PE20091081A1 - Piperazino-dihidrotienopirimidinas sustituidas como inhibidores de pde4 - Google Patents

Piperazino-dihidrotienopirimidinas sustituidas como inhibidores de pde4

Info

Publication number
PE20091081A1
PE20091081A1 PE2008001794A PE2008001794A PE20091081A1 PE 20091081 A1 PE20091081 A1 PE 20091081A1 PE 2008001794 A PE2008001794 A PE 2008001794A PE 2008001794 A PE2008001794 A PE 2008001794A PE 20091081 A1 PE20091081 A1 PE 20091081A1
Authority
PE
Peru
Prior art keywords
5lambda4
piperazin
pyrimidin
dihydro
oxo
Prior art date
Application number
PE2008001794A
Other languages
English (en)
Inventor
Pascale Pouzet
Ralf Anderskewitz
Horst Dollinger
Dennis Fiegen
Thomas Fox
Rolf Goeggel
Christoph Hoenke
Domnic Martyres
Peter Nickolaus
Klaus Klinder
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20091081A1 publication Critical patent/PE20091081A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
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  • Psychiatry (AREA)
  • Hematology (AREA)
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Abstract

REFERIDA A UN COMPUESTO DERIVADO DE DIHIDROTIENOPIRIMIDINSULFOXIDO DE FORMULA (1), DONDE X ES SO O SO2; R1 ES H O ALQUILO C1-C6; R2 ES H, ALQUILO C1-C10, ALQUENILO C2-C6, ENTRE OTROS; R3 ES PIRAZOL, FURANO, TIOFENO, TIAZOL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (3-FLUOROFENIL)-[5-OXO-2-(4-TIAZOL-2-IL-PIPERAZIN-1-IL)-6,7-DIHIDRO-5H-5LAMBDA4-TIENO[3,2-d]PIRIMIDIN-4-IL]-AMINA, (R)-3-METIL-2-[5-OXO-2-(4-TIAZOL-2-IL-PIPERAZIN-1-IL)-6,7-DIHIDRO-5H-5LAMBDA4-TIENO[3,2-d]PIRIMIDIN-4-ILAMINO]-BUTAN-1-OL, [2-(4-BENZOXAZOL-2-IL-PIPERAZIN-1-IL)-5-OXO-6,7-DIHIDRO-5H-5LAMBDA4-TIENO[3,2-d]PIRIMIDIN-4-IL]-(3-FLUOROFENIL)-AMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ENZIMA PDE 4 Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES GASTROINTESTINALES, ENFERMEDADES DE LAS VIAS REPIRATORIAS, ENFERMEDADES CANCERIGENAS, ENTRE OTRAS
PE2008001794A 2007-10-19 2008-10-17 Piperazino-dihidrotienopirimidinas sustituidas como inhibidores de pde4 PE20091081A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07118911 2007-10-19

Publications (1)

Publication Number Publication Date
PE20091081A1 true PE20091081A1 (es) 2009-08-24

Family

ID=39204738

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PE2008001794A PE20091081A1 (es) 2007-10-19 2008-10-17 Piperazino-dihidrotienopirimidinas sustituidas como inhibidores de pde4

Country Status (18)

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US (2) US8637519B2 (es)
EP (1) EP2205609B1 (es)
JP (1) JP5341899B2 (es)
KR (1) KR20100075930A (es)
CN (1) CN101827853A (es)
AR (1) AR069076A1 (es)
AU (1) AU2008313742B2 (es)
BR (1) BRPI0817781A2 (es)
CA (1) CA2702524A1 (es)
CL (1) CL2008003097A1 (es)
MX (1) MX2010003346A (es)
NZ (1) NZ585348A (es)
PE (1) PE20091081A1 (es)
RU (1) RU2500681C2 (es)
TW (1) TWI445535B (es)
UY (1) UY31402A1 (es)
WO (1) WO2009050242A2 (es)
ZA (1) ZA201001621B (es)

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WO2011124524A1 (de) 2010-04-08 2011-10-13 Boehringer Ingelheim International Gmbh Arzneimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten
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WO2019115775A1 (en) 2017-12-15 2019-06-20 Leo Pharma A/S Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
KR102260995B1 (ko) * 2018-11-28 2021-06-04 국립암센터 Plk1의 활성 억제제를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물
CN113880859B (zh) * 2021-11-16 2022-06-21 江西科技师范大学 2-芳基-4-芳甲胺基嘧啶类化合物及其应用
US20230190754A1 (en) 2021-12-09 2023-06-22 Boehringer Ingelheim International Gmbh Therapeutic combinations for the treatment of Progressive Fibrosing interstitial lung diseases
TW202339731A (zh) 2021-12-09 2023-10-16 德商百靈佳殷格翰國際股份有限公司 用於治療進行性纖維化間質性肺病之新穎口服醫藥組合物及劑量療法
WO2023232135A1 (zh) * 2022-06-02 2023-12-07 西藏海思科制药有限公司 Pde4b抑制剂及其用途
CN117247395A (zh) * 2022-06-16 2023-12-19 武汉人福创新药物研发中心有限公司 Pde4b抑制剂
WO2024032673A1 (zh) * 2022-08-09 2024-02-15 西藏海思科制药有限公司 Pde4b抑制剂及其用途
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AR069076A1 (es) 2009-12-30
EP2205609B1 (de) 2017-03-29
US9115142B2 (en) 2015-08-25
ZA201001621B (en) 2010-10-27
US20140107103A1 (en) 2014-04-17
UY31402A1 (es) 2009-05-29
WO2009050242A2 (de) 2009-04-23
RU2500681C2 (ru) 2013-12-10
US20100305102A1 (en) 2010-12-02
BRPI0817781A2 (pt) 2019-09-24
JP2011500639A (ja) 2011-01-06
EP2205609A2 (de) 2010-07-14
MX2010003346A (es) 2010-04-09
WO2009050242A3 (de) 2009-07-30
NZ585348A (en) 2012-02-24
CL2008003097A1 (es) 2010-01-22
RU2010119645A (ru) 2012-01-27
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CN101827853A (zh) 2010-09-08
US8637519B2 (en) 2014-01-28
CA2702524A1 (en) 2009-04-23
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KR20100075930A (ko) 2010-07-05

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