UA103314C2 - Конъюгаты антагониста пептида аналога бомбезина - Google Patents

Конъюгаты антагониста пептида аналога бомбезина

Info

Publication number
UA103314C2
UA103314C2 UAA201011560A UAA201011560A UA103314C2 UA 103314 C2 UA103314 C2 UA 103314C2 UA A201011560 A UAA201011560 A UA A201011560A UA A201011560 A UAA201011560 A UA A201011560A UA 103314 C2 UA103314 C2 UA 103314C2
Authority
UA
Ukraine
Prior art keywords
peptide antagonist
analog peptide
bombesin analog
antagonist conjugates
integer
Prior art date
Application number
UAA201011560A
Other languages
English (en)
Ukrainian (uk)
Inventor
Гельмут Мекке
Жан Клод Рьоби
Розальба Манси
Original Assignee
Университетсшпиталь Базель
Университет Берн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39677415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA103314(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Университетсшпиталь Базель, Университет Берн filed Critical Университетсшпиталь Базель
Publication of UA103314C2 publication Critical patent/UA103314C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Для обеспечения диагностического и терапевтического лекарственного средства, заявляется конъюгат антагониста пептида аналога бомбезина, который имеет общую формулу (I),(I) [А-(В)]-С,где А представляет собой хелатор металла, который содержит по крайней мере один радионуклидный металл, В представляет собой спейсер, связанный с N-концом С, или ковалентную связь, и С представляет собой антагонист пептида аналога бомбезина, который имеет последовательность, где дополнительно x представляет собой целое число от 1 до 3 и n представляет собой целое число от 1 до 6.
UAA201011560A 2008-03-07 2009-02-27 Конъюгаты антагониста пептида аналога бомбезина UA103314C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08075180A EP2100900A1 (en) 2008-03-07 2008-03-07 Bombesin analog peptide antagonist conjugates
PCT/EP2009/001403 WO2009109332A1 (en) 2008-03-07 2009-02-27 Bombesin analog peptide antagonist conjugates

Publications (1)

Publication Number Publication Date
UA103314C2 true UA103314C2 (ru) 2013-10-10

Family

ID=39677415

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201011560A UA103314C2 (ru) 2008-03-07 2009-02-27 Конъюгаты антагониста пептида аналога бомбезина

Country Status (32)

