PE20091753A1 - Conjugados antagonistas peptidicos analogos a la bombesina - Google Patents
Conjugados antagonistas peptidicos analogos a la bombesinaInfo
- Publication number
- PE20091753A1 PE20091753A1 PE2009000339A PE2009000339A PE20091753A1 PE 20091753 A1 PE20091753 A1 PE 20091753A1 PE 2009000339 A PE2009000339 A PE 2009000339A PE 2009000339 A PE2009000339 A PE 2009000339A PE 20091753 A1 PE20091753 A1 PE 20091753A1
- Authority
- PE
- Peru
- Prior art keywords
- leu
- xaa211
- gln7
- his12
- val10
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
REFERIDA A UN CONJUGADO PEPTIDICO ANALOGO A LA BOMBESINA DE FORMULA [A-(B)n]x-C (I), DONDE x ES UN ENTERO DE 1 A 3; n ES UN ENTERO DE 1 A 6; A ES UN QUELANTE PARA METALES TAL COMO DOTA-, EDTA-, TRITA-, ENTRE OTROS, QUE COMPRENDE AL MENOS UN RADIONUCLIDO DE METAL TAL COMO 67Ga, 64Cu, 51Cr; ENTRE OTROS; B ES UN SEPARADOR CONECTADO AL N-TERMINAL DE C REPRESENTADO POR LA FORMULA (B1-B2); B1 ES UNA UNION COVALENTE, UN AMINOACIDO NATURAL, UNA DIAMINA LINEAL O UNA DIAMINA CICLICA; B2 ES UNA UNION COVALENTE, UN AMINOACIDO NATURAL, UN AMINOACIDO NO NATURAL, UN ACIDO CARBOXILICO CICLICO O UN ACIDO CARBOXILICO LINEAL; C ES UN ANTAGONISTA PEPTIDICO ANALOGO A LA BOMBESINA CON LA SECUENCIA C-1 A C-4; C-1 ES Xaa16-Gln7-Trp8-Ala9-Val10-Xaa211-His12-Xaa313-Xaa414-ZH; Xaa1 ES D-Fe, D-Cpa, D-Tyr, ENTRE OTROS; Xaa2 ES Gli O BETA-Ala; Xaa3 ES UNA ESTATINA, 4-Am, 5-MeHpA, ENTRE OTROS; Xaa4 ES Leu, Cpa, Met, ENTRE OTROS; Z ES NH U O; C-2 ES Xaa16-Gln7-Trp8-Ala9-Val10-Xaa211-His12-Leu PSI (CHOH-CH2)-(CH2)2-CH3; C-3 ES Xaa16-Gln7-Trp8-Ala9-Val10-Xaa211-His12-Xaa513-Xaa614-ZH; Xaa5 ES Leu PSI-CH2NH-; Xaa6 ES Cys, Phe, Trp, ENTRE OTROS; C-4 ES Xaa16-Gln7-Trp8-Ala9-Val10-Xaa211-His12-Xaa7; Xaa7 ES Leu-O-ALQUILO O Leu-NH-ALQUILO. TAMBIEN ESTA REFERIDA A UN RADIOFARMACO QUE SE UNE A LOS RECEPTORES DE BOMBESINA, PARTICULARMENTE, AL RECEPTOR DEL PEPTIDO LIBERADOR DE GASTRINA (GRP) Y SON UTILES COMO AGENTES DE DIAGNOSTICO POR IMAGENES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08075180A EP2100900A1 (en) | 2008-03-07 | 2008-03-07 | Bombesin analog peptide antagonist conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091753A1 true PE20091753A1 (es) | 2009-12-13 |
Family
ID=39677415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000339A PE20091753A1 (es) | 2008-03-07 | 2009-03-06 | Conjugados antagonistas peptidicos analogos a la bombesina |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US9035023B2 (es) |
| EP (2) | EP2100900A1 (es) |
| JP (1) | JP5784911B2 (es) |
| KR (2) | KR20160128425A (es) |
| CN (1) | CN101965358B (es) |
| AR (1) | AR070809A1 (es) |
| AU (1) | AU2009221204C1 (es) |
| BR (1) | BRPI0909823B1 (es) |
| CA (1) | CA2717427C (es) |
| CL (1) | CL2009000537A1 (es) |
| CO (1) | CO6290707A2 (es) |
| CR (1) | CR11671A (es) |
| CY (1) | CY1118687T1 (es) |
| DK (1) | DK2252628T3 (es) |
| DO (1) | DOP2010000269A (es) |
| EC (1) | ECSP10010467A (es) |
| ES (1) | ES2615805T3 (es) |
| HU (1) | HUE032980T2 (es) |
| MX (1) | MX2010009843A (es) |
| NZ (1) | NZ587795A (es) |
| PA (1) | PA8818501A1 (es) |
| PE (1) | PE20091753A1 (es) |
| PL (1) | PL2252628T3 (es) |
| PT (1) | PT2252628T (es) |
| RU (1) | RU2523531C2 (es) |
| SI (1) | SI2252628T1 (es) |
| SV (1) | SV2010003660A (es) |
| TW (1) | TWI515011B (es) |
| UA (1) | UA103314C2 (es) |
| UY (1) | UY31693A (es) |
| WO (1) | WO2009109332A1 (es) |
| ZA (1) | ZA201006385B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2380596A1 (en) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopentapeptide derivatives and uses thereof |
| EP2380597A1 (en) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopeptide derivatives and uses thereof |
