DE60014681D1 - Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha - Google Patents
Aminobenzophenone als inhibitoren von il-1beta und tnf-alphaInfo
- Publication number
- DE60014681D1 DE60014681D1 DE60014681T DE60014681T DE60014681D1 DE 60014681 D1 DE60014681 D1 DE 60014681D1 DE 60014681 T DE60014681 T DE 60014681T DE 60014681 T DE60014681 T DE 60014681T DE 60014681 D1 DE60014681 D1 DE 60014681D1
- Authority
- DE
- Germany
- Prior art keywords
- substituent
- alkyl
- group
- carbamoyl
- alkoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/60—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- AIDS & HIV (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14406299P | 1999-07-16 | 1999-07-16 | |
US144062P | 1999-07-16 | ||
PCT/DK2000/000387 WO2001005751A1 (en) | 1999-07-16 | 2000-07-11 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60014681D1 true DE60014681D1 (de) | 2004-11-11 |
DE60014681T2 DE60014681T2 (de) | 2006-02-02 |
Family
ID=22506888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60014681T Expired - Fee Related DE60014681T2 (de) | 1999-07-16 | 2000-07-11 | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha |
Country Status (18)
Country | Link |
---|---|
US (1) | US6750253B1 (de) |
EP (1) | EP1210325B1 (de) |
JP (1) | JP2003505363A (de) |
KR (1) | KR20020033733A (de) |
CN (1) | CN1249025C (de) |
AT (1) | ATE278663T1 (de) |
AU (1) | AU768878B2 (de) |
CA (1) | CA2379293A1 (de) |
CZ (1) | CZ2002157A3 (de) |
DE (1) | DE60014681T2 (de) |
DK (1) | DK1210325T3 (de) |
ES (1) | ES2228556T3 (de) |
HK (1) | HK1048464B (de) |
HU (1) | HUP0201913A3 (de) |
PL (1) | PL353644A1 (de) |
PT (1) | PT1210325E (de) |
RU (1) | RU2247719C2 (de) |
WO (1) | WO2001005751A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001090074A2 (en) | 2000-05-22 | 2001-11-29 | Leo Pharma A/S | BENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) |
EP1423356A2 (de) * | 2001-08-28 | 2004-06-02 | Leo Pharma A/S | Neue aminobenzophenone |
US20030225089A1 (en) * | 2002-04-10 | 2003-12-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors |
AU2003245989A1 (en) | 2002-07-09 | 2004-01-23 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
ATE469878T1 (de) | 2003-07-24 | 2010-06-15 | Leo Pharma As | Aminobenzophenonverbindungen |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
PL1828148T3 (pl) | 2004-12-13 | 2010-08-31 | Leo Pharma As | Triazol podstawiony związkami aminobenzofenonu |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
PL1988779T3 (pl) * | 2006-02-16 | 2015-10-30 | Anacor Pharmaceuticals Inc | Małe cząsteczki zawierające bor jako środki przeciwzapalne |
JP2009543758A (ja) * | 2006-03-16 | 2009-12-10 | モレアク プライベート リミテッド | 神経疾患および脳梗塞患者に対する治療のための併用療法 |
EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
EP2206534A1 (de) | 2008-10-09 | 2010-07-14 | c-a-i-r biosciences GmbH | Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten |
KR100984851B1 (ko) * | 2009-02-05 | 2010-10-04 | 주식회사 엠에스엠텍 | 램프이탈방지형 엘이디 조명 |
US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
US10684274B2 (en) | 2016-01-12 | 2020-06-16 | The George Washington University, A Congressionlly Chartered Not-For-Profit Corporation | Compounds inhibiting Nef-calnexin interaction |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9701453D0 (en) * | 1997-01-24 | 1997-03-12 | Leo Pharm Prod Ltd | Aminobenzophenones |
-
2000
- 2000-07-11 CA CA002379293A patent/CA2379293A1/en not_active Abandoned
- 2000-07-11 US US10/030,970 patent/US6750253B1/en not_active Expired - Fee Related
- 2000-07-11 KR KR1020027000600A patent/KR20020033733A/ko not_active Application Discontinuation
- 2000-07-11 ES ES00943701T patent/ES2228556T3/es not_active Expired - Lifetime
- 2000-07-11 PT PT00943701T patent/PT1210325E/pt unknown
- 2000-07-11 PL PL00353644A patent/PL353644A1/xx not_active Application Discontinuation
- 2000-07-11 DE DE60014681T patent/DE60014681T2/de not_active Expired - Fee Related
- 2000-07-11 CZ CZ2002157A patent/CZ2002157A3/cs unknown
- 2000-07-11 DK DK00943701T patent/DK1210325T3/da active
- 2000-07-11 RU RU2002103865/04A patent/RU2247719C2/ru not_active IP Right Cessation
- 2000-07-11 CN CNB008115044A patent/CN1249025C/zh not_active Expired - Fee Related
- 2000-07-11 HU HU0201913A patent/HUP0201913A3/hu unknown
- 2000-07-11 AT AT00943701T patent/ATE278663T1/de not_active IP Right Cessation
- 2000-07-11 EP EP00943701A patent/EP1210325B1/de not_active Expired - Lifetime
- 2000-07-11 AU AU58070/00A patent/AU768878B2/en not_active Ceased
- 2000-07-11 JP JP2001511412A patent/JP2003505363A/ja active Pending
- 2000-07-11 WO PCT/DK2000/000387 patent/WO2001005751A1/en active IP Right Grant
-
2003
- 2003-01-23 HK HK03100584.9A patent/HK1048464B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1210325B1 (de) | 2004-10-06 |
AU768878B2 (en) | 2004-01-08 |
WO2001005751A1 (en) | 2001-01-25 |
DE60014681T2 (de) | 2006-02-02 |
US6750253B1 (en) | 2004-06-15 |
ES2228556T3 (es) | 2005-04-16 |
AU5807000A (en) | 2001-02-05 |
CN1249025C (zh) | 2006-04-05 |
EP1210325A1 (de) | 2002-06-05 |
DK1210325T3 (da) | 2005-01-31 |
HUP0201913A3 (en) | 2002-11-28 |
CN1368957A (zh) | 2002-09-11 |
KR20020033733A (ko) | 2002-05-07 |
ATE278663T1 (de) | 2004-10-15 |
CA2379293A1 (en) | 2001-01-25 |
PT1210325E (pt) | 2005-01-31 |
JP2003505363A (ja) | 2003-02-12 |
HUP0201913A2 (en) | 2002-10-28 |
PL353644A1 (en) | 2003-12-01 |
RU2247719C2 (ru) | 2005-03-10 |
HK1048464B (zh) | 2006-09-01 |
CZ2002157A3 (cs) | 2002-08-14 |
HK1048464A1 (en) | 2003-04-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |