ATE72436T1 - 2-(methyl(4-piperidinyl)>-1,2,3,4-tetrahydro-9h pyrido(3,4-b>indolderivate, ihre herstellung und therapeutische verwendung. - Google Patents
2-(methyl(4-piperidinyl)>-1,2,3,4-tetrahydro-9h pyrido(3,4-b>indolderivate, ihre herstellung und therapeutische verwendung.Info
- Publication number
- ATE72436T1 ATE72436T1 AT88402024T AT88402024T ATE72436T1 AT E72436 T1 ATE72436 T1 AT E72436T1 AT 88402024 T AT88402024 T AT 88402024T AT 88402024 T AT88402024 T AT 88402024T AT E72436 T1 ATE72436 T1 AT E72436T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- denotes
- formula
- indolderivates
- pyrido
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 101100496169 Arabidopsis thaliana CLH1 gene Proteins 0.000 abstract 1
- 101100044057 Mesocricetus auratus SYCP3 gene Proteins 0.000 abstract 1
- 101100080600 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nse6 gene Proteins 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005099 aryl alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 101150111293 cor-1 gene Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8711291A FR2619111B1 (fr) | 1987-08-07 | 1987-08-07 | Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique |
| EP88402024A EP0302788B1 (fr) | 1987-08-07 | 1988-08-03 | Dérivés de [(pipéridinyl-4)méthyl]-2 tétrahydro-1,2,3,4 9H-pyrido[3,4-b]indole, leur préparation et leur application en thérapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE72436T1 true ATE72436T1 (de) | 1992-02-15 |
Family
ID=9354027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88402024T ATE72436T1 (de) | 1987-08-07 | 1988-08-03 | 2-(methyl(4-piperidinyl)>-1,2,3,4-tetrahydro-9h pyrido(3,4-b>indolderivate, ihre herstellung und therapeutische verwendung. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4977159A (OSRAM) |
| EP (1) | EP0302788B1 (OSRAM) |
| JP (1) | JPS6466185A (OSRAM) |
| KR (1) | KR890003756A (OSRAM) |
| AT (1) | ATE72436T1 (OSRAM) |
| AU (1) | AU597188B2 (OSRAM) |
| DE (1) | DE3868301D1 (OSRAM) |
| DK (1) | DK437788A (OSRAM) |
| FI (1) | FI883669A7 (OSRAM) |
| FR (1) | FR2619111B1 (OSRAM) |
| GR (1) | GR3003920T3 (OSRAM) |
| HU (1) | HU198931B (OSRAM) |
| IL (1) | IL87343A0 (OSRAM) |
| NO (1) | NO166129C (OSRAM) |
| NZ (1) | NZ225706A (OSRAM) |
| PT (1) | PT88206B (OSRAM) |
| ZA (1) | ZA885788B (OSRAM) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4978669A (en) * | 1989-06-08 | 1990-12-18 | Neurex Corporation | Method of suppressing appetite by administration of tetrahydro-beta-carboline derivatives |
| US5102889B1 (en) * | 1990-09-27 | 1993-05-11 | 2-(4-piperidinyl)-1h-pyrido(4,3-b)indol-1-ones and related compounds | |
| US5229517A (en) * | 1990-09-27 | 1993-07-20 | Hoechst-Roussel Pharmaceuticals Incorporated | 2-(4-Piperindinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds |
| US5455254A (en) * | 1991-02-15 | 1995-10-03 | Mondadori; Cesare | Substituted benzofuranylpiperidine as a nootropic agent |
| RU2095339C1 (ru) * | 1991-10-17 | 1997-11-10 | Циба-Гейги АГ | Производные гидрохинона в свободном виде или в виде соли, способы их получения, производные пиперидина и способы их получения |
| US5693807A (en) * | 1992-10-14 | 1997-12-02 | Ciba-Geigy Corporation | Substituted hydroquinone derivatives |
| FR2715659B1 (fr) * | 1994-02-03 | 1996-03-22 | Synthelabo | Dérivés de 3-(2-aminoéthyl)-4-[3-(trifluorométhyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine, leur préparation et leur application en thérapeutique. |
| CN1109880A (zh) * | 1994-02-03 | 1995-10-11 | 合成实验室公司 | 3-(2-氨基乙基)-4-[3-(三氟甲基)苯甲酰基]-3，4-二氢-2h-1，4-苯并噁嗪衍生物、制备及其应用 |
| AU3831495A (en) * | 1994-10-20 | 1996-05-15 | American Home Products Corporation | Indole derivatives useful as serotonergic agents |
| US6255302B1 (en) | 1998-12-17 | 2001-07-03 | American Home Products Corporation | 1,4-piperazine derivatives |
| CO5180550A1 (es) | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| AR024158A1 (es) | 1999-06-01 | 2002-09-04 | Smithkline Beecham Corp | Compuestos antibacterianos |
| BRPI0014470B1 (pt) * | 1999-10-08 | 2016-08-23 | Affinium Pharm Inc | compostos inibidores de fab i, composição farmacêutica, processo de preparação dos compostos e uso dos compostos para a produção de medicamento para tratamento de infecções bacterianas |
| US6762201B1 (en) | 1999-10-08 | 2004-07-13 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| US6730684B1 (en) | 1999-10-08 | 2004-05-04 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| SK287188B6 (sk) | 1999-12-10 | 2010-02-08 | Pfizer Products Inc. | Pyrolo [2,3-d]pyrimidínová zlúčenina, jej použitie a farmaceutická kompozícia alebo kombinácia s jej obsahom |
