CA3000996A1 - Combination therapy with glutaminase inhibitors and immuno-oncology agents - Google Patents
Combination therapy with glutaminase inhibitors and immuno-oncology agents Download PDFInfo
- Publication number
- CA3000996A1 CA3000996A1 CA3000996A CA3000996A CA3000996A1 CA 3000996 A1 CA3000996 A1 CA 3000996A1 CA 3000996 A CA3000996 A CA 3000996A CA 3000996 A CA3000996 A CA 3000996A CA 3000996 A1 CA3000996 A1 CA 3000996A1
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- Canada
- Prior art keywords
- cancer
- arylalkyl
- substituted
- unsubstituted
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Health & Medical Sciences (AREA)
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| US201562237287P | 2015-10-05 | 2015-10-05 | |
| US62/237,287 | 2015-10-05 | ||
| US201662323179P | 2016-04-15 | 2016-04-15 | |
| US62/323,179 | 2016-04-15 | ||
| PCT/US2016/055316 WO2017062354A1 (en) | 2015-10-05 | 2016-10-04 | Combination therapy with glutaminase inhibitors and immuno-oncology agents |
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| EP3954686A1 (en) | 2012-11-16 | 2022-02-16 | Calithera Biosciences, Inc. | Heterocyclic glutaminase inhibitors |
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| CA2957225A1 (en) | 2014-08-07 | 2016-02-11 | Calithera Biosciences, Inc. | Crystal forms of glutaminase inhibitors |
| CN108601767A (zh) | 2015-10-05 | 2018-09-28 | 卡利泰拉生物科技公司 | 用谷氨酰胺酶抑制剂和免疫肿瘤学药剂的组合疗法 |
| WO2019055786A1 (en) * | 2017-09-14 | 2019-03-21 | Lankenau Institute For Medical Research | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER |
| EP3703822A4 (en) * | 2017-11-03 | 2021-11-10 | Calithera Biosciences, Inc. | CONJOINT THERAPY WITH GLUTAMINASE INHIBITORS |
| US20210260057A1 (en) * | 2018-07-12 | 2021-08-26 | Cedars-Sinai Medical Center | Compositions and methods targeting glutamine and its metabolism for diagnosing and treating cancer and therapy-associated side effects |
| JP2022546686A (ja) * | 2019-08-30 | 2022-11-07 | ベストランデツ イノバシオンセルスカップ アーエス | 形質細胞に対する抑制剤または細胞傷害剤を使用する慢性疲労症候群の処置のための方法 |
| CN111643669A (zh) * | 2020-06-30 | 2020-09-11 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 谷氨酰胺酶抑制剂在制备治疗银屑病的药物中的应用 |
| US11839659B2 (en) | 2020-07-02 | 2023-12-12 | Northwestern University | Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein |
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2016
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- 2016-10-04 US US15/284,865 patent/US10258619B2/en not_active Expired - Fee Related
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| WO2017062354A1 (en) | 2017-04-13 |
| AU2016335991A1 (en) | 2018-05-10 |
| EP3359150A4 (en) | 2019-11-06 |
| US20190231776A1 (en) | 2019-08-01 |
| CN108601767A (zh) | 2018-09-28 |
| KR20180059544A (ko) | 2018-06-04 |
| US10940148B2 (en) | 2021-03-09 |
| US20170095473A1 (en) | 2017-04-06 |
| EP3359150A1 (en) | 2018-08-15 |
| JP6971239B2 (ja) | 2021-11-24 |
| SG11201802830QA (en) | 2018-05-30 |
| JP2018529780A (ja) | 2018-10-11 |
| US20210361649A1 (en) | 2021-11-25 |
| IL258500A (en) | 2018-05-31 |
| US10258619B2 (en) | 2019-04-16 |
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