| JP2014500262A (ja) * | 2010-11-22 | 2014-01-09 | ピラマル イメージング ソシエテ アノニム | 放射線治療のための１７７ルテチウム標識されたボンベシン類似体 |
| EP2710027A1 (en) * | 2011-05-19 | 2014-03-26 | Universitätsspital Basel | Bombesin receptor targeting peptide incorporating a 1, 2, 3-triazole group in the backbone for preparing in vivo diagnostic and therapeutic agents |
| MX362675B (es) | 2012-09-25 | 2019-01-30 | Advanced Accelerator Applications Usa Inc | Antagonistas de receptores de péptido liberadores de gastrina para la detección, diagnóstico y tratamiento de cáncer positivo a receptores de péptido liberadores de gastrina. |
| EP2740726A1 (en) | 2012-12-07 | 2014-06-11 | 3B Pharmaceuticals GmbH | Neurotensin receptor ligands |
| WO2014164988A1 (en) * | 2013-03-13 | 2014-10-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tetrahydroxamate chelators of zirconium89 and niobium90 for use in diagnostic applications |
| US20150217006A1 (en) * | 2014-02-06 | 2015-08-06 | Immunomedics, Inc. | Al-f-18-labeled, al-f-19-labeled and ga-68-labeled gastrin-releasing peptide receptor (grpr)-antagonists for imaging of prostate cancer |
| AU2014396468B2 (en) | 2014-06-06 | 2019-02-21 | Technische Universitat Munchen | Modified cyclopentapeptides and uses thereof |
| EP2954934A1 (en) | 2014-06-11 | 2015-12-16 | 3B Pharmaceuticals GmbH | Conjugate comprising a neurotensin receptor ligand and use thereof |
| EP2954933A1 (en) | 2014-06-10 | 2015-12-16 | 3B Pharmaceuticals GmbH | Conjugate comprising a neurotensin receptor ligand |
| US10799605B2 (en) | 2014-06-10 | 2020-10-13 | 3B Pharmaceuticals Gmbh | Conjugate comprising a neurotensin receptor ligand and use thereof |
| CN113827708A (zh) | 2014-06-16 | 2021-12-24 | 科德克希思公司 | 用于治疗麸质不耐受和由其引起的病症的组合物和方法 |
| CN104610431B (zh) * | 2014-11-26 | 2017-12-15 | 南京市第一医院 | 一种多肽及其应用 |
| EP3393502A4 (en) | 2015-12-16 | 2019-06-12 | Nepetx, LLC | COMPOSITIONS AND METHODS OF TREATING GLUTENEAL COMPATIBILITY AND DISORDERS ARISING FROM THE DISEASE |
| EP3279197A1 (en) | 2016-08-03 | 2018-02-07 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Diagnosis, treatment and prevention of neurotensin receptor-related conditions |
| US11241511B2 (en) | 2016-12-29 | 2022-02-08 | The General Hospital Corporation | HER3 peptides for imaging and radiotherapy |
| JP7084417B2 (ja) | 2017-01-12 | 2022-06-14 | ラジオメディックス インコーポレイテッド | 放射性同位体にキレートされたオクトレオチド誘導体を用いるソマトスタチン受容体を過剰発現しているがん細胞の治療 |
| RU2681318C1 (ru) * | 2017-11-24 | 2019-03-06 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Способ получения иммуносупрессорного пептида Abu-TGIRIS-Abu, меченного ионом Gd3+ |
| AU2019469641A1 (en) | 2018-11-13 | 2021-07-01 | Provincial Health Services Authority | Radiolabeled bombesin-derived compounds for in vivo imaging of gastrin-releasing peptide receptor (GRPR) and treatment of GRPR-related disorders |
| BR112022000144A2 (pt) | 2019-07-08 | 2022-02-22 | 3B Pharmaceuticals Gmbh | Compostos que compreendem um ligante de proteína de ativação de fibroblastos e uso dos mesmos |
| EP3763726A1 (en) | 2019-07-08 | 2021-01-13 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| KR20220118464A (ko) * | 2019-12-19 | 2022-08-25 | 테크니쉐 우니베르지테트 뮌헨 | 암의 영상화 및 치료법을 위한 개선된 약동학을 갖는 화합물 |
| WO2021250240A1 (en) | 2020-06-12 | 2021-12-16 | Orano | Diaza-18-crown-6 derivative useful for chelating radium, conjugate and radium chelate comprising the same, and uses thereof |
| EP3973999A1 (en) | 2020-09-28 | 2022-03-30 | Orano Med | Conjugate or its salt comprising a gastrin-releasing peptide receptor antagonist and uses thereof |
| WO2022123462A1 (en) | 2020-12-09 | 2022-06-16 | 3B Pharmaceuticals Gmbh | Radiolabelled prostate specific membrane antigen (psma) inhibitors and use thereof |