| WO2003088897A2 (en) | 2001-04-06 | 2003-10-30 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| AU2002360561A1 (en) * | 2001-12-11 | 2003-06-23 | Sepracor, Inc. | 4-substituted piperidines, and methods of use thereof |
| RU2309147C9 (ru) * | 2002-11-21 | 2008-03-20 | Пфайзер Продактс Инк. | Производные 3-аминопиперидина и способы их получения |
| US7790709B2 (en) | 2002-12-06 | 2010-09-07 | Affinium Pharmaceuticals, Inc. | Heterocyclic compounds, methods of making them and their use in therapy |
| WO2004082586A2 (en) | 2003-03-17 | 2004-09-30 | Affinium Pharmaceuticals, Inc. | Phamaceutical compositions comprising inhibitors of fab i and further antibiotics |
| US20060273819A1 (en) * | 2003-04-29 | 2006-12-07 | Timothy Opperman | Antibiotic tetrahydro-beta-carboline derivatives |
| US8450307B2 (en) | 2004-06-04 | 2013-05-28 | Affinium Pharmaceuticals, Inc. | Therapeutic agents, and methods of making and using the same |
| WO2008009122A1 (en) | 2006-07-20 | 2008-01-24 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as fab i inhibitors |
| EP3255045A1 (en) | 2007-02-16 | 2017-12-13 | Debiopharm International SA | Salts, prodrugs and polymorphs of fab i inhibitors |
| BR122021020778B1 (pt) | 2012-06-19 | 2022-07-12 | Debiopharm International Sa | Derivados de pró-fármaco de (e)-n-metil-n-((3-metilbenzofuran-2-il) metil)-3-(7-oxo-5,6,7,8-tetraidro- 1, 8- naftirindin-3-il) acrilamida |
| HUE052140T2 (hu) | 2016-02-26 | 2021-04-28 | Debiopharm Int Sa | Diabéteszes lábfertõzések kezelésére szolgáló gyógyszer |
| PL3923914T3 (pl) | 2019-02-14 | 2023-08-07 | Debiopharm International S.A. | Preparat afabicyny, sposób jego wytwarzania |
| WO2020249731A1 (en) | 2019-06-14 | 2020-12-17 | Debiopharm International S.A. | Afabicin for use for treating bacterial infections involving biofilm |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4539407A (en) * | 1983-12-13 | 1985-09-03 | American Home Products Corporation | β-Carboline anticonvulsants |
| US4663456A (en) * | 1985-09-16 | 1987-05-05 | American Home Products Corporation | 2-(substituted piperazinylalkyl)β-carbolines useful in treatment of psychological disorders |
-
1987
- 1987-08-07 FR FR8711291A patent/FR2619111B1/fr not_active Expired - Fee Related
-
1988
- 1988-08-03 AT AT88402024T patent/ATE72436T1/de not_active IP Right Cessation
- 1988-08-03 DE DE8888402024T patent/DE3868301D1/de not_active Expired - Fee Related
- 1988-08-03 EP EP88402024A patent/EP0302788B1/fr not_active Expired - Lifetime
- 1988-08-04 IL IL87343A patent/IL87343A0/xx unknown
- 1988-08-05 PT PT88206A patent/PT88206B/pt not_active IP Right Cessation
- 1988-08-05 NZ NZ225706A patent/NZ225706A/en unknown
- 1988-08-05 ZA ZA885788A patent/ZA885788B/xx unknown
- 1988-08-05 HU HU884105A patent/HU198931B/hu not_active IP Right Cessation
- 1988-08-05 US US07/228,751 patent/US4977159A/en not_active Expired - Fee Related
- 1988-08-05 KR KR1019880010017A patent/KR890003756A/ko not_active Withdrawn
- 1988-08-05 FI FI883669A patent/FI883669A7/fi not_active Application Discontinuation
- 1988-08-05 DK DK437788A patent/DK437788A/da not_active Application Discontinuation
- 1988-08-05 JP JP63197011A patent/JPS6466185A/ja active Pending
- 1988-08-05 NO NO883487A patent/NO166129C/no unknown
- 1988-08-05 AU AU20445/88A patent/AU597188B2/en not_active Ceased
-
1992
- 1992-02-27 GR GR920400343T patent/GR3003920T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO883487D0 (no) | 1988-08-05 |
| IL87343A0 (en) | 1989-01-31 |
| ZA885788B (en) | 1989-04-26 |
| NO883487L (no) | 1989-02-08 |
| DK437788D0 (da) | 1988-08-05 |
| NO166129C (no) | 1991-06-05 |
| NO166129B (no) | 1991-02-25 |
| GR3003920T3 (OSRAM) | 1993-03-16 |
| FI883669A0 (fi) | 1988-08-05 |
| HUT48242A (en) | 1989-05-29 |
| DE3868301D1 (de) | 1992-03-19 |
| AU2044588A (en) | 1989-02-09 |
| FI883669A7 (fi) | 1989-02-08 |
| AU597188B2 (en) | 1990-05-24 |
| JPS6466185A (en) | 1989-03-13 |
| US4977159A (en) | 1990-12-11 |
| HU198931B (en) | 1989-12-28 |
| FR2619111B1 (fr) | 1991-01-11 |
| PT88206A (pt) | 1989-06-30 |
| EP0302788A1 (fr) | 1989-02-08 |
| EP0302788B1 (fr) | 1992-02-05 |
| DK437788A (da) | 1989-02-07 |
| KR890003756A (ko) | 1989-04-17 |
| FR2619111A1 (fr) | 1989-02-10 |
| PT88206B (pt) | 1995-05-04 |
| NZ225706A (en) | 1990-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |