NZ571288A - Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use - Google Patents

Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

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Publication number
NZ571288A
NZ571288A NZ571288A NZ57128807A NZ571288A NZ 571288 A NZ571288 A NZ 571288A NZ 571288 A NZ571288 A NZ 571288A NZ 57128807 A NZ57128807 A NZ 57128807A NZ 571288 A NZ571288 A NZ 571288A
Authority
NZ
New Zealand
Prior art keywords
pain
disorder
diaza
bicyclo
syndrome
Prior art date
Application number
NZ571288A
Other languages
English (en)
Inventor
Dan Peters
Gunnar M Olsen
Elsebet Ostergaard Nielsen
Daniel B Timmermann
Steven Charles Loechel
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NZ571288A publication Critical patent/NZ571288A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
NZ571288A 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use NZ571288A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200600731 2006-05-30
PCT/EP2007/055169 WO2007138038A1 (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

Publications (1)

Publication Number Publication Date
NZ571288A true NZ571288A (en) 2011-05-27

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ID=40616686

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ571288A NZ571288A (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

Country Status (23)

Country Link
US (4) US8158619B2 (https=)
EP (3) EP2032575B1 (https=)
JP (2) JP5290964B2 (https=)
KR (1) KR101458194B1 (https=)
CN (2) CN101432286A (https=)
AT (3) ATE463497T1 (https=)
AU (2) AU2007267174B2 (https=)
BR (1) BRPI0708843A2 (https=)
CA (2) CA2653769A1 (https=)
DE (2) DE602007005802D1 (https=)
DK (2) DK2032574T3 (https=)
ES (1) ES2342334T3 (https=)
IL (1) IL193925A (https=)
MX (2) MX2008014887A (https=)
MY (1) MY147764A (https=)
NO (1) NO20085398L (https=)
NZ (1) NZ571288A (https=)
PL (1) PL2032575T3 (https=)
PT (1) PT2032575E (https=)
RU (1) RU2427581C2 (https=)
UA (1) UA95946C2 (https=)
WO (2) WO2007138038A1 (https=)
ZA (1) ZA200807756B (https=)

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US8158619B2 (en) 2006-05-30 2012-04-17 Neurosearch A/S 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use
EP2079734A1 (en) * 2006-10-25 2009-07-22 NeuroSearch A/S Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
JP2010536726A (ja) 2007-08-17 2010-12-02 ノイロサーチ アクティーゼルスカブ ニコチン性アセチルコリン受容体リガンドとして有用な新規１，４−ジアザ−ビシクロ〔３．２．２〕ノニルヘテロアリール誘導体
CN101952288A (zh) 2008-03-11 2011-01-19 神经研究公司 可用作烟碱乙酰胆碱受体的调节剂的新颖的1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物
EP2288608A1 (en) * 2008-06-10 2011-03-02 NeuroSearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010043539A1 (en) * 2008-10-13 2010-04-22 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010063784A1 (en) * 2008-12-04 2010-06-10 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
MX2011007449A (es) 2009-01-26 2011-10-24 Neurosearch As Derivados de indolil-oxadiazolil-diazabiciclononano y su uso medico y diagnostico.
WO2010086280A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120028968A1 (en) 2009-01-27 2012-02-02 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086278A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120071469A1 (en) * 2009-05-14 2012-03-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
US20120288443A1 (en) 2009-11-11 2012-11-15 Neurosearch A/S Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
EP2513097A1 (en) 2009-12-18 2012-10-24 NeuroSearch AS Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
US8986654B2 (en) 2011-04-15 2015-03-24 Danpet Ab Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
JP7312749B2 (ja) 2017-08-04 2023-07-21 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングをモジュレートする方法および組成物
CR20200553A (es) 2018-04-18 2021-04-08 Constellation Pharmaceuticals Inc Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos
CN120097995A (zh) 2018-05-21 2025-06-06 星座制药公司 甲基修饰酶的调节剂、其组合物和用途
EP3920910A4 (en) * 2019-02-04 2022-11-09 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATION OF SPLICING
JP7551629B2 (ja) 2019-02-05 2024-09-17 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
WO2020163405A1 (en) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
JP7603595B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
JP7603594B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
WO2021016414A1 (en) 2019-07-24 2021-01-28 Constellation Pharmaceuticals, Inc. Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide

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US7807667B2 (en) 2010-10-05
US8101598B2 (en) 2012-01-24
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