NZ575511A - Processes for the preparation of 1,2,4-oxadiazole benzoic acids - Google Patents

Processes for the preparation of 1,2,4-oxadiazole benzoic acids

Info

Publication number
NZ575511A
NZ575511A NZ575511A NZ57551107A NZ575511A NZ 575511 A NZ575511 A NZ 575511A NZ 575511 A NZ575511 A NZ 575511A NZ 57551107 A NZ57551107 A NZ 57551107A NZ 575511 A NZ575511 A NZ 575511A
Authority
NZ
New Zealand
Prior art keywords
substituted
batch
steps
hours
butanol
Prior art date
Application number
NZ575511A
Other languages
English (en)
Inventor
Neil G Almstead
Peter Seongwoo Hwang
Seemon Pines
Young-Choon Moon
James J Takasugi
Original Assignee
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Priority to NZ598012A priority Critical patent/NZ598012A/xx
Publication of NZ575511A publication Critical patent/NZ575511A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ575511A 2006-09-08 2007-09-06 Processes for the preparation of 1,2,4-oxadiazole benzoic acids NZ575511A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ598012A NZ598012A (en) 2006-09-08 2007-09-06 Processes for the preparation of 1,2,4-oxadiazole benzoic acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84359506P 2006-09-08 2006-09-08
PCT/US2007/019561 WO2008030570A1 (en) 2006-09-08 2007-09-06 Processes for the preparation of 1,2,4-oxadiazole benzoic acids

Publications (1)

Publication Number Publication Date
NZ575511A true NZ575511A (en) 2012-02-24

Family

ID=38935880

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ575511A NZ575511A (en) 2006-09-08 2007-09-06 Processes for the preparation of 1,2,4-oxadiazole benzoic acids
NZ598012A NZ598012A (en) 2006-09-08 2007-09-06 Processes for the preparation of 1,2,4-oxadiazole benzoic acids

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ598012A NZ598012A (en) 2006-09-08 2007-09-06 Processes for the preparation of 1,2,4-oxadiazole benzoic acids

Country Status (24)

Country Link
US (2) US7678922B2 (https=)
EP (1) EP2059513B1 (https=)
JP (2) JP5955494B2 (https=)
KR (1) KR101466368B1 (https=)
CN (1) CN101535284B (https=)
AR (3) AR062715A1 (https=)
AU (1) AU2007292915B2 (https=)
BR (1) BRPI0716996B8 (https=)
CA (2) CA2662749C (https=)
CL (1) CL2007002606A1 (https=)
DK (1) DK2059513T3 (https=)
ES (1) ES2404348T3 (https=)
IL (1) IL197445A (https=)
MX (1) MX2009002439A (https=)
MY (1) MY148598A (https=)
NZ (2) NZ575511A (https=)
PE (2) PE20120669A1 (https=)
PL (1) PL2059513T3 (https=)
PT (1) PT2059513E (https=)
RU (1) RU2495030C2 (https=)
TW (1) TWI482761B (https=)
UA (1) UA99265C2 (https=)
WO (1) WO2008030570A1 (https=)
ZA (1) ZA200901782B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4101846B1 (en) 2003-04-11 2023-08-02 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
PL2402002T3 (pl) 2005-04-08 2018-11-30 Ptc Therapeutics, Inc. Kompozycje zawierające kwas 1,2,4-oksadiazolobenzoesowy i ich zastosowania do leczenia chorób związanych z przedwczesnym kodonem stop
EP2387995A1 (en) 2006-03-30 2011-11-23 PTC Therapeutics, Inc. Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith
UA99265C2 (ru) * 2006-09-08 2012-08-10 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способ получения 1,2,4-оксадиазолбензойной кислоты и ее производных (варианты)
US8101641B2 (en) 2006-09-25 2012-01-24 Ptc Therapeutics, Inc. Hydroxylated 1,2,4-oxadiazole benzoic acid compounds and compositions thereof
NZ575795A (en) * 2006-09-25 2012-03-30 Ptc Therapeutics Inc Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid
MX2009003909A (es) 2006-10-12 2009-05-25 Ptc Therapeutics Inc Métodos para dosificar un compuesto 1,2,4, - oxadiazol oralmente activo para el tratamiento de supresión de la mutación finalizadora.
CN101714009A (zh) * 2009-05-14 2010-05-26 翁印嵩 集成通用电话功能的计算机
ES2610362T3 (es) 2011-01-25 2017-04-27 Viviabiotech, S.L. Derivados de 1,2,4-oxadiazol como fármacos moduladores del receptor para el péptido glp-1
EP2867230B1 (en) 2012-07-02 2020-02-12 Monsanto Technology LLC Process for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles
TWI695717B (zh) 2014-03-06 2020-06-11 美商 Ptc 治療公司 １,２,４-二唑苯甲酸之鹽及醫藥組合物
CN105461650B (zh) * 2014-09-12 2018-04-13 杭州普晒医药科技有限公司 一种噁二唑化合物的溶剂化物及其制备方法
CN106316885B (zh) * 2015-07-03 2019-02-12 普济生物科技（台州）有限公司 一种3-[5-(2-氟苯基)-1,2,4-噁二唑-3-基]苯甲酸的制备方法
CN108348527A (zh) 2015-10-30 2018-07-31 Ptc医疗公司 用于治疗癫痫的方法
TW201808922A (zh) 2016-06-20 2018-03-16 台灣神隆股份有限公司 製備阿塔魯仁及其中間體的方法
WO2020128816A2 (en) 2018-12-20 2020-06-25 Pfizer Inc. Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent
EP4473971A3 (en) 2019-04-10 2025-02-19 PTC Therapeutics, Inc. Method for treating nonsense mutation mediated duchenne muscular dystrophy in pediatric patients
WO2022112919A1 (en) 2020-11-25 2022-06-02 Pfizer Inc. (aza)benzothiazolyl substituted pyrazole compounds
CN113045510B (zh) * 2021-03-31 2022-05-27 北京大学生命科学华东产业研究院 一种阿塔鲁伦的制备方法
CN114920667B (zh) * 2022-06-30 2024-06-21 湖南大学 一种阿塔鲁伦酯的电化学制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2801509A1 (de) * 1978-01-12 1979-07-19 Schering Ag 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel
DE3905242A1 (de) * 1989-02-21 1990-08-23 Basf Ag Verfahren zur herstellung von phenyloxdiazolylanilinen
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
DE4425794A1 (de) * 1994-07-21 1996-01-25 Basf Ag Nitrofarbstoffe
US6660753B2 (en) 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
KR20040004705A (ko) 2001-06-08 2004-01-13 시토비아 인크. 카스파제의 활성제 및 아폽토시스의 유도제로서의 치환된3-아릴-5-아릴-[1,2,4]-옥사디아졸과 유사체 및 이의 용도
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
MXPA05001592A (es) 2002-08-09 2005-05-05 Astrazeneca Ab Oxadiazoles como moduladores de receptor-5 de glutamato metabotropico.
GB0303503D0 (en) 2003-02-14 2003-03-19 Novartis Ag Organic compounds
EP4101846B1 (en) 2003-04-11 2023-08-02 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
US20050075375A1 (en) 2003-05-14 2005-04-07 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis C virus
PL2402002T3 (pl) * 2005-04-08 2018-11-30 Ptc Therapeutics, Inc. Kompozycje zawierające kwas 1,2,4-oksadiazolobenzoesowy i ich zastosowania do leczenia chorób związanych z przedwczesnym kodonem stop
UA99265C2 (ru) * 2006-09-08 2012-08-10 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способ получения 1,2,4-оксадиазолбензойной кислоты и ее производных (варианты)

Also Published As

Publication number Publication date
AU2007292915B2 (en) 2012-07-26
AR107474A2 (es) 2018-05-02
BRPI0716996B1 (pt) 2021-02-09
PL2059513T3 (pl) 2013-06-28
RU2495030C2 (ru) 2013-10-10
CN101535284B (zh) 2014-12-10
BRPI0716996A2 (pt) 2013-10-08
US20080139818A1 (en) 2008-06-12
AU2007292915A1 (en) 2008-03-13
TW200823180A (en) 2008-06-01
KR20090054464A (ko) 2009-05-29
US20100063297A1 (en) 2010-03-11
IL197445A (en) 2014-01-30
MY148598A (en) 2013-05-15
CA2662749A1 (en) 2008-03-13
KR101466368B1 (ko) 2014-11-27
RU2009113019A (ru) 2010-10-20
MX2009002439A (es) 2009-03-27
EP2059513B1 (en) 2013-01-23
WO2008030570A1 (en) 2008-03-13
JP5955494B2 (ja) 2016-07-20
CA2662749C (en) 2015-01-20
CL2007002606A1 (es) 2008-04-18
PT2059513E (pt) 2013-04-30
ZA200901782B (en) 2010-06-30
EP2059513A1 (en) 2009-05-20
CN101535284A (zh) 2009-09-16
PE20080771A1 (es) 2008-06-13
CA2842625A1 (en) 2008-03-13
AR118922A2 (es) 2021-11-10
JP2010502715A (ja) 2010-01-28
UA99265C2 (ru) 2012-08-10
ES2404348T3 (es) 2013-05-27
US8367841B2 (en) 2013-02-05
BRPI0716996B8 (pt) 2021-05-25
AR062715A1 (es) 2008-11-26
IL197445A0 (en) 2009-12-24
DK2059513T3 (da) 2013-05-06
NZ598012A (en) 2013-08-30
US7678922B2 (en) 2010-03-16
TWI482761B (zh) 2015-05-01
PE20120669A1 (es) 2012-06-01
HK1134094A1 (en) 2010-04-16
CA2842625C (en) 2016-07-12
JP2014193896A (ja) 2014-10-09

Similar Documents

Publication Publication Date Title
CA2662749C (en) Processes for the preparation of 1,2,4-oxadiazole benzoic acids
US9630955B2 (en) Chemical compound useful as intermediate for preparing a catechol-O-methyltransferase inhibitor
CA2716320C (en) Selective androgen receptor modulators
AU2005247110A1 (en) Crth2 receptor ligands for medicinal uses
TW201124411A (en) The manufacturing method of 6-substituted-1-methy-1H-benzimidazol derivatives and the synthesis intermediates thereof
TW202530224A (zh) 製造巴洛沙韋瑪波西酯之方法
HK1134094B (en) Processes for the preparation of 1,2,4-oxadiazole benzoic acids
JP2024503423A (ja) 脂質を生産するための方法
WO2016020403A1 (en) Preparation of a benzoic acid derivative and its use for the preparation of suvorexant
CN1980664A (zh) 用于医学用途的crth2受体配体
WO2013061105A2 (en) Glycogen phosphorylase inhibitors

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 06 SEP 2017 BY CPA GLOBAL

Effective date: 20140725

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 SEP 2018 BY JAMES + WELLS

Effective date: 20170823

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 SEP 2019 BY JAMES + WELLS

Effective date: 20180820

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 SEP 2020 BY JAMES + WELLS

Effective date: 20190903

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 SEP 2021 BY IPAN GMBH

Effective date: 20200820

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 SEP 2022 BY ANAQUA SERVICES

Effective date: 20210819

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 SEP 2023 BY ANAQUA SERVICES

Effective date: 20220819

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 SEP 2024 BY ANAQUA SERVICES

Effective date: 20230823

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 SEP 2025 BY ANAQUA SERVICES

Effective date: 20240820

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 06 SEP 2026 BY ANAQUA SERVICES

Effective date: 20250820