PL2619182T3 - Kompozycja farmaceutyczna - Google Patents

Kompozycja farmaceutyczna

Info

Publication number
PL2619182T3
PL2619182T3 PL11760631T PL11760631T PL2619182T3 PL 2619182 T3 PL2619182 T3 PL 2619182T3 PL 11760631 T PL11760631 T PL 11760631T PL 11760631 T PL11760631 T PL 11760631T PL 2619182 T3 PL2619182 T3 PL 2619182T3
Authority
PL
Poland
Prior art keywords
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
PL11760631T
Other languages
English (en)
Inventor
Mark Spyvee
Takashi Satoh
Jonathan Eric Carlson
Original Assignee
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co., Ltd. filed Critical Eisai R&D Management Co., Ltd.
Publication of PL2619182T3 publication Critical patent/PL2619182T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • C07D231/20One oxygen atom attached in position 3 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • C07D231/20One oxygen atom attached in position 3 or 5
    • C07D231/22One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41521,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL11760631T 2010-09-21 2011-09-12 Kompozycja farmaceutyczna PL2619182T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38478110P 2010-09-21 2010-09-21

Publications (1)

Publication Number Publication Date
PL2619182T3 true PL2619182T3 (pl) 2017-03-31

Family

ID=44674894

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11760631T PL2619182T3 (pl) 2010-09-21 2011-09-12 Kompozycja farmaceutyczna

Country Status (31)

Country Link
US (2) US8686018B2 (pl)
EP (2) EP3061751A1 (pl)
JP (1) JP5956448B2 (pl)
KR (1) KR101911105B1 (pl)
CN (1) CN103097358B (pl)
AU (1) AU2011305872B2 (pl)
BR (1) BR112013002484B1 (pl)
CA (1) CA2806121C (pl)
CL (1) CL2013000675A1 (pl)
CY (1) CY1118680T1 (pl)
DK (1) DK2619182T3 (pl)
ES (1) ES2610185T3 (pl)
HR (1) HRP20170042T1 (pl)
HU (1) HUE031408T2 (pl)
IL (1) IL224288A (pl)
LT (1) LT2619182T (pl)
ME (1) ME02575B (pl)
MX (1) MX2013003162A (pl)
MY (1) MY162146A (pl)
NZ (1) NZ606629A (pl)
PE (1) PE20131343A1 (pl)
PH (1) PH12013500467A1 (pl)
PL (1) PL2619182T3 (pl)
PT (1) PT2619182T (pl)
RS (1) RS55566B1 (pl)
RU (1) RU2606510C2 (pl)
SG (1) SG188188A1 (pl)
SI (1) SI2619182T1 (pl)
SM (2) SMT201700008T1 (pl)
UA (1) UA113499C2 (pl)
WO (1) WO2012039972A1 (pl)

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TW201623277A (zh) 2014-03-26 2016-07-01 安斯泰來製藥股份有限公司 醯胺化合物
US20170182003A1 (en) * 2014-05-23 2017-06-29 Eisai R&D Management Co., Ltd. Combination therapies for the treatment of cancer
TWI730959B (zh) 2015-05-19 2021-06-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺
EP3325490B1 (en) 2015-07-23 2019-12-18 Takeda Pharmaceutical Company Limited 1-substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as ep4 receptor antagonists
MX390051B (es) * 2015-10-16 2025-03-20 Eisai R&D Man Co Ltd Antagonistas de ep4.
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
AR111941A1 (es) 2017-05-18 2019-09-04 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
JP7093791B2 (ja) 2017-05-18 2022-06-30 イドーシア ファーマシューティカルズ リミテッド Pge2レセプター調節剤としてのベンゾフラン及びベンゾチオフェン誘導体
US20200069686A1 (en) 2017-05-18 2020-03-05 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives
EP3625223B1 (en) 2017-05-18 2021-08-11 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
MX388257B (es) 2017-05-18 2025-03-19 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2.
CN108929281B (zh) * 2017-05-27 2021-12-24 华东师范大学 三氮唑类化合物及其合成方法和应用
AU2019214193B2 (en) * 2018-02-05 2022-06-16 Foshan Ionova Biotherapeutics Co., Inc. Heterobicyclic carboxylic acids for treating cancer or inflammatory diseases
US20230125494A1 (en) * 2020-03-04 2023-04-27 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Synthesis of novel ep4 antagonist and use in cancer and inflammation
CN114075140A (zh) * 2020-08-18 2022-02-22 武汉人福创新药物研发中心有限公司 作为ep4受体拮抗剂的吡唑酰胺衍生物及其在癌症和炎症中的用途
EP4245301A4 (en) 2020-11-13 2024-08-21 ONO Pharmaceutical Co., Ltd. TREATMENT OF CANCER BY COMBINED USE OF AN EP4 ANTAGONIST AND AN IMMUNE CHECKPOINT INHIBITOR
TWI877433B (zh) 2020-11-30 2025-03-21 大陸商杭州阿諾生物醫藥科技有限公司 用於治療pik3ca突變癌症的組合療法
CN114790176A (zh) * 2021-01-25 2022-07-26 武汉人福创新药物研发中心有限公司 咪唑类化合物及其制备方法和用途
EP4286371A4 (en) * 2021-01-28 2025-01-08 Shenzhen Zhongge Biological Technology Co., Ltd. Pyrazolamide derivative, preparation method therefor, and application thereof
WO2023030492A1 (zh) * 2021-09-03 2023-03-09 武汉人福创新药物研发中心有限公司 一种ep4拮抗剂化合物及其盐、多晶型和用途
CN115364222A (zh) * 2021-09-09 2022-11-22 首都医科大学附属北京地坛医院 Ep4受体抑制剂治疗肝纤维化的应用
CA3242277A1 (en) 2021-12-23 2023-06-29 Eisai R&D Management Co., Ltd. Crystalline salt form of ep4 antagonist
US20250381143A1 (en) 2021-12-30 2025-12-18 Adlai Nortye Biopharma Co., Ltd. A solid pharmaceutical composition
WO2024027599A1 (zh) * 2022-08-04 2024-02-08 杭州阿诺生物医药科技有限公司 预测直肠癌对an0025联合放疗/放化疗(rt/crt)治疗敏感性的生物标志物

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Also Published As

Publication number Publication date
LT2619182T (lt) 2017-01-25
EP2619182A1 (en) 2013-07-31
EP2619182B1 (en) 2016-11-09
NZ606629A (en) 2015-03-27
PE20131343A1 (es) 2013-11-18
SMT201700008T1 (it) 2017-03-08
US20140155452A1 (en) 2014-06-05
AU2011305872B2 (en) 2015-03-26
CL2013000675A1 (es) 2013-07-05
US20130237578A1 (en) 2013-09-12
SI2619182T1 (sl) 2017-03-31
WO2012039972A1 (en) 2012-03-29
RS55566B1 (sr) 2017-05-31
UA113499C2 (xx) 2017-02-10
PH12013500467A1 (en) 2013-04-29
CY1118680T1 (el) 2017-07-12
DK2619182T3 (en) 2017-01-30
CN103097358A (zh) 2013-05-08
US9000024B2 (en) 2015-04-07
MX2013003162A (es) 2013-05-06
PT2619182T (pt) 2017-01-17
ME02575B (me) 2017-06-20
AU2011305872A1 (en) 2013-01-31
RU2606510C2 (ru) 2017-01-10
BR112013002484B1 (pt) 2021-10-13
JP2013538825A (ja) 2013-10-17
CN103097358B (zh) 2015-04-08
BR112013002484A2 (pt) 2016-05-31
RU2013118209A (ru) 2014-10-27
SG188188A1 (en) 2013-04-30
CA2806121C (en) 2018-10-09
HUE031408T2 (en) 2017-07-28
EP3061751A1 (en) 2016-08-31
ES2610185T3 (es) 2017-04-26
US8686018B2 (en) 2014-04-01
CA2806121A1 (en) 2012-03-29
MY162146A (en) 2017-05-31
HRP20170042T1 (hr) 2017-03-10
JP5956448B2 (ja) 2016-07-27
KR101911105B1 (ko) 2018-10-23
SMT201700008B (it) 2017-03-08
KR20130099008A (ko) 2013-09-05
IL224288A (en) 2015-02-26

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