NZ754171A - Ectonucleotidase inhibitors and methods of use thereof - Google Patents
Ectonucleotidase inhibitors and methods of use thereofInfo
- Publication number
- NZ754171A NZ754171A NZ754171A NZ75417117A NZ754171A NZ 754171 A NZ754171 A NZ 754171A NZ 754171 A NZ754171 A NZ 754171A NZ 75417117 A NZ75417117 A NZ 75417117A NZ 754171 A NZ754171 A NZ 754171A
- Authority
- NZ
- New Zealand
- Prior art keywords
- cancer
- amino
- dioxo
- compound
- dihydroanthracenesulfonate
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 3
- 108010047482 ectoATPase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- -1 6-amino-2-chloro-9H-purin-9-yl Chemical group 0.000 claims abstract 32
- 206010028980 Neoplasm Diseases 0.000 claims abstract 10
- 201000011510 cancer Diseases 0.000 claims abstract 10
- 125000000217 alkyl group Chemical group 0.000 claims abstract 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 6
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 125000003368 amide group Chemical group 0.000 claims abstract 4
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims abstract 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims abstract 4
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 3
- 125000001475 halogen functional group Chemical group 0.000 claims abstract 3
- 125000004475 heteroaralkyl group Chemical group 0.000 claims abstract 3
- 101100243950 Arabidopsis thaliana PIE1 gene Proteins 0.000 claims abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910019142 PO4 Inorganic materials 0.000 claims abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000005041 acyloxyalkyl group Chemical group 0.000 claims abstract 2
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 claims abstract 2
- 125000000304 alkynyl group Chemical group 0.000 claims abstract 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims abstract 2
- 125000003118 aryl group Chemical group 0.000 claims abstract 2
- 239000004202 carbamide Substances 0.000 claims abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract 2
- 239000010452 phosphate Substances 0.000 claims abstract 2
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- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims abstract 2
- 125000001424 substituent group Chemical group 0.000 claims abstract 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims abstract 2
- 125000005309 thioalkoxy group Chemical group 0.000 claims abstract 2
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Classifications
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| US201662437935P | 2016-12-22 | 2016-12-22 | |
| US201662437915P | 2016-12-22 | 2016-12-22 | |
| US201762555791P | 2017-09-08 | 2017-09-08 | |
| PCT/US2017/067980 WO2018119284A1 (en) | 2016-12-22 | 2017-12-21 | Ectonucleotidase inhibitors and methods of use thereof |
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| NZ754171A true NZ754171A (en) | 2022-12-23 |
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| NZ754171A NZ754171A (en) | 2016-12-22 | 2017-12-21 | Ectonucleotidase inhibitors and methods of use thereof |
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| EP (1) | EP3558998A4 (OSRAM) |
| JP (1) | JP7138351B2 (OSRAM) |
| KR (1) | KR102638592B1 (OSRAM) |
| CN (1) | CN110402249A (OSRAM) |
| AU (1) | AU2017382888B2 (OSRAM) |
| CA (1) | CA3047988A1 (OSRAM) |
| IL (1) | IL267291B2 (OSRAM) |
| MX (1) | MX383880B (OSRAM) |
| NZ (1) | NZ754171A (OSRAM) |
| TW (1) | TWI766923B (OSRAM) |
| WO (1) | WO2018119284A1 (OSRAM) |
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| WO2018049145A1 (en) | 2016-09-09 | 2018-03-15 | Calithera Biosciences, Inc. | Ectonucleotidase inhibitors and methods of use thereof |
| CN110402249A (zh) | 2016-12-22 | 2019-11-01 | 卡利泰拉生物科技公司 | 外核苷酸酶抑制剂及其使用方法 |
| US11129841B2 (en) | 2017-05-10 | 2021-09-28 | Oric Pharmaceuticals, Inc. | CD73 inhibitors |
| SG10202111869SA (en) | 2017-07-31 | 2021-11-29 | Trishula Therapeutics Inc | Anti-cd39 antibodies, compositions comprising anti-cd39 antibodies and methods of using anti-cd39 antibodies |
| US11377469B2 (en) | 2017-11-03 | 2022-07-05 | Oric Pharmaceuticals, Inc. | CD73 inhibitors |
| SG11202010790XA (en) | 2018-04-30 | 2020-11-27 | Oric Pharmaceuticals Inc | Cd73 inhibitors |
| EP3810109B1 (en) | 2018-05-31 | 2024-08-07 | Peloton Therapeutics, Inc. | Compounds and compositions for inhibiting cd73 |
| CN112888696B (zh) * | 2018-06-21 | 2024-04-16 | 德琪医疗有限公司 | 外核苷酸酶抑制剂及其使用方法 |
| CA3133078A1 (en) | 2019-03-12 | 2020-09-17 | Arcus Biosciences, Inc. | Treatment of oncogene-driven cancers |
| CN113874397A (zh) | 2019-03-29 | 2021-12-31 | 艾库斯生物科学有限公司 | 利用鉴定的腺苷指纹治疗癌症 |
| US20220251134A1 (en) * | 2019-06-14 | 2022-08-11 | Southern Research Institute | 2,4,7-substituted-7-deaza-2'-deoxy-2'-fluoroarabinosyl nucleoside and nucleotide pro-drugs and uses thereof |
| AU2020294724A1 (en) * | 2019-06-20 | 2022-01-20 | Antengene Therapeutics Limited | Ectonucleotidase inhibitors and methods of use thereof |
| WO2021040356A1 (en) * | 2019-08-23 | 2021-03-04 | Kainos Medicine, Inc. | C-nucleosides, c-nucleotides and their analogs, equivalents and prodrugs thereof for ectonucleotidase inhibition |
| JP7544815B2 (ja) | 2019-10-30 | 2024-09-03 | オリック ファーマシューティカルズ，インク． | Ｃｄ７３阻害剤 |
| JP7381913B2 (ja) * | 2021-10-13 | 2023-11-16 | ダイキン工業株式会社 | 有害生物防除組成物 |
| EP4422643A4 (en) * | 2021-10-26 | 2025-11-26 | Southern Res Inst | DEVELOPMENT OF NEW CLOFARABINE ANALOGUES FOR CANCER THERAPY |
| KR20250004779A (ko) | 2022-04-13 | 2025-01-08 | 길리애드 사이언시즈, 인코포레이티드 | Trop-2 발현 암을 치료하기 위한 병용 요법 |
| US20250230168A1 (en) | 2023-12-22 | 2025-07-17 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
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| WO1992019638A1 (en) | 1991-04-24 | 1992-11-12 | Yamasa Shoyu Kabushiki Kaisha | 1-β-D-ARABINOFURANOSYL-(E)-5-(2-HALOGENOVINYL)-URACIL DERIVATIVE |
| AU5449094A (en) | 1992-11-02 | 1994-05-24 | Affymax Technologies N.V. | Novel photoreactive protecting groups |
| US5635608A (en) | 1994-11-08 | 1997-06-03 | Molecular Probes, Inc. | α-carboxy caged compounds |
| RU2130029C1 (ru) * | 1994-12-13 | 1999-05-10 | Тайхо Фармасьютикал Ко., Лтд. | 3'-замещенные производные нуклеозида, способ их получения (варианты), лекарственное средство, способ лечения и профилактики |
| NL1005244C2 (nl) | 1997-02-10 | 1998-08-18 | Inst Voor Agrotech Onderzoek | Oppervlakte-actieve aminen en glycosiden. |
| WO2004079013A1 (en) * | 2003-03-03 | 2004-09-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Ecto-5’-nucleotidase (cd73) used in the diagnosis and the treatment of pancreatic cancer |
| WO2004096233A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Nucleoside phosphonate conjugates |
| EP1860113A1 (en) * | 2006-05-24 | 2007-11-28 | Rheinische Friedrich-Wilhelms-Universität Bonn | Ectonucleotidase inhibitors |
| BRPI0714831A2 (pt) | 2006-07-18 | 2013-04-02 | Anadys Pharmaceuticals Inc | composto, composiÇço farmacÊutica e mÉtodos de modulaÇço de atividades imuno da citoquina em paciente, de tratamento de infecÇço de vÍrus c da hepatite em paciente e de desordem relacionada com proliferaÇço em mamÍfero necessitado do mesmo |
| US8603998B2 (en) | 2007-11-07 | 2013-12-10 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
| EP2070938A1 (en) * | 2007-12-13 | 2009-06-17 | Heidelberg Pharma AG | Clofarabine dietherphospholipid derivatives |
| US9725479B2 (en) | 2010-04-22 | 2017-08-08 | Ionis Pharmaceuticals, Inc. | 5′-end derivatives |
| WO2012006351A1 (en) | 2010-07-08 | 2012-01-12 | Life Technologies Corporation | In situ chemiluminescent substrates and assays |
| WO2012151142A2 (en) | 2011-05-03 | 2012-11-08 | Life Technologies Corporation | Flash and glow 1,2-dioxetanes |
| MX366629B (es) | 2011-07-15 | 2019-07-17 | Boehringer Ingelheim Int | Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas. |
| GB201220843D0 (en) | 2012-11-20 | 2013-01-02 | Univ College Cork Nat Univ Ie | Compound |
| JP6657182B2 (ja) | 2014-04-25 | 2020-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌治療用のｃｄ７３阻害剤としてのプリン誘導体 |
| EP3362461B1 (en) | 2015-10-16 | 2022-03-16 | Modernatx, Inc. | Mrna cap analogs with modified phosphate linkage |
| WO2017066791A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Sugar substituted mrna cap analogs |
| WO2017066782A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Hydrophobic mrna cap analogs |
| US10611790B2 (en) | 2015-11-02 | 2020-04-07 | Mitobridge, Inc. | Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases |
| KR102772803B1 (ko) * | 2016-01-08 | 2025-02-24 | 아르커스 바이오사이언시즈 인코포레이티드 | 5'-뉴클레오티다아제, 엑토의 조절제, 및 이의 용도 |
| WO2018049145A1 (en) | 2016-09-09 | 2018-03-15 | Calithera Biosciences, Inc. | Ectonucleotidase inhibitors and methods of use thereof |
| CN110402249A (zh) | 2016-12-22 | 2019-11-01 | 卡利泰拉生物科技公司 | 外核苷酸酶抑制剂及其使用方法 |
| CN112888696B (zh) | 2018-06-21 | 2024-04-16 | 德琪医疗有限公司 | 外核苷酸酶抑制剂及其使用方法 |
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2017
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- 2017-12-21 WO PCT/US2017/067980 patent/WO2018119284A1/en not_active Ceased
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- 2017-12-21 MX MX2019007243A patent/MX383880B/es unknown
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2021
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| US20180186827A1 (en) | 2018-07-05 |
| EP3558998A1 (en) | 2019-10-30 |
| MX2019007243A (es) | 2019-09-06 |
| KR20190114972A (ko) | 2019-10-10 |
| IL267291B (en) | 2022-12-01 |
| JP2020504735A (ja) | 2020-02-13 |
| KR102638592B1 (ko) | 2024-02-19 |
| CA3047988A1 (en) | 2018-06-28 |
| US20230002437A1 (en) | 2023-01-05 |
| AU2017382888A1 (en) | 2019-06-20 |
| US20200223882A1 (en) | 2020-07-16 |
| MX383880B (es) | 2025-03-14 |
| WO2018119284A1 (en) | 2018-06-28 |
| TWI766923B (zh) | 2022-06-11 |
| EP3558998A4 (en) | 2020-06-10 |
| IL267291B2 (en) | 2023-04-01 |
| JP7138351B2 (ja) | 2022-09-16 |
| BR112019012327A2 (pt) | 2019-11-19 |
| US11034715B2 (en) | 2021-06-15 |
| CN110402249A (zh) | 2019-11-01 |
| US10570167B2 (en) | 2020-02-25 |
| AU2017382888B2 (en) | 2021-12-23 |
| IL267291A (en) | 2019-08-29 |
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