NZ225706A - 2-((4-piperidyl)methyl)-1,2,3,4-tetrahydro-9h-pyrido(3,4-b) indole derivatives and their preparation - Google Patents

2-((4-piperidyl)methyl)-1,2,3,4-tetrahydro-9h-pyrido(3,4-b) indole derivatives and their preparation

Info

Publication number
NZ225706A
NZ225706A NZ225706A NZ22570688A NZ225706A NZ 225706 A NZ225706 A NZ 225706A NZ 225706 A NZ225706 A NZ 225706A NZ 22570688 A NZ22570688 A NZ 22570688A NZ 225706 A NZ225706 A NZ 225706A
Authority
NZ
New Zealand
Prior art keywords
compound
formula
group
tetrahydro
pyrido
Prior art date
Application number
NZ225706A
Other languages
English (en)
Inventor
Mireille Sevrin
Jacques Menin
Pascal George
Claude Morel
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of NZ225706A publication Critical patent/NZ225706A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ225706A 1987-08-07 1988-08-05 2-((4-piperidyl)methyl)-1,2,3,4-tetrahydro-9h-pyrido(3,4-b) indole derivatives and their preparation NZ225706A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8711291A FR2619111B1 (fr) 1987-08-07 1987-08-07 Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
NZ225706A true NZ225706A (en) 1990-04-26

Family

ID=9354027

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ225706A NZ225706A (en) 1987-08-07 1988-08-05 2-((4-piperidyl)methyl)-1,2,3,4-tetrahydro-9h-pyrido(3,4-b) indole derivatives and their preparation

Country Status (17)

