CL2008003097A1 - Compuestos derivados de 2-il-piperazin-1-il-pirimidin-4-il-tieno[3,2-d]aminas sustituidas, composicion farmaceutica y su uso como inhibidores de pde4 para el tratamiento de trastornos gastrointestinales, respiratorios y del sistema nervioso periferico o central, tales como epoc, sinusitis cronica, asma, depresion y esquizofrenia. - Google Patents
Compuestos derivados de 2-il-piperazin-1-il-pirimidin-4-il-tieno[3,2-d]aminas sustituidas, composicion farmaceutica y su uso como inhibidores de pde4 para el tratamiento de trastornos gastrointestinales, respiratorios y del sistema nervioso periferico o central, tales como epoc, sinusitis cronica, asma, depresion y esquizofrenia.Info
- Publication number
- CL2008003097A1 CL2008003097A1 CL2008003097A CL2008003097A CL2008003097A1 CL 2008003097 A1 CL2008003097 A1 CL 2008003097A1 CL 2008003097 A CL2008003097 A CL 2008003097A CL 2008003097 A CL2008003097 A CL 2008003097A CL 2008003097 A1 CL2008003097 A1 CL 2008003097A1
- Authority
- CL
- Chile
- Prior art keywords
- thieno
- copd
- piperazin
- schizophrenia
- pyrimidin
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos derivados de 2-il-piperazin-1-il-pirimidin-4-il-tieno[3,2-d]aminas sustituidas, composición farmacéutica y su uso en el tratamiento de trastornos gastrointestinales, respiratorios y del sistema nervioso periférico o central, tales como, epoc, sinusitis crónica, asma, depresión y esquizofrenia, entre otras.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07118911 | 2007-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008003097A1 true CL2008003097A1 (es) | 2010-01-22 |
Family
ID=39204738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008003097A CL2008003097A1 (es) | 2007-10-19 | 2008-10-17 | Compuestos derivados de 2-il-piperazin-1-il-pirimidin-4-il-tieno[3,2-d]aminas sustituidas, composicion farmaceutica y su uso como inhibidores de pde4 para el tratamiento de trastornos gastrointestinales, respiratorios y del sistema nervioso periferico o central, tales como epoc, sinusitis cronica, asma, depresion y esquizofrenia. |
Country Status (18)
Country | Link |
---|---|
US (2) | US8637519B2 (es) |
EP (1) | EP2205609B1 (es) |
JP (1) | JP5341899B2 (es) |
KR (1) | KR20100075930A (es) |
CN (1) | CN101827853A (es) |
AR (1) | AR069076A1 (es) |
AU (1) | AU2008313742B2 (es) |
BR (1) | BRPI0817781A2 (es) |
CA (1) | CA2702524A1 (es) |
CL (1) | CL2008003097A1 (es) |
MX (1) | MX2010003346A (es) |
NZ (1) | NZ585348A (es) |
PE (1) | PE20091081A1 (es) |
RU (1) | RU2500681C2 (es) |
TW (1) | TWI445535B (es) |
UY (1) | UY31402A1 (es) |
WO (1) | WO2009050242A2 (es) |
ZA (1) | ZA201001621B (es) |
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EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
EP2205608B1 (en) * | 2007-10-18 | 2013-05-08 | Boehringer Ingelheim International GmbH | Preparation of dihydrothieno[3, 2-d]pyrimidines and intermediates used therein |
US8486948B2 (en) | 2007-10-19 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Piperazinodihydrothienopyrimidine derivatives |
MX2010003346A (es) | 2007-10-19 | 2010-04-09 | Boehringer Ingelheim Int | Piperazino-dihidrotienopirimidinas sustituidas en heterociclo. |
EP2610258B1 (de) | 2007-10-19 | 2014-08-27 | Boehringer Ingelheim International Gmbh | Substituierte Piperidino-Dihydrothienopyrimidine |
CA2753597A1 (en) | 2009-02-27 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Drug combinations containing pde4-inhibitors and nsaids |
JP2013529184A (ja) | 2010-04-08 | 2013-07-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Pde4阻害剤及びep4受容体アンタゴニストを含有する医薬の組み合わせ |
WO2012027495A1 (en) | 2010-08-27 | 2012-03-01 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
UA112897C2 (uk) | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань |
KR102214222B1 (ko) * | 2013-07-10 | 2021-02-08 | 메이지 세이카 파루마 가부시키가이샤 | 신규 pde4 저해제 |
CN106279173A (zh) * | 2015-05-29 | 2017-01-04 | 华东理工大学 | 蝶啶酮衍生物作为egfr抑制剂的应用 |
CN111108109A (zh) | 2017-09-20 | 2020-05-05 | 利奥制药有限公司 | 取代的二氢噻吩并嘧啶及其作为磷酸二酯酶抑制剂的用途 |
KR20200075864A (ko) | 2017-10-23 | 2020-06-26 | 베링거 인겔하임 인터내셔날 게엠베하 | 진행성 섬유화 간질성 폐 질환(pf-ild)의 치료를 위한 활성 제제들의 신규한 배합 |
JP7198820B2 (ja) | 2017-12-15 | 2023-01-04 | ユニオン・セラピューティクス・アクティエセルスカブ | 置換アゼチジンジヒドロチエノピリミジンおよびホスホジエステラーゼ阻害剤としてのそれらの使用 |
US11299497B2 (en) | 2017-12-15 | 2022-04-12 | UNION therapeutics A/S | Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors |
WO2019115776A1 (en) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors |
KR102260995B1 (ko) * | 2018-11-28 | 2021-06-04 | 국립암센터 | Plk1의 활성 억제제를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물 |
