CY1118687T1 - Συζευγματα πεπτιδικων ανταγωνιστων αναλογων της μπομπεσινης - Google Patents
Συζευγματα πεπτιδικων ανταγωνιστων αναλογων της μπομπεσινηςInfo
- Publication number
- CY1118687T1 CY1118687T1 CY20171100170T CY171100170T CY1118687T1 CY 1118687 T1 CY1118687 T1 CY 1118687T1 CY 20171100170 T CY20171100170 T CY 20171100170T CY 171100170 T CY171100170 T CY 171100170T CY 1118687 T1 CY1118687 T1 CY 1118687T1
- Authority
- CY
- Cyprus
- Prior art keywords
- bobesin
- integer
- conjugate
- competition related
- competitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Προκειμένου να παρασχεθεί ένα διαγνωστικό και θεραπευτικό φάρμακο, παρέχεται ένα σύζευγμα πεπτιδικού ανταγωνιστή αναλόγων της μπομπεσίνης το οποίο σύζευγμα έχει γενικό τύπο (I): [A-(B)n]x-C, όπου Α είναι ένα μέσο χηλίωσης μετάλλου που περιλαμβάνει τουλάχιστον ένα ραδιονουκλίδιο μετάλλου, Β είναι ένα μόριο παρεμβολής διασυνδεδεμένο με το Ν-τελικό άκρο του C ή ένας ομοιοπολικός δεσμός και C είναι ένας πεπτιδικός ανταγωνιστής αναλόγων της μπομπεσίνης με αλληλουχία όπως αυτή αξιώνεται, όπου περαιτέρω χ είναι ένας ακέραιος από το 1 έως το 3 και n είναι ένας ακέραιος από το 1 έως το 6.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08075180A EP2100900A1 (en) | 2008-03-07 | 2008-03-07 | Bombesin analog peptide antagonist conjugates |
| EP09717301.7A EP2252628B1 (en) | 2008-03-07 | 2009-02-27 | Bombesin analog peptide antagonist conjugates |
| PCT/EP2009/001403 WO2009109332A1 (en) | 2008-03-07 | 2009-02-27 | Bombesin analog peptide antagonist conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118687T1 true CY1118687T1 (el) | 2017-07-12 |
Family
ID=39677415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100170T CY1118687T1 (el) | 2008-03-07 | 2017-02-07 | Συζευγματα πεπτιδικων ανταγωνιστων αναλογων της μπομπεσινης |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US9035023B2 (el) |
| EP (2) | EP2100900A1 (el) |
| JP (1) | JP5784911B2 (el) |
| KR (2) | KR20160128425A (el) |
| CN (1) | CN101965358B (el) |
| AR (1) | AR070809A1 (el) |
| AU (1) | AU2009221204C1 (el) |
| BR (1) | BRPI0909823B1 (el) |
| CA (1) | CA2717427C (el) |
| CL (1) | CL2009000537A1 (el) |
| CO (1) | CO6290707A2 (el) |
| CR (1) | CR11671A (el) |
| CY (1) | CY1118687T1 (el) |
| DK (1) | DK2252628T3 (el) |
| DO (1) | DOP2010000269A (el) |
| EC (1) | ECSP10010467A (el) |
| ES (1) | ES2615805T3 (el) |
| HU (1) | HUE032980T2 (el) |
| MX (1) | MX2010009843A (el) |
| NZ (1) | NZ587795A (el) |
| PA (1) | PA8818501A1 (el) |
| PE (1) | PE20091753A1 (el) |
| PL (1) | PL2252628T3 (el) |
| PT (1) | PT2252628T (el) |
| RU (1) | RU2523531C2 (el) |
| SI (1) | SI2252628T1 (el) |
| SV (1) | SV2010003660A (el) |
| TW (1) | TWI515011B (el) |
| UA (1) | UA103314C2 (el) |
| UY (1) | UY31693A (el) |
| WO (1) | WO2009109332A1 (el) |
| ZA (1) | ZA201006385B (el) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2380596A1 (en) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopentapeptide derivatives and uses thereof |
| EP2380597A1 (en) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopeptide derivatives and uses thereof |
| AU2011333948A1 (en) * | 2010-11-22 | 2013-06-06 | Piramal Imaging Sa | 177 Lutetium-labeled bombesin analogs for radiotherapy |
| EP2710027A1 (en) * | 2011-05-19 | 2014-03-26 | Universitätsspital Basel | Bombesin receptor targeting peptide incorporating a 1, 2, 3-triazole group in the backbone for preparing in vivo diagnostic and therapeutic agents |
| IL312551A (en) | 2012-09-25 | 2024-07-01 | Advanced Accelerator Applications Usa Inc | GRPR antagonists for the detection, diagnosis and treatment of GRPR-positive cancer |
| EP2740726A1 (en) | 2012-12-07 | 2014-06-11 | 3B Pharmaceuticals GmbH | Neurotensin receptor ligands |
| WO2014164988A1 (en) * | 2013-03-13 | 2014-10-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tetrahydroxamate chelators of zirconium89 and niobium90 for use in diagnostic applications |
| WO2015119763A1 (en) * | 2014-02-06 | 2015-08-13 | Immunomedics, Inc. | Al-f-18-labeled, al-f-19-labeled and ga-68-labeled gastrin-releasing peptide receptor (grpr)-antagonists for imaging of prostate cancer |
| HUE044571T2 (hu) | 2014-06-06 | 2019-11-28 | Univ Muenchen Tech | Módosított ciklopentapeptidek és alkalmazásaik |
| EP3154638A1 (en) | 2014-06-10 | 2017-04-19 | 3B Pharmaceuticals GmbH | Conjugate comprising a neurotensin receptor ligand and use thereof |
| EP2954933A1 (en) | 2014-06-10 | 2015-12-16 | 3B Pharmaceuticals GmbH | Conjugate comprising a neurotensin receptor ligand |
| EP2954934A1 (en) | 2014-06-11 | 2015-12-16 | 3B Pharmaceuticals GmbH | Conjugate comprising a neurotensin receptor ligand and use thereof |
| EP3943104A1 (en) | 2014-06-16 | 2022-01-26 | Codexis, Inc. | Compositions and methods for treating gluten intolerance and disorders arising therefrom |
| CN104610431B (zh) * | 2014-11-26 | 2017-12-15 | 南京市第一医院 | 一种多肽及其应用 |
| EP3393502A4 (en) | 2015-12-16 | 2019-06-12 | Nepetx, LLC | COMPOSITIONS AND METHODS OF TREATING GLUTENEAL COMPATIBILITY AND DISORDERS ARISING FROM THE DISEASE |
| EP3279197A1 (en) | 2016-08-03 | 2018-02-07 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Diagnosis, treatment and prevention of neurotensin receptor-related conditions |
| US11241511B2 (en) | 2016-12-29 | 2022-02-08 | The General Hospital Corporation | HER3 peptides for imaging and radiotherapy |
| AU2018207190B2 (en) | 2017-01-12 | 2020-12-03 | Orano Med | Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes |
| RU2681318C1 (ru) * | 2017-11-24 | 2019-03-06 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Способ получения иммуносупрессорного пептида Abu-TGIRIS-Abu, меченного ионом Gd3+ |
| US20210402016A1 (en) * | 2018-11-13 | 2021-12-30 | Provincial Health Services Authority | Radiolabeled bombesin-derived compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders |
| EP3763726A1 (en) | 2019-07-08 | 2021-01-13 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| CN114341158B (zh) | 2019-07-08 | 2024-08-06 | 3B制药有限公司 | 包含成纤维细胞活化蛋白配体的化合物及其用途 |
| CA3153267A1 (en) * | 2019-12-19 | 2021-06-24 | Hans-Jurgen Wester | Modified grpr antagonist peptides for imaging and therapy of cancer |
| WO2021250240A1 (en) | 2020-06-12 | 2021-12-16 | Orano | Diaza-18-crown-6 derivative useful for chelating radium, conjugate and radium chelate comprising the same, and uses thereof |
| EP3973999A1 (en) | 2020-09-28 | 2022-03-30 | Orano Med | Conjugate or its salt comprising a gastrin-releasing peptide receptor antagonist and uses thereof |
| WO2022123462A1 (en) | 2020-12-09 | 2022-06-16 | 3B Pharmaceuticals Gmbh | Radiolabelled prostate specific membrane antigen (psma) inhibitors and use thereof |
| EP4050018A1 (en) | 2021-01-07 | 2022-08-31 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| KR20240133798A (ko) | 2021-12-17 | 2024-09-04 | 쓰리비 파마슈티컬스 게엠베하 | 탄산 무수화효소 ix 리간드 |
| WO2024052431A1 (en) | 2022-09-07 | 2024-03-14 | 3B Pharmaceuticals Gmbh | Prostate specific membrane antigen (psma) ligands and use thereof |
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| US5075099A (en) | 1988-05-31 | 1991-12-24 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
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| US5369094A (en) * | 1990-11-29 | 1994-11-29 | The Administrators Of The Tulane Educational Fund | Polypeptide bombesin antagonists |
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| DE69840647D1 (de) | 1997-04-22 | 2009-04-23 | Curator Of The University Of M | Konjugate aus peptiden, die liganden von gastrinrezeptoren sind |
| CA2346154A1 (en) | 2001-05-02 | 2002-11-02 | University Of Missouri | Gastrin receptor-avid peptide conjugates |
| US5886142A (en) | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
| AU2010299A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| AU2012199A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
| BR9814484A (pt) | 1997-12-24 | 2000-10-10 | Vertex Pharma | "pró-drogas de inibidores de aspartil protease" |
| GR1003661B (el) * | 2000-05-25 | 2001-09-05 | Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... | ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ |
| HUP0302496A2 (hu) * | 2000-12-20 | 2003-12-29 | Warner-Lambert Company Llc | Nempeptid bombezinreceptor-antagonisták felhasználása szorongás és pánikbetegség kezelésére |
| US20080008649A1 (en) | 2003-01-13 | 2008-01-10 | Bracco Imaging S.P.A. | Gastrin Releasing Peptide Compounds |
| US7922998B2 (en) * | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7850947B2 (en) | 2003-01-13 | 2010-12-14 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| CA2783275A1 (en) * | 2003-07-24 | 2005-02-03 | Bracco Imaging S.P.A. | Stable radiopharmaceutical compositions and methods for their preparation |
| WO2007109475A2 (en) | 2006-03-16 | 2007-09-27 | Bracco Imaging S.P.A. | Chelation of metals to thiol groups using in situ reduction of disulfide-containing compounds by phosphines |
| AU2011333948A1 (en) * | 2010-11-22 | 2013-06-06 | Piramal Imaging Sa | 177 Lutetium-labeled bombesin analogs for radiotherapy |
-
2008
- 2008-03-07 EP EP08075180A patent/EP2100900A1/en not_active Withdrawn
-
2009
- 2009-02-27 JP JP2010549043A patent/JP5784911B2/ja active Active
- 2009-02-27 HU HUE09717301A patent/HUE032980T2/en unknown
- 2009-02-27 SI SI200931607A patent/SI2252628T1/sl unknown
- 2009-02-27 CA CA2717427A patent/CA2717427C/en active Active
- 2009-02-27 PL PL09717301T patent/PL2252628T3/pl unknown
- 2009-02-27 US US12/921,209 patent/US9035023B2/en active Active
- 2009-02-27 UA UAA201011560A patent/UA103314C2/ru unknown
- 2009-02-27 BR BRPI0909823-2A patent/BRPI0909823B1/pt active IP Right Grant
- 2009-02-27 WO PCT/EP2009/001403 patent/WO2009109332A1/en active Application Filing
- 2009-02-27 PT PT97173017T patent/PT2252628T/pt unknown
- 2009-02-27 KR KR1020167029634A patent/KR20160128425A/ko not_active Application Discontinuation
- 2009-02-27 ES ES09717301.7T patent/ES2615805T3/es active Active
- 2009-02-27 KR KR1020107022308A patent/KR101734553B1/ko active IP Right Grant
- 2009-02-27 NZ NZ587795A patent/NZ587795A/en unknown
- 2009-02-27 RU RU2010140846/04A patent/RU2523531C2/ru active
- 2009-02-27 CN CN200980107992.5A patent/CN101965358B/zh active Active
- 2009-02-27 AU AU2009221204A patent/AU2009221204C1/en active Active
- 2009-02-27 MX MX2010009843A patent/MX2010009843A/es not_active Application Discontinuation
- 2009-02-27 DK DK09717301.7T patent/DK2252628T3/en active
- 2009-02-27 EP EP09717301.7A patent/EP2252628B1/en active Active
- 2009-03-06 CL CL2009000537A patent/CL2009000537A1/es unknown
- 2009-03-06 UY UY0001031693A patent/UY31693A/es not_active Application Discontinuation
- 2009-03-06 AR ARP090100799A patent/AR070809A1/es not_active Application Discontinuation
- 2009-03-06 PE PE2009000339A patent/PE20091753A1/es not_active Application Discontinuation
- 2009-03-06 TW TW098107446A patent/TWI515011B/zh active
- 2009-03-06 PA PA20098818501A patent/PA8818501A1/es unknown
-
2010
- 2010-09-06 CO CO10110036A patent/CO6290707A2/es not_active Application Discontinuation
- 2010-09-06 ZA ZA2010/06385A patent/ZA201006385B/en unknown
- 2010-09-07 SV SV2010003660A patent/SV2010003660A/es not_active Application Discontinuation
- 2010-09-07 CR CR11671A patent/CR11671A/es not_active Application Discontinuation
- 2010-09-07 DO DO2010000269A patent/DOP2010000269A/es unknown
- 2010-09-07 EC EC2010010467A patent/ECSP10010467A/es unknown
-
2015
- 2015-03-27 US US14/671,106 patent/US20150265733A1/en not_active Abandoned
-
2017
- 2017-02-07 CY CY20171100170T patent/CY1118687T1/el unknown
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