JP4615007B2 - Psca:前立腺幹細胞抗原 - Google Patents
Psca:前立腺幹細胞抗原 Download PDFInfo
- Publication number
- JP4615007B2 JP4615007B2 JP2007328082A JP2007328082A JP4615007B2 JP 4615007 B2 JP4615007 B2 JP 4615007B2 JP 2007328082 A JP2007328082 A JP 2007328082A JP 2007328082 A JP2007328082 A JP 2007328082A JP 4615007 B2 JP4615007 B2 JP 4615007B2
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- antibody
- psca
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- prostate cancer
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
Description
Claims (14)
- ヒト細胞の表面に発現されるようなネイティブPSCAに結合する、請求項1に記載の使用。
- マウス抗原結合領域残基およびヒト抗体残基を含む、請求項1に記載の使用。
- ヒト抗体である、請求項1に記載の使用。
- ポリクローナル抗体である、請求項1に記載の使用。
- モノクローナル抗体である、請求項1に記載の使用。
- マウスの抗原結合部位およびエフェクター機能を調節するヒト化された領域を有するキメラ抗体である、請求項1に記載の使用。
- 断片が、Fv断片、F(ab')断片およびF(ab')2断片からなる群より選択される、請求項1に記載の使用。
- 抗体または該抗体の断片が、TARIRAVGLLTVISK(配列番号:7)であるPSCA抗原アミノ酸配列に結合する、請求項1に記載の使用。
- 抗体または該抗体の断片が検出可能なマーカーで標識された、請求項1に記載の使用。
- 前記検出可能なマーカーが放射性同位元素、蛍光化合物、生物発光化合物、化学発光化合物、金属キレート剤または酵素である、請求項10に記載の使用。
- 前記検出可能なマーカーが、放射性同位元素または蛍光化合物である、請求項11に記載の使用。
- 再発性の前立腺がんが検出され、および診断される、請求項1に記載の使用。
- 転移性の前立腺がんが検出され、診断される、請求項1に記載の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81427997A | 1997-03-10 | 1997-03-10 | |
US7114198P | 1998-01-12 | 1998-01-12 | |
US7467598P | 1998-02-13 | 1998-02-13 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53971398A Division JP4404381B2 (ja) | 1997-03-10 | 1998-03-10 | Psca:前立腺幹細胞抗原 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009256004A Division JP2010029209A (ja) | 1997-03-10 | 2009-11-09 | Psca:前立腺幹細胞抗原 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2008133287A JP2008133287A (ja) | 2008-06-12 |
JP2008133287A5 JP2008133287A5 (ja) | 2008-11-13 |
JP4615007B2 true JP4615007B2 (ja) | 2011-01-19 |
Family
ID=27371828
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53971398A Expired - Lifetime JP4404381B2 (ja) | 1997-03-10 | 1998-03-10 | Psca:前立腺幹細胞抗原 |
JP2007328082A Expired - Lifetime JP4615007B2 (ja) | 1997-03-10 | 2007-12-19 | Psca:前立腺幹細胞抗原 |
JP2009256004A Withdrawn JP2010029209A (ja) | 1997-03-10 | 2009-11-09 | Psca:前立腺幹細胞抗原 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53971398A Expired - Lifetime JP4404381B2 (ja) | 1997-03-10 | 1998-03-10 | Psca:前立腺幹細胞抗原 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009256004A Withdrawn JP2010029209A (ja) | 1997-03-10 | 2009-11-09 | Psca:前立腺幹細胞抗原 |
Country Status (10)
Country | Link |
---|---|
US (1) | US6267960B1 (ja) |
EP (3) | EP0981541B1 (ja) |
JP (3) | JP4404381B2 (ja) |
AT (1) | ATE268340T1 (ja) |
AU (1) | AU739407C (ja) |
CA (1) | CA2281877C (ja) |
DE (1) | DE69824287T2 (ja) |
ES (1) | ES2221982T3 (ja) |
NZ (1) | NZ337413A (ja) |
WO (1) | WO1998040403A1 (ja) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
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AU771026B2 (en) * | 1998-03-10 | 2004-03-11 | Regents Of The University Of California, The | PSCA: prostate stem cell antigen and uses thereof |
US6541212B2 (en) * | 1997-03-10 | 2003-04-01 | The Regents Of The University Of California | Methods for detecting prostate stem cell antigen protein |
US20080318254A9 (en) * | 1997-03-10 | 2008-12-25 | The Regents Of The University Of California | PSCA antibodies and hybridomas producing them |
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RU2020113749A (ru) | 2017-09-20 | 2021-10-20 | пиЭйч ФАРМА Ко., ЛТД. | Аналоги таиланстатина |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
TW202037381A (zh) | 2018-10-24 | 2020-10-16 | 瑞士商赫孚孟拉羅股份公司 | 綴合化學降解誘導劑及使用方法 |
WO2020123275A1 (en) | 2018-12-10 | 2020-06-18 | Genentech, Inc. | Photocrosslinking peptides for site specific conjugation to fc-containing proteins |
GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
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WO1998000540A1 (en) * | 1996-07-03 | 1998-01-08 | Incyte Pharmaceuticals, Inc. | Human stem cell antigens, dna coding therefor and their use |
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AU6267896A (en) * | 1995-06-07 | 1996-12-30 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth oftumors |
US6890749B2 (en) * | 1997-05-15 | 2005-05-10 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the prostate |
WO1998051824A1 (en) * | 1997-05-15 | 1998-11-19 | Abbott Laboratories | Reagents and methods useful for detecting disease of the urinary tract |
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WO1998000540A1 (en) * | 1996-07-03 | 1998-01-08 | Incyte Pharmaceuticals, Inc. | Human stem cell antigens, dna coding therefor and their use |
JP2000514646A (ja) * | 1996-07-03 | 2000-11-07 | インサイト・ファーマスーティカルズ・インコーポレイテッド | ヒト幹細胞抗原、それをコードするdna及びこれらの利用 |
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CA2281877A1 (en) | 1998-09-17 |
EP0981541B1 (en) | 2004-06-02 |
DE69824287T2 (de) | 2005-06-16 |
JP2008133287A (ja) | 2008-06-12 |
US6267960B1 (en) | 2001-07-31 |
EP0981541A1 (en) | 2000-03-01 |
CA2281877C (en) | 2010-01-05 |
ATE268340T1 (de) | 2004-06-15 |
ES2221982T3 (es) | 2005-01-16 |
AU739407C (en) | 2002-08-08 |
EP1514876A3 (en) | 2007-06-20 |
JP2002511740A (ja) | 2002-04-16 |
EP2343085B1 (en) | 2014-12-10 |
EP1514876A2 (en) | 2005-03-16 |
JP4404381B2 (ja) | 2010-01-27 |
EP2343085A2 (en) | 2011-07-13 |
AU6548198A (en) | 1998-09-29 |
AU739407B2 (en) | 2001-10-11 |
JP2010029209A (ja) | 2010-02-12 |
NZ337413A (en) | 2003-02-28 |
EP2343085A3 (en) | 2011-10-26 |
EP0981541A4 (en) | 2000-03-29 |
DE69824287D1 (de) | 2004-07-08 |
EP1514876B1 (en) | 2013-05-08 |
WO1998040403A1 (en) | 1998-09-17 |
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