NO994177L - Atropisomere av 3-aryl-4(3H)-kinazoloner og deres anvendelse som AMPA-reseptor-antagonister - Google Patents

Atropisomere av 3-aryl-4(3H)-kinazoloner og deres anvendelse som AMPA-reseptor-antagonister

Info

Publication number
NO994177L
NO994177L NO994177A NO994177A NO994177L NO 994177 L NO994177 L NO 994177L NO 994177 A NO994177 A NO 994177A NO 994177 A NO994177 A NO 994177A NO 994177 L NO994177 L NO 994177L
Authority
NO
Norway
Prior art keywords
quinazolones
atropisomers
aryl
receptor antagonists
ampa receptor
Prior art date
Application number
NO994177A
Other languages
English (en)
Other versions
NO994177D0 (no
NO313630B1 (no
Inventor
Keith Michael Devries
Jr Willard Mckowan Welch
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO994177D0 publication Critical patent/NO994177D0/no
Publication of NO994177L publication Critical patent/NO994177L/no
Publication of NO313630B1 publication Critical patent/NO313630B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/91Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO19994177A 1997-02-28 1999-08-27 Atropisomere av 3-aryl-4(3H)-kinazolinoner og deres anvendelse samt farmasöytisk blanding NO313630B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3890597P 1997-02-28 1997-02-28
PCT/IB1998/000150 WO1998038173A1 (en) 1997-02-28 1998-02-06 Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as ampa-receptor antagonists

Publications (3)

Publication Number Publication Date
NO994177D0 NO994177D0 (no) 1999-08-27
NO994177L true NO994177L (no) 1999-08-27
NO313630B1 NO313630B1 (no) 2002-11-04

Family

ID=21902563

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19994177A NO313630B1 (no) 1997-02-28 1999-08-27 Atropisomere av 3-aryl-4(3H)-kinazolinoner og deres anvendelse samt farmasöytisk blanding

Country Status (40)

Country Link
US (1) US6306864B1 (no)
EP (1) EP0968194B1 (no)
JP (1) JP2000509731A (no)
KR (1) KR100358636B1 (no)
CN (1) CN1248248A (no)
AP (1) AP859A (no)
AR (1) AR011170A1 (no)
AT (1) ATE267817T1 (no)
AU (1) AU744028B2 (no)
BG (1) BG103689A (no)
BR (1) BR9807872A (no)
CA (1) CA2282277C (no)
DE (1) DE69824157T2 (no)
DK (1) DK0968194T3 (no)
DZ (1) DZ2440A1 (no)
EA (1) EA001963B1 (no)
ES (1) ES2219866T3 (no)
GT (1) GT199800038A (no)
HR (1) HRP980106A2 (no)
HU (1) HUP0000914A3 (no)
ID (1) ID22711A (no)
IL (1) IL130900A0 (no)
IS (1) IS1952B (no)
MA (1) MA24484A1 (no)
NO (1) NO313630B1 (no)
NZ (1) NZ336628A (no)
OA (1) OA11089A (no)
PA (1) PA8447001A1 (no)
PE (1) PE58399A1 (no)
PL (1) PL335418A1 (no)
PT (1) PT968194E (no)
SK (1) SK113299A3 (no)
TN (1) TNSN98035A1 (no)
TR (1) TR199902093T2 (no)
TW (1) TW504508B (no)
UA (1) UA61097C2 (no)
UY (1) UY24897A1 (no)
WO (1) WO1998038173A1 (no)
YU (1) YU41299A (no)
ZA (1) ZA981666B (no)

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EP0901487B9 (en) 1996-05-15 2004-09-29 Pfizer Inc. 2,3,6 trisubstituted-4(3h)-quinazolinones
US6323208B1 (en) * 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
JPH11279158A (ja) * 1998-02-09 1999-10-12 Pfizer Prod Inc キナゾリン―4―オン誘導体の製造方法
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
ES2527754T3 (es) * 2000-04-25 2015-01-29 Icos Corporation Inhibidores de la isoforma delta de la fosfatidilinositol 3-quinasa humana
NZ522773A (en) 2000-06-12 2005-06-24 Eisai Co Ltd 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
SK287781B6 (sk) 2000-08-18 2011-09-05 Ajinomoto Co., Inc. Fenylalanínové deriváty, farmaceutický prípravok s ich obsahom a ich použitie
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
US6939968B2 (en) * 2002-12-23 2005-09-06 Bristol-Myers Squibb Company Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives
WO2005014585A1 (en) * 2003-08-08 2005-02-17 Ulysses Pharmaceutical Products Inc. Halogenated quinazolinyl nitrofurans as antibacterial agents
US20080146562A1 (en) * 2003-08-08 2008-06-19 Ulysses Pharmaceutical Products Inc., Halogenated quinazolinyl nitrofurans as antibacterial agents
GB0325390D0 (en) * 2003-10-30 2003-12-03 Novartis Ag Organic compounds
CN103784458B (zh) 2003-12-22 2015-10-14 味之素株式会社 苯基丙氨酸衍生物
PT3153514T (pt) 2004-05-13 2021-06-25 Icos Corp Quinazolinonas como inibidoras da fosfatidilinositol 3-quinase delta humana
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
GB0416730D0 (en) * 2004-07-27 2004-09-01 Novartis Ag Organic compounds
AU2006311883A1 (en) 2005-11-04 2007-05-18 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
CA2663436A1 (en) 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
WO2008140750A1 (en) * 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
CN101429166B (zh) * 2007-11-07 2013-08-21 上海特化医药科技有限公司 喹唑啉酮衍生物及其制备方法和用途
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
KR20170060179A (ko) 2008-11-13 2017-05-31 길리아드 칼리스토가 엘엘씨 혈액 종양에 대한 요법
PE20120602A1 (es) 2009-03-24 2012-05-21 Gilead Calistoga Llc ATROPISOMEROS DE 2-[(6-AMINO-9H-PURIN-9-IL)METIL]-5-METIL-3-o-TOLILQUINAZOLIN-4(3H)-ONA
BR112012001325A2 (pt) 2009-07-21 2017-05-02 Gilead Calistoga Llc tratamento de distúrbios do fígado com inibidaores de pi3k
MD20140100A2 (ro) 2012-03-05 2015-01-31 Gilead Calistoga Llc Forme polimorfe ale (S)-2-(1-(9H-purin-6-ilamino)propil)-5-fluoro-3-fenilchinazolin-4(3H)-onei
CN103275086B (zh) * 2013-05-30 2015-04-15 温州大学 一种6-取代喹唑啉并喹唑啉酮化合物及其合成方法和用途
ES2752552T3 (es) 2013-12-20 2020-04-06 Gilead Calistoga Llc Métodos de proceso para inhibidores de fosfatidilinositol 3-quinasa
AU2014364414A1 (en) 2013-12-20 2016-06-30 Gilead Calistoga Llc Polymorphic forms of a hydrochloride salt of (S) -2-(1-(9H-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3H) -one
US9533909B2 (en) 2014-03-31 2017-01-03 Corning Incorporated Methods and apparatus for material processing using atmospheric thermal plasma reactor
EP3154960A1 (en) 2014-06-13 2017-04-19 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
DE102014217021A1 (de) * 2014-08-27 2016-03-03 Skf Lubrication Systems Germany Ag Gehäuse für eine Vorrichtung zum dosierten Verteilen eines Mediums sowie eine Dosiereinrichtung zur Verwendung in dem Gehäuse
AU2019395288A1 (en) 2018-12-14 2021-09-23 Eisai R&D Management Co., Ltd. Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds
JP2023512664A (ja) 2020-01-29 2023-03-28 カマリ ファーマ リミテッド 皮膚障害の治療に使用するための化合物及び組成物

