GB1307455A - 2,-hydroxy-3-phenylpropiophenone derivatives - Google Patents

2,-hydroxy-3-phenylpropiophenone derivatives

Info

Publication number
GB1307455A
GB1307455A GB1307455DA GB1307455A GB 1307455 A GB1307455 A GB 1307455A GB 1307455D A GB1307455D A GB 1307455DA GB 1307455 A GB1307455 A GB 1307455A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
butylamino
epoxy
reacting
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB1307455A publication Critical patent/GB1307455A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1307455 2<SP>1</SP> - Hydroxy - 3 - phenylpropiophenone derivatives W PETRICK 7 July 1971 31984/71 Heading C2C Novel compounds I: in which R is n-propylamino, n-butylamino, 1- methylpropylamino or -t-butylamino and their acid addition salts are prepared by reacting the sodium salt of 2<SP>1</SP>- hydroxy-3-phenyl-propio phenone with 1 -chloro-2,3-epoxy-propane to give 21 - (2,3 - epoxy - propox) - 3 - phenyl- - propiophenone and reacting this with RNH 2 . Pharmaceutical compositions comprise a compound I together with an excipient suitable for oral or parenteral administration and are useful as coronary dilators and local anaesthetics.
GB1307455D 1970-01-06 1971-07-07 2,-hydroxy-3-phenylpropiophenone derivatives Expired GB1307455A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE19702001431 DE2001431C3 (en) 1970-01-06 1970-01-06 2- (2'-Hydroxy-3'-alkylaminopropoxy) -Omega-phenyl-propiophenones and processes for making the same
FR7124903A FR2144601B1 (en) 1970-01-06 1971-07-07
GB3198471 1971-07-07
AT591871A AT308076B (en) 1970-01-06 1971-07-07 Process for the preparation of new o- (2'-hydroxy-3'-alkylaminopropoxy) -β-phenylpropiophenones and their salts
NL7208214A NL7208214A (en) 1970-01-06 1972-06-15
BE785318A BE785318A (en) 1970-01-06 1972-06-23 PROCESS FOR THE PREPARATION OF NEW THERAPEUTIC DERIVATIVES OF HYDROXY-2 'PHENYL-3 PROPIOPHENONE AND THEIR SALTS

Publications (1)

Publication Number Publication Date
GB1307455A true GB1307455A (en) 1973-02-21

Family

ID=27542486

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1307455D Expired GB1307455A (en) 1970-01-06 1971-07-07 2,-hydroxy-3-phenylpropiophenone derivatives

Country Status (6)

Country Link
AT (1) AT308076B (en)
BE (1) BE785318A (en)
DE (1) DE2001431C3 (en)
FR (1) FR2144601B1 (en)
GB (1) GB1307455A (en)
NL (1) NL7208214A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540697A (en) * 1982-09-09 1985-09-10 Basf Aktiengesellschaft Aminopropanol derivatives of 2-hydroxy-β-phenyl-propiophenones, pharmaceutical compositions and use
US4571409A (en) * 1981-09-18 1986-02-18 Basf Aktiengesellschaft Aminopropanol derivatives of 2-hydroxy-β-phenyl-propiophenones, their preparation and therapeutic agents containing these compounds
US4612320A (en) * 1983-03-17 1986-09-16 Basf Aktiengesellschaft Aminopropanol derivatives of 1-(2-hydroxyphenyl)-3-phenylpropanols and therapeutic agents containing these compounds
US5118685A (en) * 1983-12-02 1992-06-02 Basf Aktiengesellschaft Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and therapeutic agents containing these compounds

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48309A (en) * 1974-10-25 1980-01-31 Robins Co Inc A H 1-aryloxy-4-amino-2-butanols and pharmaceutical compositions containing them
JPS5832847A (en) * 1981-08-20 1983-02-25 Mitsubishi Chem Ind Ltd (3-aminopropoxy)bibenzyl compound
DE3133814C2 (en) * 1981-08-25 1983-12-22 Helopharm W. Petrik & Co Kg, 1000 Berlin 2- [2'-Hydroxy-3 '- (1,1-dimethylpropylamino) -propoxy] -β-phenylpropiophenone, its acid addition salts and drugs
DE3210061A1 (en) * 1982-03-19 1983-09-22 Basf Ag, 6700 Ludwigshafen METHOD FOR PRODUCING PROPAFENONE
DE3328376A1 (en) * 1983-07-21 1985-01-31 Helopharm W. Petrik & Co Kg, 1000 Berlin Aminopropanol derivatives of 2-hydroxy- beta -phenylpropiophenones, process for their preparation and medicaments containing these
DE3429667A1 (en) * 1984-08-11 1986-02-20 Knoll Ag, 6700 Ludwigshafen Process for the preparation of substituted aryl alkyl ketones
DE3907512C2 (en) * 1989-03-08 1997-08-14 Laevosan Gmbh & Co Kg Aryloxy-alkylamines, their preparation and medicaments containing them
DE3911069A1 (en) * 1989-04-06 1990-10-11 Knoll Ag CRYSTALS OF SS PHENYL PROPIOPHENON
DE4000213A1 (en) * 1990-01-05 1991-07-11 Helopharm Petrik Co Kg O-HYDROXY-SS- (1-NAPHTHYL) -PROPIOPHENONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICAMENT CONTAINING THESE COMPOUNDS

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4571409A (en) * 1981-09-18 1986-02-18 Basf Aktiengesellschaft Aminopropanol derivatives of 2-hydroxy-β-phenyl-propiophenones, their preparation and therapeutic agents containing these compounds
US4540697A (en) * 1982-09-09 1985-09-10 Basf Aktiengesellschaft Aminopropanol derivatives of 2-hydroxy-β-phenyl-propiophenones, pharmaceutical compositions and use
US4612320A (en) * 1983-03-17 1986-09-16 Basf Aktiengesellschaft Aminopropanol derivatives of 1-(2-hydroxyphenyl)-3-phenylpropanols and therapeutic agents containing these compounds
US5118685A (en) * 1983-12-02 1992-06-02 Basf Aktiengesellschaft Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and therapeutic agents containing these compounds

Also Published As

Publication number Publication date
FR2144601A1 (en) 1973-02-16
DE2001431B2 (en) 1974-05-09
BE785318A (en) 1972-10-16
NL7208214A (en) 1973-12-18
AT308076B (en) 1973-06-25
DE2001431C3 (en) 1974-12-12
DE2001431A1 (en) 1971-07-15
FR2144601B1 (en) 1974-08-02

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years