BR112022005026A2 - Conjugados terapêuticos - Google Patents
Conjugados terapêuticosInfo
- Publication number
- BR112022005026A2 BR112022005026A2 BR112022005026A BR112022005026A BR112022005026A2 BR 112022005026 A2 BR112022005026 A2 BR 112022005026A2 BR 112022005026 A BR112022005026 A BR 112022005026A BR 112022005026 A BR112022005026 A BR 112022005026A BR 112022005026 A2 BR112022005026 A2 BR 112022005026A2
- Authority
- BR
- Brazil
- Prior art keywords
- therapeutic conjugates
- conjugates
- therapeutic
- administering
- compositions
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
conjugados terapêuticos. a presente invenção refere-se, de modo geral, a conjugados terapêuticos que se ligam covalentemente a um alvo biológico. também são fornecidos, neste documento, métodos de administração das composições a um indivíduo em necessidade.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962902554P | 2019-09-19 | 2019-09-19 | |
US202063078055P | 2020-09-14 | 2020-09-14 | |
PCT/US2020/051491 WO2021055747A1 (en) | 2019-09-19 | 2020-09-18 | Therapeutic conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022005026A2 true BR112022005026A2 (pt) | 2022-06-21 |
Family
ID=74883745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022005026A BR112022005026A2 (pt) | 2019-09-19 | 2020-09-18 | Conjugados terapêuticos |
Country Status (16)
Country | Link |
---|---|
US (2) | US20220387603A1 (pt) |
EP (1) | EP4031143A4 (pt) |
JP (1) | JP2022548135A (pt) |
KR (1) | KR20220079866A (pt) |
CN (1) | CN114599366A (pt) |
AU (1) | AU2020349543A1 (pt) |
BR (1) | BR112022005026A2 (pt) |
CA (1) | CA3154079A1 (pt) |
CL (1) | CL2022000665A1 (pt) |
CO (1) | CO2022003703A2 (pt) |
IL (1) | IL291486A (pt) |
MX (1) | MX2022003217A (pt) |
PE (1) | PE20230091A1 (pt) |
TW (1) | TW202126307A (pt) |
WO (1) | WO2021055747A1 (pt) |
ZA (1) | ZA202203201B (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021055747A1 (en) | 2019-09-19 | 2021-03-25 | Totus Medicines Inc. | Therapeutic conjugates |
WO2022198024A1 (en) * | 2021-03-18 | 2022-09-22 | Totus Medicines Inc. | Therapeutic conjugates |
WO2023183936A2 (en) * | 2022-03-24 | 2023-09-28 | Totus Medicines Inc. | Combination therapy of a pi3k inhibitor and kras inhibitor and methods of use thereof |
WO2023179771A1 (en) | 2022-03-24 | 2023-09-28 | Totus Medicines Inc. | Crystalline forms and salts of a pi3k inhibitor and methods of making and methods of use thereof |
CN117126164A (zh) * | 2023-08-30 | 2023-11-28 | 山东轩硕医药科技有限公司 | 一种吡咯并三嗪类化合物,其制备方法及用途 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585245A (en) | 1994-04-22 | 1996-12-17 | California Institute Of Technology | Ubiquitin-based split protein sensor |
US6342345B1 (en) | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
US6982265B1 (en) | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
US7306631B2 (en) | 2004-03-30 | 2007-12-11 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
WO2007035428A1 (en) | 2005-09-15 | 2007-03-29 | Bristol-Myers Squibb Company | Met kinase inhibitors |
AU2008287421A1 (en) | 2007-08-10 | 2009-02-19 | Glaxosmithkline Llc | Nitrogen containing bicyclic chemical entities for treating viral infections |
AU2009270856B2 (en) * | 2008-07-16 | 2013-07-25 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors |
US20100204265A1 (en) | 2009-02-09 | 2010-08-12 | Genelabs Technologies, Inc. | Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections |
RU2595718C2 (ru) * | 2009-09-09 | 2016-08-27 | Селджен Авиломикс Рисерч,Инк. | Ингибиторы pi3-киназы и их применение |
EP2526102B1 (en) | 2010-01-22 | 2017-03-08 | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III | Inhibitors of PI3 kinase |
US20130131057A1 (en) | 2010-05-13 | 2013-05-23 | Centro Nacional De Investigaciones Oncologicas (Cnio | New bicyclic compounds as pi3-k and mtor inhibitors |
MX2012013824A (es) | 2010-05-28 | 2013-03-12 | Biocryst Pharm Inc | Compuestos heterociclicos como inhibidores de cinasa janus. |
US20120231963A1 (en) | 2011-03-10 | 2012-09-13 | Raybiotech, Inc, | Biotin-label-based antibody array for high-content profiling of protein expression |
US9580427B2 (en) * | 2011-05-17 | 2017-02-28 | The Regents Of The University Of California | Kinase inhibitors |
EP2524918A1 (en) | 2011-05-19 | 2012-11-21 | Centro Nacional de Investigaciones Oncológicas (CNIO) | Imidazopyrazines derivates as kinase inhibitors |
US9724352B2 (en) * | 2012-05-31 | 2017-08-08 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof |
CN103450204B (zh) * | 2012-05-31 | 2016-08-17 | 中国科学院上海药物研究所 | 吡咯[2,1-f][1,2,4]并三嗪类化合物,其制备方法及用途 |
CN102675323B (zh) | 2012-06-01 | 2014-04-09 | 南京药石药物研发有限公司 | 吡咯并[2,1-f][1,2,4]三嗪衍生物及其抗肿瘤用途 |
MX2016016583A (es) | 2014-06-17 | 2017-04-27 | Chiesi Farm Spa | Derivados de indolizina como inhibidores de fosfoinositido-3 cinasas. |
EP3925622A1 (en) * | 2014-09-13 | 2021-12-22 | Novartis AG | Combination therapies |
WO2017004134A1 (en) | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
CN109111447A (zh) * | 2017-06-23 | 2019-01-01 | 中国科学院上海药物研究所 | 7-位取代吡咯并三嗪类化合物或其药学上可用的盐,及其制备方法和用途 |
CN111386259A (zh) | 2017-08-02 | 2020-07-07 | 西北大学 | 经取代稠合的嘧啶化合物及其用途 |
WO2019113523A1 (en) | 2017-12-08 | 2019-06-13 | Ashok Bajji | Compounds and therapeutic uses thereof |
CN109081905A (zh) | 2018-08-03 | 2018-12-25 | 浩力森涂料(上海)有限公司 | 水性环氧固化剂及其制备方法 |
US20220054496A1 (en) | 2018-09-13 | 2022-02-24 | Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncologicas Carlos III (F.S. | Modulation of trf1 for brain cancer treatment |
WO2020243457A1 (en) | 2019-05-29 | 2020-12-03 | Viogen Biosciences, Llc | Compounds and therapeutic uses thereof |
WO2021055747A1 (en) | 2019-09-19 | 2021-03-25 | Totus Medicines Inc. | Therapeutic conjugates |
AU2021285715A1 (en) | 2020-06-05 | 2023-01-19 | Monash University | Dual kinase-bromodomain inhibitors |
-
2020
- 2020-09-18 WO PCT/US2020/051491 patent/WO2021055747A1/en unknown
- 2020-09-18 TW TW109132462A patent/TW202126307A/zh unknown
- 2020-09-18 EP EP20865745.2A patent/EP4031143A4/en active Pending
- 2020-09-18 KR KR1020227012813A patent/KR20220079866A/ko unknown
- 2020-09-18 AU AU2020349543A patent/AU2020349543A1/en active Pending
- 2020-09-18 PE PE2022000435A patent/PE20230091A1/es unknown
- 2020-09-18 CA CA3154079A patent/CA3154079A1/en active Pending
- 2020-09-18 US US17/642,945 patent/US20220387603A1/en active Pending
- 2020-09-18 MX MX2022003217A patent/MX2022003217A/es unknown
- 2020-09-18 JP JP2022516684A patent/JP2022548135A/ja active Pending
- 2020-09-18 CN CN202080074001.4A patent/CN114599366A/zh active Pending
- 2020-09-18 BR BR112022005026A patent/BR112022005026A2/pt unknown
-
2022
- 2022-03-14 US US17/694,592 patent/US11484597B2/en active Active
- 2022-03-17 ZA ZA2022/03201A patent/ZA202203201B/en unknown
- 2022-03-18 CL CL2022000665A patent/CL2022000665A1/es unknown
- 2022-03-18 IL IL291486A patent/IL291486A/en unknown
- 2022-03-28 CO CONC2022/0003703A patent/CO2022003703A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2022003217A (es) | 2022-06-29 |
CN114599366A (zh) | 2022-06-07 |
JP2022548135A (ja) | 2022-11-16 |
WO2021055747A1 (en) | 2021-03-25 |
EP4031143A4 (en) | 2023-11-01 |
ZA202203201B (en) | 2023-11-29 |
TW202126307A (zh) | 2021-07-16 |
IL291486A (en) | 2022-05-01 |
US20220211855A1 (en) | 2022-07-07 |
US20230096658A1 (en) | 2023-03-30 |
US20220387603A1 (en) | 2022-12-08 |
US11484597B2 (en) | 2022-11-01 |
AU2020349543A1 (en) | 2022-03-24 |
KR20220079866A (ko) | 2022-06-14 |
CA3154079A1 (en) | 2021-03-25 |
CO2022003703A2 (es) | 2022-07-08 |
PE20230091A1 (es) | 2023-01-16 |
EP4031143A1 (en) | 2022-07-27 |
CL2022000665A1 (es) | 2022-10-28 |
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