OA11123A - 6-Phenylpyridyl-2-amine derivatives useful as nos inhibitors - Google Patents
6-Phenylpyridyl-2-amine derivatives useful as nos inhibitors Download PDFInfo
- Publication number
- OA11123A OA11123A OA9900115A OA9900115A OA11123A OA 11123 A OA11123 A OA 11123A OA 9900115 A OA9900115 A OA 9900115A OA 9900115 A OA9900115 A OA 9900115A OA 11123 A OA11123 A OA 11123A
- Authority
- OA
- OAPI
- Prior art keywords
- phenyl
- pyridin
- ylamine
- nmr
- methyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract description 6
- 102000008299 Nitric Oxide Synthase Human genes 0.000 claims abstract description 26
- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims abstract description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims description 89
- -1 hydroxy, methyl Chemical group 0.000 claims description 46
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- 125000001424 substituent group Chemical group 0.000 claims description 24
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 23
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 21
- 201000010099 disease Diseases 0.000 claims description 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 17
- 241000124008 Mammalia Species 0.000 claims description 16
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- 125000003118 aryl group Chemical group 0.000 claims description 12
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 12
- 230000002401 inhibitory effect Effects 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 125000003282 alkyl amino group Chemical group 0.000 claims description 10
- 125000005843 halogen group Chemical group 0.000 claims description 10
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- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 7
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
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- 125000001624 naphthyl group Chemical group 0.000 claims description 4
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims description 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 3
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 3
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- 230000006378 damage Effects 0.000 claims description 2
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- AFXPRGRPBFUARV-UHFFFAOYSA-N 3-[(6-aminopyridin-2-yl)-phenylmethylidene]-1-[2-(dimethylamino)ethyl]indol-2-one Chemical compound C12=CC=CC=C2N(CCN(C)C)C(=O)C1=C(C=1N=C(N)C=CC=1)C1=CC=CC=C1 AFXPRGRPBFUARV-UHFFFAOYSA-N 0.000 claims 1
- MNUHYQZBNHDABI-UHFFFAOYSA-N 3-azabicyclo[3.1.0]hexan-6-amine Chemical compound C1NCC2C(N)C21 MNUHYQZBNHDABI-UHFFFAOYSA-N 0.000 claims 1
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- RISWCGKBVILZDK-UHFFFAOYSA-N n-[4-[4-(6-aminopyridin-2-yl)phenyl]piperidin-1-yl]acetamide Chemical compound C1CN(NC(=O)C)CCC1C1=CC=C(C=2N=C(N)C=CC=2)C=C1 RISWCGKBVILZDK-UHFFFAOYSA-N 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 210000003169 central nervous system Anatomy 0.000 abstract description 2
- XDWUSBKLDNVDDQ-UHFFFAOYSA-N 6-phenylpyridin-2-amine Chemical class NC1=CC=CC(C=2C=CC=CC=2)=N1 XDWUSBKLDNVDDQ-UHFFFAOYSA-N 0.000 abstract 1
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Addiction (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3279396P | 1996-12-06 | 1996-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA11123A true OA11123A (en) | 2003-04-07 |
Family
ID=21866837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA9900115A OA11123A (en) | 1996-12-06 | 1999-06-01 | 6-Phenylpyridyl-2-amine derivatives useful as nos inhibitors |
Country Status (42)
| Country | Link |
|---|---|
| US (3) | US6235750B1 (cs) |
| EP (1) | EP0946512B1 (cs) |
| JP (2) | JP3604399B2 (cs) |
| KR (1) | KR100360633B1 (cs) |
| CN (1) | CN1117077C (cs) |
| AP (1) | AP848A (cs) |
| AR (1) | AR010331A1 (cs) |
| AT (1) | ATE251612T1 (cs) |
| AU (2) | AU4791797A (cs) |
| BG (1) | BG103540A (cs) |
| BR (1) | BR9714381A (cs) |
| CA (1) | CA2273479C (cs) |
| CZ (1) | CZ293863B6 (cs) |
| DE (1) | DE69725465T2 (cs) |
| DK (1) | DK0946512T3 (cs) |
| DZ (1) | DZ2361A1 (cs) |
| EA (1) | EA002907B1 (cs) |
| ES (1) | ES2206691T3 (cs) |
| HN (2) | HN1997000027A (cs) |
| HR (1) | HRP970664A2 (cs) |
| HU (1) | HUP0001848A3 (cs) |
| ID (1) | ID19056A (cs) |
| IL (1) | IL130111A0 (cs) |
| IS (1) | IS5053A (cs) |
| MA (1) | MA26453A1 (cs) |
| NO (1) | NO313517B1 (cs) |
| NZ (1) | NZ335733A (cs) |
| OA (1) | OA11123A (cs) |
| PA (1) | PA8442201A1 (cs) |
| PE (1) | PE46499A1 (cs) |
| PL (1) | PL333918A1 (cs) |
| PT (1) | PT946512E (cs) |
| SI (1) | SI0946512T1 (cs) |
| SK (1) | SK70899A3 (cs) |
| TN (1) | TNSN97198A1 (cs) |
| TR (1) | TR199901259T2 (cs) |
| TW (1) | TW491840B (cs) |
| UA (1) | UA59379C2 (cs) |
| UY (1) | UY24799A1 (cs) |
| WO (1) | WO1998024766A1 (cs) |
| YU (1) | YU25399A (cs) |
| ZA (1) | ZA9710906B (cs) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3455229B2 (ja) * | 1996-03-29 | 2003-10-14 | ファイザー インク． | ６―フェニルピリジル―２―アミン誘導体 |
| US20010049379A1 (en) | 1997-08-27 | 2001-12-06 | Lowe John Adams | 2-aminopyridines containing fused ring substituents |
| HN1998000118A (es) | 1997-08-27 | 1999-02-09 | Pfizer Prod Inc | 2 - aminopiridinas que contienen sustituyentes de anillos condensados. |
| HN1998000125A (es) * | 1997-08-28 | 1999-02-09 | Pfizer Prod Inc | 2-aminopiridinas con sustituyentes alcoxi ramificados |
| NZ508057A (en) | 1998-06-03 | 2003-07-25 | Pfizer Prod Inc | 2-aminopyridines containing fused ring substituents as nitric oxide synthase inhibitors |
| FR2791674A1 (fr) * | 1999-04-02 | 2000-10-06 | Sod Conseils Rech Applic | Nouveaux derives de 2-aminopyridines, leur utilisation en tant que medicaments et compositions pharmaceutiques les contenant |
| FR2780971B1 (fr) * | 1998-07-08 | 2001-09-28 | Sod Conseils Rech Applic | Nouveaux derives de 2-aminopyridines, leur application en tant que medicaments et compositions pharmaceutiques les contenant |
| AR019190A1 (es) * | 1998-07-08 | 2001-12-26 | Sod Conseils Rech Applic | Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos |
| AP2001002067A0 (en) * | 1998-08-11 | 2001-03-31 | Pfizer Prod Inc | New pharmaceutical uses for nos inhibitors. |
| SE9803710L (sv) | 1998-09-25 | 2000-03-26 | A & Science Invest Ab | Användning av vissa substanser för behandling av nervrotsskador |
| US7115557B2 (en) | 1998-09-25 | 2006-10-03 | Sciaticon Ab | Use of certain drugs for treating nerve root injury |
