ES2570458T3 - Peptidomiméticos fijados sobre una matriz con actividad moduladora de CXCR7 - Google Patents

Peptidomiméticos fijados sobre una matriz con actividad moduladora de CXCR7

Info

Publication number
ES2570458T3
ES2570458T3 ES10703641T ES10703641T ES2570458T3 ES 2570458 T3 ES2570458 T3 ES 2570458T3 ES 10703641 T ES10703641 T ES 10703641T ES 10703641 T ES10703641 T ES 10703641T ES 2570458 T3 ES2570458 T3 ES 2570458T3
Authority
ES
Spain
Prior art keywords
trp
dpro
cycle
arg
tic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10703641T
Other languages
English (en)
Inventor
Frank Otto Gombert
Alexander Lederer
Daniel Obrecht
Barbara Romagnoli
Christian Bisang
Christian Ludin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spexis AG
Original Assignee
Polyphor AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor AG filed Critical Polyphor AG
Application granted granted Critical
Publication of ES2570458T3 publication Critical patent/ES2570458T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • AIDS & HIV (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)

Abstract

Compuestos de fórmula general (I)**Fórmula** en la que los elementos individuales T o P son aminoácidos, o residuos de aminoácidos, que están conectados desde el punto de carbonilo (C>=O) de fijación al nitrógeno (N) del siguiente elemento en la dirección de las agujas del reloj, en la que dichos elementos están conectados para formar péptidos cíclicos seleccionados entre ciclo(-Ala-DPhe-Trp-Arg-DPro-Tic-); ciclo(-Phe-DPhe-10 Trp-Arg-DPro-Tic-); ciclo(-His-DPhe-Trp-Arg-DPro-Tic-); ciclo(-His(Me)-DPhe-Trp-Arg-DPro-Tic-); ciclo(-Tyr-DPhe-Trp-Arg-DPro-Tic-); ciclo(-Arg-DPhe-Trp-Arg-DPro-Tic-); ciclo(-1Nal-DPhe-Trp-Arg-DPro-Tic-); ciclo(-2Na1-DPhe-Trp-Arg-DPro-Tic-); ciclo(-Trp-DPhe-Trp-Arg-DPro-Tic-); ciclo(-Trp-DTrp-Trp-Arg-DPro-Tic-); ciclo(-Trp-Dlle-Trp-Arg-DPro-Tic-); ciclo(-Trp-DHis-Trp-Arg-DPro-Tic-); ciclo(-Trp-DArg-Trp-Arg-DPro-Tic-); ciclo(-Trp-DOm-Trp-Arg-DPro-Tic-); ciclo(-Trp-DPhe-Phe-Arg-DPro-Tic-); ciclo(-Trp-DPhe-Tyr-Arg-DPro-Tic-); ciclo(-Trp-DPhe-2Nal-Arg-DPro-Tic-); ciclo(-Trp-DPhe-lle-Arg-DPro-Tic-); ciclo(-Trp-DPhe-Arg-Arg-DPro-Tic-); ciclo(-Trp-DPhe-Trp-Lys-DPro-Tic-); ciclo(-Trp-DPhe-Trp-Om-DPro-Tic-); ciclo(-Trp-DPhe-Trp-Dab-DPro-Tic-); ciclo(-Trp-DPhe-Trp-His-DPro-Tic-); ciclo(-Trp-DPhe-Trp-Tyr-DPro-Tic-); ciclo(-Trp-DPhe-Trp-Arg-DPro-Tiq-); ciclo(-Trp-DPhe-Trp-Arg-DPro-(4S) -Hyp (Bn) -); ciclo(-1Nal-DArg-Trp-Arg-DPro-Tic-); ciclo(-1Nal-DHis-lle-Arg-DPro-Tic-); ciclo(-Abu-DArg-Arg-Trp-DPro-Tic-); ciclo(-His-DTrp-His-Arg-DPro-Tic-); ciclo(-lle-DHis-Trp-Arg-DPro-Tic-); ciclo(-lle-DHis-lle-Arg-DPro-Tic-); ciclo(-lle-DTrp-His-Arg-DPro-Tic-); ciclo(-Arg-DTrp-His-Arg-DPro-Tic-); ciclo(-Arg-DHis-Trp-Arg-DPro-Tic-); ciclo(-Trp-DArg-His-Arg-DPro-Tic-); ciclo(-Trp-DArg-His-Trp-DPro-Tic-); ciclo(-His-D1Nal-His-Trp-DPro-Tic-); ciclo(-Trp-DPhe-Trp-Arg-DPro-Tic-); ciclo(-Trp-DPhe-Trp-Arg-DPip-Pro-); ciclo(-1Nal-DHis-lle-Arg-DPro-Azt-); ciclo(-1Nal-DArg-lle-Arg-DPro-Azt-); ciclo(-1Nal-DArg-Trp-Arg-DPro-Azt-); ciclo(-1Nal-DHis-Tyr-Arg-DPro-Azt-); ciclo(-Trp-DArg-Trp-lle-DPro-Azt-); ciclo(-Trp-DHis-lle-Arg-DPro-Azt-); ciclo(-Trp-DHis-Trp-Arg-DPro-Azt-); ciclo(-Trp-DThr-Tyr-Arg-DPro-Azt-); ciclo(-Trp-DArg-lle-Arg-DPro-Azt-); y sales farmacéuticamente aceptables de los mismos.
ES10703641T 2010-02-05 2010-02-05 Peptidomiméticos fijados sobre una matriz con actividad moduladora de CXCR7 Active ES2570458T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2010/051440 WO2011095220A1 (en) 2010-02-05 2010-02-05 Template - fixed peptidomimetics with cxcr7 modulating activity

Publications (1)

Publication Number Publication Date
ES2570458T3 true ES2570458T3 (es) 2016-05-18

Family

ID=42562967

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10703641T Active ES2570458T3 (es) 2010-02-05 2010-02-05 Peptidomiméticos fijados sobre una matriz con actividad moduladora de CXCR7

Country Status (6)

Country Link
US (1) US8629112B2 (es)
EP (1) EP2531204B1 (es)
AU (1) AU2010344997B2 (es)
CA (1) CA2789030C (es)
ES (1) ES2570458T3 (es)
WO (1) WO2011095220A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
EP2114986B1 (en) 2007-01-29 2013-05-22 Polyphor Ltd. Template-fixed peptidomimetics
JP5140686B2 (ja) 2007-02-28 2013-02-06 ポリファー リミテッド テンプレート固定ペプチド模倣薬
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
JP6807831B2 (ja) 2014-05-21 2021-01-06 エントラーダ セラピューティクス，インコーポレイテッド 細胞膜透過性ペプチド、並びにこの作製方法及び使用方法
EP3185880B1 (en) 2014-08-27 2020-02-12 Ohio State Innovation Foundation Improved peptidyl calcineurin inhibitors
WO2019148194A2 (en) 2018-01-29 2019-08-01 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-nfat interaction
EP3755351A4 (en) 2018-02-22 2021-11-24 Entrada Therapeutics, Inc. COMPOSITIONS AND TREATMENT METHODS FOR MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0323728D0 (en) * 2003-10-10 2003-11-12 Royal College Of Surgeons Ie Peptidomimetics and uses thereof
US7807704B2 (en) 2006-03-30 2010-10-05 Chemocentryx, Inc. Bicyclic, nitrogen-containing compounds modulating CXCR4 and/or CCXCKR2
EP2114986B1 (en) 2007-01-29 2013-05-22 Polyphor Ltd. Template-fixed peptidomimetics

Also Published As

Publication number Publication date
EP2531204B1 (en) 2016-02-03
WO2011095220A1 (en) 2011-08-11
US20130023483A1 (en) 2013-01-24
CA2789030C (en) 2020-07-21
AU2010344997A1 (en) 2012-08-30
US8629112B2 (en) 2014-01-14
AU2010344997B2 (en) 2015-09-10
CA2789030A1 (en) 2011-08-11
EP2531204A1 (en) 2012-12-12

Similar Documents

Publication Publication Date Title
ES2570458T3 (es) Peptidomiméticos fijados sobre una matriz con actividad moduladora de CXCR7
ES2486675T3 (es) Análogo de péptido de oxintomodulina
ES2512141T3 (es) Análogo peptídico de oxintomodulina
CY1117478T1 (el) Πεπτιδιο ικανο να παρατεινει το χρονο ημιζωης πεπτιδιου ενδιαφεροντος στο πλασμα
ES2616658T3 (es) Péptidos que mimetizan el factor de crecimiento y sus usos
ES2691070T3 (es) Péptidos antiinflamatorios y composición que comprende los mismos
ES2693321T3 (es) Péptidos antiinflamatorios y composición que comprende los mismos
ES2572260T3 (es) Péptidos útiles en el tratamiento y/o cuidado de la piel y/o membranas mucosas y su uso en composiciones cosméticas o farmacéuticas
UA118167C2 (uk) Пептид та його застосування
BR112013031268A8 (pt) polipeptídeos
CL2016002513A1 (es) Método para preparar amg 416
PE20120914A1 (es) Compuestos glucagon activo de receptor de gip
PE20150181A1 (es) Variantes de oxm pegilada
AR087020A1 (es) Polipeptidos de fusion de relaxina y usos de los mismos
DOP2013000142A (es) Derivados de biciclo[3,2,1]octilamida y sus usos.
PE20141672A1 (es) FORMULACION PARA ANTICUERPO ANTI-alfa4�7
UY30338A1 (es) Acidos carboxilicos sustituidos con fenilaminobenzoxazol, procedimientos para su preparacion y su uso como productos farmacéuticos.
DE602005008996D1 (de) Radiofluorierte peptide
NI201100076A (es) Péptidos antivirales terapéuticos.
AR083126A1 (es) Composicion vacunal para el control de las infestaciones por ectoparasitos
AR061097A1 (es) Procedimiento para sintetizar timosinas
PE20130379A1 (es) Metodos para el tratamiento de las ulceras del pie diabetico
AR081866A1 (es) Variantes de peptidos antimicrobianos y polinucleotidos que las codifican
EA201492068A1 (ru) Гидрохлоридная соль пептида и ее применение в комбинации с другими пептидами в иммунотерапии
ES2536238T3 (es) Péptidos antimicrobianos