JP2018529780A5 - - Google Patents

Download PDF

Info

Publication number
JP2018529780A5
JP2018529780A5 JP2018536710A JP2018536710A JP2018529780A5 JP 2018529780 A5 JP2018529780 A5 JP 2018529780A5 JP 2018536710 A JP2018536710 A JP 2018536710A JP 2018536710 A JP2018536710 A JP 2018536710A JP 2018529780 A5 JP2018529780 A5 JP 2018529780A5
Authority
JP
Japan
Prior art keywords
cancer
independently
substituted
arylalkyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018536710A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018529780A (ja
JP6971239B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/055316 external-priority patent/WO2017062354A1/en
Publication of JP2018529780A publication Critical patent/JP2018529780A/ja
Publication of JP2018529780A5 publication Critical patent/JP2018529780A5/ja
Application granted granted Critical
Publication of JP6971239B2 publication Critical patent/JP6971239B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018536710A 2015-10-05 2016-10-04 グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法 Expired - Fee Related JP6971239B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562237287P 2015-10-05 2015-10-05
US62/237,287 2015-10-05
US201662323179P 2016-04-15 2016-04-15
US62/323,179 2016-04-15
PCT/US2016/055316 WO2017062354A1 (en) 2015-10-05 2016-10-04 Combination therapy with glutaminase inhibitors and immuno-oncology agents

Publications (3)

Publication Number Publication Date
JP2018529780A JP2018529780A (ja) 2018-10-11
JP2018529780A5 true JP2018529780A5 (OSRAM) 2019-11-07
JP6971239B2 JP6971239B2 (ja) 2021-11-24

Family

ID=58447081

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018536710A Expired - Fee Related JP6971239B2 (ja) 2015-10-05 2016-10-04 グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法

Country Status (10)

Country Link
US (3) US10258619B2 (OSRAM)
EP (1) EP3359150A4 (OSRAM)
JP (1) JP6971239B2 (OSRAM)
KR (1) KR20180059544A (OSRAM)
CN (1) CN108601767A (OSRAM)
AU (1) AU2016335991A1 (OSRAM)
CA (1) CA3000996A1 (OSRAM)
IL (1) IL258500A (OSRAM)
SG (1) SG11201802830QA (OSRAM)
WO (1) WO2017062354A1 (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS62447B1 (sr) 2012-11-16 2021-11-30 Calithera Biosciences Inc Heterociklični inhibitori glutaminaze
CA2974651A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
US10316030B2 (en) 2014-08-07 2019-06-11 Calithera Biosciences, Inc. Crystal forms of glutaminase inhibitors
EP3359150A4 (en) 2015-10-05 2019-11-06 Calithera Biosciences, Inc. COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS AND IMMUNO-ONCOLOGICAL AGENTS
EP4176876A1 (en) * 2017-09-14 2023-05-10 Lankenau Institute for Medical Research Methods and compositions for the treatment of cancer
WO2019089952A1 (en) * 2017-11-03 2019-05-09 Calithera Biosciences, Inc. Conjoint therapy with glutaminase inhibitors
US20210260057A1 (en) * 2018-07-12 2021-08-26 Cedars-Sinai Medical Center Compositions and methods targeting glutamine and its metabolism for diagnosing and treating cancer and therapy-associated side effects
AU2020339737A1 (en) * 2019-08-30 2022-03-17 Vestlandets Innovasjonsselskap As Method for the treatment of chronic fatigue syndrome using an inhibitory or cytotoxic agent against plasma cells
CN111643669A (zh) * 2020-06-30 2020-09-11 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) 谷氨酰胺酶抑制剂在制备治疗银屑病的药物中的应用
US11839659B2 (en) 2020-07-02 2023-12-12 Northwestern University Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein
US20250281609A1 (en) * 2021-10-19 2025-09-11 Organoidsciences Ltd. Composition for treating or preventing cancer
TW202406539A (zh) * 2022-04-21 2024-02-16 大陸商北京加科思新藥研發有限公司 藥物組合及其用途
CN116284398A (zh) * 2023-01-30 2023-06-23 中山大学附属第五医院 一种表达pd-l1抗体的细胞囊泡及其制备方法和应用

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1019519A (en) 1911-07-11 1912-03-05 Oscar Martin Polin Apparatus for making backing for teeth.
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
DK1348427T3 (da) 1997-07-29 2008-06-30 Alcon Lab Inc Oftalmiske sammensætninger indeholdende galactomannanpolymerer og borater
US6110973A (en) 1998-01-29 2000-08-29 Sepracor Methods for treating obesity and weight gain using optically pure (-)-bupropion
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
US6451828B1 (en) 2000-08-10 2002-09-17 Elan Pharmaceuticals, Inc. Selective inhibition of glutaminase by bis-thiadiazoles
WO2002076939A2 (en) 2001-02-05 2002-10-03 Exegenics Inc. Cysteine protease inhibitors
EP2260846B1 (en) * 2003-03-27 2018-11-28 Lankenau Institute for Medical Research Novel methods for the treatment of cancer
US6933289B2 (en) 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
ES2593113T3 (es) 2003-08-07 2016-12-05 Allergan, Inc. Composiciones para el suministro de agentes terapéuticos en los ojos y métodos para obtener y usar los mismos
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
EP1747282B1 (en) 2004-04-15 2011-06-08 University of Florida Research Foundation, Inc. Map-2 proteolytic breakdown products as diagnostic biomarkers for neural injury
EP2183232B1 (en) 2007-08-02 2013-03-06 Amgen, Inc Pi3 kinase modulators and methods of use
EP2227233B1 (en) * 2007-11-30 2013-02-13 Newlink Genetics Ido inhibitors
EP2255818B1 (en) 2008-02-19 2018-08-22 Earnest Medicine Co., Ltd. Oral or enteral composition useful for recovery of physical functions
PL2389352T3 (pl) * 2009-01-26 2019-10-31 Univ Pennsylvania Inhibitory arginazy oraz sposoby zastosowania
WO2011143160A2 (en) 2010-05-10 2011-11-17 The Johns Hopkins University Metabolic inhibitor against tumors having an idh mutation
WO2012006506A1 (en) 2010-07-09 2012-01-12 Massachusetts Institute Of Technology Metabolic gene, enzyme, and flux targets for cancer therapy
EP2640189A4 (en) 2010-11-18 2014-03-19 Deuteria Pharmaceuticals Inc 3-deutero-pomalidomide
US8894970B2 (en) * 2010-12-31 2014-11-25 Corridor Pharmaceuticals, Inc. Arginase inhibitors and methods of use thereof
CA2742342A1 (en) 2011-02-12 2012-08-12 Baylor Research Institute Msh3 expression status determines the responsiveness of cancer cells to the chemotherapeutic treatment with parp inhibitors and platinum drugs
FI20115876A0 (fi) 2011-09-06 2011-09-06 Turun Yliopisto Yhdistelmähoito
CN103030597B (zh) 2011-09-30 2014-10-01 南昌滨西科技有限公司 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途
AU2012326109A1 (en) * 2011-10-19 2014-05-29 Mars, Incorporated Inhibitors of arginase and their therapeutic applications
US8604016B2 (en) 2011-11-21 2013-12-10 Calithera Biosciences Inc. Heterocyclic inhibitors of glutaminase
WO2013078123A1 (en) * 2011-11-21 2013-05-30 Calithera Biosciences Inc. Heterocyclic inhibitors of glutaminase
US10138479B2 (en) 2012-05-24 2018-11-27 Dana-Farber Cancer Institute, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer
WO2014039960A1 (en) 2012-09-10 2014-03-13 Celgene Corporation Methods for the treatment of locally advanced breast cancer
EP2895623B1 (en) 2012-09-17 2018-08-22 Agios Pharmaceuticals, Inc. Use of e-cadherin and vimentin for selection of treatment responsive patients
RS62447B1 (sr) 2012-11-16 2021-11-30 Calithera Biosciences Inc Heterociklični inhibitori glutaminaze
EP2922832B1 (en) 2012-11-21 2019-10-09 Agios Pharmaceuticals, Inc. Glutaminase inhibitors and methods of use
WO2014079011A1 (en) 2012-11-22 2014-05-30 Agios Pharmaceuticals, Inc. Heterocyclic compounds for inhibiting glutaminase and their methods of use
US9029531B2 (en) 2012-11-22 2015-05-12 Agios Pharmaceuticals, Inc. Compounds and their methods of use
CA2892817A1 (en) * 2012-12-03 2014-06-12 Calithera Biosciences Inc. Treatment of cancer with heterocyclic inhibitors of glutaminase
JP6313415B2 (ja) * 2013-03-15 2018-04-18 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Ido阻害剤
TWI660739B (zh) * 2013-10-25 2019-06-01 製藥公司 使用布魯頓氏酪胺酸激酶抑制劑之治療及免疫療法
WO2015061432A1 (en) 2013-10-25 2015-04-30 Calithera Biosciences, Inc. Treatment of viral infections with inhibitors of glutaminase
GB201322725D0 (en) * 2013-12-20 2014-02-05 Immodulon Therapeutics Ltd Cancer therapy
US20170165364A1 (en) * 2014-02-21 2017-06-15 Idac Theranostics, Inc. Therapeutic agent for solid cancer
EP3116872A4 (en) 2014-03-14 2017-08-30 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
US10221459B2 (en) 2014-05-13 2019-03-05 Case Western Reserve University Compositions and methods of treating cancer harboring PIKC3A mutations
KR20170012562A (ko) 2014-06-13 2017-02-02 칼리테라 바이오사이언시즈 인코포레이티드 글루타미나제 억제제를 사용하는 병용 요법
WO2016004413A2 (en) 2014-07-03 2016-01-07 Board Of Regents, University Of Texas System Gls1 inhibitors for treating disease
WO2016004418A1 (en) 2014-07-03 2016-01-07 Board Of Regents, University Of Texas System Glutaminase inhibitor therapy
WO2016014890A1 (en) 2014-07-24 2016-01-28 Calithera Biosciences, Inc. Treatment of multiple myeloma with heterocyclic inhibitors of glutaminase
US10316030B2 (en) 2014-08-07 2019-06-11 Calithera Biosciences, Inc. Crystal forms of glutaminase inhibitors
WO2016054388A1 (en) 2014-10-03 2016-04-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Glutaminase inhibitors
WO2016077632A2 (en) 2014-11-13 2016-05-19 Buck Institute For Research On Aging Inhibition of proline catabolism for the treatment of cancer and other therapeutic applications
MX379263B (es) 2015-03-30 2025-03-11 Calithera Biosciences Inc Uso de inhibidores de glutaminasa para el tratamiento o prevención de cáncer.
EA035354B1 (ru) 2015-04-06 2020-06-01 Калитера Байосайенсиз, Инк. Лечение рака легких ингибиторами глутаминазы
CA2994165A1 (en) 2015-07-31 2017-02-09 The Johns Hopkins University Methods for cancer and immunotherapy using glutamine analogues, including don
JP2018530550A (ja) 2015-10-01 2018-10-18 ギリアド サイエンシズ, インコーポレイテッド 癌を治療するためのbtk阻害剤とチェックポイント阻害剤との組合せ
EP3359150A4 (en) 2015-10-05 2019-11-06 Calithera Biosciences, Inc. COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS AND IMMUNO-ONCOLOGICAL AGENTS
EA201892587A1 (ru) 2016-05-20 2019-04-30 Биохэйвен Фармасьютикал Холдинг Компани Лтд. Использование глутамат-модулирующих средств вместе с иммунотерапией для лечения рака
SG11201901389XA (en) 2016-08-25 2019-03-28 Calithera Biosciences Inc Combination therapy with glutaminase inhibitors
JP2019524852A (ja) 2016-08-25 2019-09-05 キャリセラ バイオサイエンシーズ, インコーポレイテッド グルタミナーゼ阻害剤を用いる併用療法
US20180055825A1 (en) 2016-08-25 2018-03-01 Yu Liang Treatment of cancer with inhibitors of glutaminase
AU2018231058A1 (en) 2017-03-10 2019-09-19 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
WO2019089952A1 (en) * 2017-11-03 2019-05-09 Calithera Biosciences, Inc. Conjoint therapy with glutaminase inhibitors

Similar Documents

Publication Publication Date Title
JP2018529780A5 (OSRAM)
JP2017517548A5 (OSRAM)
JP2016505526A5 (OSRAM)
JP2016502544A5 (OSRAM)
AU2017263478B2 (en) Combination therapies of HDAC inhibitors and PD-1 inhibitors
JP2020510032A5 (OSRAM)
JP2014533699A5 (OSRAM)
AU2017264857B2 (en) Combination therapies of HDAC inhibitors and PD-L1 inhibitors
JP2019518741A5 (OSRAM)
JP2020128432A (ja) がんの処置のための併用治療
JP2017523991A5 (OSRAM)
JP7491220B2 (ja) 免疫チェックポイント阻害薬およびfolfirinox療法との併用によるがん治療
JP5911929B2 (ja) 特定の癌の治療のためのrdea119/bay869766を含む組み合わせ医薬
ES2808565T3 (es) Composiciones que comprenden anticuerpos anti-CD38 y carfilzomib
RU2017145026A (ru) Соединение, ингибирующее brk
JP2014500295A5 (OSRAM)
JP2019517487A5 (OSRAM)
JP2019526560A5 (OSRAM)
JP2020527173A5 (OSRAM)
JP2019524852A5 (OSRAM)
JP2018529780A (ja) グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法
WO2019222538A1 (en) Aminopyrimidines and aminopyridines as mertk inhibitors and their application in cancer treatment
JP2010535211A (ja) 炎症性障害、脱髄障害および癌を治療するためのインダゾール化合物
JP2018519332A5 (OSRAM)
JPWO2022246177A5 (OSRAM)