NZ530806A - Quinoline derivatives and use thereof as antitumor agents - Google Patents
Quinoline derivatives and use thereof as antitumor agentsInfo
- Publication number
- NZ530806A NZ530806A NZ530806A NZ53080602A NZ530806A NZ 530806 A NZ530806 A NZ 530806A NZ 530806 A NZ530806 A NZ 530806A NZ 53080602 A NZ53080602 A NZ 53080602A NZ 530806 A NZ530806 A NZ 530806A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- day
- mice
- cage
- tumor
- Prior art date
Links
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- 231100000816 toxic dose Toxicity 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30914401P | 2001-07-31 | 2001-07-31 | |
| PCT/US2002/024442 WO2003011832A1 (en) | 2001-07-31 | 2002-07-31 | Quinoline derivatives and use thereof as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ530806A true NZ530806A (en) | 2006-05-26 |
Family
ID=23196886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ530806A NZ530806A (en) | 2001-07-31 | 2002-07-31 | Quinoline derivatives and use thereof as antitumor agents |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US6867219B2 (enExample) |
| EP (1) | EP1412332B1 (enExample) |
| JP (1) | JP4310185B2 (enExample) |
| KR (1) | KR20040055774A (enExample) |
| AT (1) | ATE287397T1 (enExample) |
| AU (1) | AU2002355747B2 (enExample) |
| CA (1) | CA2456173A1 (enExample) |
| DE (1) | DE60202682T2 (enExample) |
| DK (1) | DK1412332T3 (enExample) |
| EA (1) | EA007205B1 (enExample) |
| ES (1) | ES2236548T3 (enExample) |
| GE (1) | GEP20063754B (enExample) |
| HU (1) | HUP0401562A2 (enExample) |
| IL (2) | IL160082A0 (enExample) |
| MX (1) | MXPA04000968A (enExample) |
| NO (1) | NO326463B1 (enExample) |
| NZ (1) | NZ530806A (enExample) |
| PL (1) | PL367340A1 (enExample) |
| PT (1) | PT1412332E (enExample) |
| UA (1) | UA75691C2 (enExample) |
| WO (1) | WO2003011832A1 (enExample) |
| ZA (1) | ZA200401185B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2254385T3 (es) * | 2000-02-29 | 2006-06-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
| JP4310185B2 (ja) * | 2001-07-31 | 2009-08-05 | ウェイン・ステイト・ユニバーシティ | キノリン誘導体およびその抗腫瘍剤としての使用 |
| UA79293C2 (en) * | 2002-07-03 | 2007-06-11 | Univ Wayne State | 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents |
| WO2004024149A1 (de) * | 2002-08-24 | 2004-03-25 | Zentaris Gmbh | Arzneimittel enthaltend disorale und ihre derivate und deren anwendung zur behandlung gutartiger und bosärtiger tumorerkrankungen |
| US7470788B2 (en) * | 2005-09-07 | 2008-12-30 | Wayne State University | Antitumor agents |
| US8183379B2 (en) * | 2005-09-07 | 2012-05-22 | Wayne State University | Antitumor agents |
| US20070054938A1 (en) * | 2005-09-07 | 2007-03-08 | Horwitz Jerome P | Antitumor agents |
| EP1897542A1 (en) * | 2006-09-07 | 2008-03-12 | Sanofi-Aventis | Aqueous formulation comprising an antitumor agent |
| JO2685B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| WO2009002955A1 (en) * | 2007-06-27 | 2008-12-31 | Sanofi-Aventis U.S. Llc | Process for the preparation of (2r)-2-[4-(7-bromo-2-quinolyloxy)phenoxy]propanoic acid |
| JP2014516075A (ja) | 2011-06-06 | 2014-07-07 | シェブロン フィリップス ケミカル カンパニー エルピー | 癌治療のためのメタロセン化合物の使用 |
| EP4583874A1 (en) * | 2022-12-21 | 2025-07-16 | Charles University, Faculty Of Pharmacy In Hradec Kralove | Multitarget nuclear receptor ligands based on 2-(4-(quinolin-2-yloxy)phenoxy)propanoic acid and 2-(4-(quinoxalin-2-yloxy)phenoxy)propanoic acid for the treatment of metabolic and liver diseases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6033389B2 (ja) * | 1979-02-22 | 1985-08-02 | 日産化学工業株式会社 | 複素環エ−テル系フェノシキ脂肪酸誘導体、その製造法および該誘導体を含有する除草剤 |
