PE20020802A1 - COMPUESTO DE LACTAMA COMO INHIBIDOR DE LA LIBERACION DEL PEPTIDO ß-AMILOIDE - Google Patents

COMPUESTO DE LACTAMA COMO INHIBIDOR DE LA LIBERACION DEL PEPTIDO ß-AMILOIDE

Info

Publication number
PE20020802A1
PE20020802A1 PE2001001142A PE2001001142A PE20020802A1 PE 20020802 A1 PE20020802 A1 PE 20020802A1 PE 2001001142 A PE2001001142 A PE 2001001142A PE 2001001142 A PE2001001142 A PE 2001001142A PE 20020802 A1 PE20020802 A1 PE 20020802A1
Authority
PE
Peru
Prior art keywords
inhibitor
release
amyloid peptide
lactam compound
compound
Prior art date
Application number
PE2001001142A
Other languages
English (en)
Spanish (es)
Inventor
James Edmund Audia
Varghese John
Stacey Leigh Mcdaniel
Eugene D Thorsett
Jay S Tung
Jeffrey Scott Nissen
Lee H Latimer
Original Assignee
Lilly Co Eli
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Elan Pharm Inc filed Critical Lilly Co Eli
Publication of PE20020802A1 publication Critical patent/PE20020802A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
PE2001001142A 2000-11-17 2001-11-16 COMPUESTO DE LACTAMA COMO INHIBIDOR DE LA LIBERACION DEL PEPTIDO ß-AMILOIDE PE20020802A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24955200P 2000-11-17 2000-11-17

Publications (1)

Publication Number Publication Date
PE20020802A1 true PE20020802A1 (es) 2002-09-10

Family

ID=22943982

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001142A PE20020802A1 (es) 2000-11-17 2001-11-16 COMPUESTO DE LACTAMA COMO INHIBIDOR DE LA LIBERACION DEL PEPTIDO ß-AMILOIDE

Country Status (33)

Country Link
US (1) US20050261495A1 (cg-RX-API-DMAC10.html)
EP (1) EP1341531B1 (cg-RX-API-DMAC10.html)
JP (1) JP4116437B2 (cg-RX-API-DMAC10.html)
KR (1) KR100819679B1 (cg-RX-API-DMAC10.html)
CN (1) CN1486184A (cg-RX-API-DMAC10.html)
AR (1) AR035927A1 (cg-RX-API-DMAC10.html)
AU (2) AU2002243192B2 (cg-RX-API-DMAC10.html)
BR (1) BR0115427A (cg-RX-API-DMAC10.html)
CA (1) CA2427227C (cg-RX-API-DMAC10.html)
CY (1) CY1106366T1 (cg-RX-API-DMAC10.html)
CZ (1) CZ20031351A3 (cg-RX-API-DMAC10.html)
DE (1) DE60126132T2 (cg-RX-API-DMAC10.html)
DK (1) DK1341531T3 (cg-RX-API-DMAC10.html)
DZ (1) DZ3453A1 (cg-RX-API-DMAC10.html)
EA (1) EA005954B1 (cg-RX-API-DMAC10.html)
EC (1) ECSP034600A (cg-RX-API-DMAC10.html)
ES (1) ES2278804T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20030383B1 (cg-RX-API-DMAC10.html)
HU (1) HU228117B1 (cg-RX-API-DMAC10.html)
IL (2) IL155960A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA03004292A (cg-RX-API-DMAC10.html)
MY (1) MY134559A (cg-RX-API-DMAC10.html)
NO (1) NO324324B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ525854A (cg-RX-API-DMAC10.html)
PE (1) PE20020802A1 (cg-RX-API-DMAC10.html)
PL (1) PL212199B1 (cg-RX-API-DMAC10.html)
PT (1) PT1341531E (cg-RX-API-DMAC10.html)
SI (1) SI1341531T1 (cg-RX-API-DMAC10.html)
SK (1) SK288065B6 (cg-RX-API-DMAC10.html)
TW (1) TWI305204B (cg-RX-API-DMAC10.html)
UA (1) UA74849C2 (cg-RX-API-DMAC10.html)
WO (1) WO2002047671A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200303789B (cg-RX-API-DMAC10.html)

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TW200920362A (en) 2007-09-11 2009-05-16 Daiichi Sankyo Co Ltd Alkylsulfone derivatives
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WO2009128057A2 (en) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Psycho-pharmaceuticals
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EP2584903B1 (en) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
CN103068980B (zh) 2010-08-02 2017-04-05 瑟纳治疗公司 使用短干扰核酸（siNA）的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1（CTNNB1）基因表达的抑制
RU2745848C2 (ru) 2010-08-17 2021-04-01 Сирна Терапьютикс, Инк. ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
WO2012040444A2 (en) * 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Treatment of patients with incipient alzheimer's disease
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EP2892506B1 (en) 2012-09-07 2021-11-03 Massachusetts Eye & Ear Infirmary Treating hearing loss with the gamma-secretase inhibitor ly411575
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EP3212773B1 (en) 2014-10-29 2021-09-15 Massachusetts Eye and Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
KR102362222B1 (ko) 2016-05-16 2022-02-11 더 제너럴 하스피탈 코포레이션 폐 상피 공학에서 인간 기도 줄기 세포
US10975084B2 (en) 2016-10-12 2021-04-13 Merck Sharp & Dohme Corp. KDM5 inhibitors
EP3706742B1 (en) 2017-11-08 2023-03-15 Merck Sharp & Dohme LLC Prmt5 inhibitors
WO2019094312A1 (en) 2017-11-08 2019-05-16 Merck Sharp & Dohme Corp. Prmt5 inhibitors
US11590152B2 (en) 2018-01-26 2023-02-28 Massachusetts Eye And Ear Infirmary Treatment of hearing loss
CA3108388A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
WO2020033282A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
WO2020033285A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
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EP4076460B1 (en) 2019-12-17 2026-01-21 Merck Sharp & Dohme LLC 1,4-dihydro-2h-spiro[isoquinoline-3,4'-piperidine derivatives as prmt5 inhibitors for the treatment of cancer
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Also Published As

Publication number Publication date
AR035927A1 (es) 2004-07-28
JP2004517090A (ja) 2004-06-10
AU2002243192B2 (en) 2006-07-20
NO20032236L (no) 2003-07-10
HUP0301842A3 (en) 2010-03-29
UA74849C2 (en) 2006-02-15
NZ525854A (en) 2004-06-25
EA200300580A1 (ru) 2003-10-30
HUP0301842A2 (hu) 2003-09-29
SI1341531T1 (sl) 2007-06-30
HK1059731A1 (en) 2004-07-16
EA005954B1 (ru) 2005-08-25
MY134559A (en) 2007-12-31
WO2002047671A2 (en) 2002-06-20
IL155960A (en) 2009-06-15
PL362688A1 (en) 2004-11-02
US20050261495A1 (en) 2005-11-24
JP4116437B2 (ja) 2008-07-09
CN1486184A (zh) 2004-03-31
SK5592003A3 (en) 2003-12-02
KR20030051846A (ko) 2003-06-25
MXPA03004292A (es) 2004-02-12
DE60126132D1 (de) 2007-03-08
CA2427227C (en) 2010-08-17
ZA200303789B (en) 2004-08-16
ECSP034600A (es) 2003-06-25
WO2002047671A3 (en) 2003-03-06
BR0115427A (pt) 2003-10-07
CZ20031351A3 (cs) 2003-11-12
KR100819679B1 (ko) 2008-04-04
DK1341531T3 (da) 2007-05-14
ES2278804T3 (es) 2007-08-16
TWI305204B (en) 2009-01-11
EP1341531A2 (en) 2003-09-10
NO324324B1 (no) 2007-09-24
HRP20030383B1 (hr) 2007-12-31
CA2427227A1 (en) 2002-06-20
DZ3453A1 (fr) 2002-06-20
HRP20030383A2 (en) 2005-10-31
IL155960A0 (en) 2003-12-23
AU4319202A (en) 2002-06-24
EP1341531B1 (en) 2007-01-17
DE60126132T2 (de) 2007-10-18
HU228117B1 (en) 2012-11-28
PL212199B1 (pl) 2012-08-31
SK288065B6 (sk) 2013-04-03
CY1106366T1 (el) 2011-10-12
PT1341531E (pt) 2007-04-30
NO20032236D0 (no) 2003-05-16

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