Country Link
US (1) US4977159A (OSRAM)
EP (1) EP0302788B1 (OSRAM)
JP (1) JPS6466185A (OSRAM)
KR (1) KR890003756A (OSRAM)
AT (1) ATE72436T1 (OSRAM)
AU (1) AU597188B2 (OSRAM)
DE (1) DE3868301D1 (OSRAM)
DK (1) DK437788A (OSRAM)
FI (1) FI883669A7 (OSRAM)
FR (1) FR2619111B1 (OSRAM)
GR (1) GR3003920T3 (OSRAM)
HU (1) HU198931B (OSRAM)
IL (1) IL87343A0 (OSRAM)
NO (1) NO166129C (OSRAM)
NZ (1) NZ225706A (OSRAM)
PT (1) PT88206B (OSRAM)
ZA (1) ZA885788B (OSRAM)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978669A (en) * 1989-06-08 1990-12-18 Neurex Corporation Method of suppressing appetite by administration of tetrahydro-beta-carboline derivatives
US5102889B1 (en) * 1990-09-27 1993-05-11 2-(4-piperidinyl)-1h-pyrido(4,3-b)indol-1-ones and related compounds
US5229517A (en) * 1990-09-27 1993-07-20 Hoechst-Roussel Pharmaceuticals Incorporated 2-(4-Piperindinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds
US5455254A (en) * 1991-02-15 1995-10-03 Mondadori; Cesare Substituted benzofuranylpiperidine as a nootropic agent
RU2095339C1 (ru) * 1991-10-17 1997-11-10 Циба-Гейги АГ Производные гидрохинона в свободном виде или в виде соли, способы их получения, производные пиперидина и способы их получения
US5693807A (en) * 1992-10-14 1997-12-02 Ciba-Geigy Corporation Substituted hydroquinone derivatives
FR2715659B1 (fr) * 1994-02-03 1996-03-22 Synthelabo Dérivés de 3-(2-aminoéthyl)-4-[3-(trifluorométhyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine, leur préparation et leur application en thérapeutique.
CN1109880A (zh) * 1994-02-03 1995-10-11 合成实验室公司 3-(2-氨基乙基)-4-[3-(三氟甲基)苯甲酰基]-3，4-二氢-2h-1，4-苯并噁嗪衍生物、制备及其应用
AU3831495A (en) * 1994-10-20 1996-05-15 American Home Products Corporation Indole derivatives useful as serotonergic agents
US6255302B1 (en) 1998-12-17 2001-07-03 American Home Products Corporation 1,4-piperazine derivatives
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
BRPI0014470B1 (pt) * 1999-10-08 2016-08-23 Affinium Pharm Inc compostos inibidores de fab i, composição farmacêutica, processo de preparação dos compostos e uso dos compostos para a produção de medicamento para tratamento de infecções bacterianas
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6730684B1 (en) 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
SK287188B6 (sk) 1999-12-10 2010-02-08 Pfizer Products Inc. Pyrolo [2,3-d]pyrimidínová zlúčenina, jej použitie a farmaceutická kompozícia alebo kombinácia s jej obsahom
WO2003088897A2 (en) 2001-04-06 2003-10-30 Affinium Pharmaceuticals, Inc. Fab i inhibitors
AU2002360561A1 (en) * 2001-12-11 2003-06-23 Sepracor, Inc. 4-substituted piperidines, and methods of use thereof
RU2309147C9 (ru) * 2002-11-21 2008-03-20 Пфайзер Продактс Инк. Производные 3-аминопиперидина и способы их получения
US7790709B2 (en) 2002-12-06 2010-09-07 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
WO2004082586A2 (en) 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
US20060273819A1 (en) * 2003-04-29 2006-12-07 Timothy Opperman Antibiotic tetrahydro-beta-carboline derivatives
US8450307B2 (en) 2004-06-04 2013-05-28 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
EP3255045A1 (en) 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
BR122021020778B1 (pt) 2012-06-19 2022-07-12 Debiopharm International Sa Derivados de pró-fármaco de (e)-n-metil-n-((3-metilbenzofuran-2-il) metil)-3-(7-oxo-5,6,7,8-tetraidro- 1, 8- naftirindin-3-il) acrilamida
HUE052140T2 (hu) 2016-02-26 2021-04-28 Debiopharm Int Sa Diabéteszes lábfertõzések kezelésére szolgáló gyógyszer
PL3923914T3 (pl) 2019-02-14 2023-08-07 Debiopharm International S.A. Preparat afabicyny, sposób jego wytwarzania
WO2020249731A1 (en) 2019-06-14 2020-12-17 Debiopharm International S.A. Afabicin for use for treating bacterial infections involving biofilm

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539407A (en) * 1983-12-13 1985-09-03 American Home Products Corporation β-Carboline anticonvulsants
US4663456A (en) * 1985-09-16 1987-05-05 American Home Products Corporation 2-(substituted piperazinylalkyl)β-carbolines useful in treatment of psychological disorders

Also Published As

Publication number Publication date
NO883487D0 (no) 1988-08-05
IL87343A0 (en) 1989-01-31
ZA885788B (en) 1989-04-26
NO883487L (no) 1989-02-08
DK437788D0 (da) 1988-08-05
NO166129C (no) 1991-06-05
NO166129B (no) 1991-02-25
ATE72436T1 (de) 1992-02-15
GR3003920T3 (OSRAM) 1993-03-16
FI883669A0 (fi) 1988-08-05
HUT48242A (en) 1989-05-29
DE3868301D1 (de) 1992-03-19
AU2044588A (en) 1989-02-09
FI883669A7 (fi) 1989-02-08
AU597188B2 (en) 1990-05-24
JPS6466185A (en) 1989-03-13
US4977159A (en) 1990-12-11
HU198931B (en) 1989-12-28
FR2619111B1 (fr) 1991-01-11
PT88206A (pt) 1989-06-30
EP0302788A1 (fr) 1989-02-08
EP0302788B1 (fr) 1992-02-05
DK437788A (da) 1989-02-07
KR890003756A (ko) 1989-04-17
FR2619111A1 (fr) 1989-02-10
PT88206B (pt) 1995-05-04

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