IL267291B2 - Actonucleotidase inhibitors and methods of using them - Google Patents

Info

Publication number

IL267291B2

IL267291B2 IL267291A IL26729119A IL267291B2 IL 267291 B2 IL267291 B2 IL 267291B2 IL 267291 A IL267291 A IL 267291A IL 26729119 A IL26729119 A IL 26729119A IL 267291 B2 IL267291 B2 IL 267291B2

Authority

IL

Israel

Prior art keywords

6alkyl

compound

amino

alkyl

fluoro

Prior art date

2016-12-22

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 title description 78
• 239000003112 inhibitor Substances 0.000 title description 15
• 108010047482 ectoATPase Proteins 0.000 title description 4
• 150000001875 compounds Chemical class 0.000 claims description 387
• -1 hydroxy-C1-6alkyl Chemical group 0.000 claims description 204
• 125000000217 alkyl group Chemical group 0.000 claims description 153
• 125000001424 substituent group Chemical group 0.000 claims description 131
• 125000001072 heteroaryl group Chemical group 0.000 claims description 97
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 81
• 125000000623 heterocyclic group Chemical group 0.000 claims description 77
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 74
• 125000003118 aryl group Chemical group 0.000 claims description 61
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 57
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 56
• 206010028980 Neoplasm Diseases 0.000 claims description 44
• 125000004475 heteroaralkyl group Chemical group 0.000 claims description 42
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 36
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 34
• 229910052760 oxygen Inorganic materials 0.000 claims description 34
• 125000003831 tetrazolyl group Chemical group 0.000 claims description 32
• 201000011510 cancer Diseases 0.000 claims description 31
• 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 30
• 125000003545 alkoxy group Chemical group 0.000 claims description 27
• 238000011282 treatment Methods 0.000 claims description 27
• 229910052717 sulfur Inorganic materials 0.000 claims description 26
• 125000003342 alkenyl group Chemical group 0.000 claims description 25
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• 239000008194 pharmaceutical composition Substances 0.000 claims description 19
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
• 150000003839 salts Chemical class 0.000 claims description 19
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• 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims description 11
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