009-11-05
MY152021A (en) 2014-08-15

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