NZ571113A - Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix - Google Patents

Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix

Info

Publication number
NZ571113A
NZ571113A NZ571113A NZ57111306A NZ571113A NZ 571113 A NZ571113 A NZ 571113A NZ 571113 A NZ571113 A NZ 571113A NZ 57111306 A NZ57111306 A NZ 57111306A NZ 571113 A NZ571113 A NZ 571113A
Authority
NZ
New Zealand
Prior art keywords
pdgf
bone
kit
biocompatible matrix
augmentation
Prior art date
Application number
NZ571113A
Other languages
English (en)
Inventor
Samuel Lynch
Myron Nevins
Massimo Simion
Original Assignee
Biomimetic Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomimetic Therapeutics Inc filed Critical Biomimetic Therapeutics Inc
Publication of NZ571113A publication Critical patent/NZ571113A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003—Not used, see subgroups
    • A61C8/0004—Consolidating natural teeth
    • A61C8/0006—Periodontal tissue or bone regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2803—Bones for mandibular reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Dentistry (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
NZ571113A 2005-11-17 2006-11-17 Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix NZ571113A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73807605P 2005-11-17 2005-11-17
PCT/US2006/044766 WO2007061889A2 (en) 2005-11-17 2006-11-17 Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix

Publications (1)

Publication Number Publication Date
NZ571113A true NZ571113A (en) 2012-02-24

Family

ID=38067796

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ571113A NZ571113A (en) 2005-11-17 2006-11-17 Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix

Country Status (11)

Country Link
US (2) US8114841B2 (enExample)
EP (2) EP2431060B1 (enExample)
JP (1) JP5368102B2 (enExample)
KR (1) KR20080084808A (enExample)
CN (1) CN101370531A (enExample)
BR (1) BRPI0618794A2 (enExample)
CA (1) CA2630077C (enExample)
NO (1) NO20082393L (enExample)
NZ (1) NZ571113A (enExample)
WO (1) WO2007061889A2 (enExample)
ZA (1) ZA200804548B (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040081704A1 (en) 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
WO2007061889A2 (en) 2005-11-17 2007-05-31 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
ES2427993T3 (es) * 2006-02-09 2013-11-05 Biomimetic Therapeutics, Llc Composiciones y métodos para el tratamiento de hueso
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
WO2008005427A2 (en) * 2006-06-30 2008-01-10 Biomimetic Therapeutics, Inc. Pdgf-biomatrix compositions and methods for treating rotator cuff injuries
US9943410B2 (en) 2011-02-28 2018-04-17 DePuy Synthes Products, Inc. Modular tissue scaffolds
EP2462895B1 (en) 2006-11-03 2016-11-02 BioMimetic Therapeutics, LLC Compositions and methods for arthrodetic procedures
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
FI3345607T3 (fi) 2006-12-29 2022-11-30 Menetelmiä luun kasvun muuttamiseksi antamalla SOST- tai WISE-antagonistia tai antagonistia
WO2008103690A2 (en) * 2007-02-20 2008-08-28 Biomimetic Therapeutics, Inc. Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw using pdgf and a bone matrix
US20090042158A1 (en) * 2007-08-09 2009-02-12 Gregory Gene Steiner Method for regenerating bone in the maxillary sinus
CA2715254A1 (en) 2008-02-07 2009-08-13 Biomimetic Therapeutics, Inc. Compositions and methods for distraction osteogenesis
US9616153B2 (en) * 2008-04-17 2017-04-11 Warsaw Orthopedic, Inc. Rigid bone graft substitute
CN102231992B (zh) 2008-09-09 2015-05-20 生物模拟治疗公司 用于治疗肌腱和韧带损伤的血小板衍生生长因子的组合物和方法
EP2376106A4 (en) * 2008-12-19 2013-01-09 Biomimetic Therapeutics Inc BONE TRANSPLANTS WITH REDUCED PROTEASE EFFECT AND SELECTION AND APPLICATION PROCEDURES
JP2012519556A (ja) * 2009-03-05 2012-08-30 バイオミメティック セラピューティクス， インコーポレイテッド 骨軟骨欠損を治療するための血小板由来増殖因子組成物および方法
WO2011038354A1 (en) * 2009-09-25 2011-03-31 Tuffs University Dental graft for treating periodontal conditions and thin biotypes
US8994666B2 (en) * 2009-12-23 2015-03-31 Colin J. Karpfinger Tactile touch-sensing interface system
BR112012020566B1 (pt) * 2010-02-22 2021-09-21 Biomimetic Therapeutics, Llc Composição de fator de crescimento derivado de plaqueta
AU2011329054B2 (en) 2010-11-15 2015-05-28 Zimmer Orthobiologics, Inc. Bone void fillers
WO2012082773A1 (en) * 2010-12-13 2012-06-21 Biomimetic Therapeutics, Inc. Compositions and methods for spine fusion procedures
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
SG11201404500SA (en) * 2012-02-01 2014-11-27 Organ Technologies Inc Dental implant and method for producing same
CN105085652B (zh) * 2014-05-16 2021-06-22 中国人民解放军军事医学科学院生物工程研究所 血小板衍生生长因子b突变体、其制备方法及用途
MX2017004520A (es) * 2014-10-14 2018-03-15 Lynch Samuel Composiciones para tratar heridas.
