NZ337413A - Antibodies that bind to Prostate Stem Cell Antigen (PSCA) to treat prostate cancer. - Google Patents
Antibodies that bind to Prostate Stem Cell Antigen (PSCA) to treat prostate cancer.Info
- Publication number
- NZ337413A NZ337413A NZ337413A NZ33741398A NZ337413A NZ 337413 A NZ337413 A NZ 337413A NZ 337413 A NZ337413 A NZ 337413A NZ 33741398 A NZ33741398 A NZ 33741398A NZ 337413 A NZ337413 A NZ 337413A
- Authority
- NZ
- New Zealand
- Prior art keywords
- psca
- stem cell
- cell antigen
- antibodies
- bind
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Hospice & Palliative Care (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ516660A NZ516660A (en) | 1997-03-10 | 1998-03-10 | PSCA: Prostate stem cell antigen for diagnosis and treatment of prostate cancer |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81427997A | 1997-03-10 | 1997-03-10 | |
| US7114198P | 1998-01-12 | 1998-01-12 | |
| US7467598P | 1998-02-13 | 1998-02-13 | |
| PCT/US1998/004665 WO1998040403A1 (en) | 1997-03-10 | 1998-03-10 | Psca: prostate stem cell antigen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ337413A true NZ337413A (en) | 2003-02-28 |
Family
ID=27371828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ337413A NZ337413A (en) | 1997-03-10 | 1998-03-10 | Antibodies that bind to Prostate Stem Cell Antigen (PSCA) to treat prostate cancer. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6267960B1 (enExample) |
| EP (3) | EP0981541B1 (enExample) |
| JP (3) | JP4404381B2 (enExample) |
| AT (1) | ATE268340T1 (enExample) |
| AU (1) | AU739407C (enExample) |
| CA (1) | CA2281877C (enExample) |
| DE (1) | DE69824287T2 (enExample) |
| ES (1) | ES2221982T3 (enExample) |
| NZ (1) | NZ337413A (enExample) |
| WO (1) | WO1998040403A1 (enExample) |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU771026B2 (en) * | 1998-03-10 | 2004-03-11 | Regents Of The University Of California, The | PSCA: prostate stem cell antigen and uses thereof |
| US6541212B2 (en) * | 1997-03-10 | 2003-04-01 | The Regents Of The University Of California | Methods for detecting prostate stem cell antigen protein |
| AU2004200093B8 (en) * | 1997-03-10 | 2008-05-29 | The Regents Of The University Of California | "PSCA: Prostate Stem Cell Antigen and uses thereof" |
| US20080318254A9 (en) * | 1997-03-10 | 2008-12-25 | The Regents Of The University Of California | PSCA antibodies and hybridomas producing them |
| US6261791B1 (en) * | 1997-03-10 | 2001-07-17 | The Regents Of The University Of California | Method for diagnosing cancer using specific PSCA antibodies |
| WO1998051805A1 (en) * | 1997-05-15 | 1998-11-19 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the prostate |
| ATE458049T1 (de) | 1998-09-30 | 2010-03-15 | Agensys Inc | In prostatakrebs exprimiertes gen |
| US6824780B1 (en) * | 1999-10-29 | 2004-11-30 | Genentech, Inc. | Anti-tumor antibody compositions and methods of use |
| ES2309012T3 (es) * | 1999-10-29 | 2008-12-16 | Genentech, Inc. | Composiciones del anticuerpo anti-psca y a sus procedimientos contra celulas cancerigenas que expresen psca. |
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| US6632620B1 (en) | 2000-06-22 | 2003-10-14 | Andrew N. Makarovskiy | Compositions for identification and isolation of stem cells |
| EP2319524B1 (en) * | 2003-05-30 | 2013-08-21 | Agensys, Inc. | Prostate stem cell antigen (PSCA) variants and subsequences thereof |
