SI2619182T1 - Farmacevtski sestavek - Google Patents

Farmacevtski sestavek

Info

Publication number
SI2619182T1
SI2619182T1 SI201131067A SI201131067A SI2619182T1 SI 2619182 T1 SI2619182 T1 SI 2619182T1 SI 201131067 A SI201131067 A SI 201131067A SI 201131067 A SI201131067 A SI 201131067A SI 2619182 T1 SI2619182 T1 SI 2619182T1
Authority
SI
Slovenia
Prior art keywords
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
SI201131067A
Other languages
English (en)
Slovenian (sl)
Inventor
Mark Spyvee
Takashi Satoh
Jonathan Eric Carlson
Original Assignee
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co., Ltd. filed Critical Eisai R&D Management Co., Ltd.
Publication of SI2619182T1 publication Critical patent/SI2619182T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI201131067A 2010-09-21 2011-09-12 Farmacevtski sestavek SI2619182T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38478110P 2010-09-21 2010-09-21
PCT/US2011/051163 WO2012039972A1 (en) 2010-09-21 2011-09-12 Pharmaceutical composition
EP11760631.9A EP2619182B1 (en) 2010-09-21 2011-09-12 Pharmaceutical composition

Publications (1)

Publication Number Publication Date
SI2619182T1 true SI2619182T1 (sl) 2017-03-31

Family

ID=44674894

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201131067A SI2619182T1 (sl) 2010-09-21 2011-09-12 Farmacevtski sestavek

Country Status (31)

Country Link
US (2) US8686018B2 (enExample)
EP (2) EP2619182B1 (enExample)
JP (1) JP5956448B2 (enExample)
KR (1) KR101911105B1 (enExample)
CN (1) CN103097358B (enExample)
AU (1) AU2011305872B2 (enExample)
BR (1) BR112013002484B1 (enExample)
CA (1) CA2806121C (enExample)
CL (1) CL2013000675A1 (enExample)
CY (1) CY1118680T1 (enExample)
DK (1) DK2619182T3 (enExample)
ES (1) ES2610185T3 (enExample)
HR (1) HRP20170042T1 (enExample)
HU (1) HUE031408T2 (enExample)
IL (1) IL224288A (enExample)
LT (1) LT2619182T (enExample)
ME (1) ME02575B (enExample)
MX (1) MX2013003162A (enExample)
MY (1) MY162146A (enExample)
NZ (1) NZ606629A (enExample)
PE (1) PE20131343A1 (enExample)
PH (1) PH12013500467A1 (enExample)
PL (1) PL2619182T3 (enExample)
PT (1) PT2619182T (enExample)
RS (1) RS55566B1 (enExample)
RU (1) RU2606510C2 (enExample)
SG (1) SG188188A1 (enExample)
SI (1) SI2619182T1 (enExample)
SM (2) SMT201700008T1 (enExample)
UA (1) UA113499C2 (enExample)
WO (1) WO2012039972A1 (enExample)

