DE69824157D1 - Atropisomere von 3-aryl-4(3h)-chinazolinonen und ihre verwendung als ampa-rezeptor - Google Patents
Atropisomere von 3-aryl-4(3h)-chinazolinonen und ihre verwendung als ampa-rezeptorInfo
- Publication number
- DE69824157D1 DE69824157D1 DE69824157T DE69824157T DE69824157D1 DE 69824157 D1 DE69824157 D1 DE 69824157D1 DE 69824157 T DE69824157 T DE 69824157T DE 69824157 T DE69824157 T DE 69824157T DE 69824157 D1 DE69824157 D1 DE 69824157D1
- Authority
- DE
- Germany
- Prior art keywords
- quinazolinones
- atropisomers
- aryl
- ampa receptor
- ampa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Adhesives Or Adhesive Processes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3890597P | 1997-02-28 | 1997-02-28 | |
| US38905P | 1997-02-28 | ||
| PCT/IB1998/000150 WO1998038173A1 (en) | 1997-02-28 | 1998-02-06 | Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as ampa-receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69824157D1 true DE69824157D1 (de) | 2004-07-01 |
| DE69824157T2 DE69824157T2 (de) | 2004-10-14 |
Family
ID=21902563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69824157T Expired - Fee Related DE69824157T2 (de) | 1997-02-28 | 1998-02-06 | Atropisomere von 3-aryl-4(3h)-chinazolinonen und ihre verwendung als ampa-rezeptor |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US6306864B1 (de) |
| EP (1) | EP0968194B1 (de) |
| JP (1) | JP2000509731A (de) |
| KR (1) | KR100358636B1 (de) |
| CN (1) | CN1248248A (de) |
| AP (1) | AP859A (de) |
| AR (1) | AR011170A1 (de) |
| AT (1) | ATE267817T1 (de) |
| AU (1) | AU744028B2 (de) |
| BG (1) | BG103689A (de) |
| BR (1) | BR9807872A (de) |
| CA (1) | CA2282277C (de) |
| DE (1) | DE69824157T2 (de) |
| DK (1) | DK0968194T3 (de) |
| DZ (1) | DZ2440A1 (de) |
| EA (1) | EA001963B1 (de) |
| ES (1) | ES2219866T3 (de) |
| GT (1) | GT199800038A (de) |
| HR (1) | HRP980106A2 (de) |
| HU (1) | HUP0000914A3 (de) |
| ID (1) | ID22711A (de) |
| IL (1) | IL130900A0 (de) |
| IS (1) | IS1952B (de) |
| MA (1) | MA24484A1 (de) |
| NO (1) | NO313630B1 (de) |
| NZ (1) | NZ336628A (de) |
| OA (1) | OA11089A (de) |
| PA (1) | PA8447001A1 (de) |
| PE (1) | PE58399A1 (de) |
| PL (1) | PL335418A1 (de) |
| PT (1) | PT968194E (de) |
| SK (1) | SK113299A3 (de) |
| TN (1) | TNSN98035A1 (de) |
| TR (1) | TR199902093T2 (de) |
| TW (1) | TW504508B (de) |
| UA (1) | UA61097C2 (de) |
| UY (1) | UY24897A1 (de) |
| WO (1) | WO1998038173A1 (de) |
| YU (1) | YU41299A (de) |
| ZA (1) | ZA981666B (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT901487E (pt) | 1996-05-15 | 2003-08-29 | Pfizer | 4(3h)-quinazolinonas 2,3,6-trissubstituidas |
| US6323208B1 (en) * | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
| JPH11279158A (ja) * | 1998-02-09 | 1999-10-12 | Pfizer Prod Inc | キナゾリン―４―オン誘導体の製造方法 |
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| EP1278748B1 (de) * | 2000-04-25 | 2011-03-23 | ICOS Corporation | Hemmer der menschlichen phosphatidyl-inositol-3-kinase delta |
| US6949571B2 (en) | 2000-06-12 | 2005-09-27 | Eisai Co., Ltd. | 1,2-dihydropyridine compounds, process for preparation of the same and use thereof |
