NZ591362A - Multiple-variable dose regimen for treating tnfa-related disorders - Google Patents
Multiple-variable dose regimen for treating tnfa-related disordersInfo
- Publication number
- NZ591362A NZ591362A NZ591362A NZ59136205A NZ591362A NZ 591362 A NZ591362 A NZ 591362A NZ 591362 A NZ591362 A NZ 591362A NZ 59136205 A NZ59136205 A NZ 59136205A NZ 591362 A NZ591362 A NZ 591362A
- Authority
- NZ
- New Zealand
- Prior art keywords
- dose
- treatment
- antigen
- medicament
- related disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56113904P | 2004-04-09 | 2004-04-09 | |
| US56171004P | 2004-04-12 | 2004-04-12 | |
| US56910004P | 2004-05-07 | 2004-05-07 | |
| NZ579302A NZ579302A (en) | 2004-04-09 | 2005-04-11 | Multiple-variable dose regimen for treating TNFalpha-related disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ591362A true NZ591362A (en) | 2012-10-26 |
Family
ID=35006312
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ591362A NZ591362A (en) | 2004-04-09 | 2005-04-11 | Multiple-variable dose regimen for treating tnfa-related disorders |
| NZ579302A NZ579302A (en) | 2004-04-09 | 2005-04-11 | Multiple-variable dose regimen for treating TNFalpha-related disorders |
| NZ549959A NZ549959A (en) | 2004-04-09 | 2005-04-11 | Multiple-variable dose regimen for treating TNFalpha-related disorders using anti TNFalpha antibodies |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ579302A NZ579302A (en) | 2004-04-09 | 2005-04-11 | Multiple-variable dose regimen for treating TNFalpha-related disorders |
| NZ549959A NZ549959A (en) | 2004-04-09 | 2005-04-11 | Multiple-variable dose regimen for treating TNFalpha-related disorders using anti TNFalpha antibodies |
Country Status (21)
| Country | Link |
|---|---|
| US (16) | US8889136B2 (enExample) |
| EP (4) | EP2335732A3 (enExample) |
| JP (5) | JP5748317B2 (enExample) |
| KR (8) | KR101636446B1 (enExample) |
| CN (5) | CN103251945A (enExample) |
| AU (1) | AU2005244261B2 (enExample) |
| BR (1) | BRPI0509326A (enExample) |
| CA (4) | CA2847331A1 (enExample) |
| CY (1) | CY1118564T1 (enExample) |
| DK (1) | DK1737491T3 (enExample) |
| ES (1) | ES2611286T3 (enExample) |
| HU (1) | HUE031558T2 (enExample) |
| IL (3) | IL178430A (enExample) |
| LT (1) | LT1737491T (enExample) |
| MX (1) | MXPA06011677A (enExample) |
| NZ (3) | NZ591362A (enExample) |
| PL (1) | PL1737491T3 (enExample) |
| PT (1) | PT1737491T (enExample) |
| TW (4) | TWI439284B (enExample) |
| WO (1) | WO2005110452A2 (enExample) |
| ZA (1) | ZA200608097B (enExample) |
Families Citing this family (129)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| DK0929578T3 (da) * | 1996-02-09 | 2003-08-25 | Abbott Lab Bermuda Ltd | Humane antistoffer, der binder human TNFalfa |
| US7115557B2 (en) * | 1998-09-25 | 2006-10-03 | Sciaticon Ab | Use of certain drugs for treating nerve root injury |
| CA2385745C (en) | 2001-06-08 | 2015-02-17 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
| US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| NZ555692A (en) * | 2002-07-19 | 2009-02-28 | Abbott Biotech Ltd | Treatment of TNF alpha related disorders |
| US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| MY150740A (en) * | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| TWI439284B (zh) * | 2004-04-09 | 2014-06-01 | Abbvie Biotechnology Ltd | 用於治療TNFα相關失調症之多重可變劑量療法 |
| GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
| US20060083741A1 (en) * | 2004-10-08 | 2006-04-20 | Hoffman Rebecca S | Treatment of respiratory syncytial virus (RSV) infection |
| PT1836665E (pt) * | 2004-11-19 | 2013-04-11 | Glaxosmithkline Llc | Método para fornecimento personalizado de produtos de combinação de medicamentos em doses variáveis para individualização de terapêuticas |
| JP5757495B2 (ja) | 2005-05-16 | 2015-07-29 | アッヴィ バイオテクノロジー リミテッド | びらん性多発性関節炎の治療のためのtnf阻害剤の使用 |
| US20070041905A1 (en) * | 2005-08-19 | 2007-02-22 | Hoffman Rebecca S | Method of treating depression using a TNF-alpha antibody |
| TWI424161B (zh) | 2005-11-01 | 2014-01-21 | Abbvie Biotechnology Ltd | 利用生物標記診斷關節黏連脊椎炎之方法及組合物 |
| CA2641160A1 (en) * | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| LT2676967T (lt) | 2006-02-28 | 2019-09-10 | Biogen Ma Inc. | Uždegiminių ir autoimuninių ligų gydymo būdai su natalizumabu |
| BRPI0708392A2 (pt) * | 2006-03-03 | 2011-05-24 | Elan Pharm Inc | métodos de tratamento de um paciente com uma doença inflamatória ou autoimune com natalizumab e de uso de natalizumab para tratar um paciente com uma doença inflamatória ou autoimune |
| WO2007118084A2 (en) * | 2006-04-03 | 2007-10-18 | Stowers Institute For Medical Research | Compositions and methods for treating polycystic kidney disease |
| WO2007117490A2 (en) | 2006-04-05 | 2007-10-18 | Abbott Biotechnology Ltd. | Antibody purification |
| EP2708242A3 (en) * | 2006-04-10 | 2014-03-26 | Abbott Biotechnology Ltd | Uses and compositions for treatment of ankylosing spondylitis |
| CA2564435A1 (en) | 2006-04-10 | 2007-10-10 | Abbott Biotechnology Ltd. | Methods for monitoring and treating intestinal disorders |
| EP2007426A4 (en) | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | COMPOSITIONS FOR THE TREATMENT OF PSORIASTIC POLYARTHRITIS AND THEIR APPLICATIONS |
| US20090317399A1 (en) * | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
| WO2007120626A2 (en) | 2006-04-10 | 2007-10-25 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of ankylosing spondylitis |
| US9399061B2 (en) * | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
| US20080118496A1 (en) * | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
| US9605064B2 (en) | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| EP2012824A4 (en) * | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | USE AND COMPOSITIONS FOR THE TREATMENT OF PSORIASIS |
| US20080131374A1 (en) * | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
| US20080311043A1 (en) * | 2006-06-08 | 2008-12-18 | Hoffman Rebecca S | Uses and compositions for treatment of psoriatic arthritis |
| US20100021451A1 (en) * | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
| CN103316402A (zh) * | 2006-06-30 | 2013-09-25 | 艾伯维生物技术有限公司 | 自动注射装置 |
| CA2692430A1 (en) * | 2006-07-07 | 2008-01-10 | Bioassets Development Corporation | Methods for preventing, postponing or improving the outcome of spinal device and fusion procedures |
| US8034906B2 (en) | 2006-10-27 | 2011-10-11 | Abbott Biotechnology Ltd. | Crystalline anti-hTNFalpha antibodies |
| JP2010513245A (ja) * | 2006-12-14 | 2010-04-30 | アクトジェニックス・エヌブイ | 免疫調節を誘起するための結合分子の送達 |
| WO2008147869A2 (en) * | 2007-05-22 | 2008-12-04 | Centocor, Inc. | Markers and methods for assessing and treating crohn's disease and related disorders |
| WO2008150491A2 (en) * | 2007-05-31 | 2008-12-11 | Abbott Laboratories | BIOMARKERS PREDICTIVE OF THE RESPONSIVENESS TO TNFα INHIBITORS IN AUTOIMMUNE DISORDERS |
| EP2171451A4 (en) | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS |
| JP2010533181A (ja) * | 2007-07-13 | 2010-10-21 | アボツト・バイオテクノロジー・リミテツド | TNFα阻害剤の肺投与のための方法及び組成物 |
| CA2697163A1 (en) | 2007-08-08 | 2009-02-12 | Abbott Laboratories | Compositions and methods for crystallizing antibodies |
| US8647626B2 (en) | 2007-10-02 | 2014-02-11 | Avaxia Biologics, Incorporated | Compositions comprising TNF-specific antibodies for oral delivery |
| EP2244735A4 (en) * | 2007-10-02 | 2011-02-23 | Avaxia Biologics Inc | ANTIBODY THERAPY FOR USE IN THE DIGESTIVE TUBE |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| KR20150080038A (ko) | 2007-11-30 | 2015-07-08 | 애브비 바이오테크놀로지 리미티드 | 단백질 제형 및 이의 제조방법 |
| KR101616758B1 (ko) | 2007-12-26 | 2016-04-29 | 젠코어 인코포레이티드 | FcRn에 대한 변경된 결합성을 갖는 Fc 변이체 |
| CA2710333A1 (en) * | 2008-01-03 | 2009-07-09 | Abbott Biotechnology Ltd. | Predicting long-term efficacy of a compound in the treatment of psoriasis |
| KR20100120289A (ko) | 2008-01-15 | 2010-11-15 | 애보트 게엠베하 운트 콤파니 카게 | 분말상 단백질 조성물 및 이의 제조 방법 |
| US20100183558A1 (en) | 2008-10-17 | 2010-07-22 | Zhennan Lai | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| EP2918602A1 (en) | 2009-04-16 | 2015-09-16 | AbbVie Biotherapeutics Inc. | Anti-TNF-alpha antibodies and their uses |
| EP2424594A4 (en) | 2009-04-29 | 2014-12-24 | Abbvie Biotechnology Ltd | AUTOMATIC INJECTION DEVICE |
| US8758301B2 (en) * | 2009-12-15 | 2014-06-24 | Abbvie Biotechnology Ltd | Firing button for automatic injection device |
| WO2011075578A1 (en) | 2009-12-16 | 2011-06-23 | Philip Bosch | Methods of treating interstitial cystitis |
| EP4524571A3 (en) | 2010-01-11 | 2025-06-11 | Biogen MA Inc. | Assay for jc virus antibodies |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| SG184473A1 (en) * | 2010-04-07 | 2012-11-29 | Abbvie Inc | Tnf-alpha binding proteins |
| WO2011146727A1 (en) | 2010-05-19 | 2011-11-24 | Philip Bosch | Methods of treating interstitial cystitis |
| LT2575884T (lt) * | 2010-06-03 | 2018-09-25 | Abbvie Biotechnology Ltd | Panaudojimai ir kompozicijos, skirti pūlingo hidradenito (hs) gydymui |
| US20120076791A1 (en) * | 2010-09-29 | 2012-03-29 | Philip Bosch | Methods Of Treating Chronic Prostatitis/Chronic Pelvic Pain Syndrome |
| CN103154031A (zh) | 2010-10-08 | 2013-06-12 | 诺华有限公司 | 利用il-17拮抗剂治疗牛皮癣的方法 |
| US8821865B2 (en) | 2010-11-11 | 2014-09-02 | Abbvie Biotechnology Ltd. | High concentration anti-TNFα antibody liquid formulations |
| RU2727040C2 (ru) | 2011-01-24 | 2020-07-17 | Эббви Байотекнолоджи Лтд. | Автоматические инъекционные устройства, имеющие наформованные поверхности захвата |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| CA2834552A1 (en) | 2011-04-29 | 2012-11-01 | Bristol-Myers Squibb Company | Ip-10 antibody dosage escalation regimens |
| KR102473834B1 (ko) | 2011-05-31 | 2022-12-02 | 바이오젠 엠에이 인코포레이티드 | Pml의 위험을 판단하는 방법 |
| US20140017174A1 (en) | 2011-11-30 | 2014-01-16 | Raja Atreya | Methods and compositions for determining responsiveness to treatment with a tnf-alpha inhibitor |
| WO2013158628A1 (en) * | 2012-04-16 | 2013-10-24 | New York University | Modulation of angiotensin ii peceptors for the prevention and treatment of cerebral malaria |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| EP2890782A1 (en) | 2012-09-02 | 2015-07-08 | AbbVie Inc. | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| IN2015DN01967A (enExample) * | 2012-09-19 | 2015-08-14 | Abbvie Biotherapeutics Inc | |
| HK1207960A1 (en) | 2013-03-12 | 2016-02-19 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| HK1216546A1 (zh) | 2013-05-28 | 2016-11-18 | Biogen Ma Inc. | 评估pml风险的方法 |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| CN106170298B (zh) | 2013-10-16 | 2024-01-09 | 前瞻疗法公司 | 用于提高抗体稳定性的缓冲液制剂 |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| US20170183376A1 (en) | 2014-06-24 | 2017-06-29 | Insight Biopharmaceuticals Ltd. | Methods of purifying antibodies |
| US20170360929A1 (en) | 2014-12-23 | 2017-12-21 | Pfizer Inc. | Stable aqueous antibody formulation for anti tnf alpha antibodies |
| US9452344B2 (en) * | 2015-01-02 | 2016-09-27 | William J Ritter | Puck system |
| US10696735B2 (en) | 2015-01-21 | 2020-06-30 | Outlook Therapeutics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
| CN107530363A (zh) * | 2015-01-27 | 2018-01-02 | 阿斯利康(瑞典)有限公司 | 治疗或预防具有心肌梗塞病史的患者的动脉粥样硬化血栓形成事件的方法 |
| WO2016156466A1 (en) | 2015-03-31 | 2016-10-06 | Vhsquared Limited | Peptide construct having a protease-cleavable linker |
| CA3255406A1 (en) | 2015-03-31 | 2025-07-03 | Sorriso Pharmaceuticals, Inc. | Tnf-alpha binding polypeptides |
| JP2018511346A (ja) | 2015-03-31 | 2018-04-26 | ブイエイチスクエアード リミテッド | ポリペプチド |
| EP3078675A1 (en) | 2015-04-10 | 2016-10-12 | Ares Trading S.A. | Induction dosing regimen for the treatment of tnf alpha mediated disorders |
| AU2016275149A1 (en) | 2015-06-12 | 2018-01-04 | Georgia State University Research Foundation | Compositions and methods for treating opioid tolerance |
| JP6890831B2 (ja) | 2015-07-08 | 2021-06-18 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Hiv予備免疫化および免疫療法 |
| US12382777B2 (en) * | 2015-10-12 | 2025-08-05 | The Regents Of The University Of Michigan | Organic light emitting diode having a mixed blocking layer |
| CN109293777A (zh) * | 2015-11-13 | 2019-02-01 | 叶才果 | 双功能抗体及其用途 |
| GB201522394D0 (en) * | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| AU2017207906B2 (en) | 2016-01-15 | 2021-03-11 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| MX2018009341A (es) | 2016-02-03 | 2019-05-15 | Oncobiologics Inc | Formulaciones tamponadas para una mayor estabilidad de anticuerpos. |
| US10465003B2 (en) | 2016-02-05 | 2019-11-05 | Janssen Biotech, Inc. | Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes |
| WO2017139065A1 (en) | 2016-02-08 | 2017-08-17 | American Gene Technologies International Inc. | Hiv vaccination and immunotherapy |
| WO2017153702A1 (en) | 2016-03-08 | 2017-09-14 | Mereo Biopharma 1 Limited | Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease |
| AU2016397046B2 (en) * | 2016-03-08 | 2022-05-12 | Mereo Biopharma 1 Limited | Dosage regimen for the treatment of acute exacerbations of inflammatory conditions |
| WO2017156311A2 (en) | 2016-03-09 | 2017-09-14 | American Gene Technologies International Inc. | Combination vectors and methods for treating cancer |
| WO2017213697A1 (en) * | 2016-06-08 | 2017-12-14 | American Gene Technologies International Inc. | Non-integrating viral delivery system and methods related thereto |
| WO2018009246A1 (en) | 2016-07-08 | 2018-01-11 | American Gene Technologies International Inc. | Hiv pre-immunization and immunotherapy |
| EP3487507A4 (en) | 2016-07-21 | 2020-04-08 | American Gene Technologies International, Inc. | VIRAL VECTORS FOR THE TREATMENT OF PARKINSON'S DISEASE |
| WO2018060453A1 (en) | 2016-09-30 | 2018-04-05 | Vhsquared Limited | Compositions |
| EP4467565A3 (en) | 2016-12-21 | 2025-03-12 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| US11820999B2 (en) | 2017-04-03 | 2023-11-21 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| WO2018201130A1 (en) * | 2017-04-28 | 2018-11-01 | The Brigham And Women's Hospital, Inc. | Targeting gamma-delta t cells in obesity and cachexia |
| KR20190024572A (ko) * | 2017-08-30 | 2019-03-08 | (주)셀트리온 | TNFα 관련 질환을 치료하기 위한 피하 투여 요법 |
| DE102017215154A1 (de) | 2017-08-30 | 2019-02-28 | Markus Bläss | Zusammensetzung zur topischen Behandlung von nicht-Mikroorganismus-verursachten entzündlichen Haut- und Schleimhauterkrankungen |
| KR102760007B1 (ko) | 2017-12-11 | 2025-02-03 | 메레오 바이오파마 1 리미티드 | 만성 폐쇄성 폐 질환의 급성 악화의 예방 또는 감소에서의 3-[5-아미노-4-(3-시아노벤조일)-피라졸-1-일]-n-시클로프로필-4-메틸벤즈아미드의 용도 |
| PT3585382T (pt) | 2017-12-11 | 2021-08-19 | Mereo Biopharma 1 Ltd | Utilização de 3-[5-amino-4-(3-cianobenzoil)-pirazol-1-il]-n-ciclopropil-4-metilbenzamida no tratamento de exacerbações agudas da doença pulmonar obstrutiva crónica |
| CN113015746A (zh) * | 2018-09-19 | 2021-06-22 | 拉荷亚免疫研究所 | 在类风湿性关节炎中的ptprs和蛋白聚糖 |
| KR101982667B1 (ko) | 2018-12-24 | 2019-05-27 | 가톨릭대학교 산학협력단 | 신규한 유도체를 유효성분으로 포함하는 tnf-관련 질환 예방 또는 치료용 조성물 및 이를 이용한 tnf 활성 억제 방법 |
| AR118191A1 (es) * | 2019-02-28 | 2021-09-22 | Celltrion Inc | MÉTODOS PARA EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON TNFa |
| EP3947450A4 (en) * | 2019-04-05 | 2023-05-31 | The Regents Of The University Of California | METHODS AND COMPOSITIONS USING CHIMERIC BINDING POLYPEPTIDES |
| JP7680377B2 (ja) | 2019-06-21 | 2025-05-20 | ソリッソ ファーマシューティカルズ,インク. | ポリペプチド |
| CN114466864B (zh) | 2019-06-21 | 2024-12-27 | 索瑞索制药公司 | 多肽 |
| WO2021096199A1 (ko) * | 2019-11-11 | 2021-05-20 | 에스케이케미칼 주식회사 | 피리메타민을 유효성분으로 포함하는 면역 관련 질환의 치료 또는 예방용 약학 조성물 |
| EP4096647A1 (en) | 2020-01-30 | 2022-12-07 | Yeda Research and Development Co. Ltd | Treating acute liver disease with tlr-mik inhibitors |
| WO2022010150A1 (ko) | 2020-07-07 | 2022-01-13 | (주)아이랩 | 신규한 tnf 활성 억제제 화합물 및 이의 약학적으로 허용가능한 염 |
| CN116808068A (zh) * | 2023-06-30 | 2023-09-29 | 漆树学 | 一种治疗炎症性肠病的有效物质及其制备方法 |
Family Cites Families (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2859205A (en) * | 1954-08-06 | 1958-11-04 | Monsanto Chemicals | Process of making styrenated phenolformaldehyde resins |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| CA1208546A (en) | 1981-09-08 | 1986-07-29 | Anthony Cerami | Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay) |
| US4510245A (en) | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
| US5672347A (en) | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| IL73883A (en) | 1984-12-20 | 1990-12-23 | Yeda Res & Dev | Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| DE3650150T2 (de) | 1985-08-16 | 1995-04-27 | The Rockefeller University, New York, N.Y. | Modulator der anabolischen Aktivität und seine Verwendungen. |
| US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
| EP0230574A3 (en) | 1986-01-31 | 1989-03-22 | Yale University | Pharmaceutical compositions against infections caused by lav/htlv iii virus and the use thereof |
| DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
| JP2638652B2 (ja) | 1988-07-18 | 1997-08-06 | カイロン・コーポレーション | カケクチンと反応するモノクロナール抗体 |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE68914244T2 (de) | 1988-10-24 | 1994-10-27 | Otsuka Pharma Co Ltd | Monoklonaler Antikörper. |
| SG43205A1 (en) | 1988-12-19 | 1997-10-17 | American Cyanamid Co | A method for the treatment of endotoxic shock in a mammal |
| JP2989002B2 (ja) | 1988-12-22 | 1999-12-13 | キリン―アムジエン・インコーポレーテツド | 化学修飾顆粒球コロニー刺激因子 |
| CA2003981C (en) | 1988-12-27 | 2000-06-13 | Hiroshi Ishimaru | Pharmaceutical compositions and use thereof in the treatment of psoriasis |
| DE69027121T3 (de) | 1989-08-07 | 2001-08-30 | Peptech Ltd., Dee Why | Bindeligande für tumornekrosisfaktor |
| WO1991003553A1 (en) | 1989-09-05 | 1991-03-21 | Immunex Corporation | TUMOR NECROSIS FACTOR-α AND -β RECEPTORS |
| GB8921123D0 (en) | 1989-09-19 | 1989-11-08 | Millar Ann B | Treatment of ards |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| DE4037604A1 (de) | 1990-04-25 | 1991-10-31 | Bayer Ag | Verwendung von anti-tnf-antikoerpern als arzneimittel bei der behandlung von ischaemien und deren folgen |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| DK0585287T3 (da) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| CA2095633C (en) | 1990-12-03 | 2003-02-04 | Lisa J. Garrard | Enrichment method for variant proteins with altered binding properties |
| US5994510A (en) | 1990-12-21 | 1999-11-30 | Celltech Therapeutics Limited | Recombinant antibodies specific for TNFα |
| GB2279077B (en) | 1990-12-21 | 1995-06-14 | Celltech Ltd | Therapeutic compositions comprising recombinant antibodies specific for the TNFalpha |
| GB9109645D0 (en) | 1991-05-03 | 1991-06-26 | Celltech Ltd | Recombinant antibodies |
| GB9028123D0 (en) | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
| ES2287206T3 (es) | 1991-03-01 | 2007-12-16 | Dyax Corporation | Proceso para el desarrollo de mini-proteinas de union. |
| ATE240740T1 (de) | 1991-03-15 | 2003-06-15 | Amgen Inc | Pegylation von polypeptiden |
| US20060246073A1 (en) | 1991-03-18 | 2006-11-02 | Knight David M | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| US5656272A (en) | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| EP1681305A3 (en) | 1991-03-18 | 2008-02-27 | New York University | Monoclonal and chimeric antibodies specific for human tumor necrosis factor |
| US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| US20070298040A1 (en) | 1991-03-18 | 2007-12-27 | Centocor, Inc. | Methods of treating seronegative arthropathy with anti-TNF antibodies |
| US20040120952A1 (en) | 2000-08-07 | 2004-06-24 | Centocor, Inc | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| ATE171471T1 (de) | 1991-03-29 | 1998-10-15 | Immunex Corp | Isolierte virale proteine als cytokinantagonisten |
| WO1992018619A1 (en) | 1991-04-10 | 1992-10-29 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| EP0605522B1 (en) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methods for the production of humanized antibodies |
| WO1993011793A1 (en) | 1991-12-17 | 1993-06-24 | Schering Corporation | Use of the combination of anti-tumor necrosis factor plus interleukin-6 to treat septic shock |
| WO1993019751A1 (en) | 1992-04-02 | 1993-10-14 | Smithkline Beecham Corporation | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor |
| DE69321909T2 (de) | 1992-08-28 | 1999-04-01 | Bayer Corp., Pittsburgh, Pa. | Verwendung von monoklonalen Anti-TNF-Antikörpern für die Behandlung von bakteriellen Meningitiden |
| NZ256293A (en) | 1992-09-15 | 1997-06-24 | Immunex Corp | Method of treating tumour necrosis factor - mediated inflammation by use of tnf antagonist |
| US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| JPH08509203A (ja) | 1992-10-15 | 1996-10-01 | ダナ−ファーバー キャンサー インステテュート インコーポレイテッド | TNF−α作用の拮抗剤を用いる肥満関連糖尿病▲II▼型のインスリン耐性の治療 |
| ATE204299T1 (de) | 1993-03-05 | 2001-09-15 | Bayer Ag | Humane monoklonale anti-tnf alpha antikörper |
| DE4307508A1 (de) | 1993-03-10 | 1994-09-15 | Knoll Ag | Verwendung von anti-TNF-Antikörpern als Arzneimittel bei der Behandlung von Herzinsuffizienz (Herzmuskelschwäche) |
| CA2163032C (en) | 1993-06-03 | 2001-02-06 | John Landon | Antibody fragments in therapy |
| EP0659766A1 (en) | 1993-11-23 | 1995-06-28 | Schering-Plough | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
| NZ278607A (en) | 1994-02-07 | 1999-05-28 | Knoll Ag | Use of tnf antagonists for treating disorders involving elevated serum levels of il-6 wherein the serum levels are 500pg/ml or above |
| JPH09509835A (ja) | 1994-03-04 | 1997-10-07 | メルク エンド カンパニー インコーポレーテッド | アラニン走査型突然変異誘発によるin vitro抗体アフィニティー成熟 |
| AU2365795A (en) | 1995-04-20 | 1996-11-07 | Centocor Inc. | Multiple administrations of anti-tnf antibody |
| US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| DK0929578T3 (da) | 1996-02-09 | 2003-08-25 | Abbott Lab Bermuda Ltd | Humane antistoffer, der binder human TNFalfa |
| EP0938334A4 (en) | 1996-07-26 | 2004-12-15 | Smithkline Beecham Corp | IMPROVED METHOD FOR TREATING IMMUNE-MEDIATED SYSTEMIC DISEASES |
| ES2200783T3 (es) | 1999-03-31 | 2004-03-16 | Pfizer Products Inc. | Acidos dioxociclopentil hidroxamicos. |
| CA2369145A1 (en) | 1999-06-24 | 2001-01-04 | Pharmacia Corporation | Combination of tumors necrocis factor (tnf) antagonists and cox-2 inhibitors for the treatment of inflammation |
| NZ517150A (en) | 1999-08-27 | 2005-01-28 | Genentech Inc | Dosages for treatment with anti-ErbB2 antibodies |
| TWI245645B (en) | 1999-09-08 | 2005-12-21 | Chugai Pharmaceutical Co Ltd | Protein solution formulations and stabilization methods thereof |
| AU3082401A (en) | 1999-11-24 | 2001-06-04 | Centocor Inc. | Therapy of psoriasis |
| JP4955185B2 (ja) * | 2000-06-29 | 2012-06-20 | アボット・ラボラトリーズ | 二重特異性抗体ならびに作製方法および使用方法 |
| DE10034390C2 (de) | 2000-07-14 | 2003-06-26 | Eads Deutschland Gmbh | Drucksensor und Verfahren zu seiner Herstellung, sowie Verbrennungskraftmaschine mit Drucksensor |
| US20050249735A1 (en) | 2000-08-07 | 2005-11-10 | Centocor, Inc. | Methods of treating ankylosing spondylitis using anti-TNF antibodies and peptides of human tumor necrosis factor |
| UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
| US20060018907A1 (en) | 2000-08-07 | 2006-01-26 | Centocor, Inc. | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| JP4731793B2 (ja) | 2000-12-28 | 2011-07-27 | アルセア テクノロジーズ インコーポレイテッド | 抗体全体またはそのフラグメントの結晶、ならびにこの結晶を作製および使用するための方法 |
| US20030012786A1 (en) | 2001-05-25 | 2003-01-16 | Teoh Leah S. | Use of anti-TNF antibodies as drugs in treating septic disorders of anemic patients |
| CA2385745C (en) | 2001-06-08 | 2015-02-17 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
| US20030161828A1 (en) | 2002-02-19 | 2003-08-28 | Abbott Gmbh & Co. Kg | Use of TNF antagonists as drugs for the treatment of patients with an inflammatory reaction and without suffering from total organ failure |
| US20040009172A1 (en) | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| US20030206898A1 (en) | 2002-04-26 | 2003-11-06 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| NZ555692A (en) | 2002-07-19 | 2009-02-28 | Abbott Biotech Ltd | Treatment of TNF alpha related disorders |
| US20090280065A1 (en) | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| MY150740A (en) | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| US7285256B2 (en) | 2003-04-04 | 2007-10-23 | Newmont Usa Limited | Precious metal recovery using thiocyanate lixiviant |
| TWI439284B (zh) * | 2004-04-09 | 2014-06-01 | Abbvie Biotechnology Ltd | 用於治療TNFα相關失調症之多重可變劑量療法 |
| US20060083741A1 (en) | 2004-10-08 | 2006-04-20 | Hoffman Rebecca S | Treatment of respiratory syncytial virus (RSV) infection |
| JP5757495B2 (ja) | 2005-05-16 | 2015-07-29 | アッヴィ バイオテクノロジー リミテッド | びらん性多発性関節炎の治療のためのtnf阻害剤の使用 |
| US20070041905A1 (en) | 2005-08-19 | 2007-02-22 | Hoffman Rebecca S | Method of treating depression using a TNF-alpha antibody |
| TWI424161B (zh) | 2005-11-01 | 2014-01-21 | Abbvie Biotechnology Ltd | 利用生物標記診斷關節黏連脊椎炎之方法及組合物 |
| WO2007117490A2 (en) | 2006-04-05 | 2007-10-18 | Abbott Biotechnology Ltd. | Antibody purification |
| EP2007426A4 (en) | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | COMPOSITIONS FOR THE TREATMENT OF PSORIASTIC POLYARTHRITIS AND THEIR APPLICATIONS |
| US9605064B2 (en) | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| US9399061B2 (en) | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
| US20090317399A1 (en) | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
| WO2007120626A2 (en) | 2006-04-10 | 2007-10-25 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of ankylosing spondylitis |
| US20080118496A1 (en) | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
| US20080131374A1 (en) | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
| US20080311043A1 (en) | 2006-06-08 | 2008-12-18 | Hoffman Rebecca S | Uses and compositions for treatment of psoriatic arthritis |
| US20100021451A1 (en) | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
| CN103316402A (zh) | 2006-06-30 | 2013-09-25 | 艾伯维生物技术有限公司 | 自动注射装置 |
| CA2842964A1 (en) | 2006-09-13 | 2008-03-20 | Abbvie Inc. | Cell culture improvements |
| US8034906B2 (en) | 2006-10-27 | 2011-10-11 | Abbott Biotechnology Ltd. | Crystalline anti-hTNFalpha antibodies |
| WO2008150491A2 (en) | 2007-05-31 | 2008-12-11 | Abbott Laboratories | BIOMARKERS PREDICTIVE OF THE RESPONSIVENESS TO TNFα INHIBITORS IN AUTOIMMUNE DISORDERS |
| EP2152318A4 (en) | 2007-06-01 | 2011-12-07 | Abbott Biotech Ltd | COMPOSITIONS AND USES FOR THE TREATMENT OF PSORIASIS AND CROHN'S DISEASE |
| EP2171451A4 (en) | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS |
| JP2010533181A (ja) | 2007-07-13 | 2010-10-21 | アボツト・バイオテクノロジー・リミテツド | TNFα阻害剤の肺投与のための方法及び組成物 |
| CA2697163A1 (en) | 2007-08-08 | 2009-02-12 | Abbott Laboratories | Compositions and methods for crystallizing antibodies |
| JP5759722B2 (ja) | 2007-08-28 | 2015-08-05 | アッヴィ バイオテクノロジー リミテッド | アダリムマブの結合蛋白質を含む組成物及び方法 |
| KR20150080038A (ko) | 2007-11-30 | 2015-07-08 | 애브비 바이오테크놀로지 리미티드 | 단백질 제형 및 이의 제조방법 |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| CA2710333A1 (en) | 2008-01-03 | 2009-07-09 | Abbott Biotechnology Ltd. | Predicting long-term efficacy of a compound in the treatment of psoriasis |
| EP2240581B1 (en) | 2008-01-15 | 2016-05-11 | AbbVie Inc. | Improved mammalian expression vectors and uses thereof |
| KR20100120289A (ko) | 2008-01-15 | 2010-11-15 | 애보트 게엠베하 운트 콤파니 카게 | 분말상 단백질 조성물 및 이의 제조 방법 |
| JP2011517672A (ja) | 2008-03-24 | 2011-06-16 | アボツト・バイオテクノロジー・リミテツド | 骨損失を治療するための方法及び組成物 |
| EP2424594A4 (en) | 2009-04-29 | 2014-12-24 | Abbvie Biotechnology Ltd | AUTOMATIC INJECTION DEVICE |
| CA2760185A1 (en) | 2009-05-04 | 2010-11-11 | Abbott Biotechnology Ltd. | Stable high protein concentration formulations of human anti-tnf-alpha antibodies |
| EP2531613A2 (en) | 2010-02-02 | 2012-12-12 | Abbott Biotechnology Ltd. | Methods and compositions for predicting responsiveness to treatment with tnf-alpha inhibitor |
| LT2575884T (lt) | 2010-06-03 | 2018-09-25 | Abbvie Biotechnology Ltd | Panaudojimai ir kompozicijos, skirti pūlingo hidradenito (hs) gydymui |
-
2005
- 2005-04-08 TW TW094111276A patent/TWI439284B/zh active
- 2005-04-08 TW TW103101889A patent/TWI556829B/zh not_active IP Right Cessation
- 2005-04-08 TW TW105115825A patent/TW201705980A/zh unknown
- 2005-04-09 TW TW100135941A patent/TW201206478A/zh unknown
- 2005-04-11 KR KR1020137022221A patent/KR101636446B1/ko not_active Expired - Lifetime
- 2005-04-11 CA CA2847331A patent/CA2847331A1/en not_active Abandoned
- 2005-04-11 PT PT57773178T patent/PT1737491T/pt unknown
- 2005-04-11 CA CA2970891A patent/CA2970891A1/en not_active Abandoned
- 2005-04-11 CN CN2013101166334A patent/CN103251945A/zh active Pending
- 2005-04-11 LT LTEP05777317.8T patent/LT1737491T/lt unknown
- 2005-04-11 NZ NZ591362A patent/NZ591362A/xx not_active IP Right Cessation
- 2005-04-11 KR KR1020177008060A patent/KR20170036138A/ko not_active Withdrawn
- 2005-04-11 HU HUE05777317A patent/HUE031558T2/en unknown
- 2005-04-11 KR KR1020167017366A patent/KR20160079933A/ko not_active Withdrawn
- 2005-04-11 EP EP10196121A patent/EP2335732A3/en not_active Withdrawn
- 2005-04-11 ES ES05777317.8T patent/ES2611286T3/es not_active Expired - Lifetime
- 2005-04-11 NZ NZ579302A patent/NZ579302A/en not_active IP Right Cessation
- 2005-04-11 CN CN201510459644.1A patent/CN105106951A/zh active Pending
- 2005-04-11 NZ NZ549959A patent/NZ549959A/en not_active IP Right Cessation
- 2005-04-11 KR KR1020187023479A patent/KR20180094148A/ko not_active Withdrawn
- 2005-04-11 JP JP2007507540A patent/JP5748317B2/ja not_active Expired - Lifetime
- 2005-04-11 CN CN2012100807929A patent/CN102614512A/zh active Pending
- 2005-04-11 AU AU2005244261A patent/AU2005244261B2/en not_active Expired
- 2005-04-11 KR KR1020177036302A patent/KR20170143008A/ko not_active Withdrawn
- 2005-04-11 CA CA2504868A patent/CA2504868C/en not_active Expired - Lifetime
- 2005-04-11 KR KR1020197009624A patent/KR20190039349A/ko not_active Ceased
- 2005-04-11 MX MXPA06011677A patent/MXPA06011677A/es active IP Right Grant
- 2005-04-11 BR BRPI0509326-0A patent/BRPI0509326A/pt active Search and Examination
- 2005-04-11 KR KR1020067023531A patent/KR101282801B1/ko not_active Expired - Lifetime
- 2005-04-11 KR KR1020127028692A patent/KR101378873B1/ko not_active Ceased
- 2005-04-11 CN CN2013101166565A patent/CN103203019A/zh active Pending
- 2005-04-11 WO PCT/US2005/012007 patent/WO2005110452A2/en not_active Ceased
- 2005-04-11 EP EP10196132A patent/EP2338516A3/en not_active Withdrawn
- 2005-04-11 US US11/104,117 patent/US8889136B2/en active Active
- 2005-04-11 DK DK05777317.8T patent/DK1737491T3/en active
- 2005-04-11 EP EP10196136A patent/EP2335731A3/en not_active Withdrawn
- 2005-04-11 CA CA 2847142 patent/CA2847142C/en not_active Expired - Lifetime
- 2005-04-11 EP EP05777317.8A patent/EP1737491B1/en not_active Expired - Lifetime
- 2005-04-11 CN CN201510461398.3A patent/CN105148273A/zh active Pending
- 2005-04-11 PL PL05777317T patent/PL1737491T3/pl unknown
-
2006
- 2006-09-28 ZA ZA2006/08097A patent/ZA200608097B/en unknown
- 2006-10-03 IL IL178430A patent/IL178430A/en unknown
-
2008
- 2008-01-07 US US12/008,064 patent/US20090304682A1/en not_active Abandoned
-
2011
- 2011-09-15 JP JP2011202171A patent/JP2012046524A/ja not_active Withdrawn
-
2012
- 2012-03-28 US US13/433,205 patent/US9061005B2/en active Active
- 2012-06-05 IL IL220192A patent/IL220192A/en active IP Right Grant
-
2014
- 2014-03-28 US US14/229,709 patent/US20140212430A1/en not_active Abandoned
- 2014-03-28 US US14/229,722 patent/US8961974B2/en not_active Expired - Lifetime
- 2014-03-28 US US14/229,602 patent/US20140248275A1/en not_active Abandoned
- 2014-03-28 US US14/229,664 patent/US8961973B2/en not_active Expired - Lifetime
- 2014-03-28 US US14/229,703 patent/US20140248276A1/en not_active Abandoned
- 2014-08-14 JP JP2014165187A patent/JP6145434B2/ja not_active Expired - Lifetime
-
2015
- 2015-02-20 US US14/628,068 patent/US9187559B2/en not_active Expired - Lifetime
- 2015-06-19 US US14/745,092 patent/US20170044249A1/en not_active Abandoned
- 2015-07-20 US US14/804,164 patent/US9499615B2/en not_active Expired - Lifetime
- 2015-08-20 IL IL240740A patent/IL240740A0/en unknown
-
2016
- 2016-01-21 JP JP2016009605A patent/JP2016155801A/ja active Pending
- 2016-10-07 US US15/288,750 patent/US20170022271A1/en not_active Abandoned
- 2016-12-28 CY CY20161101350T patent/CY1118564T1/el unknown
-
2017
- 2017-05-22 JP JP2017100968A patent/JP2017197547A/ja active Pending
-
2018
- 2018-03-08 US US15/915,615 patent/US20190055308A1/en not_active Abandoned
-
2019
- 2019-02-25 US US16/284,798 patent/US20200017580A1/en not_active Abandoned
-
2020
- 2020-12-17 US US17/124,991 patent/US20210347874A1/en not_active Abandoned
- 2020-12-17 US US17/125,275 patent/US20210347875A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ591362A (en) | Multiple-variable dose regimen for treating tnfa-related disorders | |
| El‐Mofty et al. | Different low doses of broad‐band UVA in the treatment of morphea and systemic sclerosis: a clinico‐pathologic study | |
| WO2009086072A3 (en) | Therapy of rituximab-refractory rheumatoid arthritis patients | |
| BRPI0407485A (pt) | utilização de anticorpos anti-receptores de factor crescimento i semelhantes aos anti-insulina | |
| SG170058A1 (en) | Methods of treating inflammatory and autoimmune diseases with natalizumab | |
| TNSN07191A1 (en) | Antiangiogenesis therapy of autoimmune disease in patients who have failed prior therapy | |
| UA94899C2 (ru) | Фиксированное дозирование антител к her | |
| NZ596878A (en) | Methods of administering anti-tnfalpha antibodies | |
| HK1202776A1 (en) | Use of laquinimod for treating crohn's disease patients who failed first-line anti-tnf therapy | |
| NZ578065A (en) | Methods for treating psoriasis with an antibody which binds to an epitope | |
| MXPA04004355A (es) | Tratamiento de combinacion que comprende zd6474 y un taxano. | |
| WO2003092617A3 (en) | Combinations for the treatment of inflammatory skin disorders | |
| WO2020186132A8 (en) | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack | |
| WO2005020903A3 (en) | Methods of improving the safety of zonisamide therapy | |
| TW200630089A (en) | Treatment methods | |
| WO2003057162A3 (en) | Combination for the treatment of immunoinflammatory disorders and proliferative skin diseases | |
| Lee et al. | Effects of Bee Venom on the pain, edema, and acute inflammatory reactant of Rheumatoid Arthritis patients | |
| DE602004024221D1 (de) | Behandlung von entzündlichen darmerkrankungen mit 2-methylen-19-nor-vitamin d verbindungen | |
| ATE447426T1 (de) | Elektromagnetische stimulation bei patienten mit osteoporose | |
| DK1675611T3 (da) | Terapeutiske anvendelser for C-peptid | |
| TW200724158A (en) | Combination therapy in the treatment of cancer | |
| AU2020360413A8 (en) | Methods of treating conditions related to the S1P1 receptor | |
| WO2004053064A3 (en) | Engineered fab'fragment anti-tumor necrosis factor alpha in combination with disease modifying anti-rheumatic drugs | |
| WO2007002571A3 (en) | Use of an anti c5 complement antibody to treat patients with sickle cell disease | |
| MD2491G2 (ro) | Utilizarea bromurii de S-etilizotiouroniu (izoturonului) pentru tratamentul algodismenoreii |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 6 YEARS UNTIL 11 APR 2015 BY AJ PARK Effective date: 20130513 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 APR 2016 BY THOMSON REUTERS Effective date: 20150319 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 APR 2017 BY THOMSON REUTERS Effective date: 20160317 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 APR 2018 BY THOMSON REUTERS Effective date: 20170322 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 APR 2019 BY THOMSON REUTERS Effective date: 20180321 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 APR 2020 BY THOMSON REUTERS Effective date: 20190319 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 APR 2021 BY THOMSON REUTERS Effective date: 20200317 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 APR 2022 BY THOMSON REUTERS Effective date: 20210310 |
|
| ERR | Error or correction |
Free format text: THE INVENTOR HAS BEEN CORRECTED TO 1100242, HOFFMAN, REBECA S; 1100243, CHARTASH, ELLIOT; 1100244, TAYLOR, LORI K; 1100246, YAN, PHILIP; 1372501, GRANNEMAN, GEORGE RICHARD; 3780341, ALBERT ASSAD, 401 JUSTISON STREET, APT. 515, WILMINGTON, DE 19801, US Effective date: 20210617 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 APR 2023 BY THOMSON REUTERS Effective date: 20220308 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 APR 2024 BY THOMSON REUTERS Effective date: 20230307 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 11 APR 2025 BY THOMSON REUTERS Effective date: 20240305 |
|
| EXPY | Patent expired |