GB862248A - Di-isopropylammonium salts of chloroacetic and chloropropionic acids - Google Patents

Di-isopropylammonium salts of chloroacetic and chloropropionic acids

Info

Publication number
GB862248A
GB862248A GB26172/59A GB2617259A GB862248A GB 862248 A GB862248 A GB 862248A GB 26172/59 A GB26172/59 A GB 26172/59A GB 2617259 A GB2617259 A GB 2617259A GB 862248 A GB862248 A GB 862248A
Authority
GB
United Kingdom
Prior art keywords
chlorine atoms
chloroacetic
mgm
acetic
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB26172/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ITALSEBER SpA
Original Assignee
ITALSEBER SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ITALSEBER SpA filed Critical ITALSEBER SpA
Publication of GB862248A publication Critical patent/GB862248A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/16—Halogenated acetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises diisopropyl-ammonium salts of acetic and propionic acids which have been substituted by one, two or three chlorine atoms, the alpha-carbon atom of the acid being substituted by at most two chlorine atoms, and the preparation thereof by reacting equimolecular proportions of di-isopropylamine with the appropriate acid.ALSO:Pharmaceutical compositions suitable for parenteral or enteral administration contain a di-isopropyl-ammonium salts of acetic or propionic acid containing one, two or three chlorine atoms, the alpha carbon of which contains at most two chlorine atoms. For example, 25-50 mgm. of the salt may be dissolved in 2 c.c. of sterile water for parenteral administration or included in a tablet of 260 mgm. weight for oral administration.
GB26172/59A 1958-08-04 1959-07-30 Di-isopropylammonium salts of chloroacetic and chloropropionic acids Expired GB862248A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH862248X 1958-08-04

Publications (1)

Publication Number Publication Date
GB862248A true GB862248A (en) 1961-03-08

Family

ID=4543258

Family Applications (1)

Application Number Title Priority Date Filing Date
GB26172/59A Expired GB862248A (en) 1958-08-04 1959-07-30 Di-isopropylammonium salts of chloroacetic and chloropropionic acids

Country Status (1)

Country Link
GB (1) GB862248A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004017964A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
WO2007062314A2 (en) 2005-11-23 2007-05-31 Bristol-Myers Squibb Company Heterocyclic cetp inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
EP2392567A1 (en) 2005-10-21 2011-12-07 Bristol-Myers Squibb Company Benzothiazine derivatives and their use as lxr modulators
RU2480212C1 (en) * 2012-03-30 2013-04-27 Общество с ограниченной ответственностью "Базис" (ООО "Базис") Method for preparing diisopropylammonium dichloroacetate
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof
CN115784901A (en) * 2022-12-01 2023-03-14 山东北大高科华泰制药有限公司 Diisopropylamine dichloroacetate and application thereof

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004017964A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
EP2392567A1 (en) 2005-10-21 2011-12-07 Bristol-Myers Squibb Company Benzothiazine derivatives and their use as lxr modulators
WO2007062314A2 (en) 2005-11-23 2007-05-31 Bristol-Myers Squibb Company Heterocyclic cetp inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
RU2480212C1 (en) * 2012-03-30 2013-04-27 Общество с ограниченной ответственностью "Базис" (ООО "Базис") Method for preparing diisopropylammonium dichloroacetate
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof
CN115784901A (en) * 2022-12-01 2023-03-14 山东北大高科华泰制药有限公司 Diisopropylamine dichloroacetate and application thereof

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