WO2016126220A1 (en) * 2015-02-04 2016-08-11 Polat Serkan Membrane system for forming bone without graft
CN105126172B (zh) * 2015-09-28 2017-12-12 武汉大学 一种增高牙槽嵴的牙支架的制备及安装方法
US20230120120A1 (en) * 2016-11-18 2023-04-20 Cutting Edge Technology, LLC Pharmaceutical formulation
CN110236710A (zh) * 2018-03-09 2019-09-17 中日友好医院 一种促进植骨材料在牙种植上颌窦外提升术后成骨的方法
US12419752B2 (en) * 2019-11-27 2025-09-23 Igor Roshkovan Surgical technique for alveolar ridge augmentation with maxillary sinus elevation (lateral approach) using a pre-portioned and ready pre-packaged bone graft composition in gelatin bag and method of producing it

Family Cites Families (223)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943072A (en) * 1971-12-15 1976-03-09 United Kingdom Atomic Energy Authority Separation of molecules
USRE33161E (en) * 1982-04-29 1990-02-06 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
NL8402158A (nl) 1983-07-09 1985-02-01 Sumitomo Cement Co Poreus keramisch materiaal en werkwijze voor de bereiding daarvan.
US4889919A (en) * 1986-08-13 1989-12-26 Zymogenetics, Inc. Biologically active PDGF derived A-chain homodimers
US4766073A (en) * 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US5187263A (en) 1984-10-12 1993-02-16 Zymogenetics, Inc. Expression of biologically active PDGE analogs in eucaryotic cells
US5165938A (en) 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US5629191A (en) 1985-01-03 1997-05-13 Integra Lifesciences Corporation Method of making a porous matrix particle
US5045633A (en) * 1985-02-25 1991-09-03 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US5516896A (en) * 1985-02-25 1996-05-14 Zymogenetics, Inc. Biologically active B-chain homodimers
CA1260391A (en) * 1985-03-28 1989-09-26 Karl A. Piez Xenogeneic collagen/mineral preparations in bone repair
DE3530825A1 (de) * 1985-08-29 1987-03-05 Boehringer Mannheim Gmbh Neue benzodipyrrole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5187076A (en) 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
ZA874681B (en) * 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5108922A (en) 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5019559A (en) * 1986-11-14 1991-05-28 President And Fellows Of Harvard College Wound healing using PDGF and IGF-II
US5124316A (en) 1986-11-14 1992-06-23 President And Fellows Of Harvard College Method for periodontal regeneration
US4861757A (en) 1986-11-14 1989-08-29 Institute Of Molecular Biology Wound healing and bone regeneration using PDGF and IGF-I
KR960005708B1 (ko) 1986-11-14 1996-05-01 인스티튜트 오브 몰레큘러 바이올로지, 인코오포레이티드 외상 치료 및 뼈 재생용 조성물
US5219759A (en) 1987-04-22 1993-06-15 Chiron Corporation Recombinant DNA encoding PDGF A-chain polypeptide and expression vectors
US5457093A (en) * 1987-09-18 1995-10-10 Ethicon, Inc. Gel formulations containing growth factors
US4874746A (en) 1987-12-22 1989-10-17 Institute Of Molecular Biology, Inc. Wound headling composition of TGF-alpha and PDGF
US5759815A (en) 1988-02-11 1998-06-02 Creative Biomolecules, Inc. Production of platelet derived growth factor (PDGF) an muteins thereof
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US4975526A (en) 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5053212A (en) * 1988-04-20 1991-10-01 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US5129905A (en) * 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
US5962028A (en) 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
US4904259A (en) * 1988-04-29 1990-02-27 Samuel Itay Compositions and methods for repair of cartilage and bone
US5219576A (en) 1988-06-30 1993-06-15 Collagen Corporation Collagen wound healing matrices and process for their production
US5034375A (en) * 1988-08-10 1991-07-23 Institute Of Molecular Biology, Inc. Process of wound healing using PDGF and EGF
US6028105A (en) * 1989-04-06 2000-02-22 Nigra; Thomas P. Topical drug delivery composition and method
US5035887A (en) * 1989-09-07 1991-07-30 Institute Of Moelcular Biology, Inc. Wound healing composition of IL-1 and PDGF or IGF-1
US5599558A (en) * 1989-09-15 1997-02-04 Curative Technologies, Inc. Selecting amounts of platelet releasate for efficacious treatment of tissue
US5112354A (en) 1989-11-16 1992-05-12 Northwestern University Bone allograft material and method
US5011910A (en) * 1989-12-28 1991-04-30 Washington University Reagent and method for determining activity of retroviral protease
JP3159216B2 (ja) * 1990-02-01 2001-04-23 ユニバーシティ オブ サウス フロリダ 白血球由来の成長因子
TW199858B (enExample) 1990-03-30 1993-02-11 Fujirebio Kk
DE69031218T2 (de) 1990-04-10 1997-12-11 Harvard College Wundheilung
US5108322A (en) * 1990-07-24 1992-04-28 Zebco Corporation Relay control of auxiliary functions in a trolling motor
US5853746A (en) 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
US5149691A (en) 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
DE4120325A1 (de) * 1991-06-20 1992-12-24 Merck Patent Gmbh Implantatwerkstoff
US5837258A (en) 1991-08-30 1998-11-17 University Of South Florida Induction of tissue, bone or cartilage formation using connective tissue growth factor
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
CN1104257C (zh) * 1993-03-29 2003-04-02 津莫吉尼蒂克斯公司 含pdgf和维生素d的刺激成骨细胞生长的组合物
AU7205894A (en) 1993-06-08 1995-01-03 Neogenix, Inc. Purified natural and synthetic compounds for the treatment of osteoarthritis
US5531794A (en) 1993-09-13 1996-07-02 Asahi Kogaku Kogyo Kabushiki Kaisha Ceramic device providing an environment for the promotion and formation of new bone
US5518680A (en) * 1993-10-18 1996-05-21 Massachusetts Institute Of Technology Tissue regeneration matrices by solid free form fabrication techniques
JP3362267B2 (ja) * 1993-12-29 2003-01-07 日本特殊陶業株式会社 生体インプラント材料及びその製造方法
US5460962A (en) * 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US7963997B2 (en) 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
US6180606B1 (en) 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
US5651766A (en) 1995-06-07 1997-07-29 Transfusion Technologies Corporation Blood collection and separation system
US5614206A (en) * 1995-03-07 1997-03-25 Wright Medical Technology, Inc. Controlled dissolution pellet containing calcium sulfate
US5635372A (en) 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
US6287341B1 (en) 1995-05-19 2001-09-11 Etex Corporation Orthopedic and dental ceramic implants
US5676976A (en) 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6541037B1 (en) 1995-05-19 2003-04-01 Etex Corporation Delivery vehicle
US6027742A (en) 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
DK1486565T3 (da) 1995-10-11 2008-03-10 Novartis Vaccines & Diagnostic Kombination af PDGF, KGF, IGF og IGFBP til sårheling
US5783217A (en) 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture
US5747273A (en) 1996-05-07 1998-05-05 Diagnostic Systems Laboratories, Inc. Immunoassay of total insulin-like growth factor binding protein-1
CA2252860C (en) * 1996-05-28 2011-03-22 1218122 Ontario Inc. Resorbable implant biomaterial made of condensed calcium phosphate particles
FR2749756B1 (fr) 1996-06-14 1998-09-11 Bioland Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre
US5965403A (en) 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
ES2299183T3 (es) 1996-10-16 2008-05-16 Etex Corporation Composiciones bioceramicas.
