MX2020002666A - Conjugados de anticuerpos anti-receptor de folato, composiciones que contienen conjugados de anticuerpos anti-receptor de folato y metodos de fabricación y uso de conjugados de anticuerpos anti-receptor de folato. - Google Patents

Conjugados de anticuerpos anti-receptor de folato, composiciones que contienen conjugados de anticuerpos anti-receptor de folato y metodos de fabricación y uso de conjugados de anticuerpos anti-receptor de folato.

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Publication number
MX2020002666A
MX2020002666A MX2020002666A MX2020002666A MX2020002666A MX 2020002666 A MX2020002666 A MX 2020002666A MX 2020002666 A MX2020002666 A MX 2020002666A MX 2020002666 A MX2020002666 A MX 2020002666A MX 2020002666 A MX2020002666 A MX 2020002666A
Authority
MX
Mexico
Prior art keywords
antibody conjugates
compositions
receptor alpha
folate receptor
methods
Prior art date
Application number
MX2020002666A
Other languages
English (en)
Inventor
Ryan Stafford
Alice Yam
Xiaofan Li
Gang Yin
Toni Kline
Cristina Abrahams
Almeida Venita De
Original Assignee
Sutro Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sutro Biopharma Inc filed Critical Sutro Biopharma Inc
Publication of MX2020002666A publication Critical patent/MX2020002666A/es

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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Abstract

La presente invención se refiere a conjugados de anticuerpos con especificidad de unión para el receptor de folato alfa (FOLR1) y sus isoformas y homólogos, y composiciones que comprenden los conjugados de anticuerpos, incluyendo composiciones farmacéuticas. También se proporcionan métodos para producir los conjugados de anticuerpos y composiciones, así como métodos para usar los conjugados de anticuerpos y composiciones, tal como en métodos terapéuticos y de diagnóstico.
MX2020002666A 2017-09-18 2018-09-17 Conjugados de anticuerpos anti-receptor de folato, composiciones que contienen conjugados de anticuerpos anti-receptor de folato y metodos de fabricación y uso de conjugados de anticuerpos anti-receptor de folato. MX2020002666A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762560064P 2017-09-18 2017-09-18
PCT/US2018/051364 WO2019055931A1 (en) 2017-09-18 2018-09-17 ALPHA ANTI-FOLATE ANTIBODY-RECEPTOR CONJUGATES AND USES THEREOF

Publications (1)

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MX2020002666A true MX2020002666A (es) 2020-11-06

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MX2020002666A MX2020002666A (es) 2017-09-18 2018-09-17 Conjugados de anticuerpos anti-receptor de folato, composiciones que contienen conjugados de anticuerpos anti-receptor de folato y metodos de fabricación y uso de conjugados de anticuerpos anti-receptor de folato.

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US (3) US10596270B2 (es)
EP (1) EP3684814A1 (es)
JP (1) JP7423513B2 (es)
KR (1) KR20200051802A (es)
CN (1) CN111655726B (es)
AU (1) AU2018333945A1 (es)
BR (1) BR112020005212A2 (es)
CA (1) CA3075087A1 (es)
IL (1) IL273285A (es)
MA (1) MA50265A (es)
MX (1) MX2020002666A (es)
RU (1) RU2020111503A (es)
SG (1) SG11202002310UA (es)
WO (2) WO2019055909A1 (es)

Families Citing this family (19)

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Publication number Priority date Publication date Assignee Title
EP3472197A1 (en) * 2016-06-15 2019-04-24 Sutro Biopharma, Inc. Antibodies with engineered ch2 domains, compositions thereof and methods of using the same
JP7423513B2 (ja) 2017-09-18 2024-01-29 ストロ バイオファーマ インコーポレーテッド 抗葉酸受容体α抗体コンジュゲート及びその使用
US20220047716A1 (en) * 2018-09-17 2022-02-17 Sutro Biopharma, Inc. Combination therapies with anti-folate receptor antibody conjugates
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