| EP4050018A1 (en) | 2021-01-07 | 2022-08-31 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| AU2022410422A1 (en) | 2021-12-17 | 2024-07-04 | 3B Pharmaceuticals Gmbh | Carbonic anhydrase ix ligands |
| WO2024052431A1 (en) | 2022-09-07 | 2024-03-14 | 3B Pharmaceuticals Gmbh | Prostate specific membrane antigen (psma) ligands and use thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4885363A (en) | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| US5021556A (en) | 1987-07-22 | 1991-06-04 | Neorx Corporation | Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides |
| US5075099A (en) | 1988-05-31 | 1991-12-24 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
| ES2070329T3 (es) * | 1989-07-20 | 1995-06-01 | Sandoz Ltd | Derivados de polipeptidos. |
| US5367080A (en) | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
| US5369094A (en) * | 1990-11-29 | 1994-11-29 | The Administrators Of The Tulane Educational Fund | Polypeptide bombesin antagonists |
| US5965107A (en) | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| EP0977579B1 (en) | 1997-04-22 | 2009-03-11 | Curator Of The University Of Missouri | Gastrin receptor-avid peptide conjugates |
| CA2346154A1 (en) | 2001-05-02 | 2002-11-02 | University Of Missouri | Gastrin receptor-avid peptide conjugates |
| US5886142A (en) | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
| AU2012199A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| KR20010033595A (ko) | 1997-12-24 | 2001-04-25 | 버텍스 파마슈티칼스 인코포레이티드 | 아스파틸 프로테아제 억제제의 전구약물 |
| AU2010299A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
| GR1003661B (el) * | 2000-05-25 | 2001-09-05 | Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... | ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ |
| EP1343498A1 (en) * | 2000-12-20 | 2003-09-17 | Warner-Lambert Company LLC | Novel uses of non-peptide bombesin receptor antagonists for treating anxiety and panic disorders |
| US7850947B2 (en) | 2003-01-13 | 2010-12-14 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7922998B2 (en) * | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7226577B2 (en) * | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US20080008649A1 (en) | 2003-01-13 | 2008-01-10 | Bracco Imaging S.P.A. | Gastrin Releasing Peptide Compounds |
| EP1654005A4 (en) * | 2003-07-24 | 2011-06-15 | Bracco Imaging Spa | STABLE RADIOPHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR PREPARATION |
| US20090062509A1 (en) | 2006-03-16 | 2009-03-05 | Aldo Cagnolini | Chelation of metals to thiol groups using in situ reduction of disulfide-containing compounds by phosphines |
| JP2014500262A (ja) * | 2010-11-22 | 2014-01-09 | ピラマル イメージング ソシエテ アノニム | 放射線治療のための１７７ルテチウム標識されたボンベシン類似体 |
-
2008
- 2008-03-07 EP EP08075180A patent/EP2100900A1/en not_active Withdrawn
-
2009
- 2009-02-27 AU AU2009221204A patent/AU2009221204C1/en active Active
- 2009-02-27 PL PL09717301T patent/PL2252628T3/pl unknown
- 2009-02-27 JP JP2010549043A patent/JP5784911B2/ja active Active
- 2009-02-27 KR KR1020167029634A patent/KR20160128425A/ko not_active Application Discontinuation
- 2009-02-27 PT PT97173017T patent/PT2252628T/pt unknown
- 2009-02-27 ES ES09717301.7T patent/ES2615805T3/es active Active
- 2009-02-27 WO PCT/EP2009/001403 patent/WO2009109332A1/en active Application Filing
- 2009-02-27 BR BRPI0909823-2A patent/BRPI0909823B1/pt active IP Right Grant
- 2009-02-27 EP EP09717301.7A patent/EP2252628B1/en active Active
- 2009-02-27 NZ NZ587795A patent/NZ587795A/en unknown
- 2009-02-27 UA UAA201011560A patent/UA103314C2/ru unknown
- 2009-02-27 RU RU2010140846/04A patent/RU2523531C2/ru active
- 2009-02-27 CN CN200980107992.5A patent/CN101965358B/zh active Active
- 2009-02-27 DK DK09717301.7T patent/DK2252628T3/en active
- 2009-02-27 US US12/921,209 patent/US9035023B2/en active Active
- 2009-02-27 CA CA2717427A patent/CA2717427C/en active Active
- 2009-02-27 SI SI200931607A patent/SI2252628T1/sl unknown
- 2009-02-27 HU HUE09717301A patent/HUE032980T2/en unknown
- 2009-02-27 MX MX2010009843A patent/MX2010009843A/es not_active Application Discontinuation
- 2009-02-27 KR KR1020107022308A patent/KR101734553B1/ko active IP Right Grant
- 2009-03-06 PE PE2009000339A patent/PE20091753A1/es not_active Application Discontinuation
- 2009-03-06 TW TW098107446A patent/TWI515011B/zh active
- 2009-03-06 UY UY0001031693A patent/UY31693A/es not_active Application Discontinuation
- 2009-03-06 CL CL2009000537A patent/CL2009000537A1/es unknown
- 2009-03-06 PA PA20098818501A patent/PA8818501A1/es unknown
- 2009-03-06 AR ARP090100799A patent/AR070809A1/es not_active Application Discontinuation
-
2010
- 2010-09-06 ZA ZA2010/06385A patent/ZA201006385B/en unknown
- 2010-09-06 CO CO10110036A patent/CO6290707A2/es not_active Application Discontinuation
- 2010-09-07 DO DO2010000269A patent/DOP2010000269A/es unknown
- 2010-09-07 EC EC2010010467A patent/ECSP10010467A/es unknown
- 2010-09-07 SV SV2010003660A patent/SV2010003660A/es not_active Application Discontinuation
- 2010-09-07 CR CR11671A patent/CR11671A/es not_active Application Discontinuation
-
2015
- 2015-03-27 US US14/671,106 patent/US20150265733A1/en not_active Abandoned
-
2017
- 2017-02-07 CY CY20171100170T patent/CY1118687T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20091753A1 (es) | Conjugados antagonistas peptidicos analogos a la bombesina | |
| HRP20120621T1 (hr) | Sna“ni analozi kompstatina | |
| CL2017001190A1 (es) | Nuevos agonistas de npr-b. (divisional de solicitud 715-2012) | |
| PE20091783A1 (es) | Anticuerpos anti-factor d humanizados | |
| CO6150201A2 (es) | Anticuerpo humanizado contra beta amiloide | |
| ATE495197T1 (de) | Chimäre konstrukte zwischen auf krebs zielenden peptiden und zellpenetrierenden peptiden gekoppelt an antikrebsmittel und/oder diagnostische mittel | |
| RU2011138011A (ru) | Миметики аполипопротеина а-i | |
| ES2683372T3 (es) | Derivados de GLP-1 acilados con un conector nuevo | |
| PE20120331A1 (es) | Agentes medicinales unidos a dipeptido | |
| PE20161153A1 (es) | Insulina de accion prolongada y uso de la misma | |
| MX2015006868A (es) | Metodos para la elaboracion de conjugados a partir de proteinas que contienen disulfuro. | |
| MX2010004571A (es) | Composiciones y metodos que comprenden peptidos y proteasas de aminoacidos basicos. | |
| ATE404225T1 (de) | Radiofluorierte peptide | |
| NZ600732A (en) | Oxyntomodulin peptide analogue | |
| AR081339A1 (es) | Conjugados peptidicos | |
| PE20150181A1 (es) | Variantes de oxm pegilada | |
| IN2014CN02050A (es) | ||
| SG10201807877TA (en) | Hybrid immunoglobulin containing non-peptidyl linkage | |
| MX369282B (es) | Composiciones para el cuidado oral, prebioticas, que contienen aminoacidos. | |
| NZ612161A (en) | Radiolabled her2 binding peptides | |
| PE20140260A1 (es) | Compuestos antidiabeticos | |
| MX2022000251A (es) | Compuestos que comprenden un ligando de proteina de activacion de fibroblasto y uso del mismo. | |
| CL2011002703A1 (es) | Anticuerpo aislado o fragmento de este porque se une a los residuos de los aminoacidos del receptor tipo toll 3 (toll3); composicion farmaceutica que lo comprende. | |
| EA200702012A1 (ru) | Пептиды механо-фактора роста и их применение | |
| WO2006108686A3 (en) | Bnp agonists |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |