CL2007002606A1 - Proceso para preparar acido de 1,2,4-oxadiazol benzoico o una sal farmaceuticamente aceptable de este que comprende hacer reaccionar un metil ester de acido cianobenzoico con hidroxilamina, acilar con cloruro de halobenzoilo, condensar e hidrolizar e - Google Patents

Proceso para preparar acido de 1,2,4-oxadiazol benzoico o una sal farmaceuticamente aceptable de este que comprende hacer reaccionar un metil ester de acido cianobenzoico con hidroxilamina, acilar con cloruro de halobenzoilo, condensar e hidrolizar e

Info

Publication number
CL2007002606A1
CL2007002606A1 CL200702606A CL2007002606A CL2007002606A1 CL 2007002606 A1 CL2007002606 A1 CL 2007002606A1 CL 200702606 A CL200702606 A CL 200702606A CL 2007002606 A CL2007002606 A CL 2007002606A CL 2007002606 A1 CL2007002606 A1 CL 2007002606A1
Authority
CL
Chile
Prior art keywords
acid
halobenzarilar
echrolid
earrollaroar
cianobenzoic
Prior art date
Application number
CL200702606A
Other languages
English (en)
Spanish (es)
Inventor
G Almstead Peter Seongwoo Neil
Original Assignee
Ptc Therapeutics Inc Soc Organ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ptc Therapeutics Inc Soc Organ filed Critical Ptc Therapeutics Inc Soc Organ
Publication of CL2007002606A1 publication Critical patent/CL2007002606A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CL200702606A 2006-09-08 2007-09-07 Proceso para preparar acido de 1,2,4-oxadiazol benzoico o una sal farmaceuticamente aceptable de este que comprende hacer reaccionar un metil ester de acido cianobenzoico con hidroxilamina, acilar con cloruro de halobenzoilo, condensar e hidrolizar e CL2007002606A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84359506P 2006-09-08 2006-09-08

Publications (1)

Publication Number Publication Date
CL2007002606A1 true CL2007002606A1 (es) 2008-04-18

Family

ID=38935880

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200702606A CL2007002606A1 (es) 2006-09-08 2007-09-07 Proceso para preparar acido de 1,2,4-oxadiazol benzoico o una sal farmaceuticamente aceptable de este que comprende hacer reaccionar un metil ester de acido cianobenzoico con hidroxilamina, acilar con cloruro de halobenzoilo, condensar e hidrolizar e

Country Status (24)

Country Link
US (2) US7678922B2 (https=)
EP (1) EP2059513B1 (https=)
JP (2) JP5955494B2 (https=)
KR (1) KR101466368B1 (https=)
CN (1) CN101535284B (https=)
AR (3) AR062715A1 (https=)
AU (1) AU2007292915B2 (https=)
BR (1) BRPI0716996B8 (https=)
CA (2) CA2662749C (https=)
CL (1) CL2007002606A1 (https=)
DK (1) DK2059513T3 (https=)
ES (1) ES2404348T3 (https=)
IL (1) IL197445A (https=)
MX (1) MX2009002439A (https=)
MY (1) MY148598A (https=)
NZ (2) NZ575511A (https=)
PE (2) PE20120669A1 (https=)
PL (1) PL2059513T3 (https=)
PT (1) PT2059513E (https=)
RU (1) RU2495030C2 (https=)
TW (1) TWI482761B (https=)
UA (1) UA99265C2 (https=)
WO (1) WO2008030570A1 (https=)
ZA (1) ZA200901782B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4101846B1 (en) 2003-04-11 2023-08-02 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
PL2402002T3 (pl) 2005-04-08 2018-11-30 Ptc Therapeutics, Inc. Kompozycje zawierające kwas 1,2,4-oksadiazolobenzoesowy i ich zastosowania do leczenia chorób związanych z przedwczesnym kodonem stop
EP2387995A1 (en) 2006-03-30 2011-11-23 PTC Therapeutics, Inc. Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith
UA99265C2 (ru) * 2006-09-08 2012-08-10 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способ получения 1,2,4-оксадиазолбензойной кислоты и ее производных (варианты)
US8101641B2 (en) 2006-09-25 2012-01-24 Ptc Therapeutics, Inc. Hydroxylated 1,2,4-oxadiazole benzoic acid compounds and compositions thereof
NZ575795A (en) * 2006-09-25 2012-03-30 Ptc Therapeutics Inc Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid
MX2009003909A (es) 2006-10-12 2009-05-25 Ptc Therapeutics Inc Métodos para dosificar un compuesto 1,2,4, - oxadiazol oralmente activo para el tratamiento de supresión de la mutación finalizadora.
CN101714009A (zh) * 2009-05-14 2010-05-26 翁印嵩 集成通用电话功能的计算机
ES2610362T3 (es) 2011-01-25 2017-04-27 Viviabiotech, S.L. Derivados de 1,2,4-oxadiazol como fármacos moduladores del receptor para el péptido glp-1
EP2867230B1 (en) 2012-07-02 2020-02-12 Monsanto Technology LLC Process for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles
TWI695717B (zh) 2014-03-06 2020-06-11 美商 Ptc 治療公司 １,２,４-二唑苯甲酸之鹽及醫藥組合物
CN105461650B (zh) * 2014-09-12 2018-04-13 杭州普晒医药科技有限公司 一种噁二唑化合物的溶剂化物及其制备方法
CN106316885B (zh) * 2015-07-03 2019-02-12 普济生物科技（台州）有限公司 一种3-[5-(2-氟苯基)-1,2,4-噁二唑-3-基]苯甲酸的制备方法
CN108348527A (zh) 2015-10-30 2018-07-31 Ptc医疗公司 用于治疗癫痫的方法
TW201808922A (zh) 2016-06-20 2018-03-16 台灣神隆股份有限公司 製備阿塔魯仁及其中間體的方法
WO2020128816A2 (en) 2018-12-20 2020-06-25 Pfizer Inc. Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent
EP4473971A3 (en) 2019-04-10 2025-02-19 PTC Therapeutics, Inc. Method for treating nonsense mutation mediated duchenne muscular dystrophy in pediatric patients
WO2022112919A1 (en) 2020-11-25 2022-06-02 Pfizer Inc. (aza)benzothiazolyl substituted pyrazole compounds
CN113045510B (zh) * 2021-03-31 2022-05-27 北京大学生命科学华东产业研究院 一种阿塔鲁伦的制备方法
CN114920667B (zh) * 2022-06-30 2024-06-21 湖南大学 一种阿塔鲁伦酯的电化学制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2801509A1 (de) * 1978-01-12 1979-07-19 Schering Ag 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel
DE3905242A1 (de) * 1989-02-21 1990-08-23 Basf Ag Verfahren zur herstellung von phenyloxdiazolylanilinen
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
DE4425794A1 (de) * 1994-07-21 1996-01-25 Basf Ag Nitrofarbstoffe
US6660753B2 (en) 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
KR20040004705A (ko) 2001-06-08 2004-01-13 시토비아 인크. 카스파제의 활성제 및 아폽토시스의 유도제로서의 치환된3-아릴-5-아릴-[1,2,4]-옥사디아졸과 유사체 및 이의 용도
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
MXPA05001592A (es) 2002-08-09 2005-05-05 Astrazeneca Ab Oxadiazoles como moduladores de receptor-5 de glutamato metabotropico.
GB0303503D0 (en) 2003-02-14 2003-03-19 Novartis Ag Organic compounds
EP4101846B1 (en) 2003-04-11 2023-08-02 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
US20050075375A1 (en) 2003-05-14 2005-04-07 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis C virus
PL2402002T3 (pl) * 2005-04-08 2018-11-30 Ptc Therapeutics, Inc. Kompozycje zawierające kwas 1,2,4-oksadiazolobenzoesowy i ich zastosowania do leczenia chorób związanych z przedwczesnym kodonem stop
UA99265C2 (ru) * 2006-09-08 2012-08-10 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способ получения 1,2,4-оксадиазолбензойной кислоты и ее производных (варианты)

Also Published As

Publication number Publication date
AU2007292915B2 (en) 2012-07-26
AR107474A2 (es) 2018-05-02
BRPI0716996B1 (pt) 2021-02-09
PL2059513T3 (pl) 2013-06-28
RU2495030C2 (ru) 2013-10-10
CN101535284B (zh) 2014-12-10
BRPI0716996A2 (pt) 2013-10-08
US20080139818A1 (en) 2008-06-12
AU2007292915A1 (en) 2008-03-13
TW200823180A (en) 2008-06-01
KR20090054464A (ko) 2009-05-29
US20100063297A1 (en) 2010-03-11
IL197445A (en) 2014-01-30
MY148598A (en) 2013-05-15
CA2662749A1 (en) 2008-03-13
KR101466368B1 (ko) 2014-11-27
RU2009113019A (ru) 2010-10-20
MX2009002439A (es) 2009-03-27
NZ575511A (en) 2012-02-24
EP2059513B1 (en) 2013-01-23
WO2008030570A1 (en) 2008-03-13
JP5955494B2 (ja) 2016-07-20
CA2662749C (en) 2015-01-20
PT2059513E (pt) 2013-04-30
ZA200901782B (en) 2010-06-30
EP2059513A1 (en) 2009-05-20
CN101535284A (zh) 2009-09-16
PE20080771A1 (es) 2008-06-13
CA2842625A1 (en) 2008-03-13
AR118922A2 (es) 2021-11-10
JP2010502715A (ja) 2010-01-28
UA99265C2 (ru) 2012-08-10
ES2404348T3 (es) 2013-05-27
US8367841B2 (en) 2013-02-05
BRPI0716996B8 (pt) 2021-05-25
AR062715A1 (es) 2008-11-26
IL197445A0 (en) 2009-12-24
DK2059513T3 (da) 2013-05-06
NZ598012A (en) 2013-08-30
US7678922B2 (en) 2010-03-16
TWI482761B (zh) 2015-05-01
PE20120669A1 (es) 2012-06-01
HK1134094A1 (en) 2010-04-16
CA2842625C (en) 2016-07-12
JP2014193896A (ja) 2014-10-09

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