KR890003756A - 2-[(4- 피페리딜)메틸]-1,2,3,4- 테트라히드로-9H-피리도[3,4-b] 인돌 유도체, 그의 제법 및 그의 치료에의 이용 - Google Patents

2-[(4- 피페리딜)메틸]-1,2,3,4- 테트라히드로-9H-피리도[3,4-b] 인돌 유도체, 그의 제법 및 그의 치료에의 이용 Download PDF

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Publication number
KR890003756A
KR890003756A KR1019880010017A KR880010017A KR890003756A KR 890003756 A KR890003756 A KR 890003756A KR 1019880010017 A KR1019880010017 A KR 1019880010017A KR 880010017 A KR880010017 A KR 880010017A KR 890003756 A KR890003756 A KR 890003756A
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KR
South Korea
Prior art keywords
group
general formula
formula
compound
pyrido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019880010017A
Other languages
English (en)
Korean (ko)
Inventor
세브랑 미레이유
조르지 파스칼
메낭 쟉끄
모렐 클로드
Original Assignee
에 뚜레 레메뜨르
신떼라보 소시에떼 아노님
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에 뚜레 레메뜨르, 신떼라보 소시에떼 아노님 filed Critical 에 뚜레 레메뜨르
Publication of KR890003756A publication Critical patent/KR890003756A/ko
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019880010017A 1987-08-07 1988-08-05 2-[(4- 피페리딜)메틸]-1,2,3,4- 테트라히드로-9H-피리도[3,4-b] 인돌 유도체, 그의 제법 및 그의 치료에의 이용 Withdrawn KR890003756A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8711291A FR2619111B1 (fr) 1987-08-07 1987-08-07 Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
FR8711291 1987-08-07

Publications (1)

Publication Number Publication Date
KR890003756A true KR890003756A (ko) 1989-04-17

Family

ID=9354027

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880010017A Withdrawn KR890003756A (ko) 1987-08-07 1988-08-05 2-[(4- 피페리딜)메틸]-1,2,3,4- 테트라히드로-9H-피리도[3,4-b] 인돌 유도체, 그의 제법 및 그의 치료에의 이용

Country Status (17)

Country Link
US (1) US4977159A (OSRAM)
EP (1) EP0302788B1 (OSRAM)
JP (1) JPS6466185A (OSRAM)
KR (1) KR890003756A (OSRAM)
AT (1) ATE72436T1 (OSRAM)
AU (1) AU597188B2 (OSRAM)
DE (1) DE3868301D1 (OSRAM)
DK (1) DK437788A (OSRAM)
FI (1) FI883669A7 (OSRAM)
FR (1) FR2619111B1 (OSRAM)
GR (1) GR3003920T3 (OSRAM)
HU (1) HU198931B (OSRAM)
IL (1) IL87343A0 (OSRAM)
NO (1) NO166129C (OSRAM)
NZ (1) NZ225706A (OSRAM)
PT (1) PT88206B (OSRAM)
ZA (1) ZA885788B (OSRAM)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978669A (en) * 1989-06-08 1990-12-18 Neurex Corporation Method of suppressing appetite by administration of tetrahydro-beta-carboline derivatives
US5102889B1 (en) * 1990-09-27 1993-05-11 2-(4-piperidinyl)-1h-pyrido(4,3-b)indol-1-ones and related compounds
US5229517A (en) * 1990-09-27 1993-07-20 Hoechst-Roussel Pharmaceuticals Incorporated 2-(4-Piperindinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds
US5455254A (en) * 1991-02-15 1995-10-03 Mondadori; Cesare Substituted benzofuranylpiperidine as a nootropic agent
RU2095339C1 (ru) * 1991-10-17 1997-11-10 Циба-Гейги АГ Производные гидрохинона в свободном виде или в виде соли, способы их получения, производные пиперидина и способы их получения
US5693807A (en) * 1992-10-14 1997-12-02 Ciba-Geigy Corporation Substituted hydroquinone derivatives
FR2715659B1 (fr) * 1994-02-03 1996-03-22 Synthelabo Dérivés de 3-(2-aminoéthyl)-4-[3-(trifluorométhyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine, leur préparation et leur application en thérapeutique.
CN1109880A (zh) * 1994-02-03 1995-10-11 合成实验室公司 3-(2-氨基乙基)-4-[3-(三氟甲基)苯甲酰基]-3，4-二氢-2h-1，4-苯并噁嗪衍生物、制备及其应用
AU3831495A (en) * 1994-10-20 1996-05-15 American Home Products Corporation Indole derivatives useful as serotonergic agents
US6255302B1 (en) 1998-12-17 2001-07-03 American Home Products Corporation 1,4-piperazine derivatives
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
BRPI0014470B1 (pt) * 1999-10-08 2016-08-23 Affinium Pharm Inc compostos inibidores de fab i, composição farmacêutica, processo de preparação dos compostos e uso dos compostos para a produção de medicamento para tratamento de infecções bacterianas
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6730684B1 (en) 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
SK287188B6 (sk) 1999-12-10 2010-02-08 Pfizer Products Inc. Pyrolo [2,3-d]pyrimidínová zlúčenina, jej použitie a farmaceutická kompozícia alebo kombinácia s jej obsahom
WO2003088897A2 (en) 2001-04-06 2003-10-30 Affinium Pharmaceuticals, Inc. Fab i inhibitors
AU2002360561A1 (en) * 2001-12-11 2003-06-23 Sepracor, Inc. 4-substituted piperidines, and methods of use thereof
RU2309147C9 (ru) * 2002-11-21 2008-03-20 Пфайзер Продактс Инк. Производные 3-аминопиперидина и способы их получения
US7790709B2 (en) 2002-12-06 2010-09-07 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
WO2004082586A2 (en) 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
US20060273819A1 (en) * 2003-04-29 2006-12-07 Timothy Opperman Antibiotic tetrahydro-beta-carboline derivatives
US8450307B2 (en) 2004-06-04 2013-05-28 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
EP3255045A1 (en) 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
BR122021020778B1 (pt) 2012-06-19 2022-07-12 Debiopharm International Sa Derivados de pró-fármaco de (e)-n-metil-n-((3-metilbenzofuran-2-il) metil)-3-(7-oxo-5,6,7,8-tetraidro- 1, 8- naftirindin-3-il) acrilamida
HUE052140T2 (hu) 2016-02-26 2021-04-28 Debiopharm Int Sa Diabéteszes lábfertõzések kezelésére szolgáló gyógyszer
PL3923914T3 (pl) 2019-02-14 2023-08-07 Debiopharm International S.A. Preparat afabicyny, sposób jego wytwarzania
WO2020249731A1 (en) 2019-06-14 2020-12-17 Debiopharm International S.A. Afabicin for use for treating bacterial infections involving biofilm

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539407A (en) * 1983-12-13 1985-09-03 American Home Products Corporation β-Carboline anticonvulsants
US4663456A (en) * 1985-09-16 1987-05-05 American Home Products Corporation 2-(substituted piperazinylalkyl)β-carbolines useful in treatment of psychological disorders

Also Published As

Publication number Publication date
NO883487D0 (no) 1988-08-05
IL87343A0 (en) 1989-01-31
ZA885788B (en) 1989-04-26
NO883487L (no) 1989-02-08
DK437788D0 (da) 1988-08-05
NO166129C (no) 1991-06-05
NO166129B (no) 1991-02-25
ATE72436T1 (de) 1992-02-15
GR3003920T3 (OSRAM) 1993-03-16
FI883669A0 (fi) 1988-08-05
HUT48242A (en) 1989-05-29
DE3868301D1 (de) 1992-03-19
AU2044588A (en) 1989-02-09
FI883669A7 (fi) 1989-02-08
AU597188B2 (en) 1990-05-24
JPS6466185A (en) 1989-03-13
US4977159A (en) 1990-12-11
HU198931B (en) 1989-12-28
FR2619111B1 (fr) 1991-01-11
PT88206A (pt) 1989-06-30
EP0302788A1 (fr) 1989-02-08
EP0302788B1 (fr) 1992-02-05
DK437788A (da) 1989-02-07
FR2619111A1 (fr) 1989-02-10
PT88206B (pt) 1995-05-04
NZ225706A (en) 1990-04-26

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PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19880805

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid