AR070809A1 - Conjugados antagonistas peptidicos analogos a la bombesina - Google Patents
Conjugados antagonistas peptidicos analogos a la bombesinaInfo
- Publication number
- AR070809A1 AR070809A1 ARP090100799A ARP090100799A AR070809A1 AR 070809 A1 AR070809 A1 AR 070809A1 AR P090100799 A ARP090100799 A AR P090100799A AR P090100799 A ARP090100799 A AR P090100799A AR 070809 A1 AR070809 A1 AR 070809A1
- Authority
- AR
- Argentina
- Prior art keywords
- cpa
- trp
- xaa211
- gln7
- his12
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicacion 1: Un conjugado antagonista peptídico análogo a la bombesina con la formula general (1): [A-(B)n]x-C (1) caracterizado porque x es un entero entre 1 y 3; n es un entero entre 1 y 6; A es un quelante para metales que comprende por lo menos un radionuclido de metal; B es un conector separador que conecta con un N terminal de C o una union covalente; C es un antagonista peptídico análogo a la bombesina con la secuencia C-1 a C-4, donde: C-1: Xaa16-Gln7-Trp8-Ala9-Val10-Xaa211-His12-Xaa313-Xaa414-ZH, donde: Xaa1 es D-Fe, D-Cpa, D-Tyr, D-Trp o un residuo cualquiera seleccionado del grupo de formulas (2); K es F, Cl, I o NO2; Xaa2 es Gli o b-Ala, Xaa3 es estatina, análogos e isomeros de estatina, 4-Am, 5-MeHpA, 4-Am, 5-MeHxA o aminoácidos sustituidos en a; Xaa4 es Leu, Cpa, Cba, CpnA, Cha, t-buGly, tBuAla, Met, Nle, o iso-Bu-Gly, y Z es NH; O; C-2: Xaa16-Gln7-Trp8-Ala9-Val10-Xaa211-His12-Leuy(CHOH-CH2)-(CH2)2-CH3 donde: Leuy(CHOH-CH2)-(CH2)2-CH3 es un resto de formula (3); Xaa1 es D-Fe, D-Cpa, D-Tyr, D-Trp o un residuo cualquiera seleccionado del grupo de formulas (2); y K es F, Cl, I, o NO2; Xaa2 es Gli o b-Ala; C-3: Xaa16-Gln7-Trp8-Ala9-Val10-Xaa211-His12-Xaa513-Xaa614-ZH donde: Xaa1 es D-Fe, D-Cpa, D-Tyr, D-Trp o un residuo cualquiera seleccionado del grupo de formulas (2); K es F, Cl, I, o NO2; Xaa2 es Gli o b-Ala; Xaa5 es Leuy-CH2NH-; Xaa6 es Cys, Phe, Trp, Tpi o Tac, donde Tpi y Tac tienen el significado de las formulas (4) y (5); y Z es NH, u O; C-4: Xaa16-Gln7-Trp8-Ala9-Val10-Xaa211-His12-Xaa7, donde: Xaa1 es D-Fe, D-Cpa, D-Tyr, D-Trp o un residuo cualquiera seleccionado del grupo de formulas (2); K es F, Cl, I, o NO2; Xaa2 es Gli o b-Ala; Xaa7 es Leu-O-alquilo, o Leu-NH-alquilo; y sales con un ácido inorgánico u orgánico, hidratos, complejos, ésteres, amidas, solvatos y prodrogas de los mismos aceptables para uso farmacéutico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08075180A EP2100900A1 (en) | 2008-03-07 | 2008-03-07 | Bombesin analog peptide antagonist conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070809A1 true AR070809A1 (es) | 2010-05-05 |
Family
ID=39677415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100799A AR070809A1 (es) | 2008-03-07 | 2009-03-06 | Conjugados antagonistas peptidicos analogos a la bombesina |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US9035023B2 (es) |
| EP (2) | EP2100900A1 (es) |
| JP (1) | JP5784911B2 (es) |
| KR (2) | KR101734553B1 (es) |
| CN (1) | CN101965358B (es) |
| AR (1) | AR070809A1 (es) |
| AU (1) | AU2009221204C1 (es) |
| BR (1) | BRPI0909823B1 (es) |
| CA (1) | CA2717427C (es) |
| CL (1) | CL2009000537A1 (es) |
| CO (1) | CO6290707A2 (es) |
| CR (1) | CR11671A (es) |
| CY (1) | CY1118687T1 (es) |
| DK (1) | DK2252628T3 (es) |
| DO (1) | DOP2010000269A (es) |
| EC (1) | ECSP10010467A (es) |
| ES (1) | ES2615805T3 (es) |
| HU (1) | HUE032980T2 (es) |
| MX (1) | MX2010009843A (es) |
| NZ (1) | NZ587795A (es) |
| PA (1) | PA8818501A1 (es) |
| PE (1) | PE20091753A1 (es) |
| PL (1) | PL2252628T3 (es) |
| PT (1) | PT2252628T (es) |
| RU (1) | RU2523531C2 (es) |
| SI (1) | SI2252628T1 (es) |
| SV (1) | SV2010003660A (es) |
| TW (1) | TWI515011B (es) |
| UA (1) | UA103314C2 (es) |
| UY (1) | UY31693A (es) |
| WO (1) | WO2009109332A1 (es) |
| ZA (1) | ZA201006385B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2380597A1 (en) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopeptide derivatives and uses thereof |
| EP2380596A1 (en) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopentapeptide derivatives and uses thereof |
| CN103476434A (zh) * | 2010-11-22 | 2013-12-25 | 皮拉马影像股份公司 | 用于放射治疗的177镥标记的铃蟾肽类似物 |
| EP2710027A1 (en) * | 2011-05-19 | 2014-03-26 | Universitätsspital Basel | Bombesin receptor targeting peptide incorporating a 1, 2, 3-triazole group in the backbone for preparing in vivo diagnostic and therapeutic agents |
| HUE045724T2 (hu) | 2012-09-25 | 2020-01-28 | Advanced Accelerator Applications Usa Inc | GRPR antagonisták GRPR-pozitív rák kimutatására, diagnózisára és kezelésére |
| EP2740726A1 (en) | 2012-12-07 | 2014-06-11 | 3B Pharmaceuticals GmbH | Neurotensin receptor ligands |
| US10137212B2 (en) | 2013-03-13 | 2018-11-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tetrahydroxamate chelators of zirconium89 and niobium90 for use in diagnostic applications |
| US20150217006A1 (en) * | 2014-02-06 | 2015-08-06 | Immunomedics, Inc. | Al-f-18-labeled, al-f-19-labeled and ga-68-labeled gastrin-releasing peptide receptor (grpr)-antagonists for imaging of prostate cancer |
| CN106573959B (zh) | 2014-06-06 | 2022-03-25 | 慕尼黑工业大学 | 修饰的环五肽及其用途 |
| EP2954934A1 (en) | 2014-06-11 | 2015-12-16 | 3B Pharmaceuticals GmbH | Conjugate comprising a neurotensin receptor ligand and use thereof |
| EP2954933A1 (en) | 2014-06-10 | 2015-12-16 | 3B Pharmaceuticals GmbH | Conjugate comprising a neurotensin receptor ligand |
| WO2015188934A1 (en) | 2014-06-10 | 2015-12-17 | 3B Pharmaceuticals Gmbh | Conjugate comprising a neurotensin receptor ligand and use thereof |
| EP3943104A1 (en) | 2014-06-16 | 2022-01-26 | Codexis, Inc. | Compositions and methods for treating gluten intolerance and disorders arising therefrom |
| CN104610431B (zh) * | 2014-11-26 | 2017-12-15 | 南京市第一医院 | 一种多肽及其应用 |
| WO2017106798A2 (en) | 2015-12-16 | 2017-06-22 | Nepetx, Llc | Compositions and methods for treating gluten intolerance and disorders arising therefrom |
| EP3279197A1 (en) | 2016-08-03 | 2018-02-07 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Diagnosis, treatment and prevention of neurotensin receptor-related conditions |
| WO2018126183A2 (en) * | 2016-12-29 | 2018-07-05 | The General Hospital Corporation | Her3 peptides for imaging and radiotherapy |
| CA3050094C (en) | 2017-01-12 | 2024-01-02 | Radiomedix Inc. | Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes |
| RU2681318C1 (ru) * | 2017-11-24 | 2019-03-06 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Способ получения иммуносупрессорного пептида Abu-TGIRIS-Abu, меченного ионом Gd3+ |
| CN113454098A (zh) * | 2018-11-13 | 2021-09-28 | 省卫生服务机构 | 用于胃泌素释放肽受体(grpr)的体内成像和治疗grpr相关病症的放射性标记蛙皮素衍生化合物 |
| CA3145872A1 (en) | 2019-07-08 | 2021-01-14 | 3B Pharmaceuticals Gmbh | Compounds comprising a fibroblast activation protein ligand and use thereof |
| EP3763726A1 (en) | 2019-07-08 | 2021-01-13 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| MX2022007260A (es) * | 2019-12-19 | 2022-07-19 | Univ Muenchen Tech | Compuestos con farmacocinetica mejorada para la obtencion de imagenes y la terapia del cancer. |
| WO2021250240A1 (en) | 2020-06-12 | 2021-12-16 | Orano | Diaza-18-crown-6 derivative useful for chelating radium, conjugate and radium chelate comprising the same, and uses thereof |
| EP3973999A1 (en) | 2020-09-28 | 2022-03-30 | Orano Med | Conjugate or its salt comprising a gastrin-releasing peptide receptor antagonist and uses thereof |
| WO2022123462A1 (en) | 2020-12-09 | 2022-06-16 | 3B Pharmaceuticals Gmbh | Radiolabelled prostate specific membrane antigen (psma) inhibitors and use thereof |
| EP4050018A1 (en) | 2021-01-07 | 2022-08-31 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| AR128023A1 (es) | 2021-12-17 | 2024-03-20 | 3B Pharmaceuticals Gmbh | Ligandos de anhidrasa carbónica ix |
| WO2024052431A1 (en) | 2022-09-07 | 2024-03-14 | 3B Pharmaceuticals Gmbh | Prostate specific membrane antigen (psma) ligands and use thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4885363A (en) | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| US5021556A (en) | 1987-07-22 | 1991-06-04 | Neorx Corporation | Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides |
| US5075099A (en) | 1988-05-31 | 1991-12-24 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| ES2070329T3 (es) * | 1989-07-20 | 1995-06-01 | Sandoz Ltd | Derivados de polipeptidos. |
| US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
| US5367080A (en) | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
| US5369094A (en) | 1990-11-29 | 1994-11-29 | The Administrators Of The Tulane Educational Fund | Polypeptide bombesin antagonists |
| US5965107A (en) | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US7060247B2 (en) | 1997-04-22 | 2006-06-13 | The Curators Of The University Of Missouri | Gastrin receptor-avid peptide conjugates |
| US6200546B1 (en) | 1997-04-22 | 2001-03-13 | The Curators Of The University Of Missouri | Gastrin receptor-avid peptide conjugates |
| US5886142A (en) | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
| AU2012199A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
| WO1999033792A2 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
| AP2000001856A0 (en) | 1997-12-24 | 2000-09-30 | Vertex Pharma | Prodrugs of aspartyl protease inhibitors. |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| GR1003661B (el) * | 2000-05-25 | 2001-09-05 | Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... | ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ |
| CA2432066A1 (en) * | 2000-12-20 | 2002-06-27 | Robert Denham Pinnock | Novel uses of non-peptide bombesin receptor antagonists for treating anxiety and panic disorders |