| ES2200813T3 (es) | 1999-02-25 | 2004-03-16 | Pfizer Products Inc. | 2-aminopiridinas que contienen sustituyentes de anillo condesado. |
| HK1046645A1 (zh) * | 1999-07-23 | 2003-01-24 | 盐野义制药株式会社 | Th2分化抑制剂 |
| FR2804429B1 (fr) * | 2000-01-31 | 2003-05-09 | Adir | Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2002080853A2 (en) * | 2001-04-09 | 2002-10-17 | Bristol-Myers Squibb Company | Fused heterocyclic inhibitors of factor xa |
| US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
| CA2522323C (en) * | 2003-04-14 | 2009-09-15 | Pfizer Products Inc. | 3-azabicyclo[3.2.1]octane derivatives as opioid receptor ligands |
| CN1295216C (zh) * | 2003-07-04 | 2007-01-17 | 中国人民解放军军事医学科学院毒物药物研究所 | 吲哚酮类衍生物及其用于制备抗肿瘤药物的用途 |
| US20080070952A1 (en) * | 2005-02-21 | 2008-03-20 | Proximagen Ltd., | Inhibition or Treatment of Dyskinesia |
| WO2006105795A1 (en) * | 2005-04-08 | 2006-10-12 | Leo Pharma A/S | Novel indolinone derivatives |
| WO2008021849A2 (en) * | 2006-08-09 | 2008-02-21 | Smithkline Beecham Corporation | Novel compounds as antagonists or inverse agonists at opioid receptors |
| US8835437B2 (en) | 2007-06-08 | 2014-09-16 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| EP2152270B1 (en) | 2007-06-08 | 2015-03-04 | Janssen Pharmaceutica, N.V. | Piperidine/piperazine derivatives |
| EP2152269B1 (en) | 2007-06-08 | 2014-04-23 | Janssen Pharmaceutica, N.V. | Piperidine/piperazine derivatives |
| CA2725933C (en) | 2008-06-05 | 2018-01-16 | Janssen Pharmaceutica Nv | Drug combinations comprising a dgat inhibitor and a ppar-agonist |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
| US8889674B2 (en) * | 2009-03-05 | 2014-11-18 | Shionogi & Co., Ltd. | Piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonism |
| US11013844B2 (en) * | 2014-11-20 | 2021-05-25 | City Of Hope | Treatment device for plasma virus inactivation |
| TWI874960B (zh) | 2016-08-12 | 2025-03-01 | 美商亞瑟尼克斯公司 | 聯芳組成物和調控激酶級聯之方法 |
| PT3684767T (pt) | 2017-09-22 | 2024-07-29 | Jubilant Epipad LLC | Compostos heterocíclicos como inibidores de pad |
| ES2941512T3 (es) | 2017-10-18 | 2023-05-23 | Jubilant Epipad LLC | Compuestos de imidazo-piridina como inhibidores de PAD |
| SG11202004143XA (en) | 2017-11-06 | 2020-06-29 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation |
| KR102780935B1 (ko) | 2017-11-24 | 2025-03-12 | 주빌런트 에피스크라이브 엘엘씨 | Prmt5 억제제로서의 헤테로사이클릭 화합물 |
| JP7279063B6 (ja) | 2018-03-13 | 2024-02-15 | ジュビラント プローデル エルエルシー | Ｐｄ１／ｐｄ－ｌ１相互作用／活性化の阻害剤としての二環式化合物 |
| CN114206843A (zh) * | 2019-06-14 | 2022-03-18 | Srx心脏有限责任公司 | 用于调节前蛋白转化酶枯草杆菌蛋白酶/Kexin 9型(PCSK9)的化合物 |
| US12115154B2 (en) * | 2020-12-16 | 2024-10-15 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992014780A1 (en) | 1991-02-19 | 1992-09-03 | Akzo N.V. | Stabilized carbon monoxide-olefin copolymers |
| EP0674627A1 (en) * | 1992-12-18 | 1995-10-04 | The Wellcome Foundation Limited | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
| US5621004A (en) | 1994-06-03 | 1997-04-15 | Robert W. Dunn | Method for treating emesis |
| AU4515696A (en) * | 1994-12-12 | 1996-07-03 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| JP3455229B2 (ja) * | 1996-03-29 | 2003-10-14 | ファイザー インク． | ６―フェニルピリジル―２―アミン誘導体 |
| US6093743A (en) | 1998-06-23 | 2000-07-25 | Medinox Inc. | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor |
-
1997
- 1997-02-18 HN HN1997000027A patent/HN1997000027A/es unknown
- 1997-11-17 PT PT97910587T patent/PT946512E/pt unknown
- 1997-11-17 DE DE69725465T patent/DE69725465T2/de not_active Expired - Fee Related
- 1997-11-17 AU AU47917/97A patent/AU4791797A/en not_active Abandoned
- 1997-11-17 PL PL97333918A patent/PL333918A1/xx unknown
- 1997-11-17 KR KR1019997004981A patent/KR100360633B1/ko not_active Expired - Fee Related
- 1997-11-17 CA CA002273479A patent/CA2273479C/en not_active Expired - Fee Related
- 1997-11-17 WO PCT/IB1997/001446 patent/WO1998024766A1/en active IP Right Grant
- 1997-11-17 SK SK708-99A patent/SK70899A3/sk unknown
- 1997-11-17 YU YU25399A patent/YU25399A/sh unknown
- 1997-11-17 JP JP52539798A patent/JP3604399B2/ja not_active Expired - Fee Related
- 1997-11-17 UA UA99063103A patent/UA59379C2/uk unknown
- 1997-11-17 EP EP97910587A patent/EP0946512B1/en not_active Expired - Lifetime
- 1997-11-17 AT AT97910587T patent/ATE251612T1/de not_active IP Right Cessation
- 1997-11-17 SI SI9730597T patent/SI0946512T1/xx unknown
- 1997-11-17 IL IL13011197A patent/IL130111A0/xx unknown
- 1997-11-17 CN CN97180350A patent/CN1117077C/zh not_active Expired - Fee Related
- 1997-11-17 ES ES97910587T patent/ES2206691T3/es not_active Expired - Lifetime
- 1997-11-17 TR TR1999/01259T patent/TR199901259T2/xx unknown
- 1997-11-17 BR BR9714381-2A patent/BR9714381A/pt not_active Application Discontinuation
- 1997-11-17 NZ NZ335733A patent/NZ335733A/xx unknown
- 1997-11-17 DK DK97910587T patent/DK0946512T3/da active
- 1997-11-17 HU HU0001848A patent/HUP0001848A3/hu unknown
- 1997-11-17 CZ CZ19992017A patent/CZ293863B6/cs not_active IP Right Cessation
- 1997-11-17 EA EA199900448A patent/EA002907B1/ru not_active IP Right Cessation
- 1997-11-18 HN HN1997000149A patent/HN1997000149A/es unknown
- 1997-11-22 TW TW086117501A patent/TW491840B/zh active
- 1997-12-01 PE PE1997001080A patent/PE46499A1/es not_active Application Discontinuation
- 1997-12-03 MA MA24884A patent/MA26453A1/fr unknown
- 1997-12-03 TN TNTNSN97198A patent/TNSN97198A1/fr unknown
- 1997-12-03 UY UY24799A patent/UY24799A1/es unknown
- 1997-12-03 DZ DZ970211A patent/DZ2361A1/xx active
- 1997-12-04 AR ARP970105713A patent/AR010331A1/es not_active Application Discontinuation
- 1997-12-04 AP APAP/P/1997/001156A patent/AP848A/en active
- 1997-12-04 ZA ZA9710906A patent/ZA9710906B/xx unknown
- 1997-12-04 HR HR60/032,793A patent/HRP970664A2/hr not_active Application Discontinuation
- 1997-12-04 PA PA19978442201A patent/PA8442201A1/es unknown
- 1997-12-05 ID IDP973838A patent/ID19056A/id unknown
-
1999
- 1999-05-18 IS IS5053A patent/IS5053A/is unknown
- 1999-06-01 OA OA9900115A patent/OA11123A/en unknown
- 1999-06-03 US US09/325,480 patent/US6235750B1/en not_active Expired - Fee Related
- 1999-06-04 NO NO19992725A patent/NO313517B1/no unknown
- 1999-06-30 BG BG103540A patent/BG103540A/bg unknown
-
2001
- 2001-03-08 US US09/802,086 patent/US20020032191A1/en not_active Abandoned
- 2001-09-13 AU AU72050/01A patent/AU766080B2/en not_active Ceased
- 2001-09-27 US US09/965,564 patent/US20020103227A1/en not_active Abandoned
-
2004
- 2004-06-24 JP JP2004186311A patent/JP2005170924A/ja active Pending
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