US6037519A (en) 1997-10-20 2000-03-14 Sdgi Holdings, Inc. Ceramic fusion implants and compositions
DE19646782C2 (de) 1996-11-13 2000-05-25 Merck Patent Gmbh Bioresorbierbare Polymerisationsprodukte aus strahlungshärtbaren Bindemittelsystemen
WO1998025963A1 (en) * 1996-12-13 1998-06-18 Chiron Corporation Analysis and separation of platelet-derived growth factor proteins
US5866165A (en) * 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
FR2758988B1 (fr) 1997-02-05 2000-01-21 S H Ind Procede d'elaboration de substituts osseux synthetiques d'architecture poreuse parfaitement maitrisee
AU6267798A (en) * 1997-02-07 1998-08-26 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
WO1998038949A1 (en) 1997-03-04 1998-09-11 Implico B.V. An artefact suitable for use as a bone implant
US20020098222A1 (en) 1997-03-13 2002-07-25 John F. Wironen Bone paste
US20010016646A1 (en) * 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
JP3334558B2 (ja) * 1997-04-23 2002-10-15 富士レビオ株式会社 酵素免疫測定方法及び試験片
US20030032586A1 (en) 1997-05-15 2003-02-13 David C. Rueger Compositions for morphogen-induced osteogenesis
GB2325934A (en) 1997-06-03 1998-12-09 Polybiomed Ltd Treating metal surfaces to enhance bio-compatibility and/or physical characteristics
US6063624A (en) 1997-06-09 2000-05-16 Baxter International Inc. Platelet suspensions and methods for resuspending platelets
ATE220564T1 (de) 1997-08-14 2002-08-15 Sulzer Innotec Ag Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren
US6136029A (en) 1997-10-01 2000-10-24 Phillips-Origen Ceramic Technology, Llc Bone substitute materials
US6090998A (en) * 1997-10-27 2000-07-18 University Of Florida Segmentally demineralized bone implant
US20020018796A1 (en) 1998-01-28 2002-02-14 John F. Wironen Thermally sterilized bone paste
ES2198067T3 (es) 1998-07-28 2004-01-16 Synthes Ag Chur Utilizacion de compuestos a base de creatina para tratar las celulas y los tejidos oseos y cartilaginosos.
US20030114936A1 (en) 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
US6224635B1 (en) * 1998-11-06 2001-05-01 Hospital For Joint Diseases Implantation of surgical implants with calcium sulfate
US6663870B2 (en) 1998-12-07 2003-12-16 Zymogenetics, Inc. Methods for promoting growth of bone using zvegf3
US6231528B1 (en) 1999-01-15 2001-05-15 Jonathan J. Kaufman Ultrasonic and growth factor bone-therapy: apparatus and method
EP1025871A1 (en) 1999-01-28 2000-08-09 F. Hoffmann-La Roche Ag Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair
ATE253385T1 (de) 1999-02-04 2003-11-15 Sdgi Holdings Inc Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung
US6294187B1 (en) * 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
ATE318625T1 (de) 1999-03-15 2006-03-15 Implant Innovations Inc Sammelsystem für thrombozyten
US6296602B1 (en) * 1999-03-17 2001-10-02 Transfusion Technologies Corporation Method for collecting platelets and other blood components from whole blood
CA2370063C (en) 1999-03-19 2012-10-02 The Regents Of The University Of Michigan Mineralization and cellular patterning on biomaterial surfaces
WO2000061256A1 (en) * 1999-04-12 2000-10-19 Harvest Technologies Corporation Method and apparatus for producing platelet rich plasma and/or platelet concentrate
SE515227C2 (sv) 1999-04-28 2001-07-02 Bruce Medical Ab Kropp för åstadkommande av in- och tillväxt av benvävnad och/ eller bindväv och sätt för framställning av kroppen
US6468543B1 (en) * 1999-05-03 2002-10-22 Zymogenetics, Inc. Methods for promoting growth of bone using ZVEGF4
