CN103251945A - 用于治疗TNFα-相关病症的多变剂量方案 - Google Patents

用于治疗TNFα-相关病症的多变剂量方案 Download PDF

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Publication number
CN103251945A
CN103251945A CN2013101166334A CN201310116633A CN103251945A CN 103251945 A CN103251945 A CN 103251945A CN 2013101166334 A CN2013101166334 A CN 2013101166334A CN 201310116633 A CN201310116633 A CN 201310116633A CN 103251945 A CN103251945 A CN 103251945A
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China
Prior art keywords
tnf alpha
disease
antibody
dose
described method
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Pending
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CN2013101166334A
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English (en)
Chinese (zh)
Inventor
R·S·霍夫曼
E·查特斯
L·K·泰勒
G·R·格兰尼曼
P·严
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AbbVie Biotechnology Ltd
Abbott Laboratories
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Abbott Laboratories
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35006312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN103251945(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CN103251945A publication Critical patent/CN103251945A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2013101166334A 2004-04-09 2005-04-11 用于治疗TNFα-相关病症的多变剂量方案 Pending CN103251945A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US56113904P 2004-04-09 2004-04-09
US60/561,139 2004-04-09
US56171004P 2004-04-12 2004-04-12
US60/561,710 2004-04-12
US56910004P 2004-05-07 2004-05-07
US60/569,100 2004-05-07

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN 200580019165 Division CN1988918A (zh) 2004-04-09 2005-04-11 用于治疗TNFα－相关病症的多变剂量方案

Publications (1)

Publication Number Publication Date
CN103251945A true CN103251945A (zh) 2013-08-21

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ID=35006312

Family Applications (5)

Application Number Title Priority Date Filing Date
CN2013101166334A Pending CN103251945A (zh) 2004-04-09 2005-04-11 用于治疗TNFα-相关病症的多变剂量方案
CN201510459644.1A Pending CN105106951A (zh) 2004-04-09 2005-04-11 用于治疗TNFα-相关病症的多变剂量方案
CN2012100807929A Pending CN102614512A (zh) 2004-04-09 2005-04-11 用于治疗TNFα-相关病症的多变剂量方案
CN2013101166565A Pending CN103203019A (zh) 2004-04-09 2005-04-11 用于治疗TNFα-相关病症的多变剂量方案
CN201510461398.3A Pending CN105148273A (zh) 2004-04-09 2005-04-11 用于治疗TNFα-相关病症的多变剂量方案

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN201510459644.1A Pending CN105106951A (zh) 2004-04-09 2005-04-11 用于治疗TNFα-相关病症的多变剂量方案
CN2012100807929A Pending CN102614512A (zh) 2004-04-09 2005-04-11 用于治疗TNFα-相关病症的多变剂量方案
CN2013101166565A Pending CN103203019A (zh) 2004-04-09 2005-04-11 用于治疗TNFα-相关病症的多变剂量方案
CN201510461398.3A Pending CN105148273A (zh) 2004-04-09 2005-04-11 用于治疗TNFα-相关病症的多变剂量方案

Country Status (21)

Country Link
US (16) US8889136B2 (enExample)
EP (4) EP2335732A3 (enExample)
JP (5) JP5748317B2 (enExample)
KR (8) KR101636446B1 (enExample)
CN (5) CN103251945A (enExample)
AU (1) AU2005244261B2 (enExample)
BR (1) BRPI0509326A (enExample)
CA (4) CA2847331A1 (enExample)
CY (1) CY1118564T1 (enExample)
DK (1) DK1737491T3 (enExample)
ES (1) ES2611286T3 (enExample)
HU (1) HUE031558T2 (enExample)
IL (3) IL178430A (enExample)
LT (1) LT1737491T (enExample)
MX (1) MXPA06011677A (enExample)
NZ (3) NZ591362A (enExample)
PL (1) PL1737491T3 (enExample)
PT (1) PT1737491T (enExample)
TW (4) TWI439284B (enExample)
WO (1) WO2005110452A2 (enExample)
ZA (1) ZA200608097B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109400709A (zh) * 2015-11-13 2019-03-01 广东医科大学 双功能抗体及其用途

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CN109400709A (zh) * 2015-11-13 2019-03-01 广东医科大学 双功能抗体及其用途
CN109400709B (zh) * 2015-11-13 2021-03-23 广东医科大学 双功能抗体及其用途

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