| US7541442B2 (en) | 2003-05-30 | 2009-06-02 | Agensys, Inc. | Antibodies and related molecules that bind to PSCA proteins |
| US7595379B2 (en) | 2003-05-30 | 2009-09-29 | Agensys, Inc. | Antibodies and related molecules that bind to PSCA proteins |
| JP2007527699A (ja) * | 2003-06-26 | 2007-10-04 | エグゾニ・テラピューティック・ソシエテ・アノニム | 前立腺特異的遺伝子、ならびにその前立腺癌治療および診断のための標的としての使用 |
| KR101520209B1 (ko) | 2003-11-06 | 2015-05-13 | 시애틀 지네틱스, 인크. | 리간드에 접합될 수 있는 모노메틸발린 화합물 |
| KR101282396B1 (ko) * | 2004-05-28 | 2013-07-04 | 어젠시스 인코포레이티드 | Psca 단백질에 결합하는 암 진단용 항체 |
| EP1753871B1 (en) * | 2004-05-28 | 2015-07-15 | Agensys, Inc. | Antibodies and related molecules that bind to psca proteins |
| AU2005249490B2 (en) | 2004-06-01 | 2010-07-29 | Genentech, Inc. | Antibody drug conjugates and methods |
| US7713693B1 (en) | 2004-09-01 | 2010-05-11 | University Of Louisiana At Monroe | Human cancer cell specific gene transcript |
| CN101065151B (zh) | 2004-09-23 | 2014-12-10 | 健泰科生物技术公司 | 半胱氨酸改造的抗体和偶联物 |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| WO2006112933A1 (en) * | 2005-04-14 | 2006-10-26 | Agensys, Inc. | Antibodies and related molecules that bind to psca proteins |
| CN101223191B (zh) * | 2005-04-14 | 2012-09-05 | 阿根西斯公司 | 与psca蛋白结合的抗体和相关分子 |
| US8088908B2 (en) | 2005-05-10 | 2012-01-03 | City Of Hope | Humanized anti-prostate stem cell antigen monoclonal antibody |
| WO2007035676A2 (en) | 2005-09-19 | 2007-03-29 | Veridex., Llc | Methods and materials for identifying the origin of a carcinoma of unknown primary origin |
| WO2007086932A2 (en) * | 2006-01-13 | 2007-08-02 | The Johns Hopkins University | Prostate stem cell antigen vaccines and uses thereof |
| JP2009531324A (ja) | 2006-03-20 | 2009-09-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 癌標的化のための操作された抗前立腺幹細胞抗原(psca)抗体 |
| US8940298B2 (en) | 2007-09-04 | 2015-01-27 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection |
| AU2010292172A1 (en) | 2009-09-09 | 2012-05-03 | Centrose, Llc | Extracellular targeted drug conjugates |
| RS52983B (sr) | 2010-04-15 | 2014-02-28 | Spirogen Sárl | Pirolobenzodiazepini i njihovi konjugati |
| CN119552249A (zh) | 2010-06-08 | 2025-03-04 | 基因泰克公司 | 半胱氨酸改造的抗体和偶联物 |
| CA2816426A1 (en) | 2010-11-17 | 2012-06-07 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
| MX2013013054A (es) | 2011-05-12 | 2014-02-20 | Genentech Inc | Metodo de monitoreo de lc-ms/ms de reaccion multiple para detectar anticuerpos terapeuticos en muestras de animales utilizando peptidos de firma de estructura. |
| DE102011118022B4 (de) * | 2011-06-30 | 2018-01-18 | Gemoab Monoclonals Gmbh | Antikörper gegen das Prostata-spezifische Stammzellenantigen und dessen Verwendung |
| SI2750713T1 (sl) | 2011-10-14 | 2016-01-29 | Medimmune Limited | Pirolobenzodiazepini in njihovi konjugati |
| WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
| EP2906297B1 (en) | 2012-10-12 | 2017-12-06 | ADC Therapeutics SA | Pyrrolobenzodiazepine-antibody conjugates |
| DK2906298T3 (en) | 2012-10-12 | 2018-12-17 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| AU2013328625B2 (en) | 2012-10-12 | 2016-12-15 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| RS57694B1 (sr) | 2012-10-12 | 2018-11-30 | Adc Therapeutics Sa | Pirolobenzodiazepin - anti-psma konjugati antitela |