US6710025B1 (en) 1999-05-26 2004-03-23 The Brigham And Women's Hospital, Inc. Treatment of damaged tissue using agents that modulate the activity of alpha-smooth muscle actin
US6312952B1 (en) 1999-05-27 2001-11-06 The Research Foundation Of State University Of New York In vitro cell culture device including cartilage and methods of using the same
DE19926083A1 (de) 1999-06-08 2000-12-14 Universitaetsklinikum Freiburg Biologisches Gelenkkonstrukt
US6429013B1 (en) * 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
DE19940717A1 (de) 1999-08-26 2001-03-01 Gerontocare Gmbh Resorblerbares Knochenersatz- und Knochenaufbaumaterial
US6280191B1 (en) * 1999-09-03 2001-08-28 Christopher B. Gordon Distractor suitable for permanent implantation into bone
JP4809963B2 (ja) * 1999-11-11 2011-11-09 オリンパス株式会社 骨補填材
US6451059B1 (en) 1999-11-12 2002-09-17 Ethicon, Inc. Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds
DE60003459T2 (de) 1999-12-09 2004-05-06 Biosyntech Canada Inc., Laval Mineral-polymer hybrid-zusammensetzung
CA2328818A1 (en) 1999-12-16 2001-06-16 Isotis B.V. Porous ceramic body
US20030103960A1 (en) * 1999-12-22 2003-06-05 Pierre Philippart Sealant and bone generating product
JP2003518411A (ja) * 1999-12-29 2003-06-10 リジェネレーション テクノロジーズ インク． ペースト再構成のためのシステムおよびその使用法
AU4234901A (en) 2000-01-28 2001-08-07 Dot Dunnschicht Und Oberflache Inorganic resorbable bone substitute material and production method
AU2000251259A1 (en) 2000-02-04 2001-08-14 Zymogenetics Inc. Methods for promoting growth of bone, ligament, and cartilage using zvegf4
IT1316769B1 (it) * 2000-02-18 2003-05-12 Getters Spa Pannello evacuato per isolamento termico con ridotta conduzione dicalore ai bordi
JP2003535620A (ja) 2000-02-18 2003-12-02 リジェネレーション テクノロジーズ インク． 増殖因子および他の添加物を注入した移植用組織
US7022506B2 (en) * 2000-02-23 2006-04-04 The Trustees Of The University Of Pennsylvania Method and device for treating osteoarthritis, cartilage disease, defects and injuries in the human knee
JP2003525696A (ja) * 2000-03-03 2003-09-02 スミス アンド ネフュー インコーポレーテッド 造形粒子および骨欠損用組成物および粒子を作る方法
US20030055511A1 (en) 2000-03-03 2003-03-20 Schryver Jeffrey E. Shaped particle comprised of bone material and method of making the particle
AU784377B2 (en) * 2000-03-14 2006-03-23 Arthur V. Sampaio Compositions and methods for affecting osteogenesis
US20020006437A1 (en) 2000-05-01 2002-01-17 Grooms Jamie M. Non-migration tissue capsule
EP1287506A2 (en) * 2000-05-19 2003-03-05 Europrint Holdings Limited Method and system for implementing a game
US20020022885A1 (en) 2000-05-19 2002-02-21 Takahiro Ochi Biomaterial
DK1294414T3 (da) * 2000-06-29 2006-07-24 Biosyntech Canada Inc Præparat og fremgangsmåde til heling og regenerering af brusk og andre væv
DK177997B1 (da) 2000-07-19 2015-02-23 Ed Geistlich Söhne Ag Für Chemische Ind Knoglemateriale og collagenkombination til opheling af beskadigede led
GB0020610D0 (en) 2000-08-21 2000-10-11 Dytech Corp Ltd Uses of porous carriers
US6739112B1 (en) * 2000-08-21 2004-05-25 Nu Vasive, Inc. Bone allograft packaging system
US6773723B1 (en) 2000-08-30 2004-08-10 Depuy Acromed, Inc. Collagen/polysaccharide bilayer matrix
EP1337266A4 (en) 2000-10-31 2006-11-02 Depuy Spine Inc MINERALIZED COLLAGEN POLYSACCHARIDE MATRIX FOR THE RECONSTRUCTION OF BONES AND CARTILES
US20020127265A1 (en) 2000-12-21 2002-09-12 Bowman Steven M. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
CA2365376C (en) * 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US7192604B2 (en) 2000-12-22 2007-03-20 Ethicon, Inc. Implantable biodegradable devices for musculoskeletal repair or regeneration
