JP2014533699A5 - - Google Patents
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- JP2014533699A5 JP2014533699A5 JP2014542546A JP2014542546A JP2014533699A5 JP 2014533699 A5 JP2014533699 A5 JP 2014533699A5 JP 2014542546 A JP2014542546 A JP 2014542546A JP 2014542546 A JP2014542546 A JP 2014542546A JP 2014533699 A5 JP2014533699 A5 JP 2014533699A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- independently
- substituted
- cycloalkyl
- heteroarylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims description 67
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 58
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 54
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 49
- 150000001875 compounds Chemical class 0.000 claims description 47
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 46
- 125000003545 alkoxy group Chemical group 0.000 claims description 45
- 125000001072 heteroaryl group Chemical group 0.000 claims description 40
- 125000003118 aryl group Chemical group 0.000 claims description 39
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 39
- 239000008194 pharmaceutical composition Substances 0.000 claims description 35
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 30
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 30
- 125000000623 heterocyclic group Chemical group 0.000 claims description 30
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 30
- 125000004945 acylaminoalkyl group Chemical group 0.000 claims description 24
- 125000003342 alkenyl group Chemical group 0.000 claims description 24
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims description 24
- 125000004104 aryloxy group Chemical group 0.000 claims description 24
- 125000005326 heteroaryloxy alkyl group Chemical group 0.000 claims description 24
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 24
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 22
- 206010028980 Neoplasm Diseases 0.000 claims description 21
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 19
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 18
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000002252 acyl group Chemical group 0.000 claims description 6
- 125000004442 acylamino group Chemical group 0.000 claims description 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 6
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims description 6
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims description 6
- 125000002837 carbocyclic group Chemical group 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- 125000005415 substituted alkoxy group Chemical group 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
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| GB201520959D0 (en) * | 2015-11-27 | 2016-01-13 | Astrazeneca Ab And Cancer Res Technology Ltd | Bis-pyridazine compounds and their use in treating cancer |
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| US10150753B2 (en) | 2015-12-22 | 2018-12-11 | Board Of Regents, The University Of Texas System | Salt forms and polymorphs of (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyrdin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide |
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-
2016
- 2016-03-10 ZA ZA2016/01655A patent/ZA201601655B/en unknown
- 2016-09-13 JP JP2016178240A patent/JP6329226B2/ja not_active Expired - Fee Related
-
2018
- 2018-04-19 JP JP2018080830A patent/JP6577623B2/ja not_active Expired - Fee Related
- 2018-06-12 IL IL259958A patent/IL259958B/en active IP Right Grant
-
2019
- 2019-12-16 CY CY20191101318T patent/CY1122707T1/el unknown
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