| KR101995621B1 (ko) | 2012-10-12 | 2019-07-03 | 에이디씨 테라퓨틱스 에스에이 | 피롤로벤조디아제핀-항-cd22 항체 컨주게이트 |
| EP2839860B1 (en) | 2012-10-12 | 2019-05-01 | MedImmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| WO2014057114A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
| BR112015014669B1 (pt) | 2012-12-21 | 2023-09-26 | Medimmune Limited | Compostos pirrolobenzodiazepinas, conjugados compreendendo os mesmos e uso destes para tratar uma doença proliferativa |
| AU2013366490B9 (en) | 2012-12-21 | 2018-02-01 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
| JP6444902B2 (ja) | 2013-03-13 | 2018-12-26 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びその結合体 |
| BR112015023070B1 (pt) | 2013-03-13 | 2022-06-07 | Genentech, Inc. | Conjugados e compostos de pirrolobenzodiazepinas, composição farmacêutica que compreende os mesmo, bem como seus usos para o tratamento de uma doença proliferativa |
| US9649390B2 (en) | 2013-03-13 | 2017-05-16 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| CN105636612B (zh) | 2013-08-12 | 2020-01-14 | 基因泰克公司 | 抗体-药物缀合物及使用和治疗方法 |
| WO2015052535A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| EP3054985B1 (en) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| EP3054983B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| EP3082874A2 (en) | 2013-12-16 | 2016-10-26 | Genentech, Inc. | Peptidomimetic compounds and antibody-drug conjugates thereof |
| CN105828840B (zh) | 2013-12-16 | 2020-08-04 | 基因泰克公司 | 1-(氯甲基)-2,3-二氢-1H-苯并[e]吲哚二聚体抗体-药物缀合物化合物及使用和治疗方法 |
| EP3082875B1 (en) | 2013-12-16 | 2020-11-25 | Genentech, Inc. | Peptidomimetic compounds and antibody-drug conjugates thereof |
| JP6531166B2 (ja) | 2014-09-10 | 2019-06-12 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びそのコンジュゲート |
| EP3191134B1 (en) | 2014-09-12 | 2019-11-20 | Genentech, Inc. | Anthracycline disulfide intermediates, antibody-drug conjugates and methods |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| TW201625688A (zh) | 2014-09-12 | 2016-07-16 | 建南德克公司 | 經半胱胺酸改造之抗體及接合物 |
| US20160074527A1 (en) | 2014-09-17 | 2016-03-17 | Genentech, Inc. | Pyrrolobenzodiazepines and antibody disulfide conjugates thereof |
| WO2016083468A1 (en) | 2014-11-25 | 2016-06-02 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| CA2969689A1 (en) | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
| MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
| MA45326A (fr) | 2015-10-20 | 2018-08-29 | Genentech Inc | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| WO2017165734A1 (en) | 2016-03-25 | 2017-09-28 | Genentech, Inc. | Multiplexed total antibody and antibody-conjugated drug quantification assay |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| JP2019522633A (ja) | 2016-05-20 | 2019-08-15 | ジェネンテック, インコーポレイテッド | Protac抗体コンジュゲート及び使用方法 |
| EP3465221B1 (en) | 2016-05-27 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Bioanalytical method for the characterization of site-specific antibody-drug conjugates |
| JP7043425B2 (ja) | 2016-06-06 | 2022-03-29 | ジェネンテック, インコーポレイテッド | シルベストロール抗体-薬物コンジュゲート及び使用方法 |
| JP7093767B2 (ja) | 2016-08-11 | 2022-06-30 | ジェネンテック, インコーポレイテッド | ピロロベンゾジアゼピンプロドラッグ及びその抗体コンジュゲート |
| WO2018065501A1 (en) | 2016-10-05 | 2018-04-12 | F. Hoffmann-La Roche Ag | Methods for preparing antibody drug conjugates |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| PL3544636T3 (pl) | 2017-02-08 | 2021-12-06 | Adc Therapeutics Sa | Koniugaty pirolobenzodiazepina-przeciwciało |