| US6197728B1 (en) * | 1980-08-06 | 2001-03-06 | Nissan Chemical Industries Ltd. | Quinoxaline derivatives and herbicidal composition |
| US5364831A (en) * | 1980-08-06 | 1994-11-15 | Nissan Chemical Industries Ltd. | Quinoxaline derivatives and herbicidal composition |
| US5250690A (en) * | 1985-05-02 | 1993-10-05 | Dowelanco | Haloalkoxy anilide derivatives of 2-4(-heterocyclic oxyphenoxy)alkanoic or alkenoic acids and their use as herbicides |
| JP4310185B2 (ja) * | 2001-07-31 | 2009-08-05 | ウェイン・ステイト・ユニバーシティ | キノリン誘導体およびその抗腫瘍剤としての使用 |
| UA79293C2 (en) * | 2002-07-03 | 2007-06-11 | Univ Wayne State | 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents |
| US7470788B2 (en) * | 2005-09-07 | 2008-12-30 | Wayne State University | Antitumor agents |
-
2002
- 2002-07-31 JP JP2003517024A patent/JP4310185B2/ja not_active Expired - Fee Related
- 2002-07-31 NZ NZ530806A patent/NZ530806A/en unknown
- 2002-07-31 US US10/210,781 patent/US6867219B2/en not_active Expired - Lifetime
- 2002-07-31 ES ES02752656T patent/ES2236548T3/es not_active Expired - Lifetime
- 2002-07-31 KR KR10-2004-7001559A patent/KR20040055774A/ko not_active Abandoned
- 2002-07-31 HU HU0401562A patent/HUP0401562A2/hu unknown
- 2002-07-31 EP EP02752656A patent/EP1412332B1/en not_active Expired - Lifetime
- 2002-07-31 GE GE5486A patent/GEP20063754B/en unknown
- 2002-07-31 AT AT02752656T patent/ATE287397T1/de not_active IP Right Cessation
- 2002-07-31 IL IL16008202A patent/IL160082A0/xx unknown
- 2002-07-31 EA EA200400219A patent/EA007205B1/ru not_active IP Right Cessation
- 2002-07-31 WO PCT/US2002/024442 patent/WO2003011832A1/en not_active Ceased
- 2002-07-31 DE DE60202682T patent/DE60202682T2/de not_active Expired - Lifetime
- 2002-07-31 CA CA002456173A patent/CA2456173A1/en not_active Abandoned
- 2002-07-31 PL PL02367340A patent/PL367340A1/xx not_active Application Discontinuation
- 2002-07-31 UA UA2004021374A patent/UA75691C2/uk unknown
- 2002-07-31 MX MXPA04000968A patent/MXPA04000968A/es active IP Right Grant
- 2002-07-31 PT PT02752656T patent/PT1412332E/pt unknown
- 2002-07-31 AU AU2002355747A patent/AU2002355747B2/en not_active Ceased
- 2002-07-31 DK DK02752656T patent/DK1412332T3/da active
-
2004
- 2004-01-27 IL IL160082A patent/IL160082A/en not_active IP Right Cessation
- 2004-01-28 NO NO20040382A patent/NO326463B1/no not_active IP Right Cessation
- 2004-02-13 ZA ZA200401185A patent/ZA200401185B/en unknown
- 2004-12-10 US US11/009,457 patent/US7241894B2/en not_active Expired - Fee Related
-
2007
- 2007-05-24 US US11/753,197 patent/US7507749B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2456173A1 (en) | 2003-02-13 |
| UA75691C2 (en) | 2006-05-15 |
| US7507749B2 (en) | 2009-03-24 |
| ES2236548T3 (es) | 2005-07-16 |
| EA007205B1 (ru) | 2006-08-25 |
| IL160082A0 (en) | 2004-06-20 |
| PT1412332E (pt) | 2005-06-30 |
| WO2003011832A1 (en) | 2003-02-13 |
| HUP0401562A2 (hu) | 2004-12-28 |
| NO20040382L (no) | 2004-03-26 |
| IL160082A (en) | 2009-06-15 |
| US20030144321A1 (en) | 2003-07-31 |
| KR20040055774A (ko) | 2004-06-26 |
| EA200400219A1 (ru) | 2004-12-30 |
| ZA200401185B (en) | 2004-10-21 |
| EP1412332B1 (en) | 2005-01-19 |
| DK1412332T3 (da) | 2005-05-30 |
| US6867219B2 (en) | 2005-03-15 |
| MXPA04000968A (es) | 2005-02-17 |
| US20070232643A1 (en) | 2007-10-04 |
| JP4310185B2 (ja) | 2009-08-05 |
| AU2002355747B2 (en) | 2007-12-20 |
| JP2004538314A (ja) | 2004-12-24 |
| US20050159447A1 (en) | 2005-07-21 |
| US7241894B2 (en) | 2007-07-10 |
| DE60202682D1 (de) | 2005-02-24 |
| GEP20063754B (en) | 2006-02-27 |
| PL367340A1 (en) | 2005-02-21 |
| ATE287397T1 (de) | 2005-02-15 |
| NO326463B1 (no) | 2008-12-08 |
| DE60202682T2 (de) | 2005-12-29 |
| EP1412332A1 (en) | 2004-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |