HUP0000914A2 - 3-Aril-4 (3H)-kinazolinon-származékok atropizomerjei és ezeket a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

3-Aril-4 (3H)-kinazolinon-származékok atropizomerjei és ezeket a vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0000914A2
HUP0000914A2 HU0000914A HUP0000914A HUP0000914A2 HU P0000914 A2 HUP0000914 A2 HU P0000914A2 HU 0000914 A HU0000914 A HU 0000914A HU P0000914 A HUP0000914 A HU P0000914A HU P0000914 A2 HUP0000914 A2 HU P0000914A2
Authority
HU
Hungary
Prior art keywords
group
atropisomers
halogen atom
aryl
quinazolinones
Prior art date
Application number
HU0000914A
Other languages
English (en)
Inventor
Keith M. Devries
Willard McKowen Welch
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0000914A2 publication Critical patent/HUP0000914A2/hu
Publication of HUP0000914A3 publication Critical patent/HUP0000914A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

A találmány az (Ia) általános képletű vegyületek atropizomerjeirevonatkozik, amelyek AMPA-receptor-antagonistaként alkalmazhatók,különösen neurodegeneratív és központi idegrendszeri sérülésselkapcsolatos állapotok kezelésére és megelőzésére. A képletben R2 jelentése adott esetben helyettesített aril- vagyheteroarilcsoport, R5 jelentése alkilcsoport, halogénatom, trifluor-metil-csoport,alkoxicsoport vagy alkil-tio-csoport, R6, R7 és R8 jelentése hidrogénatom vagy halogénatom, és R3 jelentése hidrogén- vagy halogénatom, ciano-, nitro-, trifluor-metil-, alkil- vagy alkoxicsoport. A találmány tárgykörébe tartoznakaz ilyen vegyületeket tartalmazó gyógyszerkészítmények is. Ó
HU0000914A 1997-02-28 1998-02-06 Atropisomers of 3-aryl-4(3h)-quinazolinones and pharmaceutical compositions containing them HUP0000914A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3890597P 1997-02-28 1997-02-28
PCT/IB1998/000150 WO1998038173A1 (en) 1997-02-28 1998-02-06 Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as ampa-receptor antagonists

Publications (2)

Publication Number Publication Date
HUP0000914A2 true HUP0000914A2 (hu) 2001-04-28
HUP0000914A3 HUP0000914A3 (en) 2001-09-28

Family

ID=21902563

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000914A HUP0000914A3 (en) 1997-02-28 1998-02-06 Atropisomers of 3-aryl-4(3h)-quinazolinones and pharmaceutical compositions containing them

Country Status (40)

Country Link
US (1) US6306864B1 (hu)
EP (1) EP0968194B1 (hu)
JP (1) JP2000509731A (hu)
KR (1) KR100358636B1 (hu)
CN (1) CN1248248A (hu)
AP (1) AP859A (hu)
AR (1) AR011170A1 (hu)
AT (1) ATE267817T1 (hu)
AU (1) AU744028B2 (hu)
BG (1) BG103689A (hu)
BR (1) BR9807872A (hu)
CA (1) CA2282277C (hu)
DE (1) DE69824157T2 (hu)
DK (1) DK0968194T3 (hu)
DZ (1) DZ2440A1 (hu)
EA (1) EA001963B1 (hu)
ES (1) ES2219866T3 (hu)
GT (1) GT199800038A (hu)
HR (1) HRP980106A2 (hu)
HU (1) HUP0000914A3 (hu)
ID (1) ID22711A (hu)
IL (1) IL130900A0 (hu)
IS (1) IS1952B (hu)
MA (1) MA24484A1 (hu)
NO (1) NO313630B1 (hu)
NZ (1) NZ336628A (hu)
OA (1) OA11089A (hu)
PA (1) PA8447001A1 (hu)
PE (1) PE58399A1 (hu)
PL (1) PL335418A1 (hu)
PT (1) PT968194E (hu)
SK (1) SK113299A3 (hu)
TN (1) TNSN98035A1 (hu)
TR (1) TR199902093T2 (hu)
TW (1) TW504508B (hu)
UA (1) UA61097C2 (hu)
UY (1) UY24897A1 (hu)
WO (1) WO1998038173A1 (hu)
YU (1) YU41299A (hu)
ZA (1) ZA981666B (hu)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7345049B2 (en) 2003-12-22 2008-03-18 Ajinomoto Co., Inc. Phenylalanine derivatives
US7872125B2 (en) 2000-08-18 2011-01-18 Ajinomoto Co., Inc. Phenylalanine derivatives

