MX2011005965A - Conjugados de leptina y de análogos de leptina y sus usos de los mismos. - Google Patents

Conjugados de leptina y de análogos de leptina y sus usos de los mismos.

Info

Publication number
MX2011005965A
MX2011005965A MX2011005965A MX2011005965A MX2011005965A MX 2011005965 A MX2011005965 A MX 2011005965A MX 2011005965 A MX2011005965 A MX 2011005965A MX 2011005965 A MX2011005965 A MX 2011005965A MX 2011005965 A MX2011005965 A MX 2011005965A
Authority
MX
Mexico
Prior art keywords
leptin
compound
analog conjugates
analog
linker
Prior art date
Application number
MX2011005965A
Other languages
English (en)
Inventor
Michel Demeule
Christian Che
Jean-Paul Castaigne
Betty Lawrence
Dominique Boivin
Original Assignee
Angiochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angiochem Inc filed Critical Angiochem Inc
Publication of MX2011005965A publication Critical patent/MX2011005965A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Abstract

La presente invención presenta un compuesto teniendo la formula A-X-B, donde A es un vector de péptido capaz de mejorar el transporte del compuesto a través de la barrera hematoencefalica o hacia tipos de células particulares, X es un enlazador y B es una leptina, un análogo de leptina o un agonista del receptor OB. Los compuestos de la invención pueden usarse para tratar cualquier enfermedad en la cual cantidades incrementadas de leptina se desean, tales como enfermedades metabólicas incluyendo obesidad y diabetes.
MX2011005965A 2008-12-05 2009-12-07 Conjugados de leptina y de análogos de leptina y sus usos de los mismos. MX2011005965A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20094708P 2008-12-05 2008-12-05
US17883709P 2009-05-15 2009-05-15
PCT/CA2009/001780 WO2010063123A1 (en) 2008-12-05 2009-12-07 Leptin and leptin analog conjugates and uses thereof

Publications (1)

Publication Number Publication Date
MX2011005965A true MX2011005965A (es) 2011-09-01

Family

ID=42232847

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011005965A MX2011005965A (es) 2008-12-05 2009-12-07 Conjugados de leptina y de análogos de leptina y sus usos de los mismos.

Country Status (10)

Country Link
US (1) US20110288009A1 (es)
EP (1) EP2370472A4 (es)
JP (1) JP2012510797A (es)
CN (1) CN102272163A (es)
AU (1) AU2009322044A1 (es)
BR (1) BRPI0922691A2 (es)
CA (1) CA2745527A1 (es)
MX (1) MX2011005965A (es)
RU (1) RU2011125367A (es)
WO (1) WO2010063123A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1583562B1 (en) 2003-01-06 2011-06-15 Angiochem Inc. Angiopep-1, related compounds, and uses thereof
PT2360258E (pt) 2005-02-18 2015-01-13 Angiochem Inc Moléculas para transportar um composto através da barreira hematoencefálica
PL2233156T3 (pl) 2005-07-15 2013-09-30 Angiochem Inc Zastosowanie polipeptydów aprotyninowych jako nośników w koniugatach farmaceutycznych
WO2008046228A1 (en) 2006-10-19 2008-04-24 Angiochem, Inc. Compounds for stimulating p-glycoprotein function and uses thereof
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8921314B2 (en) 2008-10-15 2014-12-30 Angiochem, Inc. Conjugates of GLP-1 agonists and uses thereof
EP2370471B1 (en) 2008-12-05 2017-02-22 Angiochem Inc. Neurotensin conjugate and uses thereof
AU2009327267A1 (en) 2008-12-17 2011-07-14 Angiochem, Inc. Membrane type-1 matrix metalloprotein inhibitors and uses thereof
US9173891B2 (en) 2009-04-20 2015-11-03 Angiochem, Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
IN2012DN00248A (es) 2009-07-02 2015-05-01 Angiochem Inc
WO2011153642A1 (en) * 2010-06-10 2011-12-15 Angiochem Inc. Leptin and leptin analog conjugates and fusion proteins and uses thereof
WO2014026283A1 (en) 2012-08-14 2014-02-20 Angiochem Inc. Peptide-dendrimer conjugates and uses thereof
MX365465B (es) 2013-03-21 2019-06-04 Sanofi Aventis Deutschland Sintesis de productos peptidicos que contienen imida ciclica.
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
JP2017532292A (ja) 2014-08-11 2017-11-02 オルバニー メディカル カレッジ ミリストイル化レプチン関連ペプチド及びその使用
WO2016081733A2 (en) * 2014-11-19 2016-05-26 Novopyxis Inc. Compositions and methods for modulating at2r activity
CN104829705B (zh) * 2015-05-06 2017-11-14 广东省生物资源应用研究所 一条c螺旋区突变的瘦素活性肽及其编码基因和应用
CN104829707B (zh) * 2015-05-06 2017-12-19 广东省生物资源应用研究所 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用
CN104829708B (zh) * 2015-05-06 2017-11-28 广东省生物资源应用研究所 一条d螺旋区突变的瘦素活性肽及其编码基因和应用
DK3307326T3 (da) 2015-06-15 2020-10-19 Angiochem Inc Fremgangsmåder til behandling af leptomeningeal karcinomatose
KR20180025962A (ko) 2015-07-06 2018-03-09 유씨비 바이오파마 에스피알엘 타우 결합 항체

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2360258E (pt) * 2005-02-18 2015-01-13 Angiochem Inc Moléculas para transportar um composto através da barreira hematoencefálica
EP2164866B1 (en) * 2007-05-29 2014-05-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues

Also Published As

Publication number Publication date
EP2370472A1 (en) 2011-10-05
BRPI0922691A2 (pt) 2018-11-06
AU2009322044A1 (en) 2011-07-07
JP2012510797A (ja) 2012-05-17
CN102272163A (zh) 2011-12-07
WO2010063123A1 (en) 2010-06-10
CA2745527A1 (en) 2010-06-10
RU2011125367A (ru) 2013-01-10
US20110288009A1 (en) 2011-11-24
EP2370472A4 (en) 2013-04-24

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