WO2007002571A3 - Use of an anti c5 complement antibody to treat patients with sickle cell disease - Google Patents

Use of an anti c5 complement antibody to treat patients with sickle cell disease Download PDF

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Publication number
WO2007002571A3
WO2007002571A3 PCT/US2006/024770 US2006024770W WO2007002571A3 WO 2007002571 A3 WO2007002571 A3 WO 2007002571A3 US 2006024770 W US2006024770 W US 2006024770W WO 2007002571 A3 WO2007002571 A3 WO 2007002571A3
Authority
WO
WIPO (PCT)
Prior art keywords
sickle cell
cell disease
treat patients
complement antibody
antibody
Prior art date
Application number
PCT/US2006/024770
Other languages
French (fr)
Other versions
WO2007002571A2 (en
Inventor
Russell Rother
Original Assignee
Alexion Pharma Inc
Russell Rother
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexion Pharma Inc, Russell Rother filed Critical Alexion Pharma Inc
Publication of WO2007002571A2 publication Critical patent/WO2007002571A2/en
Publication of WO2007002571A3 publication Critical patent/WO2007002571A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method of treating a sickle cell patient with an anti C5 complement antibody is disclosed. Treatment with said antibody decreases the extent of red blood cell lysis and decreases the consequential clinical sequelae.
PCT/US2006/024770 2005-06-23 2006-06-23 Use of an anti c5 complement antibody to treat patients with sickle cell disease WO2007002571A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69347305P 2005-06-23 2005-06-23
US60/693,473 2005-06-23

Publications (2)

Publication Number Publication Date
WO2007002571A2 WO2007002571A2 (en) 2007-01-04
WO2007002571A3 true WO2007002571A3 (en) 2007-05-03

Family

ID=37595940

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/024770 WO2007002571A2 (en) 2005-06-23 2006-06-23 Use of an anti c5 complement antibody to treat patients with sickle cell disease

Country Status (1)

Country Link
WO (1) WO2007002571A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2359834T5 (en) 2006-03-15 2017-02-06 Alexion Pharma Inc Treatment of paroxysmal nocturnal hemoglobinuria patients with a complement inhibitor
PT2894165T (en) * 2008-11-10 2023-03-17 Alexion Pharma Inc Methods and compositions for treating complement-associated disorders
IT201600121482A1 (en) * 2016-11-30 2018-05-30 Univ Degli Studi Di Verona Factor H for use in the treatment and / or prevention of the formation of heterotrombi in patients with sickle cell disease
WO2023023220A1 (en) * 2021-08-20 2023-02-23 Alexion Pharmaceuticals, Inc. Methods for treating sickle cell disease or beta thalassemia using a complement alternative pathway inhibitor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HILLMEN P ET AL: "EFFECT OF ECULIZUMAB ON HEMOLYSIS AND TRANSFUSION REQUIREMENTS IN PATIENTS WITH PAROXYSMAL NOCTRURNAL HEMAGLOBINURIA", NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, BOSTON, MA, US, vol. 350, no. 6, 5 February 2004 (2004-02-05), pages 552 - 559, XP009057948, ISSN: 1533-4406 *
MOLD CAROLYN ET AL: "Complement activation during painful crisis in sickle cell anemia", CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 76, no. 3 PART 1, 1995, pages 314 - 320, XP008073565, ISSN: 0090-1229 *
TEST SAMUEL T ET AL: "Defective regulation of complement by the sickle erythrocyte: Evidence for a defect in control of membrane attack complex formation", BLOOD, vol. 83, no. 3, 1994, pages 842 - 852, XP008073566, ISSN: 0006-4971 *
YAZDANBAKHSH KARINA: "Controlling the complement system for prevention of red cell destruction.", CURRENT OPINION IN HEMATOLOGY. MAR 2005, vol. 12, no. 2, March 2005 (2005-03-01), pages 117 - 122, XP008073571, ISSN: 1065-6251 *
YAZDANBAKHSH KARINA: "Development of complement therapeutics for inhibition of immune-mediated red cell destruction", TRANSFUSION (MALDEN), vol. 45, no. 2, Suppl. S, August 2005 (2005-08-01), pages 122S - 129S, XP008073567, ISSN: 0041-1132 *

Also Published As

Publication number Publication date
WO2007002571A2 (en) 2007-01-04

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