JP2004533276A (ja) 2001-01-25 2004-11-04 リジェネレーション テクノロジーズ インク． 注射可能な多孔性骨グラフト材料
US7005135B2 (en) * 2001-01-30 2006-02-28 Ethicon Inc. Glass scaffolds with controlled resorption rates and methods for making same
KR100877484B1 (ko) * 2001-02-22 2009-01-12 파나소닉 주식회사 광 디스크 장치
CA2438934A1 (en) 2001-02-23 2002-09-06 Wyeth Chondrogenic potential of human bone marrow-derived cd105+ cells by bmp
US6575986B2 (en) 2001-02-26 2003-06-10 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US6743232B2 (en) * 2001-02-26 2004-06-01 David W. Overaker Tissue scaffold anchor for cartilage repair
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
US20030049328A1 (en) 2001-03-02 2003-03-13 Dalal Paresh S. Porous beta-tricalcium phosphate granules and methods for producing same
JP2003010310A (ja) * 2001-06-27 2003-01-14 Olympus Optical Co Ltd 頭蓋骨用骨補填材料および補填方法
US20030109537A1 (en) * 2001-07-09 2003-06-12 Turner Russell T. Methods and materials for treating bone conditions
WO2003026714A1 (en) 2001-09-24 2003-04-03 Millenium Biologix, Inc. Porous ceramic composite bone grafts
ATE384783T1 (de) 2001-10-19 2008-02-15 Zymogenetics Inc Dimerisierter wachstumsfaktor sowie materialien und verfahren zu seiner herstellung
US6649072B2 (en) 2001-11-16 2003-11-18 Robert Brandt Method for producing autologous platelet-rich plasma
WO2003043576A2 (en) 2001-11-20 2003-05-30 Depuy Products, Inc. Flowable osteogenic and chondrogenic compositions
WO2003055418A1 (en) 2001-12-21 2003-07-10 Lagow Richard J Calcium phosphate bone replacement materials and methods of use thereof
AU2003210996A1 (en) 2002-02-11 2003-09-04 Zymogenetics, Inc. Materials and methods for preparing dimeric growth factors
US7879107B2 (en) * 2002-02-20 2011-02-01 The Cleveland Clinic Foundation Composition and method for inducing bone growth and healing
JP3739715B2 (ja) * 2002-03-19 2006-01-25 オリンパス株式会社 人工骨および組織工学用担体
KR100460685B1 (ko) 2002-04-10 2004-12-09 재단법인서울대학교산학협력재단 인산칼슘계 화합물을 이용한 인공 골 충진재 및 그 제조방법
WO2003089022A1 (en) 2002-04-18 2003-10-30 University Of Florida Biomimetic organic/inorganic composites, processes for their production, and methods of use
EP1539185A4 (en) * 2002-05-02 2006-04-05 Osteoscreen Inc METHODS AND COMPOSITIONS FOR STIMULATING BONE GROWTH USING NITRIC OXIDE FREEZING BISPHOSPHONATE CONJUGATES
WO2003094617A2 (en) * 2002-05-06 2003-11-20 Genentech, Inc. Use of vegf for treating bone defects
US7368125B2 (en) 2002-06-05 2008-05-06 Ethicon, Inc. Amphiphilic polymers for medical applications
US7041309B2 (en) 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
CA2432583A1 (en) 2002-06-20 2003-12-20 Merck Patent Gesellschaft Mit Beschraenkter Haftung Method of preparing alpha- and beta-tricalcium phosphate powders
US20040002770A1 (en) 2002-06-28 2004-01-01 King Richard S. Polymer-bioceramic composite for orthopaedic applications and method of manufacture thereof
DE60300666T2 (de) * 2002-07-11 2006-04-27 Biomet Deutschland Gmbh Verfahren zur Herstellung poröser Calciumphosphatstückchen und -granulaten aus der Gelatineverarbeitung
DE10240083A1 (de) * 2002-08-30 2004-03-11 Austriamicrosystems Ag Verfahren zur Kalibrierung einer Fotodiode, Halbleiterchip und Betriebsverfahren
US7744651B2 (en) * 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
WO2004032965A1 (ja) 2002-10-10 2004-04-22 Ono Pharmaceutical Co., Ltd. 内因性修復因子産生促進剤
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
ES2269973T3 (es) * 2003-02-13 2007-04-01 Synthes Ag Chur Mezcla inyectable para sustituir un tejido oseo.