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ295565B6 (cs) 1996-05-15 2005-08-17 Pfizer Inc. 2,3-Disubstituované 4(3H)-chinazolinony, jejich použití a farmaceutické kompozice na jejich bázi
US6323208B1 (en) * 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
JPH11279158A (ja) * 1998-02-09 1999-10-12 Pfizer Prod Inc キナゾリン―４―オン誘導体の製造方法
WO2001081346A2 (en) * 2000-04-25 2001-11-01 Icos Corporation Inhibitors of human phosphatidyl-inositol 3-kinase delta
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
NZ522773A (en) 2000-06-12 2005-06-24 Eisai Co Ltd 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
US6939968B2 (en) * 2002-12-23 2005-09-06 Bristol-Myers Squibb Company Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives
US20080146562A1 (en) * 2003-08-08 2008-06-19 Ulysses Pharmaceutical Products Inc., Halogenated quinazolinyl nitrofurans as antibacterial agents
US7410974B2 (en) * 2003-08-08 2008-08-12 Ulysses Pharmaceutical Products, Inc. Halogenated Quinazolinyl nitrofurans as antibacterial agents
GB0325390D0 (en) * 2003-10-30 2003-12-03 Novartis Ag Organic compounds
US7932260B2 (en) 2004-05-13 2011-04-26 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
GB0416730D0 (en) * 2004-07-27 2004-09-01 Novartis Ag Organic compounds
TWI409070B (zh) 2005-11-04 2013-09-21 Hydra Biosciences Inc 用於調節ｔｒｐｖ３功能之化合物
AU2007303846B2 (en) 2006-10-04 2011-03-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as calcium receptor antagonists
WO2008140750A1 (en) * 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
CN101429166B (zh) * 2007-11-07 2013-08-21 上海特化医药科技有限公司 喹唑啉酮衍生物及其制备方法和用途
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
CA2975473C (en) 2008-11-13 2021-01-19 Gilead Calistoga Llc Therapies for hematologic malignancies
JP2012521994A (ja) 2009-03-24 2012-09-20 ギリアード カリストガ エルエルシー ２−プリニル−３−トリル−キナゾリノン誘導体のアトロプ異性体および使用方法
CA2768843A1 (en) 2009-07-21 2011-01-27 Gilead Calistoga Llc Treatment of liver disorders with pi3k inhibitors
WO2013134288A1 (en) 2012-03-05 2013-09-12 Gilead Calistoga Llc Polymorphic forms of (s)-2-(1-(9h-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3h)-one
CN103275086B (zh) * 2013-05-30 2015-04-15 温州大学 一种6-取代喹唑啉并喹唑啉酮化合物及其合成方法和用途
AU2014364414A1 (en) 2013-12-20 2016-06-30 Gilead Calistoga Llc Polymorphic forms of a hydrochloride salt of (S) -2-(1-(9H-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3H) -one
JP2017502021A (ja) 2013-12-20 2017-01-19 ギリアード カリストガ エルエルシー ホスファチジルイノシトール３−キナーゼ阻害剤のためのプロセス方法
US9533909B2 (en) 2014-03-31 2017-01-03 Corning Incorporated Methods and apparatus for material processing using atmospheric thermal plasma reactor
EP3154960A1 (en) 2014-06-13 2017-04-19 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
DE102014217021A1 (de) * 2014-08-27 2016-03-03 Skf Lubrication Systems Germany Ag Gehäuse für eine Vorrichtung zum dosierten Verteilen eines Mediums sowie eine Dosiereinrichtung zur Verwendung in dem Gehäuse
WO2020124090A1 (en) 2018-12-14 2020-06-18 Eisai R&D Management Co., Ltd. Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds
AU2021212754A1 (en) 2020-01-29 2022-08-04 Kamari Pharma Ltd. Compounds and compositions for use in treating skin disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1195321B (de) * 1962-03-16 1965-06-24 Troponwerke Dinklage & Co Verfahren zur Herstellung von substituierten Chinazolon-(4)-derivaten
DE1670416A1 (de) * 1966-12-30 1971-02-11 Chem Fab Von Heyden Gmbh Muenc Verfahren zur Herstellung von aminosubstituierten Chinazolinonderivaten
US3748325A (en) * 1970-04-06 1973-07-24 Karamchand Premchand Private Process for the preparation of quinazolinone derivatives
US4183931A (en) * 1977-09-08 1980-01-15 Research Corporation 2-Ketoalkyl-4(3H)-quinazolinones
GB9022785D0 (en) * 1990-10-19 1990-12-05 Merck Sharp & Dohme Therapeutic agents
WO1992013535A1 (en) * 1991-02-06 1992-08-20 Research Corporation Technologies, Inc. Anticonvulsant substituted quinazolones
US5777271A (en) * 1996-01-18 1998-07-07 Commscope, Inc. Cable having an at least partially oxidized armor layer
CZ295565B6 (cs) * 1996-05-15 2005-08-17 Pfizer Inc. 2,3-Disubstituované 4(3H)-chinazolinony, jejich použití a farmaceutické kompozice na jejich bázi

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7872125B2 (en) 2000-08-18 2011-01-18 Ajinomoto Co., Inc. Phenylalanine derivatives
US8426588B2 (en) 2000-08-18 2013-04-23 Ajinomoto Co, Inc. Phenylalanine derivatives
US7345049B2 (en) 2003-12-22 2008-03-18 Ajinomoto Co., Inc. Phenylalanine derivatives
US8309561B2 (en) 2003-12-22 2012-11-13 Ajinomoto Co., Inc. Phenylalanine derivatives

Also Published As

Publication number Publication date
NO313630B1 (no) 2002-11-04
ES2219866T3 (es) 2004-12-01
DK0968194T3 (da) 2004-08-16
OA11089A (en) 2003-09-22
NO994177D0 (no) 1999-08-27
CA2282277A1 (en) 1998-09-03
ZA981666B (en) 1999-08-27
TW504508B (en) 2002-10-01
NZ336628A (en) 2001-03-30
SK113299A3 (en) 2001-05-10
CN1248248A (zh) 2000-03-22
UA61097C2 (uk) 2003-11-17
ATE267817T1 (de) 2004-06-15
UY24897A1 (es) 2000-12-29
DE69824157D1 (de) 2004-07-01
IL130900A0 (en) 2001-01-28
PA8447001A1 (es) 2000-05-24
CA2282277C (en) 2005-10-11
BG103689A (bg) 2000-11-30
NO994177L (no) 1999-08-27
HRP980106A2 (en) 1999-02-28
JP2000509731A (ja) 2000-08-02
EA199900693A1 (ru) 2000-02-28
TNSN98035A1 (fr) 2005-03-15
PL335418A1 (en) 2000-04-25
BR9807872A (pt) 2000-03-21
IS5140A (is) 1999-07-30
DZ2440A1 (fr) 2003-01-11
DE69824157T2 (de) 2004-10-14
IS1952B (is) 2004-10-13
KR20000075814A (ko) 2000-12-26
TR199902093T2 (xx) 1999-12-21
AP9801199A0 (en) 1998-03-31
GT199800038A (es) 1999-08-13
EA001963B1 (ru) 2001-10-22
WO1998038173A1 (en) 1998-09-03
EP0968194B1 (en) 2004-05-26
HUP0000914A3 (en) 2001-09-28
EP0968194A1 (en) 2000-01-05
MA24484A1 (fr) 1998-10-01
PT968194E (pt) 2004-08-31
AR011170A1 (es) 2000-08-02
PE58399A1 (es) 1999-06-16
AU5676898A (en) 1998-09-18
AU744028B2 (en) 2002-02-14
KR100358636B1 (ko) 2002-10-31
YU41299A (sh) 2002-09-19
US6306864B1 (en) 2001-10-23
ID22711A (id) 1999-12-09
AP859A (en) 2000-07-21

Similar Documents

Publication Publication Date Title
HUP0000914A2 (hu) 3-Aril-4 (3H)-kinazolinon-származékok atropizomerjei és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
ES2154167A1 (es) Aminoderivados ciclicos antagonistas del receptor ccr-3.
HUP0402352A2 (hu) Foszfodiészteráz (PDE) 7 inhibitorként alkalmazható pirimidinszármazékok és ezeket tartalmazó gyógyszerkészítmények
HUP0301573A2 (hu) Szubsztituált arilpirazinok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
EA200400466A1 (ru) Производные пиперазина с антагонистической активностью к рецептору ccr1
HUP0301069A2 (hu) Új biaril-karboxamidok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
DE60041973D1 (de) Substituierte piperidin-verbindungen als modulatoren der chemokine receptor aktivität
DE60021282D1 (de) Carbamat-derivate als muscarin-rezeptor antonisten
PT1000035E (pt) 6-fenilfenantridinas substituidas
ATE267200T1 (de) Bicyclische kinase inhibitoren
HUP0204413A2 (en) Quinazoline compounds, their preparation, their use and pharmaceutical compositions containing them
MXPA02012425A (es) Compuestos nuevos.
NO20062677L (no) Benzyleteraminforbindelser anvendbare som CCR-5-antagonister
YU11501A (sh) Derivati 4,4,-biarilpiperidina sa aktivnošću na receptor opijata
MA31521B1 (fr) Dérivés de 2,3-dihydrobenzo[1,4] dioxin-2-ylméthyle utilisés en tant qu'antagonistes des alpha2c pour traiter des maladies des systèmes nerveux périphérique et central
ATE293448T1 (de) Benzo(d)azepin-derivative als 5-ht6-rezeptor- antagonisten
HUP0202656A2 (hu) 1-Amino-triazolo[4,3-a]kinazolin-5-on- és/vagy -5-tion-származékok foszfodiészteráz-IV gátlására, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
ATE233754T1 (de) Diphenyl-piperidin derivate
TNSN04225A1 (fr) Derives de benzoxazine en tant que modulateurs de 5-ht6 et utilisations de ceux-ci
HUP0002300A2 (hu) 4-Kinolinkarboxamid-származékok, előállításuk, e vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk
HUP0000935A2 (hu) 3-Heteroaril-4(3H)-kinazolinon-származékok atropizomerjei és neurodegeneratív és központi idegrendszeri sérülésekkel kapcsolatos állapotok kezelésére történő alkalmazásuk
DE60101372D1 (de) Pyrimidinverbindungen und ihre verwendung als modulatoren der chemokin-rezeptor-aktivität
DE60208694D1 (de) Piperidinylmorpholinylderivate als modulatoren der aktivität des chemokinrezeptors
DE60014681D1 (de) Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
ATE429421T1 (de) Arylindenopyridin- und arylindenopyrimidinverbindungen und ihre verwendung als adenosin-a2a-rezeptor antagonisten