| CN1325480C (zh) | 2000-08-18 | 2007-07-11 | 味之素株式会社 | 苯基丙氨酸衍生物 |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| US6939968B2 (en) * | 2002-12-23 | 2005-09-06 | Bristol-Myers Squibb Company | Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives |
| US20080146562A1 (en) * | 2003-08-08 | 2008-06-19 | Ulysses Pharmaceutical Products Inc., | Halogenated quinazolinyl nitrofurans as antibacterial agents |
| AU2004262533A1 (en) * | 2003-08-08 | 2005-02-17 | Ulysses Pharmaceutical Products Inc. | Halogenated quinazolinyl nitrofurans as antibacterial agents |
| GB0325390D0 (en) * | 2003-10-30 | 2003-12-03 | Novartis Ag | Organic compounds |
| RU2390520C2 (ru) | 2003-12-22 | 2010-05-27 | Адзиномото Ко., Инк. | Новые производные фенилаланина |
| EP1761540B1 (de) | 2004-05-13 | 2016-09-28 | Icos Corporation | Chinazolinone als inhibitoren der humanen phosphatidylinosit-3-kinase delta |
| MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| GB0416730D0 (en) * | 2004-07-27 | 2004-09-01 | Novartis Ag | Organic compounds |
| WO2007056124A2 (en) | 2005-11-04 | 2007-05-18 | Hydra Biosciences, Inc. | Compounds for modulating trpv3 function |
| MX2009003673A (es) | 2006-10-04 | 2009-04-22 | Pfizer Prod Inc | Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio. |
| WO2008140750A1 (en) * | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Compounds for modulating trpv3 function |
| CN101429166B (zh) * | 2007-11-07 | 2013-08-21 | 上海特化医药科技有限公司 | 喹唑啉酮衍生物及其制备方法和用途 |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| CA3092449A1 (en) | 2008-11-13 | 2010-05-20 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| MX2011009955A (es) | 2009-03-24 | 2011-11-18 | Gilead Calistoga Llc | Atropisomeros de derivados de 2-purinil-3-tolil-quinazolinona y metodos de uso. |
| MX2012000817A (es) | 2009-07-21 | 2012-05-08 | Gilead Calistoga Llc | Tratamiento para desordenes del higado con inhibidores pi3k. |
| AU2013203620B2 (en) | 2012-03-05 | 2015-11-19 | Gilead Calistoga Llc | Polymorphic forms of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one |
| CN103275086B (zh) * | 2013-05-30 | 2015-04-15 | 温州大学 | 一种6-取代喹唑啉并喹唑啉酮化合物及其合成方法和用途 |
| PL3083630T3 (pl) | 2013-12-20 | 2020-02-28 | Gilead Calistoga Llc | Sposoby otrzymywania inhibitorów 3-kinazy fosfatydyloinozytolu |
| JP2017500319A (ja) | 2013-12-20 | 2017-01-05 | ギリアード カリストガ エルエルシー | （ｓ）−２−（１−（９ｈ−プリン−６−イルアミノ）プロピル）−５−フルオロ−３−フェニルキナゾリン−４（３ｈ）−オンの塩酸塩の多形形態 |
| US9533909B2 (en) | 2014-03-31 | 2017-01-03 | Corning Incorporated | Methods and apparatus for material processing using atmospheric thermal plasma reactor |
| NZ726360A (en) | 2014-06-13 | 2018-04-27 | Gilead Sciences Inc | Phosphatidylinositol 3-kinase inhibitors |
| DE102014217021A1 (de) * | 2014-08-27 | 2016-03-03 | Skf Lubrication Systems Germany Ag | Gehäuse für eine Vorrichtung zum dosierten Verteilen eines Mediums sowie eine Dosiereinrichtung zur Verwendung in dem Gehäuse |
| WO2020124090A1 (en) | 2018-12-14 | 2020-06-18 | Eisai R&D Management Co., Ltd. | Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds |
| AU2021212754A1 (en) | 2020-01-29 | 2022-08-04 | Kamari Pharma Ltd. | Compounds and compositions for use in treating skin disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1195321B (de) * | 1962-03-16 | 1965-06-24 | Troponwerke Dinklage & Co | Verfahren zur Herstellung von substituierten Chinazolon-(4)-derivaten |
| DE1670416A1 (de) * | 1966-12-30 | 1971-02-11 | Chem Fab Von Heyden Gmbh Muenc | Verfahren zur Herstellung von aminosubstituierten Chinazolinonderivaten |
| US3748325A (en) * | 1970-04-06 | 1973-07-24 | Karamchand Premchand Private | Process for the preparation of quinazolinone derivatives |
| US4183931A (en) * | 1977-09-08 | 1980-01-15 | Research Corporation | 2-Ketoalkyl-4(3H)-quinazolinones |
| GB9022785D0 (en) * | 1990-10-19 | 1990-12-05 | Merck Sharp & Dohme | Therapeutic agents |
| WO1992013535A1 (en) * | 1991-02-06 | 1992-08-20 | Research Corporation Technologies, Inc. | Anticonvulsant substituted quinazolones |
| US5777271A (en) * | 1996-01-18 | 1998-07-07 | Commscope, Inc. | Cable having an at least partially oxidized armor layer |
| PT901487E (pt) * | 1996-05-15 | 2003-08-29 | Pfizer | 4(3h)-quinazolinonas 2,3,6-trissubstituidas |
-
1998
- 1998-02-06 DE DE69824157T patent/DE69824157T2/de not_active Expired - Fee Related
- 1998-02-06 AT AT98900978T patent/ATE267817T1/de not_active IP Right Cessation
- 1998-02-06 SK SK1132-99A patent/SK113299A3/sk unknown
- 1998-02-06 PL PL98335418A patent/PL335418A1/xx unknown
- 1998-02-06 BR BR9807872A patent/BR9807872A/pt not_active Application Discontinuation
- 1998-02-06 WO PCT/IB1998/000150 patent/WO1998038173A1/en not_active Application Discontinuation
- 1998-02-06 KR KR1019997007887A patent/KR100358636B1/ko not_active IP Right Cessation
- 1998-02-06 CA CA002282277A patent/CA2282277C/en not_active Expired - Fee Related
- 1998-02-06 AU AU56768/98A patent/AU744028B2/en not_active Ceased
- 1998-02-06 EP EP98900978A patent/EP0968194B1/de not_active Expired - Lifetime
- 1998-02-06 CN CN98802638A patent/CN1248248A/zh active Pending
- 1998-02-06 PT PT98900978T patent/PT968194E/pt unknown
- 1998-02-06 YU YU41299A patent/YU41299A/sh unknown
- 1998-02-06 US US09/367,960 patent/US6306864B1/en not_active Expired - Fee Related
- 1998-02-06 HU HU0000914A patent/HUP0000914A3/hu unknown
- 1998-02-06 DK DK98900978T patent/DK0968194T3/da active
- 1998-02-06 TR TR1999/02093T patent/TR199902093T2/xx unknown
- 1998-02-06 EA EA199900693A patent/EA001963B1/ru not_active IP Right Cessation
- 1998-02-06 IL IL13090098A patent/IL130900A0/xx unknown
- 1998-02-06 NZ NZ336628A patent/NZ336628A/xx unknown
- 1998-02-06 JP JP10537448A patent/JP2000509731A/ja active Pending
- 1998-02-06 ES ES98900978T patent/ES2219866T3/es not_active Expired - Lifetime
- 1998-02-06 ID IDW990937A patent/ID22711A/id unknown
- 1998-02-17 PA PA19988447001A patent/PA8447001A1/es unknown
- 1998-02-19 GT GT199800038A patent/GT199800038A/es unknown
- 1998-02-20 UY UY24897A patent/UY24897A1/es not_active Application Discontinuation
- 1998-02-23 PE PE1998000126A patent/PE58399A1/es not_active Application Discontinuation
- 1998-02-25 DZ DZ980050A patent/DZ2440A1/xx active
- 1998-02-25 TN TNTNSN98035A patent/TNSN98035A1/fr unknown
- 1998-02-25 MA MA24978A patent/MA24484A1/fr unknown
