CL2013000675A1 - Compuestos derivados de pirazolamida sustituidas, con actividad sobre pge2/ep4; composicion farmaceutica que los comprende; y su uso para el tratamiento de la esclerosis multiple y la artritis reumtoide. - Google Patents

Compuestos derivados de pirazolamida sustituidas, con actividad sobre pge2/ep4; composicion farmaceutica que los comprende; y su uso para el tratamiento de la esclerosis multiple y la artritis reumtoide.

Info

Publication number
CL2013000675A1
CL2013000675A1 CL2013000675A CL2013000675A CL2013000675A1 CL 2013000675 A1 CL2013000675 A1 CL 2013000675A1 CL 2013000675 A CL2013000675 A CL 2013000675A CL 2013000675 A CL2013000675 A CL 2013000675A CL 2013000675 A1 CL2013000675 A1 CL 2013000675A1
Authority
CL
Chile
Prior art keywords
pyrazolamide
substituted
treatment
pharmaceutical composition
rheumatoid arthritis
Prior art date
Application number
CL2013000675A
Other languages
English (en)
Inventor
Mark Spyvee
Takashi Satoh
Jonathan Eric Carlson
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of CL2013000675A1 publication Critical patent/CL2013000675A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Compuestos derivados de pirazolamida sustituidas; composición farmacéutica que los comprende; y su uso para el tratamiento de la esclerosis múltiple y la artritis reumatoide.
CL2013000675A 2010-09-21 2013-03-12 Compuestos derivados de pirazolamida sustituidas, con actividad sobre pge2/ep4; composicion farmaceutica que los comprende; y su uso para el tratamiento de la esclerosis multiple y la artritis reumtoide. CL2013000675A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38478110P 2010-09-21 2010-09-21

Publications (1)

Publication Number Publication Date
CL2013000675A1 true CL2013000675A1 (es) 2013-07-05

Family

ID=44674894

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013000675A CL2013000675A1 (es) 2010-09-21 2013-03-12 Compuestos derivados de pirazolamida sustituidas, con actividad sobre pge2/ep4; composicion farmaceutica que los comprende; y su uso para el tratamiento de la esclerosis multiple y la artritis reumtoide.

Country Status (29)

Country Link
US (2) US8686018B2 (es)
EP (2) EP2619182B1 (es)
JP (1) JP5956448B2 (es)
KR (1) KR101911105B1 (es)
CN (1) CN103097358B (es)
AU (1) AU2011305872B2 (es)
CA (1) CA2806121C (es)
CL (1) CL2013000675A1 (es)
CY (1) CY1118680T1 (es)
DK (1) DK2619182T3 (es)
ES (1) ES2610185T3 (es)
HR (1) HRP20170042T1 (es)
HU (1) HUE031408T2 (es)
IL (1) IL224288A (es)
LT (1) LT2619182T (es)
ME (1) ME02575B (es)
MX (1) MX2013003162A (es)
MY (1) MY162146A (es)
NZ (1) NZ606629A (es)
PE (1) PE20131343A1 (es)
PL (1) PL2619182T3 (es)
PT (1) PT2619182T (es)
RS (1) RS55566B1 (es)
RU (1) RU2606510C2 (es)
SG (1) SG188188A1 (es)
SI (1) SI2619182T1 (es)
SM (1) SMT201700008B (es)
UA (1) UA113499C2 (es)
WO (1) WO2012039972A1 (es)

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TW202246217A (zh) * 2021-01-28 2022-12-01 大陸商深圳晶泰科技有限公司 咪唑醯胺衍生物及其製備方法和應用
TW202328073A (zh) * 2021-09-03 2023-07-16 大陸商武漢人福創新藥物研發中心有限公司 Ｅｐ４拮抗劑化合物及其鹽、多晶型及其製備方法和用途
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Also Published As

Publication number Publication date
ME02575B (me) 2017-06-20
CY1118680T1 (el) 2017-07-12
PT2619182T (pt) 2017-01-17
PE20131343A1 (es) 2013-11-18
RS55566B1 (sr) 2017-05-31
SG188188A1 (en) 2013-04-30
US8686018B2 (en) 2014-04-01
CN103097358A (zh) 2013-05-08
BR112013002484A2 (pt) 2016-05-31
WO2012039972A1 (en) 2012-03-29
NZ606629A (en) 2015-03-27
CA2806121C (en) 2018-10-09
HRP20170042T1 (hr) 2017-03-10
SMT201700008B (it) 2017-03-08
JP5956448B2 (ja) 2016-07-27
DK2619182T3 (en) 2017-01-30
ES2610185T3 (es) 2017-04-26
CA2806121A1 (en) 2012-03-29
PL2619182T3 (pl) 2017-03-31
US9000024B2 (en) 2015-04-07
EP2619182B1 (en) 2016-11-09
SI2619182T1 (sl) 2017-03-31
LT2619182T (lt) 2017-01-25
MY162146A (en) 2017-05-31
KR20130099008A (ko) 2013-09-05
US20140155452A1 (en) 2014-06-05
AU2011305872A1 (en) 2013-01-31
AU2011305872B2 (en) 2015-03-26
HUE031408T2 (en) 2017-07-28
JP2013538825A (ja) 2013-10-17
IL224288A (en) 2015-02-26
KR101911105B1 (ko) 2018-10-23
UA113499C2 (xx) 2017-02-10
MX2013003162A (es) 2013-05-06
EP2619182A1 (en) 2013-07-31
EP3061751A1 (en) 2016-08-31
RU2013118209A (ru) 2014-10-27
US20130237578A1 (en) 2013-09-12
RU2606510C2 (ru) 2017-01-10
CN103097358B (zh) 2015-04-08

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