Country Link
US (2) US9035023B2 (ru)
EP (2) EP2100900A1 (ru)
JP (1) JP5784911B2 (ru)
KR (2) KR101734553B1 (ru)
CN (1) CN101965358B (ru)
AR (1) AR070809A1 (ru)
AU (1) AU2009221204C1 (ru)
BR (1) BRPI0909823B1 (ru)
CA (1) CA2717427C (ru)
CL (1) CL2009000537A1 (ru)
CO (1) CO6290707A2 (ru)
CR (1) CR11671A (ru)
CY (1) CY1118687T1 (ru)
DK (1) DK2252628T3 (ru)
DO (1) DOP2010000269A (ru)
EC (1) ECSP10010467A (ru)
ES (1) ES2615805T3 (ru)
HU (1) HUE032980T2 (ru)
MX (1) MX2010009843A (ru)
NZ (1) NZ587795A (ru)
PA (1) PA8818501A1 (ru)
PE (1) PE20091753A1 (ru)
PL (1) PL2252628T3 (ru)
PT (1) PT2252628T (ru)
RU (1) RU2523531C2 (ru)
SI (1) SI2252628T1 (ru)
SV (1) SV2010003660A (ru)
TW (1) TWI515011B (ru)
UA (1) UA103314C2 (ru)
UY (1) UY31693A (ru)
WO (1) WO2009109332A1 (ru)
ZA (1) ZA201006385B (ru)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2380596A1 (en) 2010-04-20 2011-10-26 Technische Universität München Cyclopentapeptide derivatives and uses thereof
EP2380597A1 (en) 2010-04-20 2011-10-26 Technische Universität München Cyclopeptide derivatives and uses thereof
EA026443B1 (ru) * 2010-11-22 2017-04-28 Пирамаль Имэджинг Са Меченныелютецием аналоги бомбезина для лучевой терапии
WO2012156511A1 (en) * 2011-05-19 2012-11-22 Universitätsspital Basel Bombesin receptor targeting peptide incorporating a 1, 2, 3-triazole group in the backbone for preparing in vivo diagnostic and therapeutic agents
KR102190005B1 (ko) 2012-09-25 2020-12-15 어드밴스드 액셀러레이터 애플리케이션즈 유에스에이, 인코퍼레이티드. Grpr-양성 암의 검출, 진단과 치료를 위한 grpr-길항제
EP2740726A1 (en) 2012-12-07 2014-06-11 3B Pharmaceuticals GmbH Neurotensin receptor ligands
EP2970154B1 (en) 2013-03-13 2021-07-07 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Tetrahydroxamate chelators of zirconium89 and niobium90 for use in diagnostic applications
US20150217006A1 (en) * 2014-02-06 2015-08-06 Immunomedics, Inc. Al-f-18-labeled, al-f-19-labeled and ga-68-labeled gastrin-releasing peptide receptor (grpr)-antagonists for imaging of prostate cancer
US10919938B2 (en) 2014-06-06 2021-02-16 Technische Universität München Modified cyclopentapeptides and uses thereof
RU2743781C2 (ru) 2014-06-10 2021-02-25 3Б Фармасьютикалз Гмбх Конъюгат, содержащий лиганд рецепторов нейротензина, и его применение
EP2954934A1 (en) 2014-06-11 2015-12-16 3B Pharmaceuticals GmbH Conjugate comprising a neurotensin receptor ligand and use thereof
EP2954933A1 (en) 2014-06-10 2015-12-16 3B Pharmaceuticals GmbH Conjugate comprising a neurotensin receptor ligand
ES2883347T3 (es) 2014-06-16 2021-12-07 Codexis Inc Composiciones y procedimientos para atenuar y prevenir la inflamación intestinal debida a la presencia de antígenos alimentarios peptídicos en un intestino
CN104610431B (zh) * 2014-11-26 2017-12-15 南京市第一医院 一种多肽及其应用
EP3393502A4 (en) 2015-12-16 2019-06-12 Nepetx, LLC COMPOSITIONS AND METHODS OF TREATING GLUTENEAL COMPATIBILITY AND DISORDERS ARISING FROM THE DISEASE
EP3279197A1 (en) 2016-08-03 2018-02-07 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnosis, treatment and prevention of neurotensin receptor-related conditions
WO2018126183A2 (en) * 2016-12-29 2018-07-05 The General Hospital Corporation Her3 peptides for imaging and radiotherapy
AU2018207190B2 (en) 2017-01-12 2020-12-03 Orano Med Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes
RU2681318C1 (ru) * 2017-11-24 2019-03-06 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Способ получения иммуносупрессорного пептида Abu-TGIRIS-Abu, меченного ионом Gd3+
US20210402016A1 (en) * 2018-11-13 2021-12-30 Provincial Health Services Authority Radiolabeled bombesin-derived compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders
EP3763726A1 (en) 2019-07-08 2021-01-13 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
WO2021005131A1 (en) 2019-07-08 2021-01-14 3B Pharmaceuticals Gmbh Compounds comprising a fibroblast activation protein ligand and use thereof
KR20220118464A (ko) * 2019-12-19 2022-08-25 테크니쉐 우니베르지테트 뮌헨 암의 영상화 및 치료법을 위한 개선된 약동학을 갖는 화합물
WO2021250240A1 (en) 2020-06-12 2021-12-16 Orano Diaza-18-crown-6 derivative useful for chelating radium, conjugate and radium chelate comprising the same, and uses thereof
EP3973999A1 (en) 2020-09-28 2022-03-30 Orano Med Conjugate or its salt comprising a gastrin-releasing peptide receptor antagonist and uses thereof
WO2022123462A1 (en) 2020-12-09 2022-06-16 3B Pharmaceuticals Gmbh Radiolabelled prostate specific membrane antigen (psma) inhibitors and use thereof
EP4050018A1 (en) 2021-01-07 2022-08-31 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
WO2023111350A2 (en) 2021-12-17 2023-06-22 3B Pharmaceuticals Gmbh Carbonic anhydrase ix ligands
WO2024052431A1 (en) 2022-09-07 2024-03-14 3B Pharmaceuticals Gmbh Prostate specific membrane antigen (psma) ligands and use thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5021556A (en) 1987-07-22 1991-06-04 Neorx Corporation Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides
US5075099A (en) 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5364613A (en) 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
US5686410A (en) * 1989-07-20 1997-11-11 Novartis Ag Polypeptide derivatives
ATE120374T1 (de) * 1989-07-20 1995-04-15 Sandoz Ag Markierte polypeptidderivate.
US5367080A (en) 1990-11-08 1994-11-22 Sterling Winthrop Inc. Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods
US5369094A (en) * 1990-11-29 1994-11-29 The Administrators Of The Tulane Educational Fund Polypeptide bombesin antagonists
US5965107A (en) 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US7060247B2 (en) 1997-04-22 2006-06-13 The Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
US6200546B1 (en) 1997-04-22 2001-03-13 The Curators Of The University Of Missouri Gastrin receptor-avid peptide conjugates
US5886142A (en) 1997-05-20 1999-03-23 Thomas Jefferson University Radiolabeled thrombus imaging agents
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
CA2316218A1 (en) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
AU2012199A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
WO1999033792A2 (en) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
GR1003661B (el) * 2000-05-25 2001-09-05 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ
AU2001223816A1 (en) * 2000-12-20 2002-07-01 Warner-Lambert Company Llc Novel uses of non-peptide bombesin receptor antagonists for treating anxiety and panic disorders
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7922998B2 (en) * 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US20080008649A1 (en) 2003-01-13 2008-01-10 Bracco Imaging S.P.A. Gastrin Releasing Peptide Compounds
CA2783275A1 (en) * 2003-07-24 2005-02-03 Bracco Imaging S.P.A. Stable radiopharmaceutical compositions and methods for their preparation
US20090062509A1 (en) 2006-03-16 2009-03-05 Aldo Cagnolini Chelation of metals to thiol groups using in situ reduction of disulfide-containing compounds by phosphines
EA026443B1 (ru) * 2010-11-22 2017-04-28 Пирамаль Имэджинг Са Меченныелютецием аналоги бомбезина для лучевой терапии

Also Published As

Publication number Publication date
JP2011515338A (ja) 2011-05-19
CO6290707A2 (es) 2011-06-20
SV2010003660A (es) 2011-02-17
AU2009221204B2 (en) 2013-09-05
CR11671A (es) 2010-11-01
ECSP10010467A (es) 2010-10-30
RU2010140846A (ru) 2012-04-20
CA2717427C (en) 2016-02-23
RU2523531C2 (ru) 2014-07-20
UY31693A (es) 2010-01-05
EP2252628B1 (en) 2016-12-28
CA2717427A1 (en) 2009-09-11
HUE032980T2 (en) 2017-11-28
TWI515011B (zh) 2016-01-01
EP2252628A1 (en) 2010-11-24
JP5784911B2 (ja) 2015-09-24
ES2615805T3 (es) 2017-06-08
KR20160128425A (ko) 2016-11-07
CN101965358B (zh) 2019-09-03
AU2009221204C1 (en) 2016-12-08
BRPI0909823B1 (pt) 2022-04-19
AR070809A1 (es) 2010-05-05
DK2252628T3 (en) 2017-02-06
PA8818501A1 (es) 2010-04-21
MX2010009843A (es) 2011-03-04
SI2252628T1 (sl) 2017-05-31
US20110097266A1 (en) 2011-04-28
KR101734553B1 (ko) 2017-05-11
BRPI0909823A2 (pt) 2019-03-06
US9035023B2 (en) 2015-05-19
EP2100900A1 (en) 2009-09-16
AU2009221204A1 (en) 2009-09-11
PT2252628T (pt) 2017-02-10
CL2009000537A1 (es) 2010-07-19
WO2009109332A1 (en) 2009-09-11
CN101965358A (zh) 2011-02-02
TW200944239A (en) 2009-11-01
US20150265733A1 (en) 2015-09-24
CY1118687T1 (el) 2017-07-12
ZA201006385B (en) 2016-10-26
KR20110014565A (ko) 2011-02-11
NZ587795A (en) 2012-07-27
PE20091753A1 (es) 2009-12-13
PL2252628T3 (pl) 2017-07-31
DOP2010000269A (es) 2010-10-31

Similar Documents

Publication Publication Date Title
UA103314C2 (ru) Конъюгаты антагониста пептида аналога бомбезина
NZ604718A (en) Human antibody drug conjugates against tissue factor
MX2011005963A (es) Conjugados de neurotensina o analogos de neurotensina y sus usos.
MX2011005965A (es) Conjugados de leptina y de análogos de leptina y sus usos de los mismos.
MY157239A (en) A method to produce a highly concentrated immunoglobulin preparation for subcutaneous use
TW200621737A (en) 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof
GEP20156309B (en) Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
MY169432A (en) Bicyclo[3.2.1]octyl amide derivatives and uses of same
TN2011000172A1 (en) Therapeutic antiviral peptides
TW200609227A (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
BR112012011328A2 (pt) inibidores de akt
UA93709C2 (ru) 12-имидазолил-1-додеканол и его применение b изготовлении фармацевтических композиций
WO2009127669A3 (en) Ido inhibitors and therapeutic uses thereof
NZ599791A (en) Therapeutic peptides
BRPI0714885B8 (pt) compostos terapêuticos e seu uso
MY154970A (en) Dimers of artemisinin derivatives, preparation thereof and therapeutic use thereof
MX2009006410A (es) Conjugados de polimero-oligonucleotido, proteina y/o peptido.
IN2012DN02502A (ru)
CY1109685T1 (el) Χρησιμοποιηση συμπλοκων ενωσεων σιδηρου(ιιι)
CA2767833C (en) N-acetyl cysteine compositions and methods to improve the therapeutic efficacy of acetaminophen
MX2009001578A (es) Lactamas terapeuticas.
NZ610740A (en) 177lutetium-labeled bombesin analogs for radiotherapy
MX2011007940A (es) Conjugados de oligomero-fenotiazina.
GB2453402A (en) Bis-pyyrolo[2.1.-c] benzodiazepine-anthraquinone conjugates as antitumour agents and a process for the preparation thereof
MX2011007108A (es) Incrementadores de angiogenesis generados por derrame cerebral y usos de los mismos.