MXPA05008653A (es) 2003-02-14 2006-04-27 Depuy Spine Inc Dispositivo de fusion intervertebral formado in situ.
US8027050B2 (en) * 2003-02-26 2011-09-27 Science Park Corporation Computer containing a print control program, the program, and program recording medium
US20040243133A1 (en) 2003-03-05 2004-12-02 Therics, Inc. Method and system for manufacturing biomedical articles, such as using biomedically compatible infiltrant metal alloys in porous matrices
US20040193270A1 (en) 2003-03-31 2004-09-30 Depuyacromed, Inc. Implantable bone graft
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
EP1638486A4 (en) 2003-06-11 2010-09-29 Osteotech Inc OSTEOIMPLANTATES AND METHOD FOR THE PRODUCTION THEREOF
US6974862B2 (en) 2003-06-20 2005-12-13 Kensey Nash Corporation High density fibrous polymers suitable for implant
ATE396669T1 (de) 2003-06-24 2008-06-15 Robert Mathys Foundation Dr H Prothesenvorrichtung zur wiederherstellung von knorpel
DE10328892A1 (de) 2003-06-26 2005-05-12 Curasan Ag Knochenaufbaumittel und Herstellungsverfahren
CA2530421C (en) 2003-06-27 2015-04-21 Ethicon, Incorporated Repair and regeneration of ocular tissue using postpartum-derived cells
FI20031120A0 (fi) 2003-07-31 2003-07-31 Bci Bioabsorbable Concepts Ltd Monifunktionaalinen implanttilaite
US7163920B2 (en) * 2003-09-30 2007-01-16 Ethicon, Inc. Peptide with osteogenic activity
CU23352A1 (es) 2003-10-16 2009-03-16 Centro Nacional De Investigaciones Cientificas Biomateriales compuestos para implantes óseos
ES2522575T3 (es) 2003-10-22 2014-11-17 Encelle, Inc. Composiciones de hidrogel bioactivo para la regeneración del tejido conjuntivo
US20050098915A1 (en) * 2003-11-07 2005-05-12 Smith & Nephew Inc. Manufacture of bone graft substitutes
CA2545860A1 (en) * 2003-11-14 2005-06-02 The Trustees Of The University Of Pennsylvania Device for treating osteoarthritis and cartilage disease, defects, and injuries in the human hip
DE10355559A1 (de) 2003-11-21 2005-06-23 Orthogen Ag Transskin
EP1537839A1 (en) 2003-12-02 2005-06-08 Dr. h. c. Robert Mathys Foundation Prosthetic device for cartilage repair
WO2005067942A1 (en) * 2004-01-16 2005-07-28 Institute Of Nutraceutical Research Pty Ltd Glycosaminoglycan peptides derived from connective tissues and use thereof in the prevention of arthritis and other degenerative medical conditions
NZ579516A (en) 2004-01-27 2011-01-28 Osteotech Inc Stabilized bone graft
US7189263B2 (en) * 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US7671012B2 (en) * 2004-02-10 2010-03-02 Biosurface Engineering Technologies, Inc. Formulations and methods for delivery of growth factor analogs
US7928059B2 (en) 2004-02-24 2011-04-19 Wisconsin Alumni Research Foundation Use of neuropeptides for traumatic cartilage injury
KR101013999B1 (ko) 2004-03-19 2011-02-14 재단법인서울대학교산학협력재단 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트
US20070190101A1 (en) 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
CN101060821A (zh) 2004-09-21 2007-10-24 麻省理工学院 梯度支架及其制备方法
US7390489B2 (en) * 2004-10-08 2008-06-24 Komed Co., Ltd. Monoclonal antibody selectively recognizing listeria monocytogenes, hybridoma producing the antibody, test kit comprising the antibody and detection method of listeria monocytogenes using the antibody
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US7250550B2 (en) 2004-10-22 2007-07-31 Wright Medical Technology, Inc. Synthetic bone substitute material
WO2006050493A2 (en) 2004-11-03 2006-05-11 The Regents Of The University Of Michigan Biodegradable implant for intertransverse process fusion
US20060149392A1 (en) * 2004-12-07 2006-07-06 Kuo-Huang Hsieh Biomaterials for guided tissue regeneration and drug delivery
US20060151383A1 (en) 2005-01-12 2006-07-13 Aaf-Mcquay Inc. Pleated corrugated media and method of making
US7621963B2 (en) 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
CA2654446C (en) 2005-06-07 2014-02-25 The Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of graft rejection and promotion of graft survival
WO2007061889A2 (en) 2005-11-17 2007-05-31 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
US7749555B2 (en) 2006-01-25 2010-07-06 Medtronic, Inc Modification of chemical forces of bone constructs
WO2007090102A2 (en) 2006-01-27 2007-08-09 The Regents Of The University Of California Biomimetic scaffolds
US20070178159A1 (en) 2006-01-30 2007-08-02 Alza Corporation In-Situ Forming Porous Scaffold
ES2427993T3 (es) * 2006-02-09 2013-11-05 Biomimetic Therapeutics, Llc Composiciones y métodos para el tratamiento de hueso
US7833270B2 (en) 2006-05-05 2010-11-16 Warsaw Orthopedic, Inc Implant depots to deliver growth factors to treat osteoporotic bone
WO2007133451A1 (en) 2006-05-08 2007-11-22 Nuvasive, Inc. Cancellous bone treated with collegenase and essentially free of blood cells
WO2008005427A2 (en) 2006-06-30 2008-01-10 Biomimetic Therapeutics, Inc. Pdgf-biomatrix compositions and methods for treating rotator cuff injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
EP2462895B1 (en) 2006-11-03 2016-11-02 BioMimetic Therapeutics, LLC Compositions and methods for arthrodetic procedures
WO2008100442A1 (en) * 2007-02-09 2008-08-21 Biomet Biologics, Inc. Treatment of tissue defects with a therapeutic composition
WO2008103690A2 (en) 2007-02-20 2008-08-28 Biomimetic Therapeutics, Inc. Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw using pdgf and a bone matrix
CA2689986C (en) 2007-06-04 2020-04-07 Biomimetic Therapeutics, Inc. Compositions and methods for treating the vertebral column
AU2008265850B2 (en) * 2007-06-15 2014-06-26 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
CN104623669A (zh) * 2007-08-22 2015-05-20 斯丹姆涅恩有限公司 含细胞因子溶液的新组合物
US7993679B2 (en) 2007-09-25 2011-08-09 Integra Lifesciences Corporation Flowable wound matrix and its preparation and use
CA2715254A1 (en) * 2008-02-07 2009-08-13 Biomimetic Therapeutics, Inc. Compositions and methods for distraction osteogenesis
CN102231992B (zh) 2008-09-09 2015-05-20 生物模拟治疗公司 用于治疗肌腱和韧带损伤的血小板衍生生长因子的组合物和方法
EP2376106A4 (en) 2008-12-19 2013-01-09 Biomimetic Therapeutics Inc BONE TRANSPLANTS WITH REDUCED PROTEASE EFFECT AND SELECTION AND APPLICATION PROCEDURES
JP2012519556A (ja) 2009-03-05 2012-08-30 バイオミメティック セラピューティクス， インコーポレイテッド 骨軟骨欠損を治療するための血小板由来増殖因子組成物および方法

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