| US7850947B2 (en) | 2003-01-13 | 2010-12-14 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7922998B2 (en) * | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7226577B2 (en) * | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US20080008649A1 (en) | 2003-01-13 | 2008-01-10 | Bracco Imaging S.P.A. | Gastrin Releasing Peptide Compounds |
| BRPI0412824A (pt) * | 2003-07-24 | 2006-09-26 | Bracco Imaging Spa | composições radiofarmacêuticas estáveis e métodos para suas preparações |
| US20090062509A1 (en) | 2006-03-16 | 2009-03-05 | Aldo Cagnolini | Chelation of metals to thiol groups using in situ reduction of disulfide-containing compounds by phosphines |
| CN103476434A (zh) * | 2010-11-22 | 2013-12-25 | 皮拉马影像股份公司 | 用于放射治疗的177镥标记的铃蟾肽类似物 |
-
2008
- 2008-03-07 EP EP08075180A patent/EP2100900A1/en not_active Withdrawn
-
2009
- 2009-02-27 KR KR1020107022308A patent/KR101734553B1/ko active IP Right Grant
- 2009-02-27 DK DK09717301.7T patent/DK2252628T3/en active
- 2009-02-27 HU HUE09717301A patent/HUE032980T2/en unknown
- 2009-02-27 MX MX2010009843A patent/MX2010009843A/es not_active Application Discontinuation
- 2009-02-27 PT PT97173017T patent/PT2252628T/pt unknown
- 2009-02-27 SI SI200931607A patent/SI2252628T1/sl unknown
- 2009-02-27 EP EP09717301.7A patent/EP2252628B1/en active Active
- 2009-02-27 UA UAA201011560A patent/UA103314C2/ru unknown
- 2009-02-27 NZ NZ587795A patent/NZ587795A/en unknown
- 2009-02-27 ES ES09717301.7T patent/ES2615805T3/es active Active
- 2009-02-27 BR BRPI0909823-2A patent/BRPI0909823B1/pt active IP Right Grant
- 2009-02-27 KR KR1020167029634A patent/KR20160128425A/ko not_active Application Discontinuation
- 2009-02-27 CN CN200980107992.5A patent/CN101965358B/zh active Active
- 2009-02-27 PL PL09717301T patent/PL2252628T3/pl unknown
- 2009-02-27 US US12/921,209 patent/US9035023B2/en active Active
- 2009-02-27 WO PCT/EP2009/001403 patent/WO2009109332A1/en active Application Filing
- 2009-02-27 AU AU2009221204A patent/AU2009221204C1/en active Active
- 2009-02-27 JP JP2010549043A patent/JP5784911B2/ja active Active
- 2009-02-27 CA CA2717427A patent/CA2717427C/en active Active
- 2009-02-27 RU RU2010140846/04A patent/RU2523531C2/ru active
- 2009-03-06 CL CL2009000537A patent/CL2009000537A1/es unknown
- 2009-03-06 TW TW098107446A patent/TWI515011B/zh active
- 2009-03-06 AR ARP090100799A patent/AR070809A1/es not_active Application Discontinuation
- 2009-03-06 UY UY0001031693A patent/UY31693A/es not_active Application Discontinuation
- 2009-03-06 PE PE2009000339A patent/PE20091753A1/es not_active Application Discontinuation
- 2009-03-06 PA PA20098818501A patent/PA8818501A1/es unknown
-
2010
- 2010-09-06 CO CO10110036A patent/CO6290707A2/es not_active Application Discontinuation
- 2010-09-06 ZA ZA2010/06385A patent/ZA201006385B/en unknown
- 2010-09-07 DO DO2010000269A patent/DOP2010000269A/es unknown
- 2010-09-07 SV SV2010003660A patent/SV2010003660A/es not_active Application Discontinuation
- 2010-09-07 EC EC2010010467A patent/ECSP10010467A/es unknown
- 2010-09-07 CR CR11671A patent/CR11671A/es not_active Application Discontinuation
-
2015
- 2015-03-27 US US14/671,106 patent/US20150265733A1/en not_active Abandoned
-
2017
- 2017-02-07 CY CY20171100170T patent/CY1118687T1/el unknown
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