NZ606629A - Benzoic acid derivatives - Google Patents

Benzoic acid derivatives

Info

Publication number
NZ606629A
NZ606629A NZ60662911A NZ60662911A NZ606629A NZ 606629 A NZ606629 A NZ 606629A NZ 60662911 A NZ60662911 A NZ 60662911A NZ 60662911 A NZ60662911 A NZ 60662911A NZ 606629 A NZ606629 A NZ 606629A
Authority
NZ
New Zealand
Prior art keywords
benzoic acid
compound
acid derivatives
trifluoromethyl
methyl
Prior art date
Application number
NZ60662911A
Other languages
English (en)
Inventor
Mark Spyvee
Takashi Satoh
Jonathan Eric Carlson
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of NZ606629A publication Critical patent/NZ606629A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NZ60662911A 2010-09-21 2011-09-12 Benzoic acid derivatives NZ606629A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38478110P 2010-09-21 2010-09-21
PCT/US2011/051163 WO2012039972A1 (en) 2010-09-21 2011-09-12 Pharmaceutical composition

Publications (1)

Publication Number Publication Date
NZ606629A true NZ606629A (en) 2015-03-27

Family

ID=44674894

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ60662911A NZ606629A (en) 2010-09-21 2011-09-12 Benzoic acid derivatives

Country Status (31)

Country Link
US (2) US8686018B2 (enExample)
EP (2) EP2619182B1 (enExample)
JP (1) JP5956448B2 (enExample)
KR (1) KR101911105B1 (enExample)
CN (1) CN103097358B (enExample)
AU (1) AU2011305872B2 (enExample)
BR (1) BR112013002484B1 (enExample)
CA (1) CA2806121C (enExample)
CL (1) CL2013000675A1 (enExample)
CY (1) CY1118680T1 (enExample)
DK (1) DK2619182T3 (enExample)
ES (1) ES2610185T3 (enExample)
HR (1) HRP20170042T1 (enExample)
HU (1) HUE031408T2 (enExample)
IL (1) IL224288A (enExample)
LT (1) LT2619182T (enExample)
ME (1) ME02575B (enExample)
MX (1) MX2013003162A (enExample)
MY (1) MY162146A (enExample)
NZ (1) NZ606629A (enExample)
PE (1) PE20131343A1 (enExample)
PH (1) PH12013500467A1 (enExample)
PL (1) PL2619182T3 (enExample)
PT (1) PT2619182T (enExample)
RS (1) RS55566B1 (enExample)
RU (1) RU2606510C2 (enExample)
SG (1) SG188188A1 (enExample)
SI (1) SI2619182T1 (enExample)
SM (2) SMT201700008T1 (enExample)
UA (1) UA113499C2 (enExample)
WO (1) WO2012039972A1 (enExample)

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CN114790176B (zh) * 2021-01-25 2026-07-17 武汉人福创新药物研发中心有限公司 咪唑类化合物及其制备方法和用途
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CA3230557A1 (en) * 2021-09-03 2023-03-09 Xuejun Zhang Ep4 antagonist compound as well as salt, polymorph, and use thereof
CN115364222A (zh) * 2021-09-09 2022-11-22 首都医科大学附属北京地坛医院 Ep4受体抑制剂治疗肝纤维化的应用
KR20240124927A (ko) 2021-12-23 2024-08-19 에자이 알앤드디 매니지먼트 가부시키가이샤 Ep4 길항제의 결정질 염 형태
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Also Published As

Publication number Publication date
PT2619182T (pt) 2017-01-17
KR20130099008A (ko) 2013-09-05
HUE031408T2 (en) 2017-07-28
JP5956448B2 (ja) 2016-07-27
ME02575B (me) 2017-06-20
KR101911105B1 (ko) 2018-10-23
SMT201700008B (it) 2017-03-08
ES2610185T3 (es) 2017-04-26
CN103097358B (zh) 2015-04-08
WO2012039972A1 (en) 2012-03-29
CA2806121C (en) 2018-10-09
SG188188A1 (en) 2013-04-30
US20130237578A1 (en) 2013-09-12
US9000024B2 (en) 2015-04-07
EP2619182A1 (en) 2013-07-31
DK2619182T3 (en) 2017-01-30
CY1118680T1 (el) 2017-07-12
LT2619182T (lt) 2017-01-25
RU2606510C2 (ru) 2017-01-10
PL2619182T3 (pl) 2017-03-31
PE20131343A1 (es) 2013-11-18
SMT201700008T1 (it) 2017-03-08
AU2011305872B2 (en) 2015-03-26
US20140155452A1 (en) 2014-06-05
RU2013118209A (ru) 2014-10-27
UA113499C2 (xx) 2017-02-10
PH12013500467A1 (en) 2013-04-29
IL224288A (en) 2015-02-26
EP2619182B1 (en) 2016-11-09
AU2011305872A1 (en) 2013-01-31
SI2619182T1 (sl) 2017-03-31
HRP20170042T1 (hr) 2017-03-10
BR112013002484B1 (pt) 2021-10-13
MX2013003162A (es) 2013-05-06
RS55566B1 (sr) 2017-05-31
CN103097358A (zh) 2013-05-08
JP2013538825A (ja) 2013-10-17
CA2806121A1 (en) 2012-03-29
EP3061751A1 (en) 2016-08-31
CL2013000675A1 (es) 2013-07-05
BR112013002484A2 (pt) 2016-05-31
MY162146A (en) 2017-05-31
US8686018B2 (en) 2014-04-01

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