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TW201623277A (zh) 2014-03-26 2016-07-01 安斯泰來製藥股份有限公司 醯胺化合物
SG11201609770TA (en) * 2014-05-23 2016-12-29 Eisai R&D Man Co Ltd Combination therapies for the treatment of cancer
UY36680A (es) 2015-05-19 2016-12-30 Glaxosmithkline Ip Dev Ltd Amidas heterocíclicas como inhibidores de quinasa
JP6689297B2 (ja) 2015-07-23 2020-04-28 武田薬品工業株式会社 複素環化合物
CA3002144C (en) 2015-10-16 2024-01-23 Eisai R&D Management Co., Ltd. Ep4 antagonists
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
AR111808A1 (es) 2017-05-18 2019-08-21 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
PE20191787A1 (es) 2017-05-18 2019-12-24 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituidos
EA201992676A1 (ru) 2017-05-18 2020-05-06 Идорсия Фармасьютиклз Лтд Фенильные производные в качестве модуляторов pge2 рецепторов
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CN108929281B (zh) * 2017-05-27 2021-12-24 华东师范大学 三氮唑类化合物及其合成方法和应用
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IL296007B2 (en) * 2020-03-04 2026-03-01 Wuhan Humanwell Innovative Drug Res And Development Center Limited Company Synthesis of a novel EP4 antibody and use for cancer and inflammation
WO2022037601A1 (zh) * 2020-08-18 2022-02-24 武汉人福创新药物研发中心有限公司 作为ep4受体拮抗剂的吡唑酰胺衍生物及其在制备治疗癌症和炎症药物中的用途
JP7816164B2 (ja) 2020-11-13 2026-02-18 小野薬品工業株式会社 Ep4拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療
TWI877433B (zh) 2020-11-30 2025-03-21 大陸商杭州阿諾生物醫藥科技有限公司 用於治療pik3ca突變癌症的組合療法
CN114790176B (zh) * 2021-01-25 2026-07-17 武汉人福创新药物研发中心有限公司 咪唑类化合物及其制备方法和用途
TWI916497B (zh) 2021-01-28 2026-03-01 大陸商深圳眾格生物科技有限公司 咪唑醯胺衍生物及其藥物組合物、製備方法和應用
CA3230557A1 (en) * 2021-09-03 2023-03-09 Xuejun Zhang Ep4 antagonist compound as well as salt, polymorph, and use thereof
CN115364222A (zh) * 2021-09-09 2022-11-22 首都医科大学附属北京地坛医院 Ep4受体抑制剂治疗肝纤维化的应用
KR20240124927A (ko) 2021-12-23 2024-08-19 에자이 알앤드디 매니지먼트 가부시키가이샤 Ep4 길항제의 결정질 염 형태
US20250381143A1 (en) * 2021-12-30 2025-12-18 Adlai Nortye Biopharma Co., Ltd. A solid pharmaceutical composition
WO2024027599A1 (zh) * 2022-08-04 2024-02-08 杭州阿诺生物医药科技有限公司 预测直肠癌对an0025联合放疗/放化疗(rt/crt)治疗敏感性的生物标志物

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Also Published As

Publication number Publication date
PT2619182T (pt) 2017-01-17
KR20130099008A (ko) 2013-09-05
HUE031408T2 (en) 2017-07-28
JP5956448B2 (ja) 2016-07-27
ME02575B (me) 2017-06-20
KR101911105B1 (ko) 2018-10-23
SMT201700008B (it) 2017-03-08
ES2610185T3 (es) 2017-04-26
CN103097358B (zh) 2015-04-08
WO2012039972A1 (en) 2012-03-29
CA2806121C (en) 2018-10-09
SG188188A1 (en) 2013-04-30
US20130237578A1 (en) 2013-09-12
US9000024B2 (en) 2015-04-07
EP2619182A1 (en) 2013-07-31
DK2619182T3 (en) 2017-01-30
CY1118680T1 (el) 2017-07-12
LT2619182T (lt) 2017-01-25
RU2606510C2 (ru) 2017-01-10
PL2619182T3 (pl) 2017-03-31
PE20131343A1 (es) 2013-11-18
SMT201700008T1 (it) 2017-03-08
AU2011305872B2 (en) 2015-03-26
US20140155452A1 (en) 2014-06-05
RU2013118209A (ru) 2014-10-27
UA113499C2 (xx) 2017-02-10
PH12013500467A1 (en) 2013-04-29
IL224288A (en) 2015-02-26
EP2619182B1 (en) 2016-11-09
NZ606629A (en) 2015-03-27
AU2011305872A1 (en) 2013-01-31
HRP20170042T1 (hr) 2017-03-10
BR112013002484B1 (pt) 2021-10-13
MX2013003162A (es) 2013-05-06
RS55566B1 (sr) 2017-05-31
CN103097358A (zh) 2013-05-08
JP2013538825A (ja) 2013-10-17
CA2806121A1 (en) 2012-03-29
EP3061751A1 (en) 2016-08-31
CL2013000675A1 (es) 2013-07-05
BR112013002484A2 (pt) 2016-05-31
MY162146A (en) 2017-05-31
US8686018B2 (en) 2014-04-01

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