ECSP17068127A - Derivados de espiro-indol para el tratamiento de enfermedades parasitarias - Google Patents

Derivados de espiro-indol para el tratamiento de enfermedades parasitarias

Info

Publication number
ECSP17068127A
ECSP17068127A ECIEPI201768127A ECPI201768127A ECSP17068127A EC SP17068127 A ECSP17068127 A EC SP17068127A EC IEPI201768127 A ECIEPI201768127 A EC IEPI201768127A EC PI201768127 A ECPI201768127 A EC PI201768127A EC SP17068127 A ECSP17068127 A EC SP17068127A
Authority
EC
Ecuador
Prior art keywords
treatment
plasmodium
spiro
parasitic diseases
compounds
Prior art date
Application number
ECIEPI201768127A
Other languages
English (en)
Inventor
Liying Jocelyn Tan
Wei Lin Josephine Wong
Philipp Krastel
Bin Zou
Bryan Ks Yeung
Seh Yong Leong
Shi Hua Ang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40613087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP17068127(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP17068127A publication Critical patent/ECSP17068127A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a compuestos orgánicos, los cuales tienen propiedades farmacéuticas interesantes. En particular, los compuestos son útiles en el tratamiento y/o la prevención de infecciones tales como aquéllas causadas por Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi y parásitos del género Leishmania, tales como, por ejemplo, Leishmania donovani. La invención también se refiere a composiciones farmacéuticas que contienen los compuestos, así como a los procesos para su preparación.
ECIEPI201768127A 2008-04-29 2017-10-13 Derivados de espiro-indol para el tratamiento de enfermedades parasitarias ECSP17068127A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08155342 2008-04-29
EP09151117 2009-01-22

Publications (1)

Publication Number Publication Date
ECSP17068127A true ECSP17068127A (es) 2017-10-31

Family

ID=40613087

Family Applications (2)

Application Number Title Priority Date Filing Date
EC2010010646A ECSP10010646A (es) 2008-04-29 2010-11-29 Derivados de espiro-indol para el tratamiento de enfermedades parasitarias
ECIEPI201768127A ECSP17068127A (es) 2008-04-29 2017-10-13 Derivados de espiro-indol para el tratamiento de enfermedades parasitarias

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EC2010010646A ECSP10010646A (es) 2008-04-29 2010-11-29 Derivados de espiro-indol para el tratamiento de enfermedades parasitarias

Country Status (31)

