CL2009001007A1 - Compuestos derivados de espiroindol-2-ona derivados, composicion farmaceutica que los comprende y su uso para el tratamiento y/o prevencion de una infeccion parasitaria, tal como la malaria. - Google Patents

Compuestos derivados de espiroindol-2-ona derivados, composicion farmaceutica que los comprende y su uso para el tratamiento y/o prevencion de una infeccion parasitaria, tal como la malaria.

Info

Publication number
CL2009001007A1
CL2009001007A1 CL2009001007A CL2009001007A CL2009001007A1 CL 2009001007 A1 CL2009001007 A1 CL 2009001007A1 CL 2009001007 A CL2009001007 A CL 2009001007A CL 2009001007 A CL2009001007 A CL 2009001007A CL 2009001007 A1 CL2009001007 A1 CL 2009001007A1
Authority
CL
Chile
Prior art keywords
spiroindol
prevention
treatment
compounds derived
malaria
Prior art date
Application number
CL2009001007A
Other languages
English (en)
Inventor
Philipp Krastel
Bin Zou
Bryan Ks Yeung
Shi Hua Ang
Seh Yong Leong
Liying Jocelyn Tan
Wei Lin Josephine Wong
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40613087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2009001007(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2009001007A1 publication Critical patent/CL2009001007A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCIÓN SE REFIERE A LOS SIGUIENTES COMPUESTOS DERIVADOS DE ESPIROINDOL Y SUS SALESFARMACÉUTICAMENTE<br /> ACEPTABLES:<br /> ( 1 R,3S)-5',7-DICLORO-6-FLUORO-3-METIL-2,3,4, 9-TETRAHIDROSPIRO[B-CARBOLIN-1,3'-INDOL]-2'(1 'H)-ONA Y<br /> ( 1 R,3S)-5'-CLORO-6-FLUORO-3-METIL-2,3,4,9-TETRAHIDROSPIRO[B-CARBOLIN-1, 3'-INDOL]-2'(1 'H)-ONA.<br /> LOS COMPUESTOS SON ÚTILES EN EL TRATAMIENTO Y/O LA PREVENCIÓN DE INFECCIONES TALES COMO AQUELLAS CAUSADAS POR<br /> PLASMODIUM FALCIPARUM, PLASMODIUM VIVAX, PLASMODIUM MALARIAE, PLASMODIUM OVALE, TRYPANOSOMA CRUZI Y<br /> PARÁSITOS DEL GÉNERO LEISHMANIA, TALES COMO, POR EJEMPLO, LEISHMANIA DONAVANI. LA INVENCIÓN TAMBIÉN SE REFIERE A<br /> COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS COMPUESTOS.
CL2009001007A 2008-04-29 2009-04-28 Compuestos derivados de espiroindol-2-ona derivados, composicion farmaceutica que los comprende y su uso para el tratamiento y/o prevencion de una infeccion parasitaria, tal como la malaria. CL2009001007A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08155342 2008-04-29
EP09151117 2009-01-22

Publications (1)

Publication Number Publication Date
CL2009001007A1 true CL2009001007A1 (es) 2010-06-11

Family

ID=40613087

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009001007A CL2009001007A1 (es) 2008-04-29 2009-04-28 Compuestos derivados de espiroindol-2-ona derivados, composicion farmaceutica que los comprende y su uso para el tratamiento y/o prevencion de una infeccion parasitaria, tal como la malaria.

Country Status (31)

