NZ226163A - Pharmaceutical excipients comprising water soluble monoesters of a fatty acid and a polyol as solubilisers of pharmaceutical agents - Google Patents

Pharmaceutical excipients comprising water soluble monoesters of a fatty acid and a polyol as solubilisers of pharmaceutical agents

Info

Publication number
NZ226163A
NZ226163A NZ226163A NZ22616388A NZ226163A NZ 226163 A NZ226163 A NZ 226163A NZ 226163 A NZ226163 A NZ 226163A NZ 22616388 A NZ22616388 A NZ 22616388A NZ 226163 A NZ226163 A NZ 226163A
Authority
NZ
New Zealand
Prior art keywords
solubilisers
polyol
pharmaceutical
fatty acid
water soluble
Prior art date
Application number
NZ226163A
Other languages
English (en)
Inventor
Lorenz Hahn
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of NZ226163A publication Critical patent/NZ226163A/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NZ226163A 1987-09-15 1988-09-13 Pharmaceutical excipients comprising water soluble monoesters of a fatty acid and a polyol as solubilisers of pharmaceutical agents NZ226163A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3730909 1987-09-15
DE3802355 1988-01-27

Publications (1)

Publication Number Publication Date
NZ226163A true NZ226163A (en) 1991-08-27

Family

ID=25859774

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ226163A NZ226163A (en) 1987-09-15 1988-09-13 Pharmaceutical excipients comprising water soluble monoesters of a fatty acid and a polyol as solubilisers of pharmaceutical agents

Country Status (24)

Country Link
JP (1) JP3090666B2 (hu)
KR (1) KR0131084B1 (hu)
AT (1) AT395819B (hu)
AU (1) AU628787B2 (hu)
BE (1) BE1001204A5 (hu)
CA (1) CA1338775C (hu)
CH (1) CH683672A5 (hu)
DK (1) DK175132B1 (hu)
ES (1) ES2012118A6 (hu)
FI (1) FI94837C (hu)
FR (1) FR2620336B1 (hu)
GB (1) GB2209671B (hu)
GR (1) GR1002243B (hu)
HU (1) HU205010B (hu)
IE (1) IE61195B1 (hu)
IL (1) IL87746A (hu)
IT (1) IT1224886B (hu)
LU (1) LU87335A1 (hu)
MY (1) MY103769A (hu)
NL (1) NL195094C (hu)
NO (1) NO179434C (hu)
NZ (1) NZ226163A (hu)
PT (1) PT88492B (hu)
SE (1) SE503279C2 (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GR1000466B (el) * 1989-01-28 1992-07-30 Sandoz Ag Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης.
CH679277A5 (hu) * 1989-02-09 1992-01-31 Sandoz Ag
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
SG45449A1 (en) 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions
ES2168271T3 (es) 1992-09-25 2002-06-16 Novartis Ag Composiciones farmaceuticas que contienen ciclosporinas.
DE69426408T2 (de) 1993-09-28 2001-07-12 Scherer Gmbh R P Herstellung von Weichgelatinekapseln
PT789580E (pt) 1994-11-03 2002-09-30 Novartis Ag Formulacoes de ciclosporina para administracao oral com composicao simples e alta biodisponibilidade e processo para a sua producao
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
DE19549852B4 (de) 1995-11-29 2009-06-04 Novartis Ag Cyclosporin enthaltende Präparate
TW414696B (en) * 1996-07-01 2000-12-11 Mitsubishi Kagaku Foods Kk Anti-bacteria agent
CZ295207B6 (cs) 1997-01-30 2005-06-15 Novartis Ag Tvrdá želatinová tobolka obsahující cyklosporin A
GB2326337A (en) * 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
WO2005037252A1 (en) * 2003-10-14 2005-04-28 Wockhardt Limited Sterile gelling agents
JP5422871B2 (ja) * 2006-10-24 2014-02-19 不二製油株式会社 イソフラボン類組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE624258A (hu) * 1961-10-31
GB1134878A (en) * 1966-05-12 1968-11-27 Suga Kazuo Improvements in and relating to oryzanol solutions and compositions
FR5986M (hu) * 1966-11-22 1968-06-21
BE787842A (fr) * 1971-08-25 1972-12-18 Sumito Chemical Cy Ltd Procede de preparation d'une suspension aqueuse de cristaux stables du type non beta d'esters d'acides gras superieurs du chloramphenicol
JPS53107408A (en) * 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
SE445174B (sv) * 1978-03-07 1986-06-09 Sandoz Ag Farmaceutisk komposition innehallande en cyklosporin och en berarsubstans
JPS57128634A (en) * 1981-02-03 1982-08-10 Eisai Co Ltd Elastase-containing compound increasing absorption
EP0179583A1 (en) * 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs
JPS61280435A (ja) * 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤

Also Published As

Publication number Publication date
NO884052D0 (no) 1988-09-13
BE1001204A5 (fr) 1989-08-16
GB8821443D0 (en) 1988-10-12
IE882772L (en) 1989-03-15
JPH01151526A (ja) 1989-06-14
IT8848349A0 (it) 1988-09-14
AU628787B2 (en) 1992-09-24
DK511188D0 (da) 1988-09-14
NO884052L (no) 1989-03-16
GR1002243B (en) 1996-04-22
GR880100602A (el) 1989-06-22
SE8803221L (sv) 1989-03-16
HUT49494A (en) 1989-10-30
FR2620336B1 (fr) 1991-10-25
SE503279C2 (sv) 1996-05-13
AU2217288A (en) 1989-04-27
LU87335A1 (fr) 1989-04-06
FR2620336A1 (fr) 1989-03-17
ES2012118A6 (es) 1990-03-01
DK175132B1 (da) 2004-06-14
JP3090666B2 (ja) 2000-09-25
AT395819B (de) 1993-03-25
GB2209671B (en) 1991-11-13
HU205010B (en) 1992-03-30
NO179434C (no) 1996-10-09
IL87746A (en) 1992-07-15
NL8802275A (nl) 1989-04-03
IL87746A0 (en) 1989-02-28
KR0131084B1 (ko) 1998-04-17
GB2209671A (en) 1989-05-24
ATA224988A (de) 1992-08-15
FI94837B (fi) 1995-07-31
IT1224886B (it) 1990-10-24
CA1338775C (en) 1996-12-10
PT88492A (pt) 1988-10-01
CH683672A5 (de) 1994-04-29
FI884192A (fi) 1989-03-16
DK511188A (da) 1989-03-16
PT88492B (pt) 1993-03-31
FI884192A0 (fi) 1988-09-13
NL195094C (nl) 2003-12-17
SE8803221D0 (sv) 1988-09-13
KR890004694A (ko) 1989-05-09
FI94837C (fi) 1995-11-10
MY103769A (en) 1993-09-30
IE61195B1 (en) 1994-10-19
NO179434B (no) 1996-07-01

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Legal Events

Date Code Title Description
RENW Renewal (renewal fees accepted)
ERR Error or correction

Free format text: THE OWNER HAS BEEN CORRECTED TO 890887, NOVARTIS AG, LICHTSTRASSE 35, CH-4056 BASEL, CH

Effective date: 20140409