Country Link
US (2) US8053442B2 (es)
EP (2) EP2285808B1 (es)
JP (2) JP5438098B2 (es)
KR (1) KR101390081B1 (es)
CN (1) CN102015711B (es)
AR (1) AR071222A1 (es)
AU (1) AU2009242279B2 (es)
BR (1) BRPI0911577B8 (es)
CA (1) CA2719365C (es)
CL (1) CL2009001007A1 (es)
CO (1) CO6300940A2 (es)
CY (1) CY1114874T1 (es)
DK (1) DK2285808T3 (es)
EA (1) EA019601B1 (es)
EC (2) ECSP10010646A (es)
ES (1) ES2447590T3 (es)
HK (1) HK1149935A1 (es)
HR (1) HRP20140151T1 (es)
IL (1) IL208357A (es)
JO (1) JO2904B1 (es)
MA (1) MA32316B1 (es)
MX (1) MX2010011868A (es)
MY (2) MY152021A (es)
NZ (1) NZ588217A (es)
PE (1) PE20091787A1 (es)
PL (1) PL2285808T3 (es)
PT (1) PT2285808E (es)
SI (1) SI2285808T1 (es)
TW (1) TWI442921B (es)
WO (1) WO2009132921A1 (es)
ZA (1) ZA201006752B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009242279B2 (en) * 2008-04-29 2012-08-30 Novartis Ag Spiro-indole derivatives for the treatment of parasitic diseases
CN102584835B (zh) * 2011-01-17 2014-08-27 苏州大学 一种含吲哚结构的螺杂环化合物及其制备方法
AP2014007906A0 (en) * 2012-03-23 2014-08-31 Novartis Ag Chemical process for preparing spiroindolones and intermediates thereof
EP2828385B1 (en) 2012-03-23 2018-02-07 Codexis, Inc. Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
CN104185634B (zh) * 2012-03-23 2017-05-03 诺华股份有限公司 制备螺旋吲哚酮和其中间体的化学工艺
JP6643987B2 (ja) 2013-11-13 2020-02-12 コデクシス， インコーポレイテッド ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法
CN107002050A (zh) 2014-11-25 2017-08-01 科德克希思公司 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法
KR20230113416A (ko) 2014-12-18 2023-07-28 에프. 호프만-라 로슈 아게 테트라하이드로-피리도[3,4-b]인돌 에스트로겐 수용체조절제 및 이의 용도
CN107406452B (zh) * 2015-01-23 2019-07-23 葛兰素史密斯克莱知识产权发展有限公司 吡唑并[3,4-d]嘧啶衍生物及其治疗利什曼病的用途
WO2016147205A1 (en) * 2015-03-13 2016-09-22 Council Of Scientific & Industrial Research Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
US11174267B2 (en) 2015-06-12 2021-11-16 The Regents Of The University Of California Spiroindolinones and therapeutic uses thereof
JP2017024992A (ja) * 2015-07-15 2017-02-02 公益財団法人微生物化学研究会 化合物の製造方法
SG11202012171SA (en) 2018-06-21 2021-01-28 Hoffmann La Roche Solid forms of 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
CN110590795B (zh) * 2019-10-10 2021-01-22 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一类多并杂环螺羟吲哚类化合物的合成方法
WO2021186348A1 (en) * 2020-03-17 2021-09-23 The University Of Buea Dihydro-spiro[indoline-3:1'-isoquinolin]-2-ones as antimalarial agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
RU2236413C2 (ru) * 1998-07-14 2004-09-20 Байер Акциенгезельшафт Производные артемизинина, способ их получения, фармацевтическая композиция на их основе и способ лечения
EA004500B1 (ru) 1998-12-19 2004-04-29 Янссен Фармацевтика Н.В. Антигистаминные спиросоединения
US20050143371A1 (en) * 2003-07-23 2005-06-30 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
MY145694A (en) 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
EP2102207B1 (en) 2006-12-07 2010-06-02 F.Hoffmann-La Roche Ag Spiro-piperidine derivatives as via receptor antagonists
EP2219646A4 (en) * 2007-12-21 2010-12-22 Univ Rochester METHOD FOR MODIFYING THE LIFETIME OF EUKARYOTIC ORGANISMS
PE20091315A1 (es) 2008-01-09 2009-09-21 Array Biopharma Inc Ciclopentanos de pirimidilo como inhibidores de la proteina cinasa akt
AU2009242279B2 (en) * 2008-04-29 2012-08-30 Novartis Ag Spiro-indole derivatives for the treatment of parasitic diseases

Also Published As

Publication number Publication date
ZA201006752B (en) 2011-05-25
EP2722333A1 (en) 2014-04-23
US8053442B2 (en) 2011-11-08
NZ588217A (en) 2012-10-26
KR101390081B1 (ko) 2014-04-29
TWI442921B (zh) 2014-07-01
HK1149935A1 (en) 2011-10-21
MY152021A (en) 2014-08-15
DK2285808T3 (da) 2014-02-03
US20090275560A1 (en) 2009-11-05
KR20100135320A (ko) 2010-12-24
JP2011518852A (ja) 2011-06-30
PL2285808T3 (pl) 2014-04-30
AU2009242279B2 (en) 2012-08-30
ECSP10010646A (es) 2010-12-30
US20110275613A1 (en) 2011-11-10
JP5438098B2 (ja) 2014-03-12
JP2014065729A (ja) 2014-04-17
EP2285808B1 (en) 2013-11-20
ES2447590T3 (es) 2014-03-12
SI2285808T1 (sl) 2014-03-31
PT2285808E (pt) 2014-02-24
BRPI0911577A2 (pt) 2016-01-05
CO6300940A2 (es) 2011-07-21
US8399453B2 (en) 2013-03-19
WO2009132921A1 (en) 2009-11-05
MA32316B1 (fr) 2011-05-02
EA019601B1 (ru) 2014-04-30
IL208357A (en) 2014-11-30
CA2719365A1 (en) 2009-11-05
CY1114874T1 (el) 2016-12-14
CA2719365C (en) 2017-03-07
CL2009001007A1 (es) 2010-06-11
MX2010011868A (es) 2010-11-26
HRP20140151T1 (hr) 2014-03-28
EP2285808A1 (en) 2011-02-23
IL208357A0 (en) 2010-12-30
CN102015711A (zh) 2011-04-13
PE20091787A1 (es) 2009-12-14
TW200948357A (en) 2009-12-01
BRPI0911577B1 (pt) 2021-02-23
AU2009242279A1 (en) 2009-11-05
BRPI0911577A8 (pt) 2018-03-06
BRPI0911577B8 (pt) 2021-05-25
CN102015711B (zh) 2013-05-01
JO2904B1 (en) 2015-09-15
AR071222A1 (es) 2010-06-02
EA201001689A1 (ru) 2011-08-30
MY156601A (en) 2016-03-15

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