CN101432286A - 新颖的1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途 - Google Patents

新颖的1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途 Download PDF

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Publication number
CN101432286A
CN101432286A CNA200780015245XA CN200780015245A CN101432286A CN 101432286 A CN101432286 A CN 101432286A CN A200780015245X A CNA200780015245X A CN A200780015245XA CN 200780015245 A CN200780015245 A CN 200780015245A CN 101432286 A CN101432286 A CN 101432286A
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China
Prior art keywords
diaza
bicyclo
alkyl
phenyl
oxadiazol
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Pending
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CNA200780015245XA
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Chinese (zh)
Inventor
D·彼得斯
G·M·奥尔森
E·Φ·尼尔森
D·B·蒂默曼
S·C·勒歇尔
J·D·米克尔森
H·B·汉森
J·P·雷德罗布
J·K·克里斯滕森
T·迪赫林
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NTG Nordic Transport Group AS
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Neurosearch AS
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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CNA200780015245XA 2006-05-30 2007-05-29 新颖的1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途 Pending CN101432286A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200600731 2006-05-30
DKPA200600731 2006-05-30

Publications (1)

Publication Number Publication Date
CN101432286A true CN101432286A (zh) 2009-05-13

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ID=40616686

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA200780015245XA Pending CN101432286A (zh) 2006-05-30 2007-05-29 新颖的1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途
CN200780014526.3A Expired - Fee Related CN101426790B (zh) 2006-05-30 2007-05-29 1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途

Family Applications After (1)

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CN200780014526.3A Expired - Fee Related CN101426790B (zh) 2006-05-30 2007-05-29 1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物和它们的医药用途

Country Status (23)

Country Link
US (4) US8158619B2 (https=)
EP (3) EP2032575B1 (https=)
JP (2) JP5290964B2 (https=)
KR (1) KR101458194B1 (https=)
CN (2) CN101432286A (https=)
AT (3) ATE463497T1 (https=)
AU (2) AU2007267174B2 (https=)
BR (1) BRPI0708843A2 (https=)
CA (2) CA2653769A1 (https=)
DE (2) DE602007005802D1 (https=)
DK (2) DK2032574T3 (https=)
ES (1) ES2342334T3 (https=)
IL (1) IL193925A (https=)
MX (2) MX2008014887A (https=)
MY (1) MY147764A (https=)
NO (1) NO20085398L (https=)
NZ (1) NZ571288A (https=)
PL (1) PL2032575T3 (https=)
PT (1) PT2032575E (https=)
RU (1) RU2427581C2 (https=)
UA (1) UA95946C2 (https=)
WO (2) WO2007138038A1 (https=)
ZA (1) ZA200807756B (https=)

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US8158619B2 (en) 2006-05-30 2012-04-17 Neurosearch A/S 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use
EP2079734A1 (en) * 2006-10-25 2009-07-22 NeuroSearch A/S Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
JP2010536726A (ja) 2007-08-17 2010-12-02 ノイロサーチ アクティーゼルスカブ ニコチン性アセチルコリン受容体リガンドとして有用な新規１，４−ジアザ−ビシクロ〔３．２．２〕ノニルヘテロアリール誘導体
CN101952288A (zh) 2008-03-11 2011-01-19 神经研究公司 可用作烟碱乙酰胆碱受体的调节剂的新颖的1,4-二氮杂-双环[3.2.2]壬基二唑基衍生物
EP2288608A1 (en) * 2008-06-10 2011-03-02 NeuroSearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010043539A1 (en) * 2008-10-13 2010-04-22 Neurosearch A/S Novel oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010063784A1 (en) * 2008-12-04 2010-06-10 Neurosearch A/S Novel diaza-bicyclononyl-phenyl derivatives and their medical use
MX2011007449A (es) 2009-01-26 2011-10-24 Neurosearch As Derivados de indolil-oxadiazolil-diazabiciclononano y su uso medico y diagnostico.
WO2010086280A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120028968A1 (en) 2009-01-27 2012-02-02 Neurosearch A/S Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
WO2010086278A1 (en) 2009-01-27 2010-08-05 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
US20120071469A1 (en) * 2009-05-14 2012-03-22 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
US20120288443A1 (en) 2009-11-11 2012-11-15 Neurosearch A/S Labelled pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their use in diagnostic methods
EP2513097A1 (en) 2009-12-18 2012-10-24 NeuroSearch AS Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators
US8986654B2 (en) 2011-04-15 2015-03-24 Danpet Ab Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
JP7312749B2 (ja) 2017-08-04 2023-07-21 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングをモジュレートする方法および組成物
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CN120097995A (zh) 2018-05-21 2025-06-06 星座制药公司 甲基修饰酶的调节剂、其组合物和用途
EP3920910A4 (en) * 2019-02-04 2022-11-09 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATION OF SPLICING
JP7551629B2 (ja) 2019-02-05 2024-09-17 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
WO2020163405A1 (en) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
JP7603595B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
JP7603594B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
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