| SMT202200490T1 (it) | 2017-04-18 | 2023-01-13 | Medimmune Ltd | Coniugati di pirrolobenzodiazepina |
| PL3612234T3 (pl) | 2017-04-20 | 2024-09-02 | Adc Therapeutics Sa | Terapia skojarzona z koniugatem anty-AXL przeciwciało-lek |
| BR112019026564A2 (pt) | 2017-06-14 | 2020-06-30 | Adc Therapeutics Sa | regimes de dosagem para a administração de um adc anti-cd19 |
| SMT202200225T1 (it) | 2017-08-18 | 2022-07-21 | Medimmune Ltd | Coniugati di pirrolobenzodiazepina |
| IL273387B2 (en) | 2017-09-20 | 2023-10-01 | Ph Pharma Co Ltd | Thylanstatin analogs |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| CA3115110A1 (en) | 2018-10-24 | 2020-04-30 | F. Hoffmann-La Roche Ag | Conjugated chemical inducers of degradation and methods of use |
| EP3894427A1 (en) | 2018-12-10 | 2021-10-20 | Genentech, Inc. | Photocrosslinking peptides for site specific conjugation to fc-containing proteins |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| AU2020242747B2 (en) | 2019-03-15 | 2025-09-18 | Medimmune Limited | Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| JP2024541058A (ja) | 2021-11-03 | 2024-11-06 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ. | 抗体の特異的共役 |
| TW202432187A (zh) | 2022-12-23 | 2024-08-16 | 美商建南德克公司 | 小腦蛋白降解劑結合物及其用途 |
| WO2024220546A2 (en) | 2023-04-17 | 2024-10-24 | Peak Bio, Inc. | Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates |
| USD1094985S1 (en) * | 2024-09-17 | 2025-09-30 | Skechers U.S.A., Inc. Ii | Outsole bottom |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3684578D1 (de) * | 1985-12-17 | 1992-04-30 | Eastern Virginia Medical Autho | Monoklonale antikoerper mit bindungsspezifitaet fuer menschliche prostatatumorantigene und methoden fuer ihre verwendung. |
| CA2222231A1 (en) * | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth of tumors |
| US5856136A (en) * | 1996-07-03 | 1999-01-05 | Incyte Pharmaceuticals, Inc. | Human stem cell antigens |
| WO1998051805A1 (en) * | 1997-05-15 | 1998-11-19 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the prostate |
| WO1998051824A1 (en) * | 1997-05-15 | 1998-11-19 | Abbott Laboratories | Reagents and methods useful for detecting disease of the urinary tract |
-
1998
- 1998-03-10 NZ NZ337413A patent/NZ337413A/xx not_active IP Right Cessation
- 1998-03-10 AU AU65481/98A patent/AU739407C/en not_active Expired
- 1998-03-10 EP EP98911548A patent/EP0981541B1/en not_active Expired - Lifetime
- 1998-03-10 EP EP04012820.9A patent/EP1514876B1/en not_active Expired - Lifetime
- 1998-03-10 WO PCT/US1998/004665 patent/WO1998040403A1/en not_active Ceased
- 1998-03-10 AT AT98911548T patent/ATE268340T1/de active
- 1998-03-10 US US09/038,261 patent/US6267960B1/en not_active Expired - Lifetime
- 1998-03-10 JP JP53971398A patent/JP4404381B2/ja not_active Expired - Lifetime
- 1998-03-10 CA CA002281877A patent/CA2281877C/en not_active Expired - Lifetime
- 1998-03-10 EP EP10009651.0A patent/EP2343085B1/en not_active Expired - Lifetime
- 1998-03-10 DE DE69824287T patent/DE69824287T2/de not_active Expired - Lifetime
- 1998-03-10 ES ES98911548T patent/ES2221982T3/es not_active Expired - Lifetime
-
2007
- 2007-12-19 JP JP2007328082A patent/JP4615007B2/ja not_active Expired - Lifetime
-
2009
- 2009-11-09 JP JP2009256004A patent/JP2010029209A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1514876B1 (en) | 2013-05-08 |
| EP2343085A3 (en) | 2011-10-26 |
| EP0981541A1 (en) | 2000-03-01 |
| AU739407C (en) | 2002-08-08 |
| DE69824287D1 (de) | 2004-07-08 |
| ES2221982T3 (es) | 2005-01-16 |
| EP2343085B1 (en) | 2014-12-10 |
| EP0981541B1 (en) | 2004-06-02 |
| AU6548198A (en) | 1998-09-29 |
| JP2010029209A (ja) | 2010-02-12 |
| JP2008133287A (ja) | 2008-06-12 |
| ATE268340T1 (de) | 2004-06-15 |
| US6267960B1 (en) | 2001-07-31 |
| AU739407B2 (en) | 2001-10-11 |
| CA2281877A1 (en) | 1998-09-17 |
| CA2281877C (en) | 2010-01-05 |
| EP0981541A4 (en) | 2000-03-29 |
| DE69824287T2 (de) | 2005-06-16 |
| EP1514876A3 (en) | 2007-06-20 |
| WO1998040403A1 (en) | 1998-09-17 |
| JP2002511740A (ja) | 2002-04-16 |
| JP4615007B2 (ja) | 2011-01-19 |
| EP2343085A2 (en) | 2011-07-13 |
| JP4404381B2 (ja) | 2010-01-27 |
| EP1514876A2 (en) | 2005-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ337413A (en) | Antibodies that bind to Prostate Stem Cell Antigen (PSCA) to treat prostate cancer. | |
| IL126314A (en) | Monoclonal antibodies having an antigen binding region specific for the extracellular domain of prostate specific membrane antigen (psma) | |
| IL138497A0 (en) | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen | |
| GEP20105118B (en) | Anti-vegf antibodies | |
| NZ594466A (en) | Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies | |
| PL330075A1 (en) | Antibodies against the ed-b domain of fibronectin, their construction and application | |
| ES2293973T3 (es) | Anticuerpos anti-ccr2 humanizados y metodos de uso de los mismos. | |
| ZA945364B (en) | Antibodies specific for human prostate glandular kallikrein | |
| WO1997046589A3 (en) | Humanized antibodies that bind to the same antigen as bound by antibody nr-lu-13, and their use in pretargeting methods | |
| IL139700A0 (en) | Immunotherapeutic composition and method for the treatment of prostate cancer | |
| AU2821195A (en) | Cross-reacting monoclonal antibodies specific for e-selectin and p-selectin | |
| DE69939820D1 (de) | Internalisierende erbb2 antikörper | |
| AU6054398A (en) | Stimulation of an immune response with antibodies labeled with the alpha-galactosyl epitope | |
| ZA946767B (en) | Monocional antibodies having property of causing apoptosis. | |
| BR0012195A (pt) | Método para tratar câncer de próstata num ser humano, artigo de fabricação e uso de um anticorpo que liga erbb2 | |
| GB2368796A (en) | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies | |
| MX9603080A (es) | Anticuerpos monoclonales inmuno-estimulantes. | |
| BG101024A (bg) | Моноклонално антитяло срещу сd44v6 | |
| WO2003087340A3 (en) | Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof | |
| IL138655A0 (en) | Methods of cancer diagnosis using a chimeric toxin | |
| CA2348026A1 (en) | Antibodies against semp1, methods for their production and uses thereof | |
| EP1112085A4 (en) | ANTI-THROMBOTIC AGENT AND HUMANIZED MONOCLONAL ANTIBODY AGAINST VON-WILLEBRAND FACTOR | |
| TR200001265T2 (tr) | Vasp' a karşı antikorlar, bunların hazırlanması için hibridoma hücreleri. | |
| NZ501990A (en) | Compositions containing antigen-binding fragments that recognise the antigen recognised by a recombinant 4B5 antibody | |
| WO1999067384A3 (en) | Prostate cancer-associated genes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| EXPY | Patent expired |