ZA200401185B - Quinoline derivatives and use thereof as antitumor agents. - Google Patents

Quinoline derivatives and use thereof as antitumor agents. Download PDF

Info

Publication number
ZA200401185B
ZA200401185B ZA200401185A ZA200401185A ZA200401185B ZA 200401185 B ZA200401185 B ZA 200401185B ZA 200401185 A ZA200401185 A ZA 200401185A ZA 200401185 A ZA200401185 A ZA 200401185A ZA 200401185 B ZA200401185 B ZA 200401185B
Authority
ZA
South Africa
Prior art keywords
compound
mice
day
cage
dose
Prior art date
Application number
ZA200401185A
Other languages
English (en)
Inventor
Jerome P Horwitz
Stuart T Hazeldine
Thomas H Corbett
Lisa Polin
Original Assignee
Wayne Stat University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wayne Stat University filed Critical Wayne Stat University
Publication of ZA200401185B publication Critical patent/ZA200401185B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
ZA200401185A 2001-07-31 2004-02-13 Quinoline derivatives and use thereof as antitumor agents. ZA200401185B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30914401P 2001-07-31 2001-07-31

Publications (1)

Publication Number Publication Date
ZA200401185B true ZA200401185B (en) 2004-10-21

Family

ID=23196886

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200401185A ZA200401185B (en) 2001-07-31 2004-02-13 Quinoline derivatives and use thereof as antitumor agents.

Country Status (22)

Country Link
US (3) US6867219B2 (enExample)
EP (1) EP1412332B1 (enExample)
JP (1) JP4310185B2 (enExample)
KR (1) KR20040055774A (enExample)
AT (1) ATE287397T1 (enExample)
AU (1) AU2002355747B2 (enExample)
CA (1) CA2456173A1 (enExample)
DE (1) DE60202682T2 (enExample)
DK (1) DK1412332T3 (enExample)
EA (1) EA007205B1 (enExample)
ES (1) ES2236548T3 (enExample)
GE (1) GEP20063754B (enExample)
HU (1) HUP0401562A2 (enExample)
IL (2) IL160082A0 (enExample)
MX (1) MXPA04000968A (enExample)
NO (1) NO326463B1 (enExample)
NZ (1) NZ530806A (enExample)
PL (1) PL367340A1 (enExample)
PT (1) PT1412332E (enExample)
UA (1) UA75691C2 (enExample)
WO (1) WO2003011832A1 (enExample)
ZA (1) ZA200401185B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064642A2 (en) * 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
WO2003011832A1 (en) * 2001-07-31 2003-02-13 Wayne State University Quinoline derivatives and use thereof as antitumor agents
UA79293C2 (en) * 2002-07-03 2007-06-11 Univ Wayne State 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents
CA2438001A1 (en) * 2002-08-24 2004-02-24 Zentaris Gmbh Use of the disorazoles and their derivatives for the treatment of benign and malignant oncoses
US7470788B2 (en) * 2005-09-07 2008-12-30 Wayne State University Antitumor agents
US8183379B2 (en) * 2005-09-07 2012-05-22 Wayne State University Antitumor agents
US20070054938A1 (en) * 2005-09-07 2007-03-08 Horwitz Jerome P Antitumor agents
EP1897542A1 (en) * 2006-09-07 2008-03-12 Sanofi-Aventis Aqueous formulation comprising an antitumor agent
JO2685B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
WO2009002955A1 (en) * 2007-06-27 2008-12-31 Sanofi-Aventis U.S. Llc Process for the preparation of (2r)-2-[4-(7-bromo-2-quinolyloxy)phenoxy]propanoic acid
JP2014516075A (ja) 2011-06-06 2014-07-07 シェブロン フィリップス ケミカル カンパニー エルピー 癌治療のためのメタロセン化合物の使用
WO2024132001A1 (en) * 2022-12-21 2024-06-27 Charles University, Faculty Of Pharmacy In Hradec Kralove Multitarget nuclear receptor ligands based on 2-(4-(quinolin-2-yloxy)phenoxy)propanoic acid and 2-(4-(quinoxalin-2-yloxy)phenoxy)propanoic acid for the treatment of metabolic and liver diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6033389B2 (ja) * 1979-02-22 1985-08-02 日産化学工業株式会社 複素環エ−テル系フェノシキ脂肪酸誘導体、その製造法および該誘導体を含有する除草剤
US5364831A (en) * 1980-08-06 1994-11-15 Nissan Chemical Industries Ltd. Quinoxaline derivatives and herbicidal composition
US6197728B1 (en) * 1980-08-06 2001-03-06 Nissan Chemical Industries Ltd. Quinoxaline derivatives and herbicidal composition
US5250690A (en) * 1985-05-02 1993-10-05 Dowelanco Haloalkoxy anilide derivatives of 2-4(-heterocyclic oxyphenoxy)alkanoic or alkenoic acids and their use as herbicides
WO2003011832A1 (en) * 2001-07-31 2003-02-13 Wayne State University Quinoline derivatives and use thereof as antitumor agents
UA79293C2 (en) * 2002-07-03 2007-06-11 Univ Wayne State 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents
US7470788B2 (en) * 2005-09-07 2008-12-30 Wayne State University Antitumor agents

Also Published As

Publication number Publication date
IL160082A (en) 2009-06-15
DE60202682T2 (de) 2005-12-29
GEP20063754B (en) 2006-02-27
NO20040382L (no) 2004-03-26
EP1412332B1 (en) 2005-01-19
PT1412332E (pt) 2005-06-30
AU2002355747B2 (en) 2007-12-20
PL367340A1 (en) 2005-02-21
JP2004538314A (ja) 2004-12-24
NZ530806A (en) 2006-05-26
UA75691C2 (en) 2006-05-15
US6867219B2 (en) 2005-03-15
MXPA04000968A (es) 2005-02-17
EA007205B1 (ru) 2006-08-25
US20030144321A1 (en) 2003-07-31
US7507749B2 (en) 2009-03-24
JP4310185B2 (ja) 2009-08-05
DE60202682D1 (de) 2005-02-24
EA200400219A1 (ru) 2004-12-30
ATE287397T1 (de) 2005-02-15
EP1412332A1 (en) 2004-04-28
US20050159447A1 (en) 2005-07-21
US7241894B2 (en) 2007-07-10
DK1412332T3 (da) 2005-05-30
ES2236548T3 (es) 2005-07-16
CA2456173A1 (en) 2003-02-13
KR20040055774A (ko) 2004-06-26
NO326463B1 (no) 2008-12-08
HUP0401562A2 (hu) 2004-12-28
US20070232643A1 (en) 2007-10-04
WO2003011832A1 (en) 2003-02-13
IL160082A0 (en) 2004-06-20

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