MX2020002666A - Conjugados de anticuerpos anti-receptor de folato, composiciones que contienen conjugados de anticuerpos anti-receptor de folato y metodos de fabricación y uso de conjugados de anticuerpos anti-receptor de folato. - Google Patents
Conjugados de anticuerpos anti-receptor de folato, composiciones que contienen conjugados de anticuerpos anti-receptor de folato y metodos de fabricación y uso de conjugados de anticuerpos anti-receptor de folato.Info
- Publication number
- MX2020002666A MX2020002666A MX2020002666A MX2020002666A MX2020002666A MX 2020002666 A MX2020002666 A MX 2020002666A MX 2020002666 A MX2020002666 A MX 2020002666A MX 2020002666 A MX2020002666 A MX 2020002666A MX 2020002666 A MX2020002666 A MX 2020002666A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody conjugates
- compositions
- receptor alpha
- folate receptor
- methods
- Prior art date
Links
- 229940127121 immunoconjugate Drugs 0.000 title abstract 6
- 102000010451 Folate receptor alpha Human genes 0.000 title abstract 3
- 108050001931 Folate receptor alpha Proteins 0.000 title abstract 3
- 230000003432 anti-folate effect Effects 0.000 title 1
- 229940127074 antifolate Drugs 0.000 title 1
- 239000004052 folic acid antagonist Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 229960000575 trastuzumab Drugs 0.000 abstract 1
Classifications
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
La presente invención se refiere a conjugados de anticuerpos con especificidad de unión para el receptor de folato alfa (FOLR1) y sus isoformas y homólogos, y composiciones que comprenden los conjugados de anticuerpos, incluyendo composiciones farmacéuticas. También se proporcionan métodos para producir los conjugados de anticuerpos y composiciones, así como métodos para usar los conjugados de anticuerpos y composiciones, tal como en métodos terapéuticos y de diagnóstico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201762560064P | 2017-09-18 | 2017-09-18 | |
PCT/US2018/051364 WO2019055931A1 (en) | 2017-09-18 | 2018-09-17 | ALPHA ANTI-FOLATE ANTIBODY-RECEPTOR CONJUGATES AND USES THEREOF |
Publications (1)
Publication Number | Publication Date |
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MX2020002666A true MX2020002666A (es) | 2020-11-06 |
Family
ID=63722803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020002666A MX2020002666A (es) | 2017-09-18 | 2018-09-17 | Conjugados de anticuerpos anti-receptor de folato, composiciones que contienen conjugados de anticuerpos anti-receptor de folato y metodos de fabricación y uso de conjugados de anticuerpos anti-receptor de folato. |
Country Status (14)
Country | Link |
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US (3) | US10596270B2 (es) |
EP (1) | EP3684814A1 (es) |
JP (1) | JP7423513B2 (es) |
KR (1) | KR20200051802A (es) |
CN (1) | CN111655726B (es) |
AU (1) | AU2018333945A1 (es) |
BR (1) | BR112020005212A2 (es) |
CA (1) | CA3075087A1 (es) |
IL (1) | IL273285A (es) |
MA (1) | MA50265A (es) |
MX (1) | MX2020002666A (es) |
RU (1) | RU2020111503A (es) |
SG (1) | SG11202002310UA (es) |
WO (2) | WO2019055909A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3472197A1 (en) * | 2016-06-15 | 2019-04-24 | Sutro Biopharma, Inc. | Antibodies with engineered ch2 domains, compositions thereof and methods of using the same |
JP7423513B2 (ja) | 2017-09-18 | 2024-01-29 | ストロ バイオファーマ インコーポレーテッド | 抗葉酸受容体α抗体コンジュゲート及びその使用 |
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CN111655726A (zh) | 2020-09-11 |
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WO2019055931A1 (en) | 2019-03-21 |
IL273285A (en) | 2020-04-30 |
BR112020005212A2 (pt) | 2020-09-15 |
AU2018333945A1 (en) | 2020-03-26 |
US10596270B2 (en) | 2020-03-24 |
US20200353076A1 (en) | 2020-11-12 |
RU2020111503A3 (es) | 2022-02-28 |
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