Country Link
US (2) US8053442B2 (es)
EP (2) EP2722333A1 (es)
JP (2) JP5438098B2 (es)
KR (1) KR101390081B1 (es)
CN (1) CN102015711B (es)
AR (1) AR071222A1 (es)
AU (1) AU2009242279B2 (es)
BR (1) BRPI0911577B8 (es)
CA (1) CA2719365C (es)
CL (1) CL2009001007A1 (es)
CO (1) CO6300940A2 (es)
CY (1) CY1114874T1 (es)
DK (1) DK2285808T3 (es)
EA (1) EA019601B1 (es)
EC (2) ECSP10010646A (es)
ES (1) ES2447590T3 (es)
HK (1) HK1149935A1 (es)
HR (1) HRP20140151T1 (es)
IL (1) IL208357A (es)
JO (1) JO2904B1 (es)
MA (1) MA32316B1 (es)
MX (1) MX2010011868A (es)
MY (2) MY156601A (es)
NZ (1) NZ588217A (es)
PE (1) PE20091787A1 (es)
PL (1) PL2285808T3 (es)
PT (1) PT2285808E (es)
SI (1) SI2285808T1 (es)
TW (1) TWI442921B (es)
WO (1) WO2009132921A1 (es)
ZA (1) ZA201006752B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2722333A1 (en) * 2008-04-29 2014-04-23 Novartis AG Spiro-indole derivatives for the treatment of parasitic diseases.
CN102584835B (zh) * 2011-01-17 2014-08-27 苏州大学 一种含吲哚结构的螺杂环化合物及其制备方法
CN104508126B (zh) 2012-03-23 2017-06-30 科德克希思公司 用于合成色胺和色胺类似物的衍生物的生物催化剂和方法
LT2828256T (lt) * 2012-03-23 2019-09-25 Novartis Ag Spiroindolonų ir jų tarpinių junginių gavimo būdas
CN104185634B (zh) * 2012-03-23 2017-05-03 诺华股份有限公司 制备螺旋吲哚酮和其中间体的化学工艺
EP3068793B1 (en) 2013-11-13 2021-02-17 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
WO2016085916A1 (en) 2014-11-25 2016-06-02 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
MA53837A (fr) 2014-12-18 2021-11-10 Hoffmann La Roche Tetrahydro-pyrido[3,4-b]indoles modulateurs des récepteurs des oestrogènes et leurs utilisations
UA120385C2 (uk) * 2015-01-23 2019-11-25 Глаксосмітклайн Інтеллектьюел Проперті Девелопмент Лімітед ПОХІДНА ПІРАЗОЛО[3,4-d]ПІРИМІДИНУ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ЛІКУВАННІ ЛЕЙШМАНІОЗУ
WO2016147205A1 (en) * 2015-03-13 2016-09-22 Council Of Scientific & Industrial Research Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
WO2016201440A1 (en) * 2015-06-12 2016-12-15 The Regents Of The University Of California Spiroindolinones and therapeutic uses thereof
JP2017024992A (ja) * 2015-07-15 2017-02-02 公益財団法人微生物化学研究会 化合物の製造方法
SI3810283T1 (sl) 2018-06-21 2023-10-30 F. Hoffmann-La Roche Ag Trdne oblike tartratne soli 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropil)azetidin-3-il)amino) fenil)-3-metil-1,3,4,9-tetrahidro-2H-pirido(3,4-b)indol-2-il)-2,2- difluoropropan-1-ola, postopek za njihovo pripravo in metode njihove uporabe pri zdravljenju raka
CN110590795B (zh) * 2019-10-10 2021-01-22 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一类多并杂环螺羟吲哚类化合物的合成方法
US20230132973A1 (en) * 2020-03-17 2023-05-04 The University Of Buea DIHYDRO-SPIRO[INDOLINE-3:1'-iSOQUINOLIN]-2-ONES AS ANTIMALARIAL AGENTS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
SK542001A3 (en) * 1998-07-14 2001-08-06 Bayer Ag Antiparasitic artemisinin derivatives (endoperoxides)
DE69925036T2 (de) 1998-12-19 2006-01-26 Janssen Pharmaceutica N.V. Spiro verbindungen mit antihistaminischer aktivität
US20050101623A1 (en) * 2003-07-23 2005-05-12 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
MY145694A (en) 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
CN101547923A (zh) 2006-12-07 2009-09-30 弗·哈夫曼-拉罗切有限公司 作为via受体拮抗剂的螺环-哌啶衍生物
CA2709784A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
PE20091315A1 (es) 2008-01-09 2009-09-21 Array Biopharma Inc Ciclopentanos de pirimidilo como inhibidores de la proteina cinasa akt
EP2722333A1 (en) * 2008-04-29 2014-04-23 Novartis AG Spiro-indole derivatives for the treatment of parasitic diseases.

Also Published As

Publication number Publication date
HK1149935A1 (en) 2011-10-21
DK2285808T3 (da) 2014-02-03
US8399453B2 (en) 2013-03-19
PL2285808T3 (pl) 2014-04-30
CN102015711A (zh) 2011-04-13
IL208357A0 (en) 2010-12-30
ECSP17068127A (es) 2017-10-31
ES2447590T3 (es) 2014-03-12
MA32316B1 (fr) 2011-05-02
SI2285808T1 (sl) 2014-03-31
JP5438098B2 (ja) 2014-03-12
TW200948357A (en) 2009-12-01
CY1114874T1 (el) 2016-12-14
AR071222A1 (es) 2010-06-02
WO2009132921A1 (en) 2009-11-05
US8053442B2 (en) 2011-11-08
MY156601A (en) 2016-03-15
HRP20140151T1 (hr) 2014-03-28
BRPI0911577A2 (pt) 2016-01-05
JP2014065729A (ja) 2014-04-17
BRPI0911577B1 (pt) 2021-02-23
MX2010011868A (es) 2010-11-26
EA201001689A1 (ru) 2011-08-30
KR101390081B1 (ko) 2014-04-29
AU2009242279A1 (en) 2009-11-05
PT2285808E (pt) 2014-02-24
EP2285808B1 (en) 2013-11-20
EP2722333A1 (en) 2014-04-23
AU2009242279B2 (en) 2012-08-30
BRPI0911577B8 (pt) 2021-05-25
TWI442921B (zh) 2014-07-01
US20090275560A1 (en) 2009-11-05
CA2719365A1 (en) 2009-11-05
EA019601B1 (ru) 2014-04-30
MY152021A (en) 2014-08-15
IL208357A (en) 2014-11-30
CA2719365C (en) 2017-03-07
KR20100135320A (ko) 2010-12-24
CO6300940A2 (es) 2011-07-21
CN102015711B (zh) 2013-05-01
JO2904B1 (en) 2015-09-15
PE20091787A1 (es) 2009-12-14
BRPI0911577A8 (pt) 2018-03-06
EP2285808A1 (en) 2011-02-23
ZA201006752B (en) 2011-05-25
US20110275613A1 (en) 2011-11-10
NZ588217A (en) 2012-10-26
ECSP10010646A (es) 2010-12-30
JP2011518852A (ja) 2011-06-30

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