- 1998-02-25 TW TW087102714A patent/TW504508B/zh not_active IP Right Cessation
- 1998-02-26 AP APAP/P/1998/001199A patent/AP859A/en active
- 1998-02-26 AR ARP980100871A patent/AR011170A1/es not_active Application Discontinuation
- 1998-02-27 ZA ZA9801666A patent/ZA981666B/xx unknown
- 1998-02-27 HR HR60/038,905A patent/HRP980106A2/hr not_active Application Discontinuation
- 1998-06-02 UA UA99084849A patent/UA61097C2/uk unknown
-
1999
- 1999-07-30 IS IS5140A patent/IS1952B/is unknown
- 1999-08-20 OA OA9900187A patent/OA11089A/en unknown
- 1999-08-24 BG BG103689A patent/BG103689A/bg unknown
- 1999-08-27 NO NO19994177A patent/NO313630B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69824157D1 (de) | Atropisomere von 3-aryl-4(3h)-chinazolinonen und ihre verwendung als ampa-rezeptor | |
| ATE268761T1 (de) | Substituierte quinazolin-derivate und ihre verwendung als tyrosin-kinase inhibitoren | |
| DE59903869D1 (de) | Verwendung von nanoskaligen sterolen und sterolestern | |
| ATE402177T1 (de) | Bicyclische pyrimidine und bicyclische 3,4- dihydropyrimidine als inhibitoren der zellvermehrung | |
| ATE375344T1 (de) | Azolotriazine und pyrimidine | |
| DE69332898D1 (de) | 4-Carboxamidopiperidinderivate und ihre Verwendung als Neurokinin Antagonisten | |
| DE60036803D1 (de) | Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel | |
| ATE250035T1 (de) | Chinolin- und chinazolin-derivate als crf antagonisten | |
| DE69430279D1 (de) | Pyrimidinverbindungen und ihre Verwendung als Pharmazeutika | |
| DE69826693D1 (de) | Amidinoderivate und ihre verwendung als thrombininhibitoren | |
| DE60106607D1 (de) | Substituierte 1-aminoalkyl-lactame und ihre verwendung als muscarinrezeptor antagonisten | |
| DE59710003D1 (de) | Salze von 1-Hydroxy-dihydrophospholoxiden und 1-Hydroxy-phospholanoxiden und ihre Verwendung als Flammschutzmittel | |
| DE69610316T2 (de) | Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste | |
| DZ2438A1 (fr) | Atropisomères de 3-hétéroaryl-4(3h)-quinazolinones. | |
| ATE221529T1 (de) | Oxadiazolinderivate und ihre verwendung als insektizide | |
| DE69703437T2 (de) | 2-(3h)-oxazolone-derivate und ihre verwendung als cox-2 inhibitoren | |
| DE69827393D1 (de) | Kosmetische verwendung von bis-resorcinol-triazinderivaten | |
| ATE253059T1 (de) | Substituierte 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2- one und ihre verwendung als lipase-hemmer | |
| ATE260258T1 (de) | Substituierte isochinoline derivate und ihre verwendung als anticonvulsiva | |
| DE59905472D1 (de) | Verwendung von 2-(n-phenylamino)pyrimidinen als fungizide sowie neue 2-(n-phenylamino)pyrimidine | |
| DE59806523D1 (de) | Substituierte heterocyclische Benzocycloalkene und ihre Verwendung als analgetisch wirksame Substanzen | |
| DE59809194D1 (de) | 8-Ocimenylester und ihre Verwendung als Riech- und Aromastoffe | |
| DE69623941T2 (de) | Phenyl derivate und ihre verwendung als endothelin rezeptor | |
| DE59610382D1 (de) | Halogenbenzimidazole und ihre verwendung als mikrobizide | |
| DE60008539D1 (de) | Substituierte isochinolinderivate und ihre verwendung als anticonvulsiva |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |