KR101458194B1 - 신규한 1，4―디아자―비사이클로［3．2．2］노닐 옥사디아졸릴 유도체 및 이의 의학적 용도 - Google Patents

신규한 1，4―디아자―비사이클로［3．2．2］노닐 옥사디아졸릴 유도체 및 이의 의학적 용도 Download PDF

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KR101458194B1
KR101458194B1 KR1020087031858A KR20087031858A KR101458194B1 KR 101458194 B1 KR101458194 B1 KR 101458194B1 KR 1020087031858 A KR1020087031858 A KR 1020087031858A KR 20087031858 A KR20087031858 A KR 20087031858A KR 101458194 B1 KR101458194 B1 KR 101458194B1
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pain
bicyclo
diaza
disorder
nonyloxadiazolyl
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KR20090015155A (ko
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단 페터스
군나르 엠. 올센
엘세베트 외스테르가르 닐센
다니엘 베. 팀메르만
스테벤 샤를레스 로에셀
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뉴로서치 에이/에스
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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KR1020087031858A 2006-05-30 2007-05-29 신규한 1，4―디아자―비사이클로［3．2．2］노닐 옥사디아졸릴 유도체 및 이의 의학적 용도 Expired - Fee Related KR101458194B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US80902406P 2006-05-30 2006-05-30
DKPA200600731 2006-05-30
US60/809,024 2006-05-30
DKPA200600731 2006-05-30
PCT/EP2007/055169 WO2007138038A1 (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

Publications (2)

Publication Number Publication Date
KR20090015155A KR20090015155A (ko) 2009-02-11
KR101458194B1 true KR101458194B1 (ko) 2014-11-03

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Country Link
US (4) US8158619B2 (https=)
EP (3) EP2194056B1 (https=)
JP (2) JP5290964B2 (https=)
KR (1) KR101458194B1 (https=)
CN (2) CN101432286A (https=)
AT (3) ATE463497T1 (https=)
AU (2) AU2007267174B2 (https=)
BR (1) BRPI0708843A2 (https=)
CA (2) CA2653769A1 (https=)
DE (2) DE602007005802D1 (https=)
DK (2) DK2032574T3 (https=)
ES (1) ES2342334T3 (https=)
IL (1) IL193925A (https=)
MX (2) MX2008014887A (https=)
MY (1) MY147764A (https=)
NO (1) NO20085398L (https=)
NZ (1) NZ571288A (https=)
PL (1) PL2032575T3 (https=)
PT (1) PT2032575E (https=)
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UA (1) UA95946C2 (https=)
WO (2) WO2007138038A1 (https=)
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WO2007138038A1 (en) 2006-05-30 2007-12-06 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
WO2008049864A1 (en) * 2006-10-25 2008-05-02 Neurosearch A/S Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
US7935695B2 (en) 2007-08-17 2011-05-03 Neurosearch A/S 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands
CA2718194A1 (en) 2008-03-11 2009-09-17 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as modulator of nicotinic acetylcholine receptors
WO2009150138A1 (en) * 2008-06-10 2009-12-17 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
US20110263577A1 (en) * 2008-10-13 2011-10-27 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
US20110257161A1 (en) * 2008-12-04 2011-10-20 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
US8778928B2 (en) 2009-01-26 2014-07-15 Danpet Ab Indolyl-oxadiazolyl-diazabicyclononane derivatives and their medical and diagnostical use
US20120238553A1 (en) * 2009-01-27 2012-09-20 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086279A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086280A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120071469A1 (en) * 2009-05-14 2012-03-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
WO2011058002A1 (en) 2009-11-11 2011-05-19 Neurosearch A/S Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
WO2011073296A1 (en) 2009-12-18 2011-06-23 Neurosearch A/S Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
US8986654B2 (en) 2011-04-15 2015-03-24 Danpet Ab Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2019028440A1 (en) 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICING
HRP20240793T1 (hr) 2018-04-18 2024-09-13 Constellation Pharmaceuticals, Inc. Modulatori enzima koji modificiraju metil, njihovi pripravci i upotreba
EP3797108B1 (en) 2018-05-21 2022-07-20 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
WO2020163248A1 (en) 2019-02-04 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
JP2022519294A (ja) * 2019-02-04 2022-03-22 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
EP3920915A4 (en) 2019-02-05 2022-10-05 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICE
CN114126613A (zh) 2019-02-05 2022-03-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
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