CN113880859B (zh) * | 2021-11-16 | 2022-06-21 | 江西科技师范大学 | 2-芳基-4-芳甲胺基嘧啶类化合物及其应用 |
AU2022407131A1 (en) | 2021-12-09 | 2024-04-11 | Boehringer Ingelheim International Gmbh | New oral pharmaceutical composition and dose regimen for the therapy of progressive fibrosing interstitial lung diseases |
AU2022404695A1 (en) | 2021-12-09 | 2024-05-02 | Boehringer Ingelheim International Gmbh | New therapeutic combinations for the treatment of progressive fibrosing interstitial lung diseases |
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CN117247395A (zh) * | 2022-06-16 | 2023-12-19 | 武汉人福创新药物研发中心有限公司 | Pde4b抑制剂 |
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JP2005003345A (ja) | 2003-05-21 | 2005-01-06 | Showa Denko Kk | 換気兼熱交換装置および空調システム |
KR101295390B1 (ko) * | 2003-10-02 | 2013-09-17 | 마텍 바이오싸이언스스 코포레이션 | 변형량의 염소 및 칼륨을 사용하는 미세조류 중에 고농도 디에치에이의 생산 |
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WO2005082865A1 (ja) | 2004-02-27 | 2005-09-09 | Astellas Pharma Inc. | 縮合二環性ピリミジン誘導体 |
BRPI0608387A2 (pt) | 2006-04-19 | 2009-12-29 | Boehringer Ingelheim Int | compostos para o tratamento de doenças inflamatórias |
EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
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EP2205608B1 (en) | 2007-10-18 | 2013-05-08 | Boehringer Ingelheim International GmbH | Preparation of dihydrothieno[3, 2-d]pyrimidines and intermediates used therein |
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EP2610258B1 (de) * | 2007-10-19 | 2014-08-27 | Boehringer Ingelheim International Gmbh | Substituierte Piperidino-Dihydrothienopyrimidine |
BRPI0818605A2 (pt) * | 2007-10-19 | 2015-04-22 | Schering Corp | Derivados de 1,3,4-tiadiazl espiro-condensados para inibir a atividade de ksp cinesima |
FR2922550B1 (fr) | 2007-10-19 | 2009-11-27 | Sanofi Aventis | Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
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CA2753597A1 (en) * | 2009-02-27 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Drug combinations containing pde4-inhibitors and nsaids |
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-
2008
- 2008-10-16 MX MX2010003346A patent/MX2010003346A/es active IP Right Grant
- 2008-10-16 CA CA2702524A patent/CA2702524A1/en not_active Abandoned
- 2008-10-16 JP JP2010529387A patent/JP5341899B2/ja active Active
- 2008-10-16 US US12/738,429 patent/US8637519B2/en active Active
- 2008-10-16 CN CN200880112298A patent/CN101827853A/zh active Pending
- 2008-10-16 AU AU2008313742A patent/AU2008313742B2/en not_active Ceased
- 2008-10-16 EP EP08840075.9A patent/EP2205609B1/de active Active
- 2008-10-16 KR KR1020107008407A patent/KR20100075930A/ko not_active Application Discontinuation
- 2008-10-16 NZ NZ585348A patent/NZ585348A/en not_active IP Right Cessation
- 2008-10-16 RU RU2010119645/04A patent/RU2500681C2/ru not_active IP Right Cessation
- 2008-10-16 WO PCT/EP2008/063983 patent/WO2009050242A2/de active Application Filing
- 2008-10-16 BR BRPI0817781A patent/BRPI0817781A2/pt not_active IP Right Cessation
- 2008-10-17 UY UY31402A patent/UY31402A1/es not_active Application Discontinuation
- 2008-10-17 AR ARP080104561A patent/AR069076A1/es unknown
- 2008-10-17 TW TW097139972A patent/TWI445535B/zh not_active IP Right Cessation
- 2008-10-17 CL CL2008003097A patent/CL2008003097A1/es unknown
- 2008-10-17 PE PE2008001794A patent/PE20091081A1/es not_active Application Discontinuation
-
2010
- 2010-03-05 ZA ZA201001621A patent/ZA201001621B/xx unknown
-
2013
- 2013-12-19 US US14/134,367 patent/US9115142B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2008313742A1 (en) | 2009-04-23 |
AR069076A1 (es) | 2009-12-30 |
UY31402A1 (es) | 2009-05-29 |
PE20091081A1 (es) | 2009-08-24 |
US9115142B2 (en) | 2015-08-25 |
BRPI0817781A2 (pt) | 2019-09-24 |
US20100305102A1 (en) | 2010-12-02 |
RU2010119645A (ru) | 2012-01-27 |
CA2702524A1 (en) | 2009-04-23 |
KR20100075930A (ko) | 2010-07-05 |
RU2500681C2 (ru) | 2013-12-10 |
NZ585348A (en) | 2012-02-24 |
JP5341899B2 (ja) | 2013-11-13 |
TWI445535B (zh) | 2014-07-21 |
WO2009050242A3 (de) | 2009-07-30 |
ZA201001621B (en) | 2010-10-27 |
US8637519B2 (en) | 2014-01-28 |
WO2009050242A2 (de) | 2009-04-23 |
JP2011500639A (ja) | 2011-01-06 |
MX2010003346A (es) | 2010-04-09 |
AU2008313742B2 (en) | 2013-11-28 |
TW200918073A (en) | 2009-05-01 |
EP2205609A2 (de) | 2010-07-14 |
CN101827853A (zh) | 2010-09-08 |
EP2205609B1 (de) | 2017-03-29 |
US20140107103A1 (en) | 2014-04-17 |
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