AU2007292915B2 - Processes for the preparation of 1,2,4-oxadiazole benzoic acids - Google Patents

Processes for the preparation of 1,2,4-oxadiazole benzoic acids Download PDF

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Publication number
AU2007292915B2
AU2007292915B2 AU2007292915A AU2007292915A AU2007292915B2 AU 2007292915 B2 AU2007292915 B2 AU 2007292915B2 AU 2007292915 A AU2007292915 A AU 2007292915A AU 2007292915 A AU2007292915 A AU 2007292915A AU 2007292915 B2 AU2007292915 B2 AU 2007292915B2
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AU
Australia
Prior art keywords
substituted
steps
butanol
tert
carried out
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AU2007292915A
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English (en)
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AU2007292915A1 (en
Inventor
Neil G. Almstead
Peter Seongwoo Hwang
Young-Choon Moon
Seemon Pines
James J. Takasugi
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PTC Therapeutics Inc
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PTC Therapeutics Inc
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Publication of AU2007292915A1 publication Critical patent/AU2007292915A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2007292915A 2006-09-08 2007-09-06 Processes for the preparation of 1,2,4-oxadiazole benzoic acids Active AU2007292915B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84359506P 2006-09-08 2006-09-08
US60/843,595 2006-09-08
PCT/US2007/019561 WO2008030570A1 (en) 2006-09-08 2007-09-06 Processes for the preparation of 1,2,4-oxadiazole benzoic acids

Publications (2)

Publication Number Publication Date
AU2007292915A1 AU2007292915A1 (en) 2008-03-13
AU2007292915B2 true AU2007292915B2 (en) 2012-07-26

Family

ID=38935880

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007292915A Active AU2007292915B2 (en) 2006-09-08 2007-09-06 Processes for the preparation of 1,2,4-oxadiazole benzoic acids

Country Status (24)

Country Link
US (2) US7678922B2 (https=)
EP (1) EP2059513B1 (https=)
JP (2) JP5955494B2 (https=)
KR (1) KR101466368B1 (https=)
CN (1) CN101535284B (https=)
AR (3) AR062715A1 (https=)
AU (1) AU2007292915B2 (https=)
BR (1) BRPI0716996B8 (https=)
CA (2) CA2842625C (https=)
CL (1) CL2007002606A1 (https=)
DK (1) DK2059513T3 (https=)
ES (1) ES2404348T3 (https=)
IL (1) IL197445A (https=)
MX (1) MX2009002439A (https=)
MY (1) MY148598A (https=)
NZ (2) NZ598012A (https=)
PE (2) PE20080771A1 (https=)
PL (1) PL2059513T3 (https=)
PT (1) PT2059513E (https=)
RU (1) RU2495030C2 (https=)
TW (1) TWI482761B (https=)
UA (1) UA99265C2 (https=)
WO (1) WO2008030570A1 (https=)
ZA (1) ZA200901782B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE047569T2 (hu) 2003-04-11 2020-04-28 Ptc Therapeutics Inc 1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása
PT2402002T (pt) 2005-04-08 2018-10-08 Ptc Therapeutics Inc Composições de 1,2,4-oxadiazole oralmente activo para terapia de supressão de mutações nonsense
RU2462246C2 (ru) 2006-03-30 2012-09-27 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы получения функционального белка из днк, имеющей нонсенс-мутацию, и лечения нарушений, ассоциированных с ней
MX2009002439A (es) * 2006-09-08 2009-03-27 Ptc Therapeutics Inc Procesos para la preparacion de acidos 1,2,4-oxadiazolbenzoicos.
PL2076501T3 (pl) * 2006-09-25 2016-06-30 Ptc Therapeutics Inc Postacie krystaliczne kwasu 3-[5-(2-fluorofenylo)[1,2,4]oksadiazol-3-ilo]-benzoesowego
US8101641B2 (en) 2006-09-25 2012-01-24 Ptc Therapeutics, Inc. Hydroxylated 1,2,4-oxadiazole benzoic acid compounds and compositions thereof
RS54025B1 (sr) 2006-10-12 2015-10-30 Ptc Therapeutics Inc. Postupci doziranja oralno aktivnog 1,2,4-oksadiazola za supresionu terapiju nonsens mutacije
CN101714009A (zh) * 2009-05-14 2010-05-26 翁印嵩 集成通用电话功能的计算机
EP2668951B9 (en) 2011-01-25 2017-03-15 Viviabiotech, S.L. 1,2,4-oxadiazole derivatives as drugs modulating the glp-1 peptide receptor
EP2867230B1 (en) 2012-07-02 2020-02-12 Monsanto Technology LLC Process for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles
KR102497273B1 (ko) 2014-03-06 2023-02-07 피티씨 테라퓨틱스, 인크. 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염
CN105461650B (zh) * 2014-09-12 2018-04-13 杭州普晒医药科技有限公司 一种噁二唑化合物的溶剂化物及其制备方法
CN106316885B (zh) * 2015-07-03 2019-02-12 普济生物科技（台州）有限公司 一种3-[5-(2-氟苯基)-1,2,4-噁二唑-3-基]苯甲酸的制备方法
JP2018531975A (ja) 2015-10-30 2018-11-01 ピーティーシー セラピューティクス，インコーポレーテッド てんかんの治療方法
TW201808922A (zh) 2016-06-20 2018-03-16 台灣神隆股份有限公司 製備阿塔魯仁及其中間體的方法
WO2020128816A2 (en) 2018-12-20 2020-06-25 Pfizer Inc. Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent
EP3952867A4 (en) 2019-04-10 2023-01-11 PTC Therapeutics, Inc. METHODS OF TREATMENT OF NONSENSE MUTATION MEDIATED DUCHENNE MUSCULAR DYSTROPHY IN PEDIATRIC PATIENTS
WO2022112919A1 (en) 2020-11-25 2022-06-02 Pfizer Inc. (aza)benzothiazolyl substituted pyrazole compounds
CN113045510B (zh) * 2021-03-31 2022-05-27 北京大学生命科学华东产业研究院 一种阿塔鲁伦的制备方法
CN114920667B (zh) * 2022-06-30 2024-06-21 湖南大学 一种阿塔鲁伦酯的电化学制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6992096B2 (en) * 2003-04-11 2006-01-31 Ptc Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease

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Publication number Priority date Publication date Assignee Title
DE2801509A1 (de) * 1978-01-12 1979-07-19 Schering Ag 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel
DE3905242A1 (de) * 1989-02-21 1990-08-23 Basf Ag Verfahren zur herstellung von phenyloxdiazolylanilinen
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
DE4425794A1 (de) * 1994-07-21 1996-01-25 Basf Ag Nitrofarbstoffe
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
JP2005504014A (ja) * 2001-06-08 2005-02-10 サイトビア インコーポレイテッド カスパーゼの活性化因子およびアポトーシスの誘導因子としての置換された３−アリール−５−アリール−［１，２，４］−オキサジアゾール類および類似体、並びにその使用法
MY151199A (en) * 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
TW200424183A (en) * 2002-08-09 2004-11-16 Nps Pharma Inc New compounds
GB0303503D0 (en) 2003-02-14 2003-03-19 Novartis Ag Organic compounds
WO2004110351A2 (en) * 2003-05-14 2004-12-23 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis c virus
PT2402002T (pt) 2005-04-08 2018-10-08 Ptc Therapeutics Inc Composições de 1,2,4-oxadiazole oralmente activo para terapia de supressão de mutações nonsense
MX2009002439A (es) * 2006-09-08 2009-03-27 Ptc Therapeutics Inc Procesos para la preparacion de acidos 1,2,4-oxadiazolbenzoicos.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6992096B2 (en) * 2003-04-11 2006-01-31 Ptc Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease

Also Published As

Publication number Publication date
JP5955494B2 (ja) 2016-07-20
ZA200901782B (en) 2010-06-30
WO2008030570A1 (en) 2008-03-13
US7678922B2 (en) 2010-03-16
AR107474A2 (es) 2018-05-02
BRPI0716996B1 (pt) 2021-02-09
PE20080771A1 (es) 2008-06-13
JP2010502715A (ja) 2010-01-28
US20100063297A1 (en) 2010-03-11
PT2059513E (pt) 2013-04-30
US8367841B2 (en) 2013-02-05
US20080139818A1 (en) 2008-06-12
UA99265C2 (ru) 2012-08-10
CN101535284B (zh) 2014-12-10
RU2495030C2 (ru) 2013-10-10
JP2014193896A (ja) 2014-10-09
PE20120669A1 (es) 2012-06-01
PL2059513T3 (pl) 2013-06-28
CA2662749A1 (en) 2008-03-13
KR101466368B1 (ko) 2014-11-27
BRPI0716996B8 (pt) 2021-05-25
MX2009002439A (es) 2009-03-27
HK1134094A1 (en) 2010-04-16
CA2842625A1 (en) 2008-03-13
CA2842625C (en) 2016-07-12
AR062715A1 (es) 2008-11-26
IL197445A0 (en) 2009-12-24
AU2007292915A1 (en) 2008-03-13
CN101535284A (zh) 2009-09-16
CL2007002606A1 (es) 2008-04-18
ES2404348T3 (es) 2013-05-27
EP2059513B1 (en) 2013-01-23
NZ575511A (en) 2012-02-24
AR118922A2 (es) 2021-11-10
TW200823180A (en) 2008-06-01
EP2059513A1 (en) 2009-05-20
IL197445A (en) 2014-01-30
CA2662749C (en) 2015-01-20
RU2009113019A (ru) 2010-10-20
MY148598A (en) 2013-05-15
TWI482761B (zh) 2015-05-01
NZ598012A (en) 2013-08-30
KR20090054464A (ko) 2009-05-29
BRPI0716996A2 (pt) 2013-10-08
DK2059513T3 (da) 2013-05-06

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