PA8580201A1 - Terapia de combinacion para enfermedades hiperproliferativas - Google Patents

Terapia de combinacion para enfermedades hiperproliferativas

Info

Publication number
PA8580201A1
PA8580201A1 PA20038580201A PA8580201A PA8580201A1 PA 8580201 A1 PA8580201 A1 PA 8580201A1 PA 20038580201 A PA20038580201 A PA 20038580201A PA 8580201 A PA8580201 A PA 8580201A PA 8580201 A1 PA8580201 A1 PA 8580201A1
Authority
PA
Panama
Prior art keywords
hyperproliferative diseases
group
compartment
present
invention refers
Prior art date
Application number
PA20038580201A
Other languages
English (en)
Inventor
Jean Saccuzzo Beebe
Karen Jean Ferrante
Jitesh Pranlal Jani
Tracey Lee Schaeffer
Diane Ingeborg Healey
James John O'leary
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8580201A1 publication Critical patent/PA8580201A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

ESTE INVENTO SE REFIERE A UN METODO PARA TRATAR ENFERMEDADES HIPERPROLIFERATIVAS. MAS PARTICULARMENTE, EL PRESENTE INVENTO SE REFIERE A UN METODO PARA TRATAR ENFERMEDADES HIPERPROLIFERATIVAS, TALES COMO EL CANCER, QUE COMPRENDE LA OPERACION DE ADMINISTRAR A UN MAMIFERO QUE NECESITA DICHO TRATAMIENTO, SEA SIMULTANEA O SUCESIVAMENTE, (i) UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DE UN DERIVADO DE TAXANO, UN COMPLEJO DE COORDINACION DE PLATINO SELECCIONADO DEL GRUPO QUE CONSISTE EN CARBOPLATINO, TETRAPLATINO Y TOPOTECAN, UN COMPUESTO ANALOGO A NUCLEOSIDO SELECCIONADO DEL GRUPO QUE CONSISTE EN HIDROCLORURO DE GENCITABINA Y 5-FU, UNA ANTRACICLINA, UN INHIBIDOR DE TOPOISOMERASAS SELECCIONADO DEL GRUPO QUE CONSISTE EN ETOPOSIDO, TENIPOSIDO, ANSACRINA, TOPOTECAN Y CAMPTOSAR, UN INHIBIDOR DE AROMATASA; Y (ii) UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DE UN DERIVADO DE ISOTIAZOL. LAS COMBINACIONES DEL PRESENTE INVENTO PUEDEN INCLUIR OPCIONALMENTE UN AGENTE ANTIHIPERTENSIVO. ESTE INVENTO SE REFIERE TAMBIEN A COMPOSICIONES FARMACEUTICAS UTILES EN EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS EN MAMIFEROS, QUE CONTIENEN TALES COMBINACIONES. EL PRESENTE INVENTO TAMBIEN SE REFIERE A SISTEMAS QUE TIENEN UN PRIMER COMPARTIMIENTO CON UN COMPUESTO DE FORMULA 1, Y UN SEGUNDO COMPARTIMIENTO QUE CONTIENE UN DERIVADO DE TAXANO, UN COMPLEJO DE COORDINACION DE PLATINO, UN COMPUESTO ANALOGO A NUCLEOSIDO, UNA ANTRACICLINA, UN INHIBIDOR DE TOPOISOMERASAS O UN INHIBIDOR DE AROMATASA, Y UN TERCER COMPARTIMENTO QUE CONTIENE UN AGENTE ANTIHIPERTENSIVO.
PA20038580201A 2002-08-19 2003-08-12 Terapia de combinacion para enfermedades hiperproliferativas PA8580201A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40446102P 2002-08-19 2002-08-19

Publications (1)

Publication Number Publication Date
PA8580201A1 true PA8580201A1 (es) 2004-08-31

Family

ID=31946725

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20038580201A PA8580201A1 (es) 2002-08-19 2003-08-12 Terapia de combinacion para enfermedades hiperproliferativas

Country Status (33)

Country Link
US (1) US20070197517A1 (es)
EP (1) EP1545519B1 (es)
JP (1) JP3835763B2 (es)
KR (1) KR100668539B1 (es)
CN (1) CN1681495B (es)
AP (1) AP2005003232A0 (es)
AR (1) AR040995A1 (es)
AT (1) ATE502635T1 (es)
AU (1) AU2003250483A1 (es)
BR (1) BR0313593A (es)
CA (1) CA2495962A1 (es)
CR (1) CR7693A (es)
DE (1) DE60336485D1 (es)
EA (1) EA200500234A1 (es)
EC (1) ECSP055618A (es)
ES (1) ES2362998T3 (es)
GE (1) GEP20074134B (es)
GT (1) GT200300177A (es)
HK (1) HK1079106A1 (es)
HR (1) HRP20050163A2 (es)
IL (1) IL166545A0 (es)
IS (1) IS7670A (es)
MA (1) MA27385A1 (es)
MX (1) MXPA05001958A (es)
NO (1) NO20050621L (es)
OA (1) OA12905A (es)
PA (1) PA8580201A1 (es)
PE (1) PE20040993A1 (es)
PL (1) PL375713A1 (es)
RS (1) RS20050106A (es)
TN (1) TNSN05051A1 (es)
TW (1) TW200403057A (es)
WO (1) WO2004017964A1 (es)

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CR7693A (es) 2005-06-15
CA2495962A1 (en) 2004-03-04
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ATE502635T1 (de) 2011-04-15
EP1545519B1 (en) 2011-03-23
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CN1681495B (zh) 2010-05-12
NO20050621L (no) 2005-05-18
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AR040995A1 (es) 2005-04-27
ECSP055618A (es) 2005-04-18
MA27385A1 (fr) 2005-06-01
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