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DE1195321B (de) * 1962-03-16 1965-06-24 Troponwerke Dinklage & Co Verfahren zur Herstellung von substituierten Chinazolon-(4)-derivaten
DE1670416A1 (de) * 1966-12-30 1971-02-11 Chem Fab Von Heyden Gmbh Muenc Verfahren zur Herstellung von aminosubstituierten Chinazolinonderivaten
GB1298603A (en) * 1970-04-06 1972-12-06 Karamchand Premchand Private Quinazolinone derivatives
US4183931A (en) * 1977-09-08 1980-01-15 Research Corporation 2-Ketoalkyl-4(3H)-quinazolinones
GB9022785D0 (en) * 1990-10-19 1990-12-05 Merck Sharp & Dohme Therapeutic agents
WO1992013535A1 (en) * 1991-02-06 1992-08-20 Research Corporation Technologies, Inc. Anticonvulsant substituted quinazolones
US5777271A (en) * 1996-01-18 1998-07-07 Commscope, Inc. Cable having an at least partially oxidized armor layer
EP0901487B9 (en) * 1996-05-15 2004-09-29 Pfizer Inc. 2,3,6 trisubstituted-4(3h)-quinazolinones

Also Published As

Publication number Publication date
BG103689A (bg) 2000-11-30
PT968194E (pt) 2004-08-31
DK0968194T3 (da) 2004-08-16
IS1952B (is) 2004-10-13
UY24897A1 (es) 2000-12-29
DZ2440A1 (fr) 2003-01-11
KR100358636B1 (ko) 2002-10-31
IS5140A (is) 1999-07-30
AP9801199A0 (en) 1998-03-31
AU5676898A (en) 1998-09-18
EP0968194B1 (en) 2004-05-26
KR20000075814A (ko) 2000-12-26
GT199800038A (es) 1999-08-13
NO994177D0 (no) 1999-08-27
OA11089A (en) 2003-09-22
UA61097C2 (uk) 2003-11-17
EA001963B1 (ru) 2001-10-22
EP0968194A1 (en) 2000-01-05
EA199900693A1 (ru) 2000-02-28
JP2000509731A (ja) 2000-08-02
IL130900A0 (en) 2001-01-28
MA24484A1 (fr) 1998-10-01
NO313630B1 (no) 2002-11-04
DE69824157D1 (de) 2004-07-01
US6306864B1 (en) 2001-10-23
HUP0000914A3 (en) 2001-09-28
PE58399A1 (es) 1999-06-16
ZA981666B (en) 1999-08-27
WO1998038173A1 (en) 1998-09-03
AU744028B2 (en) 2002-02-14
TNSN98035A1 (fr) 2005-03-15
PL335418A1 (en) 2000-04-25
TR199902093T2 (xx) 1999-12-21
CA2282277C (en) 2005-10-11
SK113299A3 (en) 2001-05-10
CA2282277A1 (en) 1998-09-03
AR011170A1 (es) 2000-08-02
TW504508B (en) 2002-10-01
CN1248248A (zh) 2000-03-22
ATE267817T1 (de) 2004-06-15
PA8447001A1 (es) 2000-05-24
BR9807872A (pt) 2000-03-21
YU41299A (sh) 2002-09-19
DE69824157T2 (de) 2004-10-14
NZ336628A (en) 2001-03-30
AP859A (en) 2000-07-21
HUP0000914A2 (hu) 2001-04-28
ES2219866T3 (es) 2004-12-01
HRP980106A2 (en) 1999-02-28
ID22711A (id) 1999-12-09

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